Spencer MR, Minino AM, Warner M. Drug overdose deaths in the United States, 2001–2021. NCHS Data Brief. 2022;457:1–8.

Google Scholar 

Florence C, Luo F, Rice K. The economic burden of opioid use disorder and fatal opioid overdose in the United States, 2017. Drug Alcohol Depend. 2021;218: 108350. https://doi.org/10.1016/j.drugalcdep.2020.108350.

Article  CAS  PubMed  Google Scholar 

Slavova S, Quesinberry D, Hargrove S, Rock P, Brancato C, Freeman PR, Walsh SL. Trends in drug overdose mortality rates in Kentucky, 2019–2020. JAMA Netw Open. 2021;4:e2116391. https://doi.org/10.1001/jamanetworkopen.2021.16391.

Article  PubMed  PubMed Central  Google Scholar 

Centers for Disease Control and Prevention, National Center for Health Statistics. Drug overdose mortality by state. https://www.cdc.gov/nchs/pressroom/sosmap/drug_poisoning_mortality/drug_poisoning.htm. Accessed 5 Oct 2023.

Centers for Disease Control and Prevention, National Center for Health Statistics. National Vital statistics system, mortality 2018–2021 on CDC WONDER online database. http://wonder.cdc.gov/mcd-icd10-expanded.html. Accesed 27 Mar 2023.

Friedman J, Akre S. COVID-19 and the drug overdose crisis: uncovering the deadliest months in the United States, January–July 2020. Am J Public Health. 2021;111:1284–91. https://doi.org/10.2105/AJPH.2021.306256.

Article  PubMed  PubMed Central  Google Scholar 

Jones JD, Campbell AN, Brandt L, Metz VE, Martinez S, Wall M, Corbeil T, Andrews H, Castillo F, Neale J, et al. A randomized clinical trial of the effects of brief versus extended opioid overdose education on naloxone utilization outcomes by individuals with opioid use disorder. Drug Alcohol Depend. 2022;237: 109505. https://doi.org/10.1016/j.drugalcdep.2022.109505.

Article  PubMed  PubMed Central  Google Scholar 

McDonald R, Strang J. Are take-home naloxone programmes effective? Systematic review utilizing application of the Bradford Hill criteria. Addiction. 2016;111:1177–87. https://doi.org/10.1111/add.13326.

Article  PubMed  PubMed Central  Google Scholar 

Clark AK, Wilder CM, Winstanley EL. A systematic review of community opioid overdose prevention and naloxone distribution programs. J Addict Med. 2014;8:153–63. https://doi.org/10.1097/ADM.0000000000000034.

Article  CAS  PubMed  Google Scholar 

Razaghizad A, Windle SB, Filion KB, Gore G, Kudrina I, Paraskevopoulos E, Kimmelman J, Martel MO, Eisenberg MJ. The effect of overdose education and naloxone distribution: an umbrella review of systematic reviews. Am J Public Health. 2021;111:e1–12. https://doi.org/10.2105/AJPH.2021.306306.

Article  PubMed  PubMed Central  Google Scholar 

Holmes LM, Rishworth A, King BH. Disparities in opioid overdose survival and naloxone administration in Pennsylvania. Drug Alcohol Depend. 2022;238: 109555. https://doi.org/10.1016/j.drugalcdep.2022.109555.

Article  CAS  PubMed  Google Scholar 

Jones JD, Roux P, Stancliff S, Matthews W, Comer SD. Brief overdose education can significantly increase accurate recognition of opioid overdose among heroin users. Int J Drug Policy. 2014;25:166–70. https://doi.org/10.1016/j.drugpo.2013.05.006.

Article  PubMed  Google Scholar 

Tse WC, Djordjevic F, Borja V, Picco L, Lam T, Olsen A, Larney S, Dietze P, Nielsen S. Does naloxone provision lead to increased substance use? A systematic review to assess if there is evidence of a ‘moral hazard’ associated with naloxone supply. Int J Drug Policy. 2022;100: 103513. https://doi.org/10.1016/j.drugpo.2021.103513.

Article  PubMed  Google Scholar 

Naumann RB, Durrance CP, Ranapurwala SI, Austin AE, Proescholdbell S, Childs R, Marshall SW, Kansagra S, Shanahan ME. Impact of a community-based naloxone distribution program on opioid overdose death rates. Drug Alcohol Depend. 2019;204:107536. https://doi.org/10.1016/j.drugalcdep.2019.06.038.

Article  PubMed  PubMed Central  Google Scholar 

Walley AY, Xuan Z, Hackman HH, Quinn E, Doe-Simkins M, Sorensen-Alawad A, Ruiz S, Ozonoff A. Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: interrupted time series analysis. BMJ. 2013;346: f174. https://doi.org/10.1136/bmj.f174.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Irvine MA, Kuo M, Buxton JA, Balshaw R, Otterstatter M, Macdougall L, Milloy MJ, Bharmal A, Henry B, Tyndall M, et al. Modelling the combined impact of interventions in averting deaths during a synthetic-opioid overdose epidemic. Addiction. 2019;114:1602–13. https://doi.org/10.1111/add.14664.

Article  PubMed  PubMed Central  Google Scholar 

Rao IJ, Humphreys K, Brandeau ML. Effectiveness of policies for addressing the US opioid epidemic: a model-based analysis from the Stanford-Lancet Commission on the North American Opioid Crisis. Lancet Reg Health Am. 2021. https://doi.org/10.1016/j.lana.2021.100031.

Article  PubMed  PubMed Central  Google Scholar 

Pitt AL, Humphreys K, Brandeau ML. Modeling health benefits and harms of public policy responses to the US opioid epidemic. Am J Public Health. 2018;108:1394–400. https://doi.org/10.2105/AJPH.2018.304590.

Article  PubMed  PubMed Central  Google Scholar 

Irvine MA, Oller D, Boggis J, Bishop B, Coombs D, Wheeler E, Doe-Simkins M, Walley AY, Marshall BDL, Bratberg J, Green TC. Estimating naloxone need in the USA across fentanyl, heroin, and prescription opioid epidemics: a modelling study. Lancet Public Health. 2022;7:e210–8. https://doi.org/10.1016/S2468-2667(21)00304-2.

Article  PubMed  Google Scholar 

Lambdin BH, Bluthenthal RN, Wenger LD, Wheeler E, Garner B, Lakosky P, Kral AH. Overdose education and naloxone distribution within syringe service programs—United States, 2019. MMWR Morb Mortal Wkly Rep. 2020;69:1117–21. https://doi.org/10.15585/mmwr.mm6933a2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hill LG, Loera LJ, Torrez SB, Puzantian T, Evoy KE, Ventricelli DJ, Eukel HN, Peckham AM, Chen C, Ganetsky VS, et al. Availability of buprenorphine/naloxone films and naloxone nasal spray in community pharmacies in 11 U.S. states. Drug Alcohol Depend. 2022;237: 109518. https://doi.org/10.1016/j.drugalcdep.2022.109518.

Article  CAS  PubMed  Google Scholar 

Kilaru AS, Liu M, Gupta R, Perrone J, Delgado MK, Meisel ZF, Lowenstein M. Naloxone prescriptions following emergency department encounters for opioid use disorder, overdose, or withdrawal. Am J Emerg Med. 2021;47:154–7. https://doi.org/10.1016/j.ajem.2021.03.056.

Article  PubMed  PubMed Central  Google Scholar 

Katzman JG, Takeda MY, Greenberg N, Moya Balasch M, Alchbli A, Katzman WG, Salvador JG, Bhatt SR. Association of take-home naloxone and opioid overdose reversals performed by patients in an opioid treatment program. JAMA Netw Open. 2020;3:e200117. https://doi.org/10.1001/jamanetworkopen.2020.0117.

Article  PubMed  PubMed Central  Google Scholar 

Agley J, Xiao Y, Eldridge L, Meyerson B, Golzarri-Arroyo L. Beliefs and misperceptions about naloxone and overdose among U.S. laypersons: a cross-sectional study. BMC Public Health. 2022;22:924. https://doi.org/10.1186/s12889-022-13298-3.

Article  PubMed  PubMed Central  Google Scholar 

McDonald R, Campbell ND, Strang J. Twenty years of take-home naloxone for the prevention of overdose deaths from heroin and other opioids-conception and maturation. Drug Alcohol Depend. 2017;178:176–87. https://doi.org/10.1016/j.drugalcdep.2017.05.001.

Article  PubMed  Google Scholar 

Aarons GA, Hurlburt M, Horwitz SM. Advancing a conceptual model of evidence-based practice implementation in public service sectors. Adm Policy Ment Health. 2011;38:4–23. https://doi.org/10.1007/S10488-010-0327-7.

Article  PubMed  Google Scholar 

Feldstein AC, Glasgow RE. A practical, robust implementation and sustainability model (PRISM) for integrating research findings into practice. Joint Comm J Qual Patient Saf. 2008;34:228–43.

Google Scholar 

Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50. https://doi.org/10.1186/1748-5908-1184-1150.

Article  PubMed  PubMed Central  Google Scholar 

Damschroder LJ, Reardon CM, Widerquist MAO, Lowery J. The updated consolidated framework for implementation research based on user feedback. Implement Sci. 2022;17:75. https://doi.org/10.1186/s13012-022-01245-0.

Article  PubMed  PubMed Central  Google Scholar 

Proctor E, Silmere H, Raghavan R, Hovmand P, Aarons G, Bunger A, Griffey R, Hensley M. Outcomes for implementation research: conceptual distinctions, measurement challenges, and research agenda. Adm Policy Mental Health Mental Health Serv Res. 2011;38:65–76. https://doi.org/10.1007/S10488-010-0319-7.

Article  Google Scholar 

Glasgow RE, Vogt TM, Boles SM. Evaluating the public health impact of health promotion interventions: the RE-AIM framework. Am J Public Health. 1999;89:1322–7. https://doi.org/10.2105/ajph.89.9.1322.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Powell BJ, Waltz TJ, Chinman MJ, Damschroder LJ, Smith JL, Matthieu MM, Proctor EK, Kirchner JE. A refined compilation of implementation strategies: results from the expert recommendations for implementing change (ERIC) project. Implement Sci. 2015;10:21. https://doi.org/10.1186/s13012-015-0209-1.

Article  PubMed  PubMed Central  Google Scholar 

Powell BJ, McMillen JC, Proctor EK, Carpenter CR, Griffey RT, Bunger AC, Glass JE, York JL. A compilation of strategies for implementing clinical innovations in health and mental health. Med Care Res Rev. 2012;69:123–57.

Article  PubMed  Google Scholar 

Winstanley EL, Clark A, Feinberg J, Wilder CM. Barriers to implementation of opioid overdose prevention programs in Ohio. Subst Abus. 2016;37:42–6. https://doi.org/10.1080/08897077.2015.1132294.

Article  PubMed  PubMed Central