Carrat F, Fontaine H, Dorival C, Simony M, Diallo A, Hezode C, et al. Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study. Lancet. 2019;393:1453–64.
Article CAS PubMed Google Scholar
Arzumanyan A, Reis HM, Feitelson MA. Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma. Nat Rev Cancer. 2013;13:123–35.
Article CAS PubMed Google Scholar
Opar A. Excitement grows for potential revolution in hepatitis C virus treatment. Nat Rev Drug Discov. 2010;9:501–3.
Article CAS PubMed Google Scholar
Feld JJ, Jacobson IM, Hezode C, Asselah T, Ruane PJ, Gruener N, et al. Sofosbuvir and velpatasvir for HCV genotype 1, 2, 4, 5, and 6 infection. N Engl J Med. 2015;373:2599–607.
Article CAS PubMed Google Scholar
Foster GR, Afdhal N, Roberts SK, Brau N, Gane EJ, Pianko S, et al. Sofosbuvir and velpatasvir for HCV genotype 2 and 3 infection. N Engl J Med. 2015;373:2608–17.
Article CAS PubMed Google Scholar
Felmlee DJ, Coilly A, Chung RT, Samuel D, Baumert TF. New perspectives for preventing hepatitis C virus liver graft infection. Lancet Infect Dis. 2016;16:735–45.
Article PubMed PubMed Central Google Scholar
Reig M, Marino Z, Perello C, Inarrairaegui M, Ribeiro A, Lens S, et al. Unexpected high rate of early tumor recurrence in patients with HCV-related HCC undergoing interferon-free therapy. J Hepatol. 2016;65:719–26.
Article CAS PubMed Google Scholar
Tahata Y, Hikita H, Mochida S, Enomoto N, Kawada N, Kurosaki M, et al. Liver-related events after direct-acting antiviral therapy in patients with hepatitis C virus-associated cirrhosis. J Gastroenterol. 2022;57:120–32.
Article CAS PubMed Google Scholar
Okamoto T, Nishimura Y, Ichimura T, Suzuki K, Miyamura T, Suzuki T, et al. Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. EMBO J. 2006;25:5015–25.
Article CAS PubMed PubMed Central Google Scholar
Bukong TN, Hou W, Kodys K, Szabo G. Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells. Hepatology. 2013;57:70–80.
Article CAS PubMed Google Scholar
Bukong TN, Momen-Heravi F, Kodys K, Bala S, Szabo G. Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90. PLoS Pathog. 2014;10:e1004424.
Article PubMed PubMed Central Google Scholar
Xu M, Zhao C, Zhu B, Wang L, Zhou H, Yan D, et al. Discovering high potent Hsp90 inhibitors as antinasopharyngeal carcinoma agents through fragment assembling approach. J Med Chem. 2021;64:2010–23.
Article CAS PubMed Google Scholar
Li L, Wang L, You QD, Xu XL. Heat shock protein 90 inhibitors: an update on achievements, challenges, and future directions. J Med Chem. 2020;63:1798–822.
Article CAS PubMed Google Scholar
Li M, Mulkey F, Jiang C, O’Neil BH, Schneider BP, Shen F, et al. Identification of a genomic region between SLC29A1 and HSP90AB1 associated with risk of bevacizumab-induced hypertension: CALGB 80405 (Alliance). Clin Cancer Res. 2018;24:4734–44.
Article CAS PubMed PubMed Central Google Scholar
Munch C, Harper JW. Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation. Nature. 2016;534:710–3.
Article CAS PubMed PubMed Central Google Scholar
Corson TW, Crews CM. Molecular understanding and modern application of traditional medicines: triumphs and trials. Cell. 2007;130:769–74.
Article CAS PubMed PubMed Central Google Scholar
Liu J, Lee J, Salazar Hernandez MA, Mazitschek R, Ozcan U. Treatment of obesity with celastrol. Cell. 2015;161:999–1011.
Article CAS PubMed PubMed Central Google Scholar
Chen SR, Dai Y, Zhao J, Lin L, Wang Y, Wang Y. A mechanistic overview of triptolide and celastrol, natural products from tripterygium wilfordii hook F. Front Pharmacol. 2018;9:104.
Article PubMed PubMed Central Google Scholar
Venkatesha SH, Yu H, Rajaiah R, Tong L, Moudgil KD. Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses. J Biol Chem. 2011;286:15138–46.
Article CAS PubMed PubMed Central Google Scholar
Astry B, Venkatesha SH, Laurence A, Christensen-Quick A, Garzino-Demo A, Frieman MB, et al. Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ. Clin Immunol. 2015;157:228–38.
Article CAS PubMed PubMed Central Google Scholar
Zhang T, Hamza A, Cao X, Wang B, Yu S, Zhan CG, et al. A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells. Mol Cancer Ther. 2008;7:162–70.
Article CAS PubMed Google Scholar
Hieronymus H, Lamb J, Ross KN, Peng XP, Clement C, Rodina A, et al. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell. 2006;10:321–30.
Article CAS PubMed Google Scholar
Sun H, Xu L, Yu P, Jiang J, Zhang G, Wang Y. Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells. Bioorg Med Chem Lett. 2010;20:3844–7.
Article CAS PubMed Google Scholar
Guide for the Care and Use of Laboratory Animals 8th edition. The National Academies Press, 2011.
Lohmann V, Korner F, Koch J, Herian U, Theilmann L, Bartenschlager R. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science. 1999;285:110–3.
Article CAS PubMed Google Scholar
Huang L, Sineva EV, Hargittai MR, Sharma SD, Suthar M, Raney KD, et al. Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. Protein Expr Purif. 2004;37:144–53.
Article CAS PubMed Google Scholar
Yun TJ, Harning EK, Giza K, Rabah D, Li P, Arndt JW, et al. EC144, a synthetic inhibitor of heat shock protein 90, blocks innate and adaptive immune responses in models of inflammation and autoimmunity. J Immunol. 2011;186:563–75.
Article CAS PubMed Google Scholar
Halgren TA, Murphy RB, Friesner RA, Beard HS, Frye LL, Pollard WT, et al. Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening. J Med Chem. 2004;47:1750–9.
Article CAS PubMed Google Scholar
Case DA, Cheatham TE 3rd, Darden T, Gohlke H, Luo R, Merz KM Jr., et al. The Amber biomolecular simulation programs. J Comput Chem. 2005;26:1668–88.
Article CAS PubMed PubMed Central Google Scholar
Wang J, Wang W, Kollman PA, Case DA. Automatic atom type and bond type perception in molecular mechanical calculations. J Mol Graph Model. 2006;25:247–60.
Huggins DJ. Correlations in liquid water for the TIP3P-Ewald, TIP4P-2005, TIP5P-Ewald, and SWM4-NDP models. J Chem Phys. 2012;136:064518.
Eastman P, Pande VS. CCMA: a robust, parallelizable constraint method for molecular simulations. J Chem Theory Comput. 2010;6:434–7.
Article CAS PubMed PubMed Central Google Scholar
Lomenick B, Jung G, Wohlschlegel JA, Huang J. Target identification using drug affinity responsive target stability (DARTS). Curr Protoc Chem Biol. 2011;3:163–80.
Article PubMed PubMed Central Google Scholar
Xu G, Fu S, Zhan X, Wang Z, Zhang P, Shi W, et al. Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90. JCI Insight. 2021;6:e134601.
Article PubMed PubMed Central Google Scholar
Cheng Y, Tsou LK, Cai J, Aya T, Dutschman GE, Gullen EA, et al. A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro. Antimicrob Agents Chemother. 2010;54:197–206.
Article CAS PubMed Google Scholar
Ding MY, Peng Y, Li F, Li ZQ, Wang D, Zhou GC, et al. Andrographolide derivative as antagonist of vitamin D receptor to induce lipidation of microtubule associate protein 1 light chain 3 (LC3). Bioorg Med Chem. 2021;51:116505.
留言 (0)