Blain S (2008) Switching cyclin D-Cdk4 kinase activity on and off. Cell Cycle 7:892–898. https://doi.org/10.4161/cc.7.7.5637

Article  CAS  PubMed  Google Scholar 

Buck V, Russell P, Millar JBA (1995) Identification of a cdk-activating kinase in fission yeast. EMBO J 14:6173. https://doi.org/10.1002/J.1460-2075.1995.TB00308.X

Article  CAS  PubMed  PubMed Central  Google Scholar 

Donai K, Kiyono T, Eitsuka T et al (2014) Bovine and porcine fibroblasts can be immortalized with intact karyotype by the expression of mutant cyclin dependent kinase 4, cyclin D, and telomerase. J Biotechnol 176:50–57. https://doi.org/10.1016/J.JBIOTEC.2014.02.017

Article  CAS  PubMed  Google Scholar 

Fukuda T, Eitsuka T, Donai K et al (2018) Expression of human mutant cyclin dependent kinase 4, Cyclin D and telomerase extends the life span but does not immortalize fibroblasts derived from loggerhead sea turtle (Caretta caretta). Sci Rep 8:9229. https://doi.org/10.1038/S41598-018-27271-X

Fukuda T, Iino Y, Eitsuka T et al (2016a) Cellular conservation of endangered midget buffalo (Lowland Anoa, Bubalus quarlesi) by establishment of primary cultured cell, and its immortalization with expression of cell cycle regulators. Cytotechnology 68:1937–1947. https://doi.org/10.1007/S10616-016-0004-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fukuda T, Iino Y, Onuma M et al (2016b) Expression of human cell cycle regulators in the primary cell line of the African savannah elephant (loxodonta africana) increases proliferation until senescence, but does not induce immortalization. In Vitro Cell Dev Biol Anim 52:20–26. https://doi.org/10.1007/S11626-015-9943-6

Article  CAS  PubMed  Google Scholar 

Gouko R, Onuma M, Eitsuka T et al (2018) Efficient immortalization of cells derived from critically endangered Tsushima leopard cat (Prionailurus bengalensis euptilurus) with expression of mutant CDK4, Cyclin D1, and telomerase reverse transcriptase. Cytotechnology 70:1619–1630. https://doi.org/10.1007/S10616-018-0254-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hideki E, Kimiyuki T (2006) A new species of Ryukyu spiny rat, Tokudaia (Muridae: Rodentia), from Tokunoshima Island, Kagoshima Prefecture, Japan. Mammal study. 31(1):47–57. https://iss.ndl.go.jp/books/R100000002-I000000159116-00

Honda T, Itoh M, Suzuki H (1977) An unusual sex chromosome constitution found in the Amami spinous country-rat, tokudaia osimensis osimensis. Japanese J Genet 52:247–249. https://doi.org/10.1266/JJG.52.247

Article  Google Scholar 

Huschtscha LI, Reddel RR (1999) p16(INK4a) and the control of cellular proliferative life span. Carcinogenesis 20:921–926. https://doi.org/10.1093/carcin/20.6.921

Article  CAS  PubMed  Google Scholar 

Ishii N (2016) Diplothrix legata. The IUCN red list of threatened species 2016: e.T6671A22459891. https://doi.org/10.2305/IUCN.UK.2016-2.RLTS.T6671A22459891.en

Kaldis P, Russo AA, Chou HS et al (1998) Human and Yeast Cdk-activating Kinases (CAKs) Display Distinct Substrate Specificities. Mol Biol Cell 9:2545. https://doi.org/10.1091/MBC.9.9.2545

Article  CAS  PubMed  PubMed Central  Google Scholar 

Katayama M, Kiyono T, Ohmaki H et al (2019) Extended proliferation of chicken- and Okinawa rail-derived fibroblasts by expression of cell cycle regulators. J Cell Physiol 234:6709–6720. https://doi.org/10.1002/JCP.27417

Article  CAS  PubMed  Google Scholar 

Kiyono T, Foster SA, Koop JI et al (1998) Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nat 3966706(396):84–88. https://doi.org/10.1038/23962

Article  CAS  Google Scholar 

Kumari R, Jat P (2021) Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype. Front Cell Dev Biol 9:645593. https://doi.org/10.3389/FCELL.2021.645593

Kuroda K, Kiyono T, Isogai E, et al (2015) Immortalization of fetal bovine colon epithelial cells by expression of human cyclin D1, mutant cyclin dependent kinase 4, and telomerase reverse transcriptase: an in vitro model for bacterial infection. PLoS One 10(12):e0143473. https://doi.org/10.1371/journal.pone.0143473

Lundberg AS, Hahn WC, Gupta P, Weinberg RA (2000) Genes involved in senescence and immortalization. Curr Opin Cell Biol 12:705–709. https://doi.org/10.1016/S0955-0674(00)00155-1

Article  CAS  PubMed  Google Scholar 

Ministry of Environment, Government of Japan (2012) The 4th Japanese red data book. Japan Wildlife Research Center, Tokyo, Japan

O’Reilly DR (1986) p53 and transformation by SV40. Biol Cell 57:187–196. https://doi.org/10.1111/J.1768-322X.1986.TB00475.X

Article  PubMed  Google Scholar 

Orimoto A, Katayama M, Tani T et al (2020) Primary and immortalized cell lines derived from the Amami rabbit (Pentalagus furnessi) and evolutionally conserved cell cycle control with CDK4 and Cyclin D1. Biochem Biophys Res Commun 525:1046–1053. https://doi.org/10.1016/j.bbrc.2020.03.036

Article  CAS  PubMed  Google Scholar 

Semczuk A, Jakowicki JA (2004) Alterations of pRb1-cyclin D1-cdk4/6-p16INK4A pathway in endometrial carcinogenesis. Cancer Lett 203:1–12. https://doi.org/10.1016/J.CANLET.2003.09.012

Article  CAS  PubMed  Google Scholar 

Steinberg ML, Defendi V (1983) Transformation and immortalization of human keratinocytes by SV40. J Invest Dermatol 81:S131–S133. https://doi.org/10.1111/1523-1747.EP12540905

Article  Google Scholar 

Takada H, Miura T, Fujibayashi S et al (2021) Detailed chromosome analysis of wild-type, immortalized fibroblasts with SV40T, E6E7, combinational introduction of cyclin dependent kinase 4, cyclin D1, telomerase reverse transcriptase. Vitr Cell Dev Biol - Anim 57:998–1005. https://doi.org/10.1007/s11626-021-00631-0

Article  CAS  Google Scholar 

Tamanaha S, Mukai S, Yoshinaga T, Handa H, Kinjo T, Nakaya Y, Nakachi M, Kinjo M, Nagamine T, Nakata K et al (2017) Roadkill risk map for the endangered Ryukyu long-furred rat Diplothrix legata along Prefectural Route 2 on northern Okinawa-jima Island, Japan. Mammalian Science. 57(2):203–209. https://doi.org/10.11238/mammalianscience.57.203

Tani T, Eitsuka T, Katayama M et al (2019) Establishment of immortalized primary cell from the critically endangered Bonin flying fox (Pteropus pselaphon). PLoS One 14:e0221364

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thomas O (2009) X.—On a second species of Lenothrix from the Liu Ku Islands. Ann Mag Nat Hist 7(17):88–89. https://doi.org/10.1080/00222930608562493

Yumiko N, Takashi N, Michio K, Katsushi Nakata IY (2017) Long-term feeding of rescued Ryukyu long-furred rats and Okinawa spiny rat. J Vet Med Sci 57:221–226. https://doi.org/10.11238/mammalianscience.57.221