Agrawal, S., Gollapudi, S., Su, H., & Gupta, S. (2011). Leptin activates human B cells to secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 signaling pathway. Journal of Clinical Immunology, 31(3), 472–478. https://doi.org/10.1007/s10875-010-9507-1
Article CAS PubMed PubMed Central Google Scholar
Banks, W. A., Coon, A. B., Robinson, S. M., Moinuddin, A., Shultz, J. M., Nakaoke, R., & Morley, J. E. (2004). Triglycerides induce leptin resistance at the blood-brain barrier. Diabetes, 53(5), 1253–1260. https://doi.org/10.2337/diabetes.53.5.1253
Article CAS PubMed Google Scholar
Bowman, K., Thambisetty, M., Kuchel, G. A., Ferrucci, L., & Melzer, D. (2019). Obesity and longer term risks of dementia in 65–74 year olds. Age and Ageing, 48(3), 367–373. https://doi.org/10.1093/ageing/afz002
Article PubMed PubMed Central Google Scholar
Christiansen, C. B., Gabe, M. B. N., Svendsen, B., Dragsted, L. O., Rosenkilde, M. M., & Holst, J. J. (2018). The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon. American Journal of Physiology-Gastrointestinal and Liver Physiology, 315(1), G53–G65. https://doi.org/10.1152/ajpgi.00346.2017
Article CAS PubMed Google Scholar
Couillard, C., Mauriège, P., Prud’homme, D., Nadeau, A., Tremblay, A., Bouchard, C., & Després, J. P. (1997). Plasma leptin concentrations: Gender differences and associations with metabolic risk factors for cardiovascular disease. Diabetologia, 40(10), 1178–1184. https://doi.org/10.1007/s001250050804
Article CAS PubMed Google Scholar
Dinel, A. L., André, C., Aubert, A., Ferreira, G., Layé, S., & Castanon, N. (2011). Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome. PLOS ONE, 6(9), e24325. https://doi.org/10.1371/journal.pone.0024325
Article CAS PubMed PubMed Central Google Scholar
Ellulu, M. S., Patimah, I., Khaza’ai, H., Rahmat, A., & Abed, Y. (2017). Obesity and inflammation: The linking mechanism and the complications. Archives of Medical Science: AMS, 13(4), 851–863. https://doi.org/10.5114/aoms.2016.58928
Article CAS PubMed Google Scholar
Forny-Germano, L., De Felice, F. G., & Vieira, M. (2019). The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer’s disease. Frontiers in Neuroscience, 12, 1027. https://doi.org/10.3389/fnins.2018.01027
Article PubMed PubMed Central Google Scholar
Forsythe, P., Bienenstock, J., & Kunze, W. A. (2014). Vagal pathways for microbiome-brain-gut axis communication. Advances in Experimental Medicine and Biology, 817, 115–133. https://doi.org/10.1007/978-1-4939-0897-4_5
Guo, D. H., Yamamoto, M., Hernandez, C. M., Khodadadi, H., Baban, B., & Stranahan, A. M. (2020). Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells. The Journal of Clinical Investigation, 130(4), 1961–1976. https://doi.org/10.1172/jci126078
Article CAS PubMed PubMed Central Google Scholar
Habbas, S., Santello, M., Becker, D., Stubbe, H., Zappia, G., Liaudet, N., Klaus, F. R., Kollias, G., Fontana, A., Pryce, C. R., Suter, T., & Volterra, A. (2015). Neuroinflammatory TNFα impairs memory via astrocyte signaling. Cell, 163(7), 1730–1741. https://doi.org/10.1016/j.cell.2015.11.023
Article CAS PubMed Google Scholar
Hajiluian, G., Abbasalizad Farhangi, M., Nameni, G., Shahabi, P., & Megari-Abbasi, M. (2018). Oxidative stress-induced cognitive impairment in obesity can be reversed by vitamin D administration in rats. Nutritional Neuroscience, 21(10), 744–752. https://doi.org/10.1080/1028415x.2017.1348436
Article CAS PubMed Google Scholar
Huijbers, W., Kirschbaum, C., Wirth, M., for the Alzheimer’s Disease Neuroimaging Initiative. (2020). Low plasma cortisol and large hippocampal volume are associated with reduced risk of clinical progression in MCI. Alzheimer’s & Dementia, 16(S6), e044462. https://doi.org/10.1002/alz.044462
Joo, S. H., Yun, S. H., Kang, D. W., Hahn, C. T., Lim, H. K., & Lee, C. U. (2018). Body mass index in mild cognitive impairment according to age, sex, cognitive intervention, and hypertension and risk of progression to Alzheimer’s disease. Frontiers in Psychiatry, 9, 142. https://doi.org/10.3389/fpsyt.2018.00142
Article PubMed PubMed Central Google Scholar
Kang, Y. E., Kim, J. M., Joung, K. H., Lee, J. H., You, B. R., Choi, M. J., Ryu, M. J., Ko, Y. B., Lee, M. A., Lee, J., Ku, B. J., Shong, M., Lee, K. H., & Kim, H. J. (2016). The Roles of adipokines proinflammatory cytokines, and adipose tissue macrophages in obesity-associated insulin resistance in modest obesity and early metabolic dysfunction. PloS one. https://doi.org/10.1371/journal.pone.0154003
Article PubMed PubMed Central Google Scholar
Kiliaan, A. J., Arnoldussen, I. A., & Gustafson, D. R. (2014). Adipokines: A link between obesity and dementia? The Lancet. Neurology, 13(9), 913–923. https://doi.org/10.1016/S1474-4422(14)70085-7
Article CAS PubMed PubMed Central Google Scholar
Kothari, V., Luo, Y., Tornabene, T., O’Neill, A. M., Greene, M. W., Geetha, T., & Babu, J. R. (2017). High fat diet induces brain insulin resistance and cognitive impairment in mice. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1863(2), 499–508. https://doi.org/10.1016/j.bbadis.2016.10.006
Article CAS PubMed Google Scholar
Lindhorst, A., Raulien, N., Wieghofer, P., Eilers, J., Rossi, F. M. V., Bechmann, I., & Gericke, M. (2021). Adipocyte death triggers a pro-inflammatory response and induces metabolic activation of resident macrophages. Cell Death & Disease, 12(6), 579. https://doi.org/10.1038/s41419-021-03872-9
Liu, S., Gao, J., Zhu, M., Liu, K., & Zhang, H. L. (2020). Gut microbiota and dysbiosis in Alzheimer’s disease: implications for pathogenesis and treatment. Molecular Neurobiology, 57(12), 5026–5043. https://doi.org/10.1007/s12035-020-02073-3
Article CAS PubMed PubMed Central Google Scholar
Loffredo, L., Ettorre, E., Zicari, A. M., Inghilleri, M., Nocella, C., Perri, L., Spalice, A., Fossati, C., De Lucia, M. C., Pigozzi, F., Cacciafesta, M., Violi, F., Carnevale, R., Neurodegenerative Disease study group. (2020). Oxidative stress and gut-derived lipopolysaccharides in neurodegenerative disease: Role of NOX2. Oxidative Medicine and Cellular Longevity, 2020, 8630275. https://doi.org/10.1155/2020/8630275
Article CAS PubMed PubMed Central Google Scholar
Loos, R. J. F., & Yeo, G. S. H. (2022). The genetics of obesity: From discovery to biology. Nature Reviews Genetics, 23(2), 120–133. https://doi.org/10.1038/s41576-021-00414-z
Article CAS PubMed Google Scholar
Mirmonsef, P., Zariffard, M. R., Gilbert, D., Makinde, H., Landay, A. L., & Spear, G. T. (2012). Short-chain fatty acids induce pro-inflammatory cytokine production alone and in combination with toll-like receptor ligands. American Journal of Reproductive Immunology, 67(5), 391–400. https://doi.org/10.1111/j.1600-0897.2011.01089.x
Article CAS PubMed Google Scholar
Nichols, E., Steinmetz, J. D., Vollset, S. E., Fukutaki, K., Chalek, J., Abd-Allah, F., Abdoli, A., Abualhasan, A., Abu-Gharbieh, E., Akram, T. T., Al Hamad, H., Alahdab, F., Alanezi, F. M., Alipour, V., Almustanyir, S., Amu, H., Ansari, I., Arabloo, J., Ashraf, T., . . . Vos, T. (2022). Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. The Lancet Public Health, 7(2), e105-e125. https://doi.org/10.1016/S2468-2667(21)00249-8
Pasqualetti, G., Brooks, D. J., & Edison, P. (2015). The role of neuroinflammation in dementias. Current Neurology and Neuroscience Reports, 15(4), 17. https://doi.org/10.1007/s11910-015-0531-7
Article CAS PubMed Google Scholar
Rochfort, K. D., Collins, L. E., McLoughlin, A., & Cummins, P. M. (2016). Tumour necrosis factor-α-mediated disruption of cerebrovascular endothelial barrier integrity in vitro involves the production of proinflammatory interleukin-6. Journal of Neurochemistry, 136(3), 564–572. https://doi.org/10.1111/jnc.13408
Article CAS PubMed Google Scholar
Saiyasit, N., Chunchai, T., Prus, D., Suparan, K., Pittayapong, P., Apaijai, N., Pratchayasakul, W., Sripetchwandee, J., Chattipakorn, N., & Chattipakorn, S. C. (2020). Gut dysbiosis develops before metabolic disturbance and cognitive decline in high-fat diet-induced obese condition. Nutrition, 69, 110576. https://doi.org/10.1016/j.nut.2019.110576
Article CAS PubMed Google Scholar
Salami, M. (2021). Interplay of good bacteria and central nervous system: Cognitive aspects and mechanistic considerations. Frontiers in Neuroscience, 15, 613120. https://doi.org/10.3389/fnins.2021.613120
Article PubMed PubMed Central Google Scholar
Singh-Manoux, A., Dugravot, A., Shipley, M., Brunner, E. J., Elbaz, A., Sabia, S., & Kivimaki, M. (2018). Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 14(2), 178–186. https://doi.org/10.1016/j.jalz.2017.06.2637
Tanida, M., Yamano, T., Maeda, K., Okumura, N., Fukushima, Y., & Nagai, K. (2005). Effects of intraduodenal injection of Lactobacillus johnsonii La1 on renal sympathetic nerve activity and blood pressure in urethane-anesthetized rats. Neuroscience Letters, 389(2), 109–114. https://doi.org/10.1016/j.neulet.2005.07.036
Article CAS PubMed Google Scholar
Thundyil, J., Pavlovski, D., Sobey, C. G., & Arumugam, T. V. (2012). Adiponectin receptor signalling in the brain. British Journal of Pharmacology, 165(2), 313–327. https://doi.org/10.1111/j.1476-5381.2011.01560.x
Article CAS PubMed PubMed Central Google Scholar
Turner, A., Hoyos, C., Mowszowski, L., LaMonica, H., Lagopoulos, J., DeMayo, M. M., Ireland, C., Hickie, I. B., Naismith, S. L., & Duffy, S. L. (2021). Obesity and oxidative stress in older adults at risk for dementia: A magnetic resonance spectroscopy study. Alzheimer Disease and Associated Disorders, 35(2), 121–127. https://doi.org/10.1097/WAD.0000000000000434
Article CAS PubMed Google Scholar
Vamanu, E., & Rai, S. N. (2021). The link between obesity, microbiota dysbiosis, and neurodegenerative pathogenesis. Diseases, 9(3), 45. https://doi.org/10.3390/diseases9030045
Article PubMed PubMed Central Google Scholar
Van Dyken, P., & Lacoste, B. (2018). Impact of metabolic syndrome on neuroinflammation and the blood-brain barrier. Frontiers in Neuroscience, 12, 930. https://doi.org/10.3389/fnins.2018.00930
留言 (0)