Exploring the underlying mechanisms of fisetin in the treatment of hepatic insulin resistance via network pharmacology and in vitro validation

Pandey AR, Aryal KK, Shrestha N, Sharma D, Maskey J, Dhimal M. Burden of diabetes mellitus in Nepal: an analysis of global burden of disease study 2019. J Diabetes Res. 2022;20:4701796.

Google Scholar 

Taylor R. Type 2 diabetes: etiology and reversibility. Diabetes Care. 2013;36(4):1047–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cook JR, Langlet F, Kido Y, Accili D. Pathogenesis of selective insulin resistance in isolated hepatocytes. J Biol Chem. 2015;290(22):13972–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yen FS, Qin CS, Xuan STS, Ying PJ, Le HY, Darmarajan T, et al. Hypoglycemic effects of plant flavonoids: a review. Evid Based Complement Alternat Med. 2021;2021:2057333.

Google Scholar 

Shen B, Shang X, Yin Z, Wu S, Zhang Q, Peng W, et al. Inhibitory effect of fisetin on α-glucosidase activity: kinetic and molecular docking studies. Molecules. 2021;26(17):5306.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi YS, Li CB, Li XY, Wu J, Li Y, Fu X, et al. Fisetin attenuates metabolic dysfunction in mice challenged with a high-fructose diet. J Agric Food Chem. 2018;66(31):8291–8.

Article  CAS  PubMed  Google Scholar 

Choi MS, Choi JY, Kwon EY. Fisetin Alleviates hepatic and adipocyte fibrosis and insulin resistance in diet-induced obese mice. J Med Food. 2020;23(10):1019–32.

Article  CAS  PubMed  Google Scholar 

Menacer R, Rekkab S, Kabouche Z. Fisetin and Robinetin antiradical activity under solvent effect: density functional theory study. J Mol Model. 2022;28(8):240.

Article  CAS  PubMed  Google Scholar 

Lee ER, Kang GH, Cho SG. Effect of flavonoids on human health: old subjects but new challenges. Recent Pat Biotechol. 2007;1(2):139–50.

Article  CAS  Google Scholar 

Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, et al. PubChem in 2021: new data content and improved web interfaces. Nucleic Acids Res. 2021;49(D1):D1388–95.

Article  CAS  PubMed  Google Scholar 

Stelzer G, Dalah I, Stein TI, Satanower Y, Rosen N, Nativ N, et al. In-silico human genomics with GeneCards. Hum Genomics. 2011;5(6):709–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu W, Li Y, Zhao J, Wang Y, Li Y, Wang Y. The mechanism of triptolide in the treatment of connective tissue disease-related interstitial lung disease based on network pharmacology and molecular docking. Ann Med. 2022;54(1):541–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kerrien S, Aranda B, Breuza L, Bridge A, Broackes-Carter F, Chen C, et al. The IntAct molecular interaction database in 2012. Nucleic Acids Res. 2012;40:D41-846.

Article  Google Scholar 

Hu L, Mao Q, Wang YM, Jiang YG, Deng GH, Jiang L. A study on the situations of human L02 hepatocytes in genetically tolerized immunocompetent rats”. Zhonghua Gan Zang Bing Za Zhi. 2006;14(8):578–81.

Google Scholar 

Ferguson KM, Hu C, Lemmon MA. Insulin and epidermal growth factor receptor family members share parallel activation mechanisms. Protein Sci. 2020;29(6):1331–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2001;2(2):127–37.

Article  CAS  PubMed  Google Scholar 

Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer. 2004;4(5):361–70.

Article  CAS  PubMed  Google Scholar 

Burgess AW. EGFR family: structure physiology signalling and therapeutic targets. Growth Factors. 2008;26(5):263–74.

Article  CAS  PubMed  Google Scholar 

Sabbah DA, Hajjo R, Sweidan K. Review on epidermal growth factor receptor (EGFR) structure, signalling pathways, interactions, and recent updates of EGFR inhibitors. Curr Top Med Chem. 2020;20(10):815–34.

Article  CAS  PubMed  Google Scholar 

Prasath GS, Subramanian SP. Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2011;668(3):492–6.

Article  CAS  PubMed  Google Scholar 

Wang L, Chen N, Cheng H. Fisetin inhibits vascular endothelial growth factor-induced angiogenesis in retinoblastoma cells. Oncol lett. 2020;20(2):1239–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pal HC, Athar M, Elmets CA, Afaq F. Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFκB signaling pathways in SKH-1 hairless mice. Photochem Photobiol. 2015;91(1):225–34.

Article  CAS  PubMed  Google Scholar 

Bäck M, Hansson GK. Anti-inflammatory therapies for atherosclerosis. Nat Rev Cardiol. 2015;12(4):199–211.

Article  PubMed  Google Scholar 

Li X, Chen G, Zhang X, Zhang Q, Zheng S, Wang G, et al. A new class of flavonol-based anti-prostate cancer agents: Design, synthesis, and evaluation in cell models. Bioorg Med Chem Lett. 2016;26(17):4241–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pei J, Wang B, Wang D. Current studies on molecular mechanisms of insulin resistance. J Diabetes Res. 2022;2022:1863429.

Article  PubMed  PubMed Central  Google Scholar 

Yaribeygi H, Farrokhi FR, Butler AE, Sahebkar A. insulin resistance: Review of the underlying molecular mechanisms. J Cell Physiol. 2019;234(6):8152–61.

Article  CAS  PubMed  Google Scholar 

Han JDJ, Bertin N, Hao T, Goldberg DS, Berriz GF, Zhang LV, et al. Evidence for dynamically organized modularity in the yeast protein-protein interaction network. Nature. 2004;430(6995):88–93.

Article  CAS  PubMed  Google Scholar 

Das S, Meher PK, Rai A, Bhar LM, Mandal BN. Statistical approaches for gene selection, hub gene identification and module interaction in gene co-expression network analysis: an application to aluminum stress in soybean (glycine max L.). PLoS ONE. 2017;12(1):e0169605.

Article  PubMed  PubMed Central  Google Scholar 

Demir S, Wolff G, Wieder A, Maida A, Buhler L, Brune M, et al. TSC22D4 interacts with Akt1 to regulate glucose metabolism. Sci adv. 2022;8(42):eabo5555.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borst SE. The role of TNF-alpha in insulin resistance. Endocrine. 2004;23(2–3):177–82.

Article  CAS  PubMed  Google Scholar 

Schliess F, Reissmann R, Reinehr R, Dahl SV, Häussinger D. Involvement of integrins and Src in insulin signaling toward autophagic proteolysis in rat liver. J Biol Chem. 2004;279(20):21294–301.

Article  CAS  PubMed  Google Scholar 

Sato H, Nagashima K, Ogura M, Sato Y, Tahara Y, Ogura K, et al. Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β-cells. J Diabetes investig. 2016;7(2):171–8.

Article  CAS  PubMed  Google Scholar 

Sommerfeld A, Reinehr R, Häussinger D. Free fatty acids shift insulin-induced hepatocyte proliferation towards CD95-dependent apoptosis. J Biol Chem. 2015;290(7):4398–409.

Article  CAS  PubMed  Google Scholar 

Sabbah DA, Hajjo R, Sweidan K. Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR Inhibitors. Cur Top Med Chem. 2020;20(10):815–34.

Article  CAS  Google Scholar 

Gao P, Hu Y, Wang J, Ni Y, Zhu Z, Wang H, et al. Underlying mechanism of insulin resistance: a bioinformatics analysis based on validated related-genes from public disease databases. Med Sci Monit. 2020;26: e924334.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riedel H, Dull TJ, Schlessinger J, Ullrich A. A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor. Nature. 1986;324(6092):68–70.

Article  CAS  PubMed  Google Scholar 

Tomas A, Futter CE, Eden ER. EGF receptor trafficking: consequences for signaling and cancer. Trends Cell Biol. 2014;24(1):26–34.

Article  CAS  PubMed  PubMed Central 

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