Gut P, Verdin E. The nexus of chromatin regulation and intermediary metabolism. Nature. 2013;502(7472):489–98.

Article  CAS  PubMed  Google Scholar 

Dai Z, Ramesh V, Locasale JW. The evolving metabolic landscape of chromatin biology and epigenetics. Nat Rev Genet. 2020;21(12):737–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carey BW, Finley LWS, Cross JR, Allis CD, Thompson CB. Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature. 2015;518(7539):413–6.

Article  CAS  PubMed  Google Scholar 

Thienpont B, Steinbacher J, Zhao H, D’Anna F, Kuchnio A, Ploumakis A, et al. Tumour hypoxia causes DNA hypermethylation by reducing TET activity. Nature. 2016;537(7618):63–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, et al. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 2013;500(7461):222–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Young JI, Züchner S, Wang G. Regulation of the epigenome by vitamin C. Annu Rev Nutr. 2015;6(35):545–64.

Article  Google Scholar 

Minor EA, Court BL, Young JI, Wang G. Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine. J Biol Chem. 2013;288(19):13669–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Monfort A, Wutz A. Breathing-in epigenetic change with vitamin C. EMBO Rep. 2013;14(4):337–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chung T-L, Brena RM, Kolle G, Grimmond SM, Berman BP, Laird PW, et al. Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells. 2010;28(10):1848–55.

Article  CAS  PubMed  Google Scholar 

Stadtfeld M, Apostolou E, Ferrari F, Choi J, Walsh RM, Chen T, et al. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet. 2012;44(4):398–405.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Esteban MA, Wang T, Qin B, Yang J, Qin D, Cai J, et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell. 2010;6(1):71–9.

Article  CAS  PubMed  Google Scholar 

Chen J, Guo L, Zhang L, Wu H, Yang J, Liu H, et al. Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet. 2013;45(12):1504–9.

Article  CAS  PubMed  Google Scholar 

Doege CA, Inoue K, Yamashita T, Rhee DB, Travis S, Fujita R, et al. Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature. 2012;488(7413):652–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Costa Y, Ding J, Theunissen TW, Faiola F, Hore TA, Shliaha PV, et al. NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature. 2013;495(7441):370–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Y, Chen J, Li K, Wu T, Huang B, Liu W, et al. Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming. Cell Stem Cell. 2013;12(4):453–69.

Article  CAS  PubMed  Google Scholar 

Chen J, Liu H, Liu J, Qi J, Wei B, Yang J, et al. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet. 2013;45(1):34–42.

Article  CAS  PubMed  Google Scholar 

Wang T, Chen K, Zeng X, Yang J, Wu Y, Shi X, et al. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell. 2011;9(6):575–87.

Article  CAS  PubMed  Google Scholar 

Dickson KM, Gustafson CB, Young JI, Züchner S, Wang G. Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate. Biochem Biophys Res Commun. 2013;439(4):522–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin R, Mao S-Q, Zhao B, Chong Z, Yang Y, Zhao C, et al. Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals. J Am Chem Soc. 2013;135(28):10396–403.

Article  CAS  PubMed  Google Scholar 

Ebata KT, Mesh K, Liu S, Bilenky M, Fekete A, Acker MG, et al. Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b. Epigenet Chromatin. 2017;12(10):36.

Article  Google Scholar 

DiTroia SP, Percharde M, Guerquin M-J, Wall E, Collignon E, Ebata KT, et al. Maternal vitamin C regulates reprogramming of DNA methylation and germline development. Nature. 2019;573(7773):271–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yue X, Rao A. TET family dioxygenases and the TET activator vitamin C in immune responses and cancer. Blood. 2020;136(12):1394–401.

Article  PubMed  PubMed Central  Google Scholar 

Gustafson CB, Yang C, Dickson KM, Shao H, Van Booven D, Harbour JW, et al. Epigenetic reprogramming of melanoma cells by vitamin C treatment. Clin Epigenet. 2015;7(1):51.

Article  Google Scholar 

Agathocleous M, Meacham CE, Burgess RJ, Piskounova E, Zhao Z, Crane GM, et al. Ascorbate regulates haematopoietic stem cell function and leukaemogenesis. Nature. 2017;549(7673):476–81.

Article  PubMed  PubMed Central  Google Scholar 

Bourque G, Burns KH, Gehring M, Gorbunova V, Seluanov A, Hammell M, et al. Ten things you should know about transposable elements. Genome Biol. 2018;19(1):199.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klawitter S, Fuchs NV, Upton KR, Muñoz-Lopez M, Shukla R, Wang J, et al. Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nat Commun. 2016;8(7):10286.

Article  Google Scholar 

Gerdes P, Lim SM, Ewing AD, Larcombe MR, Chan D, Sanchez-Luque FJ, et al. Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells. Nat Commun. 2022;13(1):7470.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wissing S, Muñoz-Lopez M, Macia A, Yang Z, Montano M, Collins W, et al. Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobility. Hum Mol Genet. 2012;21(1):208–18.

Article  PubMed  Google Scholar 

Fueyo R, Judd J, Feschotte C, Wysocka J. Roles of transposable elements in the regulation of mammalian transcription. Nat Rev Mol Cell Biol. 2022;23(7):481–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lawson HA, Liang Y, Wang T. Transposable elements in mammalian chromatin organization. Nat Rev Genet. 2023;24:712.

Article  CAS  PubMed  Google Scholar 

Gazquez-Gutierrez A, Witteveldt J, Heras SR, Macias S. Sensing of transposable elements by the antiviral innate immune system. RNA. 2021;27(7):735–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de la Rica L, Deniz Ö, Cheng KCL, Todd CD, Cruz C, Houseley J, et al. TET-dependent regulation of retrotransposable elements in mouse embryonic stem cells. Genome Biol. 2016;17(1):234.

Article  PubMed  PubMed Central  Google Scholar 

Deniz Ö, de la Rica L, Cheng KCL, Spensberger D, Branco MR. SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells. Genome Biol. 2018;19(1):6.

Article  PubMed  PubMed Central  Google Scholar 

Walter M, Teissandier A, Pérez-Palacios R, Bourc’his D. An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells. Elife. 2016;27(5): e11418.

Article  Google Scholar 

Liu M, Ohtani H, Zhou W, Ørskov AD, Charlet J, Zhang YW, et al. Vitamin C increases viral mimicry induced by 5-aza-2’-deoxycytidine. Proc Natl Acad Sci USA. 2016;113(37):10238–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Silva J, Barrandon O, Nichols J, Kawaguchi J, Theunissen TW, Smith A. Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol. 2008;6(10): e253.

Article