Akhter, F., Haque, T., Sato, F., Kato, T., Ohara, H., Fujio, T., et al. (2014). Projections from the dorsal peduncular cortex to the trigeminal subnucleus caudalis (medullary dorsal horn) and other lower brainstem areas in rats. Neuroscience, 266, 23–37.

Article  CAS  PubMed  Google Scholar 

Alonso-Matielo, H., Gonçalves, E. S., Campos, M., Oliveira, V. R., Toniolo, E. F., Alves, A. S., et al. (2021). Electrical stimulation of the posterior insula induces mechanical analgesia in a rodent model of neuropathic pain by modulating GABAergic signaling and activity in the pain circuitry. Brain Research, 1754, 147237.

Article  CAS  PubMed  Google Scholar 

Alvarez, P., Dieb, W., Hafidi, A., Voisin, D. L., & Dallel, R. (2009). Insular cortex representation of dynamic mechanical allodynia in trigeminal neuropathic rats. Neurobiology of Disease, 33(1), 89–95.

Article  PubMed  Google Scholar 

Araya, E. I., Carvalho, E. C., Andreatini, R., Zamponi, G. W., & Chichorro, J. G. (2022). Trigeminal neuropathic pain causes changes in affective processing of pain in rats. Molecular Pain, 18, 17448069211057750.

Article  PubMed  PubMed Central  Google Scholar 

Bangash, T. H. (2011). Trigeminal neuralgia: Frequency of occurrence in different nerve branches. Anesthesiology and Pain Medicine, 1(2), 70.

Article  PubMed  PubMed Central  Google Scholar 

Bansal, H., Gupta, N., & Roy, S. (2020). Comparison of low-power, high-frequency and temporally precise optogenetic inhibition of spiking in NpHR, eNpHR3.0 and Jaws-expressing neurons. Biomedical Physics & Engineering Express, 6(4), 045011.

Article  Google Scholar 

Caldwell, D. J., Ojemann, J. G., & Rao, R. P. (2019). Direct electrical stimulation in electrocorticographic brain–computer interfaces: Enabling technologies for input to cortex. Frontiers in Neuroscience, 13, 804.

Article  PubMed  PubMed Central  Google Scholar 

Craig, A. D. (2002). How do you feel? Interoception: The sense of the physiological condition of the body. Nature Reviews Neuroscience, 3(8), 655–666.

Article  CAS  PubMed  Google Scholar 

Deisseroth, K. (2011). Optogenetics. Nature Methods, 8(1), 26–29.

Article  CAS  PubMed  Google Scholar 

Dimov, L. F., Toniolo, E. F., Alonso-Matielo, H., de Andrade, D. C., Garcia-Larrea, L., Ballester, G., et al. (2018). Electrical stimulation of the insular cortex as a novel target for the relief of refractory pain: An experimental approach in rodents. Behavioural Brain Research, 346, 86–95.

Article  PubMed  Google Scholar 

Dum, R. P., Levinthal, D. J., & Strick, P. L. (2009). The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys. Journal of Neuroscience, 29(45), 14223–14235.

Article  CAS  PubMed  Google Scholar 

Emmert, K., Breimhorst, M., Bauermann, T., Birklein, F., Van De Ville, D., & Haller, S. (2014). Comparison of anterior cingulate vs. insular cortex as targets for real-time fMRI regulation during pain stimulation. Frontiers in Behavioral Neuroscience, 8, 350.

Article  PubMed  PubMed Central  Google Scholar 

Gehrlach, D. A., Dolensek, N., Klein, A. S., Roy Chowdhury, R., Matthys, A., Junghänel, M., et al. (2019). Aversive state processing in the posterior insular cortex. Nature Neuroscience, 22(9), 1424–1437.

Article  CAS  PubMed  Google Scholar 

Gehrlach, D. A., Weiand, C., Gaitanos, T. N., Cho, E., Klein, A. S., Hennrich, A. A., et al. (2020). A whole-brain connectivity map of mouse insular cortex. eLife, 9, e55585.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gogolla, N. (2017). The insular cortex. Current Biology, 27(12), R580–R586.

Article  CAS  PubMed  Google Scholar 

Han, J., Cha, M., Kwon, M., Hong, S.-K., Bai, S. J., & Lee, B. H. (2016). In vivo voltage-sensitive dye imaging of the insular cortex in nerve-injured rats. Neuroscience Letters, 634, 146–152.

Article  CAS  PubMed  Google Scholar 

Han, J., Kwon, M., Cha, M., Tanioka, M., Hong, S.-K., Bai, S. J., et al. (2015). Plasticity-related PKMζ signaling in the insular cortex is involved in the modulation of neuropathic pain after nerve injury. Neural Plasticity. https://doi.org/10.1155/2015/601767

Article  PubMed  PubMed Central  Google Scholar 

Harris, R. E., Sundgren, P. C., Craig, A., Kirshenbaum, E., Sen, A., Napadow, V., et al. (2009). Elevated insular glutamate in fibromyalgia is associated with experimental pain. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology, 60(10), 3146–3152.

Article  CAS  Google Scholar 

Henderson, J. M., & Lad, S. P. (2006). Motor cortex stimulation and neuropathic facial pain. Neurosurgical Focus, 21(6), 1–4.

Article  Google Scholar 

Islam, J., Kc, E., Kim, S., Kim, H. K., & Park, Y. S. (2021). Stimulating GABAergic neurons in the nucleus accumbens core alters the trigeminal neuropathic pain responses in a rat model of infraorbital nerve injury. International Journal of Molecular Sciences, 22(16), 8421.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Islam, J., Kc, E., Oh, B. H., Kim, S., Hyun, S.-H., & Park, Y. S. (2020). Optogenetic stimulation of the motor cortex alleviates neuropathic pain in rats of infraorbital nerve injury with/without CGRP knock-down. The Journal of Headache and Pain, 21, 1–13.

Article  Google Scholar 

Islam, J., Kc, E., So, K. H., Kim, S., Kim, H. K., Park, Y. Y., et al. (2023). Modulation of trigeminal neuropathic pain by optogenetic inhibition of posterior hypothalamus in CCI-ION rat. Scientific Reports, 13(1), 489.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ju, A., Fernandez-Arroyo, B., Wu, Y., Jacky, D., & Beyeler, A. (2020). Expression of serotonin 1A and 2A receptors in molecular-and projection-defined neurons of the mouse insular cortex. Molecular Brain, 13(1), 1–13.

Article  Google Scholar 

Karl, D. (2011). Optogenetics. Nature Methods, 8(1), 26–29.

Article  Google Scholar 

Kc, E., Islam, J., Kim, S., Kim, H. K., & Park, Y. S. (2022). Pain relief in a trigeminal neuralgia model via optogenetic inhibition on trigeminal ganglion itself with flexible optic fiber cannula. Frontiers in Cellular Neuroscience, 16, 175.

Article  Google Scholar 

Kobayashi, M. (2011). Macroscopic connection of rat insular cortex: Anatomical bases underlying its physiological functions. International Review of Neurobiology, 97, 285–303.

Article  CAS  PubMed  Google Scholar 

Korczeniewska, O. A., James, M. H., Eliav, T., Katzmann Rider, G., Mehr, J. B., Affendi, H., et al. (2022). Chemogenetic inhibition of trigeminal ganglion neurons attenuates behavioural and neural pain responses in a model of trigeminal neuropathic pain. European Journal of Pain, 26(3), 634–647.

Article  CAS  PubMed  Google Scholar 

Kovács, K. (2008). Measurement of immediate-early gene activation-c-fos and beyond. Journal of Neuroendocrinology, 20(6), 665–672.

Article  PubMed  Google Scholar 

Lambru, G., Zakrzewska, J., & Matharu, M. (2021). Trigeminal neuralgia: A practical guide. Practical Neurology, 21(5), 392–402.

Article  PubMed  PubMed Central  Google Scholar 

Liberati, G., Mulders, D., Algoet, M., van den Broeke, E. N., Santos, S. F., Ribeiro Vaz, J. G., et al. (2020). Insular responses to transient painful and non-painful thermal and mechanical spinothalamic stimuli recorded using intracerebral EEG. Scientific Reports, 10(1), 22319.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, M.-G., Kang, S. J., Shi, T.-Y., Koga, K., Zhang, M.-M., Collingridge, G. L., et al. (2013). Long-term potentiation of synaptic transmission in the adult mouse insular cortex: Multielectrode array recordings. Journal of Neurophysiology, 110(2), 505–521.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu, C., Yang, T., Zhao, H., Zhang, M., Meng, F., Fu, H., et al. (2016). Insular cortex is critical for the perception, modulation, and chronification of pain. Neuroscience Bulletin, 32(2), 191–201.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mazzola, L., Isnard, J., Peyron, R., Guénot, M., & Mauguiere, F. (2009). Somatotopic organization of pain responses to direct electrical stimulation of the human insular cortex. Pain, 146(1–2), 99–104.

Article  CAS  PubMed  Google Scholar 

Ostrowsky, K., Magnin, M., Ryvlin, P., Isnard, J., Guenot, M., & Mauguiere, F. (2002). Representation of pain and somatic sensation in the human insula: A study of responses to direct electrical cortical stimulation. Cerebral Cortex, 12(4), 376–385.

Article  PubMed  Google Scholar 

Pereira, R. C. M., Medeiros, P., Coimbra, N. C., Machado, H. R., & de Freitas, R. L. (2022). Cortical neurostimulation and N-methyl-D-aspartate glutamatergic receptor activation in the dysgranular layer of the posterior insular cortex modulate chronic neuropathic pain. Neuromodulation: Technology at the Neural Interface. https://doi.org/10.1016/j.neurom.2022.05.009

Article  Google Scholar 

Petrou, M., Pop-Busui, R., Foerster, B. R., Edden, R. A., Callaghan, B. C., Harte, S. E., et al. (2012). Altered excitation-inhibition balance in the brain of patients with diabetic neuropathy. Academic Radiology, 19(5), 607–612.

Article  PubMed  PubMed Central  Google Scholar 

Sato, F., Akhter, F., Haque, T., Kato, T., Takeda, R., Nagase, Y., et al. (2013). Projections from the insular cortex to pain-receptive trigeminal caudal subnucleus (medullary dorsal horn) and other lower brainstem areas in rats. Neuroscience, 233, 9–27.

Article  CAS  PubMed