Neumuller, R. A. & Knoblich, J. A. Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev. 23, 2675–2699 (2009).

Article  Google Scholar 

Sedzinski, J. et al. Polar actomyosin contractility destabilizes the position of the cytokinetic furrow. Nature 476, 462–466 (2011).

Article  CAS  Google Scholar 

Yamamoto, K. et al. Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis. Nat. Commun. 12, 7145 (2021).

Article  CAS  Google Scholar 

Cadart, C., Zlotek-Zlotkiewicz, E., Le Berre, M., Piel, M. & Matthews, H. K. Exploring the function of cell shape and size during mitosis. Dev. Cell 29, 159–169 (2014).

Article  CAS  Google Scholar 

Ou, G., Stuurman, N., D’Ambrosio, M. & Vale, R. D. Polarized myosin produces unequal-size daughters during asymmetric cell division. Science 330, 677–680 (2010).

Article  CAS  Google Scholar 

Kitajima, A., Fuse, N., Isshiki, T. & Matsuzaki, F. Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development. Dev. Biol. 347, 9–23 (2010).

Article  CAS  Google Scholar 

Betschinger, J. & Knoblich, J. A. Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr. Biol. 14, R674–R685 (2004).

Article  CAS  Google Scholar 

Clevers, H. Stem cells, asymmetric division and cancer. Nat. Genet. 37, 1027–1028 (2005).

Article  CAS  Google Scholar 

Doe, C. Q. Neural stem cells: balancing self-renewal with differentiation. Development 135, 1575–1587 (2008).

Article  CAS  Google Scholar 

McCarthy, E. K. & Goldstein, B. Asymmetric spindle positioning. Curr. Opin. Cell Biol. 18, 79–85 (2006).

Article  CAS  Google Scholar 

Kiyomitsu, T. Mechanisms of daughter cell-size control during cell division. Trends Cell Biol. 25, 286–295 (2015).

Article  CAS  Google Scholar 

Cai, Y., Yu, F., Lin, S., Chia, W. & Yang, X. Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions. Cell 112, 51–62 (2003).

Article  CAS  Google Scholar 

Roubinet, C. & Cabernard, C. Control of asymmetric cell division. Curr. Opin. Cell Biol. 31, 84–91 (2014).

Article  CAS  Google Scholar 

Cabernard, C., Prehoda, K. E. & Doe, C. Q. A spindle-independent cleavage furrow positioning pathway. Nature 467, 91–94 (2010).

Article  CAS  Google Scholar 

Connell, M., Cabernard, C., Ricketson, D., Doe, C. Q. & Prehoda, K. E. Asymmetric cortical extension shifts cleavage furrow position in Drosophila neuroblasts. Mol. Biol. Cell 22, 4220–4226 (2011).

Article  CAS  Google Scholar 

Stewart, M. P. et al. Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding. Nature 469, 226–230 (2011).

Article  CAS  Google Scholar 

Maddox, A. S. & Burridge, K. RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J. Cell Biol. 160, 255–265 (2003).

Article  CAS  Google Scholar 

Couturier, L. et al. Regulation of cortical stability by RhoGEF3 in mitotic sensory organ precursor cells in Drosophila. Biol. Open 6, 1851–1860 (2017).

CAS  Google Scholar 

Ramanathan, S. P. et al. Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement. Nat. Cell Biol. 17, 148–159 (2015).

Article  CAS  Google Scholar 

Kunda, P., Pelling, A. E., Liu, T. & Baum, B. Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis. Curr. Biol. 18, 91–101 (2008).

Article  CAS  Google Scholar 

Bovellan, M. et al. Cellular control of cortical actin nucleation. Curr. Biol. 24, 1628–1635 (2014).

Article  CAS  Google Scholar 

Pollard, T. D., Blanchoin, L. & Mullins, R. D. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu. Rev. Biophys. Biomol. Struct. 29, 545–576 (2000).

Article  CAS  Google Scholar 

Watanabe, N. & Higashida, C. Formins: processive cappers of growing actin filaments. Exp. Cell. Res. 301, 16–22 (2004).

Article  CAS  Google Scholar 

O'Connell, M. E. et al. The Drosophila protein, Nausicaa, regulates lamellipodial actin dynamics in a Cortactin-dependent manner. Biol. Open 8, bio038232 (2019).

Article  CAS  Google Scholar 

Rizvi, S. A. et al. Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. Chem. Biol. 16, 1158–1168 (2009).

Article  CAS  Google Scholar 

Yaniv, S. P., Meltzer, H., Alyagor, I. & Schuldiner, O. Developmental axon regrowth and primary neuron sprouting utilize distinct actin elongation factors. J. Cell Biol. 219, e201903181 (2020).

Article  CAS  Google Scholar 

Gao, Y. et al. Genetic dissection of active forgetting in labile and consolidated memories in Drosophila. Proc. Natl Acad. Sci. USA 116, 21191–21197 (2019).

Article  CAS  Google Scholar 

Sit, S.-T. & Manser, E. Rho GTPases and their role in organizing the actin cytoskeleton. J. Cell Sci 124, 679–683 (2011).

Article  CAS  Google Scholar 

Chugh, P. & Paluch, E. K. The actin cortex at a glance. J. Cell Sci. 131, jcs186254 (2018).

Article  Google Scholar 

Rogers, S. L., Wiedemann, U., Stuurman, N. & Vale, R. D. Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J. Cell Biol. 162, 1079–1088 (2003).

Article  CAS  Google Scholar 

Watanabe, S. et al. mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells. Mol. Biol. Cell 19, 2328–2338 (2008).

Article  CAS  Google Scholar 

Gorlin, J. B. et al. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J. Cell Biol. 111, 1089–1105 (1990).

Article  CAS  Google Scholar 

Seppala, J. et al. Flexible structure of peptide-bound filamin a mechanosensor domain pair 20-21. PLoS ONE 10, e0136969 (2015).

Article  Google Scholar 

Edwards, R. A. & Bryan, J. Fascins, a family of actin bundling proteins. Cell Motil. Cytoskeleton 32, 1–9 (1995).

Article  CAS  Google Scholar 

Winkelman, J. D. et al. Fascin- and alpha-actinin-bundled networks contain intrinsic structural features that drive protein sorting. Curr. Biol. 26, 2697–2706 (2016).

Article  CAS  Google Scholar 

Klein, M. G. et al. Structure of the actin crosslinking core of fimbrin. Structure 12, 999–1013 (2004).

Article  CAS  Google Scholar 

Albertson, R. & Doe, C. Q. Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nat. Cell Biol. 5, 166–170 (2003).

Article  CAS  Google Scholar 

Langevin, J. et al. Lethal giant larvae controls the localization of notch-signaling regulators numb, neuralized, and Sanpodo in Drosophila sensory-organ precursor cells. Curr. Biol. 15, 955–962 (2005).

Article  CAS  Google Scholar 

Rhyu, M. S., Jan, L. Y. & Jan, Y. N. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells. Cell 76, 477–491 (1994).

Article  CAS  Google Scholar 

Siller, K. H., Cabernard, C. & Doe, C. Q. The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts. Nat. Cell Biol. 8, 594–600 (2006).

Article  CAS  Google Scholar 

Bowman, S. K., Neumuller, R. A., Novatchkova, M., Du, Q. & Knoblich, J. A. The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. Dev. Cell 10, 731–742 (2006).

Article  CAS  Google Scholar 

Wang, C. et al. An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts. Dev. Cell 21, 520–533 (2011).

Article  CAS  Google Scholar 

Izumi, Y., Ohta, N., Hisata, K., Raabe, T. & Matsuzaki, F. Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization. Nat. Cell Biol. 8, 586–593 (2006).

Article  CAS  Google Scholar 

Gotta, M., Abraham, M. C. & Ahringer, J. CDC-42 controls early cell polarity and spindle orientation in C. elegans. Curr. Biol. 11, 482–488 (2001).

Article  CAS  Google Scholar 

Joberty, G., Petersen, C., Gao, L. & Macara, I. G. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat. Cell Biol. 2, 531–539 (2000).

Article  CAS  Google Scholar 

Lin, D. et al. A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat. Cell Biol. 2, 540–547 (2000).

Article  CAS