Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice

Abrahamson, E. E., Leak, R. K., & Moore, R. Y. (2001). The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems. Neuroreport, 12(2), 435–440. https://doi.org/10.1097/00001756-200102120-00048.

Article  CAS  PubMed  Google Scholar 

Baloyannis, S. J., Mavroudis, I., Mitilineos, D., Baloyannis, I. S., & Costa, V. G. (2015). The hypothalamus in Alzheimer’s Disease: A golgi and electron microscope study. Am J Alzheimers Dis Other Demen, 30(5), 478–487. https://doi.org/10.1177/1533317514556876.

Article  PubMed  Google Scholar 

Belfiore, R., Rodin, A., Ferreira, E., Velazquez, R., Branca, C., Caccamo, A., & Oddo, S. (2019). Temporal and regional progression of Alzheimer’s disease-like pathology in 3xTg-AD mice. Aging Cell, 18(1), e12873. https://doi.org/10.1111/acel.12873.

Article  CAS  PubMed  Google Scholar 

Bellanti, F., Iannelli, G., Blonda, M., Tamborra, R., Villani, R., Romano, A., Calcagnini, S., Mazzoccoli, G., Vinciguerra, M., Gaetani, S., Giudetti, A. M., Vendemiale, G., Cassano, T., & Serviddio, G. (2017). Alterations of clock gene RNA expression in brain regions of a Triple Transgenic Model of Alzheimer’s Disease. Journal of Alzheimer’s Disease, 59(2), 615–631. https://doi.org/10.3233/jad-160942.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belle, M. D., Hughes, A. T., Bechtold, D. A., Cunningham, P., Pierucci, M., Burdakov, D., & Piggins, H. D. (2014). Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock. Journal of Neuroscience, 34(10), 3607–3621. https://doi.org/10.1523/jneurosci.3388-13.2014.

Article  CAS  PubMed  Google Scholar 

Beuckmann, C. T., Suzuki, H., Musiek, E. S., Ueno, T., Sato, T., Bando, M., Osada, Y., & Moline, M. (2021). Evaluation of SAMP8 mice as a Model for Sleep-Wake and Rhythm disturbances Associated with Alzheimer’s Disease: Impact of treatment with the dual orexin (hypocretin) receptor antagonist Lemborexant. Journal of Alzheimer’s Disease, 81(3), 1151–1167. https://doi.org/10.3233/jad-201054.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carrero, L., Antequera, D., Alcalde, I., Megias, D., Figueiro-Silva, J., Merayo-Lloves, J., Municio, C., & Carro, E. (2023). Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer’s Disease. Acta Neuropathol Commun, 11(1), 55. https://doi.org/10.1186/s40478-023-01529-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Luca, R., Nardone, S., Grace, K. P., Venner, A., Cristofolini, M., Bandaru, S. S., Sohn, L. T., Kong, D., Mochizuki, T., Viberti, B., Zhu, L., Zito, A., Scammell, T. E., Saper, C. B., Lowell, B. B., Fuller, P. M., & Arrigoni, E. (2022). Orexin neurons inhibit sleep to promote arousal. Nature Communications, 13(1), 4163. https://doi.org/10.1038/s41467-022-31591-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Do, K., Laing, B. T., Landry, T., Bunner, W., Mersaud, N., Matsubara, T., Li, P., Yuan, Y., Lu, Q., & Huang, H. (2018). The effects of exercise on hypothalamic neurodegeneration of Alzheimer’s Disease mouse model. PLoS One, 13(1), e0190205. https://doi.org/10.1371/journal.pone.0190205.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elahdadi Salmani, M., Sarfi, M., & Goudarzi, I. (2022). Hippocampal orexin receptors: Localization and function. Vitamins and Hormones, 118, 393–421. https://doi.org/10.1016/bs.vh.2021.12.004.

Article  PubMed  Google Scholar 

Gao, F., Liu, T., Tuo, M., & Chi, S. (2021). The role of orexin in Alzheimer Disease: From sleep-wake disturbance to therapeutic target. Neuroscience Letters, 765, 136247. https://doi.org/10.1016/j.neulet.2021.136247.

Article  CAS  PubMed  Google Scholar 

Gao, W. R., Hu, X. H., Yu, K. Y., Cai, H. Y., Wang, Z. J., Wang, L., & Wu, M. N. (2023). Selective orexin 1 receptor antagonist SB-334867 aggravated cognitive dysfunction in 3xTg-AD mice. Behavioural Brain Research, 438, 114171. https://doi.org/10.1016/j.bbr.2022.114171.

Article  CAS  PubMed  Google Scholar 

Guo, P., Zhang, W. J., Lian, T. H., Zhang, W. J., He, M. Y., Zhang, Y. N., Huang, Y., Ding, D. Y., Guan, H. Y., Li, J. H., Li, D. N., Luo, D. M., Zhang, W. J., Yue, H., Wang, X. M., & Zhang, W. (2023). Alzheimer’s Disease with sleep insufficiency: A cross-sectional study on correlations among clinical characteristics, orexin, its receptors, and the blood-brain barrier. Neural Regen Res, 18(8), 1757–1762. https://doi.org/10.4103/1673-5374.360250.

Article  PubMed  Google Scholar 

Hampel, H., Vassar, R., De Strooper, B., Hardy, J., Willem, M., Singh, N., Zhou, J., Yan, R., Vanmechelen, E., De Vos, A., Nisticò, R., Corbo, M., Imbimbo, B. P., Streffer, J., Voytyuk, I., Timmers, M., Tahami Monfared, A. A., Irizarry, M., Albala, B., Koyama, A., Watanabe, N., Kimura, T., Yarenis, L., Lista, S., Kramer, L., & Vergallo, A. (2021). The β-Secretase BACE1 in Alzheimer’s Disease. Biological Psychiatry, 89(8), 745–756. https://doi.org/10.1016/j.biopsych.2020.02.001.

Article  CAS  PubMed  Google Scholar 

Han, D., Han, F., Shi, Y., Zheng, S., & Wen, L. (2020). Mechanisms of Memory Impairment Induced by Orexin-A via Orexin 1 and Orexin 2 receptors in post-traumatic stress disorder rats. Neuroscience, 432, 126–136. https://doi.org/10.1016/j.neuroscience.2020.02.026.

Article  CAS  PubMed  Google Scholar 

Holth, J. K., Fritschi, S. K., Wang, C., Pedersen, N. P., Cirrito, J. R., Mahan, T. E., Finn, M. B., Manis, M., Geerling, J. C., Fuller, P. M., Lucey, B. P., & Holtzman, D. M. (2019). The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science, 363(6429), 880–884. https://doi.org/10.1126/science.aav2546.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hughes, M. E., Hogenesch, J. B., & Kornacker, K. (2010). JTK_CYCLE: An efficient nonparametric algorithm for detecting rhythmic components in genome-scale data sets. J Biol Rhythms, 25(5), 372–380. https://doi.org/10.1177/0748730410379711.

Article  PubMed  PubMed Central  Google Scholar 

Kang, J. E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009). Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science, 326(5955), 1005–1007. https://doi.org/10.1126/science.1180962.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim, E., Nohara, K., Wirianto, M., Escobedo, G., Lim, J., Morales, J. Y., Yoo, R. S. H., & Chen, Z. (2021). Effects of the clock modulator nobiletin on circadian rhythms and pathophysiology in female mice of an Alzheimer’s Disease model. Biomolecules. https://doi.org/10.3390/biom11071004

Article  PubMed  PubMed Central  Google Scholar 

Kourosh-Arami, M., Komaki, A., Joghataei, M. T., & Mohsenzadegan, M. (2020). Phospholipase Cbeta3 in the hippocampus may mediate impairment of memory by long-term blockade of orexin 1 receptors assessed by the Morris water maze. Life Sciences, 257, 118046. https://doi.org/10.1016/j.lfs.2020.118046.

Article  CAS  PubMed  Google Scholar 

Liguori, C., Romigi, A., Nuccetelli, M., Zannino, S., Sancesario, G., Martorana, A., Albanese, M., Mercuri, N. B., Izzi, F., Bernardini, S., Nitti, A., Sancesario, G. M., Sica, F., Marciani, M. G., & Placidi, F. (2014). Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer Disease. JAMA Neurol, 71(12), 1498–1505. https://doi.org/10.1001/jamaneurol.2014.2510.

Article  PubMed  Google Scholar 

Liguori, C., Nuccetelli, M., Izzi, F., Sancesario, G., Romigi, A., Martorana, A., Amoroso, C., Bernardini, S., Marciani, M. G., Mercuri, N. B., & Placidi, F. (2016). Rapid eye movement sleep disruption and sleep fragmentation are associated with increased orexin-A cerebrospinal-fluid levels in mild cognitive impairment due to Alzheimer’s Disease. Neurobiology of Aging, 40, 120–126. https://doi.org/10.1016/j.neurobiolaging.2016.01.007.

Article  CAS  PubMed  Google Scholar 

Liguori, C., Spanetta, M., Izzi, F., Franchini, F., Nuccetelli, M., Sancesario, G. M., Di Santo, S., Bernardini, S., Mercuri, N. B., & Placidi, F. (2020). Sleep-wake cycle in Alzheimer’s Disease is associated with Tau pathology and orexin dysregulation. Journal of Alzheimer’s Disease, 74(2), 501–508. https://doi.org/10.3233/jad-191124

Article  CAS  PubMed  Google Scholar 

Lu, Q., & Kim, J. Y. (2022). Mammalian circadian networks mediated by the suprachiasmatic nucleus. Febs j, 289(21), 6589–6604. https://doi.org/10.1111/febs.16233.

Article  CAS  PubMed  Google Scholar 

Ma, Z., Jiang, W., & Zhang, E. E. (2016). Orexin signaling regulates both the hippocampal clock and the circadian oscillation of Alzheimer’s disease-risk genes. Scientific Reports, 6, 36035. https://doi.org/10.1038/srep36035.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma, C., Hong, F., & Yang, S. (2022). Amyloidosis in Alzheimer’s Disease: Pathogeny, etiology, and related therapeutic directions. Molecules, 27(4), 1210. https://doi.org/10.3390/molecules27041210.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moussa-Pacha, N. M., Abdin, S. M., Omar, H. A., Alniss, H., & Al-Tel, T. H. (2020). BACE1 inhibitors: Current status and future directions in treating Alzheimer’s Disease. Medicinal Research Reviews, 40(1), 339–384. https://doi.org/10.1002/med.21622.

Article  PubMed  Google Scholar 

Musiek, E. S., Bhimasani, M., Zangrilli, M. A., Morris, J. C., Holtzman, D. M., & Ju, Y. S. (2018). Circadian rest-activity pattern changes in aging and preclinical Alzheimer Disease. JAMA Neurol, 75(5), 582–590. https://doi.org/10.1001/jamaneurol.2017.4719

Article  PubMed  Google Scholar 

Naseri, N. N., Wang, H., Guo, J., Sharma, M., & Luo, W. (2019). The complexity of tau in Alzheimer’s Disease. Neuroscience Letters, 705, 183–194. https://doi.org/10.1016/j.neulet.2019.04.022.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nassan, M., & Videnovic, A. (2022). Circadian rhythms in neurodegenerative disorders. Nat Rev Neurol, 18(1), 7–24. https://doi.org/10.1038/s41582-021-00577-7.

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