Reznicek L, Kolb JP, Klein T, Mohler KJ, Wieser W, Huber R, et al. Wide-field Megahertz OCT imaging of patients with diabetic retinopathy. J Diabetes Res. 2015;2015: 305084.

Article  PubMed  PubMed Central  Google Scholar 

De Pretto LR, Moult EM, Alibhai AY, Carrasco-Zevallos OM, Chen S, Lee B, et al. Controlling for artifacts in widefield optical coherence tomography angiography measurements of non-perfusion area. Sci Rep. 2019;9(1):9096.

Article  PubMed  PubMed Central  Google Scholar 

Frizziero L, Midena G, Longhin E, Berton M, Torresin T, Parrozzani R, et al. Early retinal changes by OCT angiography and multifocal electroretinography in diabetes. J Clin Med. 2020;9(11):3514.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bekkers A, Borren N, Ederveen V, Fokkinga E, Andrade De Jesus D, Sánchez Brea L, et al. Microvascular damage assessed by optical coherence tomography angiography for glaucoma diagnosis: a systematic review of the most discriminative regions. Acta Ophthalmol. 2020;98(6):537–58.

Article  PubMed  PubMed Central  Google Scholar 

Mitchell SL, Ma C, Scott WK, Agarwal A, Pericak-Vance MA, Haines JL, et al. Plasma metabolomics of intermediate and neovascular age-related macular degeneration patients. Cells. 2021;10(11):3141.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joussen AM, Poulaki V, Qin W, Kirchhof B, Mitsiades N, Wiegand SJ, et al. Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol. 2002;160(2):501–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Figueira J, Fletcher E, Massin P, Silva R, Bandello F, Midena E, et al. Ranibizumab plus panretinal photocoagulation versus panretinal photocoagulation alone for high-risk proliferative diabetic retinopathy (PROTEUS Study). Ophthalmology. 2018;125(5):691–700.

Article  PubMed  Google Scholar 

Bressler SB, Beaulieu WT, Glassman AR, Gross JG, Melia M, Chen E, et al. Panretinal photocoagulation versus ranibizumab for proliferative diabetic retinopathy: factors associated with vision and edema outcomes. Ophthalmology. 2018;125(11):1776–83.

Article  PubMed  Google Scholar 

Snowden S, Dahlén SE, Wheelock CE. Application of metabolomics approaches to the study of respiratory diseases. Bioanalysis. 2012;4(18):2265–90.

Article  CAS  PubMed  Google Scholar 

Wang H, Fang J, Chen F, Sun Q, Xu X, Lin SH, et al. Metabolomic profile of diabetic retinopathy: a GC-TOFMS-based approach using vitreous and aqueous humor. Acta Diabetol. 2020;57(1):41–51.

Article  PubMed  Google Scholar 

Xie S, Zhang H, Liu Y, Gao K, Zhang J, Fan R, et al. The role of serum metabolomics in distinguishing chronic rhinosinusitis with nasal polyp phenotypes. Front Mol Biosci. 2020;7:593976.

Article  CAS  PubMed  Google Scholar 

Li X, Luo X, Lu X, Duan J, Xu G. Metabolomics study of diabetic retinopathy using gas chromatography-mass spectrometry: a comparison of stages and subtypes diagnosed by western and Chinese medicine. Mol Biosyst. 2011;7(7):2228–37.

Article  CAS  PubMed  Google Scholar 

Campochiaro PA, Iftikhar M, Hafiz G, Akhlaq A, Tsai G, Wehling D, et al. Oral N-acetylcysteine improves cone function in retinitis pigmentosa patients in phase I trial. J Clin Invest. 2020;130(3):1527–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berber E, Rouse BT. Controlling herpes simplex virus-induced immunoinflammatory lesions using metabolic therapy: a comparison of 2-deoxy-d-glucose with metformin. J Virol. 2022;96(14): e0068822.

Article  PubMed  Google Scholar 

Haines NR, Manoharan N, Olson JL, D’Alessandro A, Reisz JA. Metabolomics analysis of human vitreous in diabetic retinopathy and rhegmatogenous retinal detachment. J Proteome Res. 2018;17(7):2421–7.

Article  CAS  PubMed  Google Scholar 

Young SP, Nessim M, Falciani F, Trevino V, Banerjee SP, Scott RA, et al. Metabolomic analysis of human vitreous humor differentiates ocular inflammatory disease. Mol Vis. 2009;15:1210–7.

CAS  PubMed  PubMed Central  Google Scholar 

Chen L, Gao Y, Wang LZ, Cheung N, Tan GSW, Cheung GCM, et al. Recent advances in the applications of metabolomics in eye research. Anal Chim Acta. 2018;1037:28–40.

Article  CAS  PubMed  Google Scholar 

Tan SZ, Begley P, Mullard G, Hollywood KA, Bishop PN. Introduction to metabolomics and its applications in ophthalmology. Eye (Lond). 2016;30(6):773–83.

Article  CAS  PubMed  Google Scholar 

Laíns I, Gantner M, Murinello S, Lasky-Su JA, Miller JW, Friedlander M, et al. Metabolomics in the study of retinal health and disease. Prog Retin Eye Res. 2019;69:57–79.

Article  PubMed  Google Scholar 

Aribindi K, Guerra Y, Piqueras Mdel C, Banta JT, Lee RK, Bhattacharya SK. Cholesterol and glycosphingolipids of human trabecular meshwork and aqueous humor: comparative profiles from control and glaucomatous donors. Curr Eye Res. 2013;38(10):1017–26.

Article  CAS  PubMed  Google Scholar 

Hou XW, Wang Y, Pan CW. Metabolomics in age-related macular degeneration: a systematic review. Invest Ophthalmol Vis Sci. 2020;61(14):13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chakravarthy U, Wong TY, Fletcher A, Piault E, Evans C, Zlateva G, et al. Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis. BMC Ophthalmol. 2010;10:31.

Article  PubMed  PubMed Central  Google Scholar 

Jian Q, Wu Y, Zhang F. Metabolomics in diabetic retinopathy: from potential biomarkers to molecular basis of oxidative stress. Cells. 2022;11(19):3005.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Edwards G, Aribindi K, Guerra Y, Lee RK, Bhattacharya SK. Phospholipid profiles of control and glaucomatous human aqueous humor. Biochimie. 2014;101:232–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aljohani AJ, Edwards G, Guerra Y, Dubovy S, Miller D, Lee RK, et al. Human trabecular meshwork sphingolipid and ceramide profiles and potential latent fungal commensalism. Invest Ophthalmol Vis Sci. 2014;55(6):3413–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji Y, Rao J, Rong X, Lou S, Zheng Z, Lu Y. Metabolic characterization of human aqueous humor in relation to high myopia. Exp Eye Res. 2017;159:147–55.

Article  CAS  PubMed  Google Scholar 

Hioki T, Kamiya K, Tsuda H, Maekawa T, Komine M, Murata S, et al. Acute generalized exanthematous pustulosis induced by amoxicillin/clavulanic acid, manifesting as severe laryngeal edema. J Dermatol. 2019;46(11):e443–4.

Article  PubMed  Google Scholar 

Ban N, Lee TJ, Sene A, Choudhary M, Lekwuwa M, Dong Z, et al. Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. JCI Insight. 2018;3(17): 120824.

Article  PubMed  Google Scholar 

Albouery M, Buteau B, Grégoire S, Martine L, Gambert S, Bron AM, et al. Impact of a high-fat diet on the fatty acid composition of the retina. Exp Eye Res. 2020;196:108059.

Article  CAS  PubMed  Google Scholar 

Picklo MJ, Murphy EJ. A high-fat, high-oleic diet, but not a high-fat, saturated diet, reduces hepatic alpha-linolenic acid and eicosapentaenoic acid content in mice. Lipids. 2016;51(5):537–47.

Article  CAS  PubMed  Google Scholar 

Kamegawa M, Nakanishi-Ueda T, Iwai S, Ueda T, Kosuge S, Ogura H, et al. Effect of lipid-hydroperoxide-induced oxidative stress on vitamin E, ascorbate and glutathione in the rabbit retina. Ophthalmic Res. 2007;39(1):49–54.

Article  CAS  PubMed  Google Scholar 

Wilkinson-Berka JL, Suphapimol V, Jerome JR, Deliyanti D, Allingham MJ. Angiotensin II and aldosterone in retinal vasculopathy and inflammation. Exp Eye Res. 2019;187:107766.

Article  CAS  PubMed  Google Scholar 

Tomita Y, Lee D, Miwa Y, Jiang X, Ohta M, Tsubota K, et al. Pemafibrate protects against retinal dysfunction in a murine model of diabetic retinopathy. Int J Mol Sci. 2020;21(17):6243.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Cai S, He Z, Reilly J, Zeng Z, Strang N, et al. Metabolomics in retinal diseases: an update. Biology (Basel). 2021;10(10):944.

CAS  PubMed  Google Scholar 

Ye P, Zhang X, Xu Y, Xu J, Song X, Yao K. Alterations of the gut microbiome and metabolome in patients with proliferative diabetic retinopathy. Front Microbiol. 2021;12:667632.

Article  PubMed  PubMed Central  Google Scholar