Spexin ameliorated obesity-related metabolic disorders through promoting white adipose browning mediated by JAK2-STAT3 pathway

Upadhyay J, Farr O, Perakakis N, Ghaly W, Mantzoros C. Obesity as a disease. MED CLIN N AM. 2018;102:13–33.

Article  PubMed  Google Scholar 

Swinburn BA, Kraak VI, Allender S, Atkins VJ, Baker PI, Bogard JR, Brinsden H, Calvillo A, De Schutter O, Devarajan R, Ezzati M, Friel S, Goenka S, Hammond RA, Hastings G, Hawkes C, Herrero M, Hovmand PS, Howden M, Jaacks LM, Kapetanaki AB, Kasman M, Kuhnlein HV, Kumanyika SK, Larijani B, Lobstein T, Long MW, Matsudo V, Mills S, Morgan G, Morshed A, Nece PM, Pan A, Patterson DW, Sacks G, Shekar M, Simmons GL, Smit W, Tootee A, Vandevijvere S, Waterlander WE, Wolfenden L, Dietz WH. 2019 The Global Syndemic of obesity, Undernutrition, and Climate Change: the Lancet Commission report. Lancet 393:791–846.

Piche ME, Tchernof A, Despres JP. 2020 obesity phenotypes, diabetes, and Cardiovascular diseases. CIRC RES 126:1477–500.

Marcelin G, Silveira A, Martins LB, Ferreira AV. Clement K 2019 deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis. J CLIN INVEST 129:4032–40.

Morigny P, Boucher J, Arner P, Langin D. Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics. NAT REV ENDOCRINOL. 2021;17:276–95.

Article  CAS  PubMed  Google Scholar 

Hu J, Christian M. Hormonal factors in the control of the browning of white adipose tissue. HORM MOL BIOL CLIN I 31; 2017.

Mu WJ, Zhu JY, Chen M, Guo L. 2021 Exercise-Mediated Browning of White Adipose tissue: its significance, mechanism and effectiveness. INT J MOL SCI 22.

Aldiss P, Betts J, Sale C, Pope M, Budge H. Symonds ME 2018 Exercise-induced ‘browning’ of adipose tissues. METABOLISM 81:63–70.

Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Bostrom EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Hojlund K, Gygi SP. Spiegelman BM 2012 a PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481:463–8.

Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E. Spiegelman BM 2012 FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis. GENE DEV 26:271–81.

Crandall JP, Fraum TJ, Wahl RL. 2022 Brown adipose tissue: a protective mechanism against Preprediabetes? J NUCL MED 63:1433–40.

Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken LW, Hoeks J, Enerback S, Schrauwen P. Spiegelman BM 2012 Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150:366–76.

Kurylowicz A, Puzianowska-Kuznicka M. 2020 Induction of adipose tissue Browning as a strategy to combat obesity. INT J MOL SCI 21.

Betz MJ, Enerback S. Human Brown Adipose tissue: what we have learned so far. Diabetes. 2015;64:2352–60.

Article  CAS  PubMed  Google Scholar 

Behrooz M, Vaghef-Mehrabany E, Maleki V, Pourmoradian S, Fathifar Z, Ostadrahimi. A 2020 Spexin status in relation to obesity and its related comorbidities: a systematic review. J DIABETES METAB DIS 19:1943–57.

Gu L, Ma Y, Gu M, Zhang Y, Yan S, Li N, Wang Y, Ding X, Yin J, Fan N. Peng Y 2015 Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes. Peptides 71:232–9.

Wong M, Chen Y, He M, Lin C, Bian Z, Wong A. Mouse spexin: (II) functional role as a Satiety Factor Inhibiting Food Intake by Regulatory actions within the Hypothalamus. FRONT ENDOCRINOL. 2021;12:681647.

Article  Google Scholar 

Liu Y, Sun L, Zheng L, Su M, Liu H, Wei Y, Li D, Wang Y, Dai C, Gong Y, Zhao C, Li Y. 2020 Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction. N-S ARCH PHARMACOL 393:25–33.

Said MA, Nafeh NY, Abdallah HA. 2021 Spexin alleviates hypertension, hyperuricaemia, dyslipidemia and insulin resistance in high fructose diet induced metabolic syndrome in rats via enhancing PPAR-ɣ and AMPK and inhibiting IL-6 and TNF-alpha. ARCH PHYSIOL BIOCHEM:1–6.

Gu L, Ding X, Wang Y, Gu M, Zhang J, Yan S, Li N, Song Z, Yin J, Lu L, Peng Y. Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1alpha pathway in high-fat-diet-induced rats and insulin resistant cells. INT J BIOL SCI. 2019;15:2815–29.

Article  PubMed  PubMed Central  Google Scholar 

Mina AI, LeClair RA, LeClair KB, Cohen DE, Lantier L. Banks AS 2018 CalR: a web-based analysis Tool for Indirect Calorimetry experiments. CELL METAB 28:656–66.

Muller TD, Klingenspor M, Tschop MH. 2021 revisiting energy expenditure: how to correct mouse metabolic rate for body mass. NAT METAB 3:1134–6.

Suarez-Zamorano N, Fabbiano S, Chevalier C, Stojanovic O, Colin DJ, Stevanovic A, Veyrat-Durebex C, Tarallo V, Rigo D, Germain S, Ilievska M, Montet X, Seimbille Y, Hapfelmeier S, Trajkovski M. Microbiota depletion promotes browning of white adipose tissue and reduces obesity. NAT MED. 2015;21:1497–501.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-Daghri NM, Alenad A, Al-Hazmi H, Amer OE, Hussain SD, Alokail MS. 2018 Spexin levels are Associated with metabolic Syndrome Components. DIS MARKERS 2018:1679690.

Kolodziejski PA, Pruszynska-Oszmalek E, Korek E, Sassek M, Szczepankiewicz D, Kaczmarek P, Nogowski L, Mackowiak P, Nowak KW, Krauss H. Strowski MZ 2018 serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women. PHYSIOL RES 67:45–56.

Ge JF, Walewski JL, Anglade D, Berk PD. Regulation of hepatocellular fatty acid uptake in mouse models of fatty liver disease with and without functional Leptin Signaling: roles of NfKB and SREBP-1 C and the effects of Spexin. SEMIN LIVER DIS. 2016;36:360–72.

Article  CAS  PubMed  Google Scholar 

Gambaro SE, Zubiria MG, Giordano AP, Portales AE, Alzamendi A, Rumbo M, Giovambattista A. Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice. BBA-MOL CELL BIOL L. 2020;1865:158700.

CAS  Google Scholar 

Jeong B, Kim KK, Lee TH, Kim HR, Park BS, Park JW, Jeong JK, Seong JY. Lee BJ 2022 Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior. BIOMOLECULES 12.

Walewski JL, Ge F, Lobdell HT, Levin N, Schwartz GJ, Vasselli JR, Pomp A, Dakin G, Berk. PD 2014 Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. OBESITY 22:1643–52.

Ha N-HKNKC. Hypothalamic spexin and galanin receptor 2 are Novel regulators of Energy Balance in mice. DIABETES; 2018.

Lone J, Choi JH, Kim SW, Yun JW. Curcumin induces brown fat-like phenotype in 3T3-L1 and primary white adipocytes. J NUTR BIOCHEM. 2016;27:193–202.

Article  CAS  PubMed  Google Scholar 

Goldenthal MJ, Marin-Garcia J. Mitochondrial signaling pathways: a receiver/integrator organelle. MOL CELL BIOCHEM. 2004;262:1–16.

Article  CAS  PubMed  Google Scholar 

Heinonen S, Jokinen R, Rissanen A, Pietilainen. KH 2020 White adipose tissue mitochondrial metabolism in health and in obesity. OBES REV 21:e12958.

Scheele C, Wolfrum C. Brown Adipose Crosstalk in tissue plasticity and human metabolism. ENDOCR REV. 2020;41:53–65.

Article  PubMed  Google Scholar 

Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: is beige the new brown? GENE DEV. 2013;27:234–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Jong JM, Larsson O, Cannon B, Nedergaard J. 2015 a stringent validation of mouse adipose tissue identity markers. AM J PHYSIOL-ENDOC M 308:E1085–105.

Wu L, Zhou L, Chen C, Gong J, Xu L, Ye J, Li D, Li P. Cidea controls lipid droplet fusion and lipid storage in brown and white adipose tissue. SCI CHINA LIFE SCI. 2014;57:107–16.

Article  CAS  PubMed  Google Scholar 

Inagaki T, Sakai J, Kajimura S. Transcriptional and epigenetic control of brown and beige adipose cell fate and function. NAT REV MOL CELL BIO. 2016;17:480–95.

Article  CAS  Google Scholar 

Okamatsu-Ogura Y, Kuroda M, Tsutsumi R, Tsubota A, Saito M, Kimura K, Sakaue H. 2020 UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice. METABOLISM 113:154396.

Chouchani ET, Kazak L, Spiegelman BM. New advances in adaptive thermogenesis: UCP1 and Beyond. CELL METAB. 2019;29:27–37.

Article  CAS  PubMed  Google Scholar 

Kim SH, Plutzky J. 2016 Brown Fat and Browning for the Treatment of Obesity and related metabolic disorders. DIABETES METAB J 40:12–21.

Pandey R, Bakay M, Strenkowski BP, Hain HS, Hakonarson H. 2021 JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice. SCI REP-UK 11:7372.

Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, Harris TE, Seale P, Russell AP, McAinch AJ, O’Brien PE, Keller SR, Croniger CM, Kordula T. Larner AC 2012 Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. CELL METAB 16:814–24.

Shi SY, Zhang W, Luk CT, Sivasubramaniyam T, Brunt JJ, Schroer SA, Desai HR, Majerski A, Woo M. 2016 JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice. Diabetologia 59:187–96.

留言 (0)

沒有登入
gif