1Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois

2Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio

3Department of Ophthalmology, University of Virginia, Charlottesville, Virginia

4Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan

5Casey Eye Institute, Oregon Health and Science University, Portland, Oregon

6Wilmer Eye Institute, John Hopkins University, Baltimore, Maryland

7Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio

∗[email protected]

Submitted: January 12, 2023

Accepted: February 19, 2023

Funding/Support: None of the authors have reported funding/support.

Conflict of Interest Disclosure: None of the authors have reported a financial conflict of interest.

Author Contributions and Acknowledgments: Conceptualization: SCQ, EK, SD, DL, TS; Data Curation: SCQ, EK, TS; Formal Analysis: SCQ, SS, BK, PS, TS; Investigation: SCQ, EK, TS; Methodology: SCQ, EK, SD, DL, TS; Resources: SCQ; Software: SS, BK, PS; Supervision: SCQ, SD, DL, TS; Validation: SCQ; Visualization: SCQ; Writing – Original Draft: SCQ; Writing – Review & Editing: SCQ, SS, SD, DL, BSC, TS.

We would like to thank Mark Beno for guiding our discussions on how to tackle the data analysis and for providing resources from the Cleveland Institute for Computational Biology.