Current Trends in the Treatment of Traumatic Nail Injuries and the Prospect of Solutions from Regenerative Engineering

Matthew F. “Touch”, The Stanford Encyclopedia of Philosophy. https://plato.stanford.edu/archives/sum2020/entries/touch/. 2020. Edward N. Zalta (ed.),(Summer 2020 Edition).

Singal A. Nail as a window of systemic diseases. Indian. Dermatol Online J. 2015;6(2):67–74.

Article  Google Scholar 

Lee DK. Optimal diagnosis and management of common nail disorders. Ann Med. 2022;54(1):694–712.

Article  Google Scholar 

Channel BH. Nails - fingernail and toenail problems. https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/nails-fingernail-and-toenail-problems. Retreived 04-20-2023, 2023.

Publishing HH. Nail trauma. Harvard Health Publishing- https://www.health.harvard.edu/a_to_z/nail-trauma-a-to-z. Retrieved 03-20-2023, 2022.

Haneke E. Advanced nail surgery. J Cutan Aesthet Surg. 2011;4(3)

Shieh SJ, Cheng CT. Regeneration and repair of human digits and limbs: fact and fiction. Regeneration (Oxf). 2015;2(4):149–68.

Article  Google Scholar 

Wang B. Keratin: structure, mechanical properties, occurrence in biological organisms, and efforts at bioinspiration. Progr Mater Sci. 2016;76:229–318.

Article  CAS  Google Scholar 

Chinazzo M, Lorette G, Baran R, Finon A, Saliba É, Maruani A. J Eur Acad Dermatol Venereol. 2017;31(2):371–5.

Article  CAS  Google Scholar 

Masataka Saito MO. Masayuki Amagai, Exploring the biology of the nail_ an intriguing but less-investigated skin appendage. J Dermatol Sci. 2015;79:187–93.

Article  Google Scholar 

Bharathi RR, Bajantri B. Nail bed injuries and deformities of nail. Indian J Plast Surg. 2011;44(2):197–202.

Article  Google Scholar 

Nails HM. The history, physical, and laboratory examinations. In: Walker HK, Hall WD, Hurst JW, editors. Clinical methods. 3rd ed. Boston: Butterworths; 1990. p. 108.

Google Scholar 

Tosti A, Piraccini B. Biology of nails and nail disorders In: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, Wolff K. Fitzpatrick’s dermatology in general medicine: 2012. 8e. McGraw Hill. Accessed 29 Mar 2023.

Care IfQaEiH. Structure of the nails. http://informedhealth.org. [Internet]. Cologne, Germany: Inst Qual Efficiency Health Care (IQWiG). 2006;2018.

Pulawska-Czub A, Mazurek P, Kobielak K. The potential of nail mini-organ stem cells in kin, nail and digit tips regeneration. Int J Mol Sci. 2021;22(6):2864.

Article  CAS  Google Scholar 

Yaemsiri S, Hou N, Slining MM, He K. Growth rate of human fingernails and toenails in healthy American young adults. J Eur Acad Dermatol Venereol. 2010;24(4):420–3.

Article  CAS  Google Scholar 

George A, Alexander R, Manju C. Management of nail bed injuries associated with fingertip injuries. Indian J Orthop. 2017;51(6):709–13.

Article  Google Scholar 

Tos P, Titolo P, Chirila NL, Catalano F, Artiaco S. Surgical treatment of acute fingernail injuries. J Orthop Traumatol. 2012;13(2):57–62. https://doi.org/10.1007/s10195-011-0161-z.

Article  CAS  Google Scholar 

Pandhi D, Verma P. Nail avulsion: indications and methods (surgical nail avulsion). Indian J Dermatol Venereol Leprol. 2012;78:299–308.

Article  Google Scholar 

Shepard GH. Treatment of nail bed avulsions with split-thickness nail bed grafts. J Hand Surg Am. 1983;8:49–54.

Article  CAS  Google Scholar 

Fehrenbacher V. Nail bed injury. J Hand Surg Am. 2015;40(3):581–2.

Article  Google Scholar 

(n.d.), A.O.C.o.D.A. Subungual hematoma. American Osteopathic College of Dermatology (AOCD). (n.d.). https://www.aocd.org/page/SubungualHematoma. Retrieved: 03-01-2023.

Pingel CMC. Subungual hematoma drainage. [Updated 2022 Jul 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan: Retreived 03-01-2023, 2023.

Champagne L, Hustedt JW, Walker R, Wiebelhaus J, Nystrom NA. Digital tip amputations from the perspective of the nail. Adv Orthop. 2016;2016(1967192).

Kawaiah A, Thakur M, Garg S, Kawasmi SH, Hassan A. Fingertip injuries and amputations: a review of the literature. Cureus. 2020;12(5):e8291.

Google Scholar 

Chessa MA, Iorizzo M, Richert B, López-Estebaranz JL, Rigopoulos D, Tosti A, Gupta AK, Di Chiacchio N, Di Chiacchio NG, Rubin AI, Baran R. Pathogenesis, clinical signs and treatment recommendations in brittle nails: a review. Dermatol Ther (Heidelb). 2020;10(1):15–27. Erratum in: Dermatol Ther (Heidelb)

Article  Google Scholar 

Chapeskie H, Kovac JR. Nutrition and nail disease. Clin Dermatol. 2010;28(4):420–5.

Article  Google Scholar 

Chapeskie H. Case series: Soft-tissue nail-fold excision: a definitive treatment for ingrown toenails. Can J Surg. 2010;53(4):282–6.

Google Scholar 

Bostanci S, Parlak N, Gungor HK. Chemical matricectomy with sodium hydroxide. Dermatol Surg. 2014;40(1221)

Sears JK. The use of a combination nail elevator and hemostat clamp. New instruments for nail avulsion. J Dermatol Surg Oncol. 1992;18(3):223–5.

Article  CAS  Google Scholar 

Koh SH, You Y, Kim YW, Kim JS, Lee DC, Roh SY, Lee KJ, Hong MK. Long-term outcomes of nail bed reconstruction. Arch Plast Surg. 2019;46(6):580–8.

Article  Google Scholar 

Mayeaux EJ, Carter C, Murphy TE. Ingrown toenail management. Am Fam Phys. 2019;100(158)

Eekhof JAH eaIfit. Cochrane database of systematic reviews. 2021. http://www.thecochranelibrary.com. Accessed 12 Oct 2021.

Kee C, MP. Phalanx fracture. [Updated 2022 Aug 22]. . In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK545182/, 2022.

Samuel O, Poore MLB. Plastic surgery. In: Plastic Surgery Secrets Plus (Second Edition), 2010, 2010.

William N, Levine JPW. In case competencies. Orthop Surg. 2017.

Mizanur SK, Selvin B, Patel S, Phalak M, Phalak MO. Treatment of distal phalanx fracture using figure-of-eight suturing of the nail. Cureus. 2022;14(12):e32438.

CAS  Google Scholar 

Mannino G, Russo C, Maugeri G, Musumeci G, Vicario N, Tibullo D, Giuffrida R, Parenti R, Lo Furno D. Adult stem cell niches for tissue homeostasis. J Cell Physiol. 2022;237(1):239–57.

Article  CAS  Google Scholar 

Leung Y, Kandyba E, Chen YB, Ruffins S, Chuong CM, Kobielak K. Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration. Proc Natl Acad Sci U S A. 2014;111(42):15114–9.

Article  CAS  Google Scholar 

Kalmukova O. Stem cells in nail unit of mammalians. Cell Organ Transpl. 2016;4:138–43.

Article  Google Scholar 

Cotsarelis G, Sun TT, Lavker RM. Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem ells, hair cycle, and skin carcinogenesis. Cell. 1990;61:1329–37.

Article  CAS  Google Scholar 

Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E. Defining the epithelial stem cell niche in skin. Science. 2004;303:359–63.

Article  CAS  Google Scholar 

Lu CP, Polak L, Rocha AS, Pasolli HA, Chen SC, Sharma N, Blanpain C, Fuchs E. Identification of stem cell populations in sweat glands and ducts reveals roles in homeostasis and wound repair. Cell. 2012;150:136–50.

Article  CAS  Google Scholar 

Lehoczky JA, Tabin CJ. Lgr6 marks nail stem cells and is required for digit tip regeneration. Proc Natl Acad Sci USA. 2015;112:13249–54.

Article  CAS  Google Scholar 

Shi J, Lv Z, Nie M, Lu W, Liu C, Tian Y, Li L, Zhang G, Ren R, Zhang Z, Kang H. Human nail stem cells are retained but hypofunctional during aging. J Mol Histol. 2018;49:303–16.

Article  CAS  Google Scholar 

Nakamura MI O. The localization of label-retaining cells in mouse nails. J Investig Dermatol. 2008;128:728–730.

Takeo MC, Sun Q, Lee W, Rabbani P, Loomis C, Taketo MM, Ito M. Wnt activation in nail epithelium couples nail growth to digit regeneration. Nature. 2013;499:228–32.

Article  CAS  Google Scholar 

Nestle FO, Di Meglio P, Qin JZ, Nickoloff BJ. Nickoloff BJ Skin immune sentinels in health and disease. Nat Rev Immunol. 2009;9(10):679–91.

Article  CAS  Google Scholar 

Anna Pulawska-Czub TDP, Mazurek P, Kobielak K. The potential of nail mini-organ stem cells in skin, nail and digit tips regeneration. Int. J.Mol. Sci. 2021;22:2864.

Article  Google Scholar 

Shi J, Lv Z, Nie M, Lu W, Liu C, Tian Y, Li L, Zhang G, Ren R, Zhang Z, Kang H. Human nail stem cells are retained but hypofunctional during aging. J Mol Histol. 49(3):303–16.

Cai JM. L, Msx2 and Foxn1 regulate nail homeostasis. Genesis. 2011;49:449–59.

Article  CAS  Google Scholar 

Takeo M, Chou WC, Sun Q, Lee W, Rabbani P, Loomis C, Taketo MM, Ito M. Wnt activation in nail epithelium couples nail growth to digit regeneration. Nature. 2013;499(7457):228–32.

Article  CAS  Google Scholar 

Komiya Y, Habas R. Wnt signal transduction pathways. Organogenesis. 2008;4(2):68–75.

Article  Google Scholar 

Ng LF, Kaur P, Bunnag N, Suresh J, Sung IC, Tan QH, Gruber J, Tolwinski NS. WNT signaling in disease. Cells. 2019;8(8):826.

Article  CAS  Google Scholar 

Blaydon DC, Ishii Y, O'Toole EA, Unsworth HC, Teh MT, Rüschendorf F, Sinclair C, Hopsu-Havu VK, Tidman N, Moss C, Watson R. The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. Nat. Genet. 2006;38:1245–7.

Article  CAS  Google Scholar 

Khan TN, Klar J, Nawaz S, Jameel M, Tariq M, Malik NA, Baig SM, Dahl N. Novel missense mutation in the RSPO4 gene in congenital hyponychia and evidence for a polymorphic initiation codon (p.M1I). BMC Med Genet. 2012;13(120)

Khalil S, Hayashi R, Daou L, Staiteieh SA, Abbas O, Bergqvist C, Nemer G, Shimomura Y, Kurban M. A novel mutation in the RSPO4 gene in a patient with autosomal recessive anonychia. Clin Exp Dermatol. 2017;42:313–5.

Article  CAS  Google Scholar 

Simkin J, Sammarco MC, Marrero L, Dawson LA, Yan M, Tucker C, Cammack A, Muneoka K. Macrophages are required to coordinate mouse digit tip regeneration. Development. 2017;144:3907–16.

CAS  Google Scholar 

Fleckman P, Jaeger K, Silva KA, Sundberg JP. Comparative anatomy of mouse and human nail units. Anat. Rec. 2013;296:521–32.

Article  Google Scholar 

Dawson LA, Schanes PP, Marrero L, Jordan K, Brunauer R, Zimmel KN, Qureshi O, Imholt FM, Falck AR, Yan M, Dolan CP. Proximal digit tip amputation initiates simultaneous blastema and transient fibrosis formation and results in partial regeneration. Wound Repair Regen. 2021;29:196–205.

Article  Google Scholar 

Dawson LA, Schanes PP, Kim P, Imholt FM, Qureshi O, Dolan CP, Yu L, Yan M, Zimmel KN, Falck AR, Muneoka K. Blastema formation and periosteal ossification in the regenerating adult mouse digit. Wound Repair Regen. 2018;26:263–73.

Article  Google Scholar 

Currie JD, Kawaguchi A, Traspas RM, Schuez M, Chara O, Tanaka EM. Live i

留言 (0)

沒有登入
gif