H. Sung, J. Ferlay, R.L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray, Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: Cancer J. Clin. 71, 209–249 (2021)

U. Mehraj, U. Mushtaq, M.A. Mir, A. Saleem, M.A. Macha, M.N. Lone, A. Hamid, M.A. Zargar,  S.M. Ahmad, N.A. Wani, Chemokines in triple-negative breast cancer heterogeneity: New challenges for clinical implications. Semin Cancer Biol. 9, S1044–579X(22)00064–5 (2022)

S. Yardım-Akaydin, B. Karahalil, S. Nacak Baytas, New therapy strategies in the management of breast cancer. Drug Discov Today 27, 1755–1762 (2022)

Article  Google Scholar 

B. Medeiros, A.L. Allan, Molecular Mechanisms of Breast Cancer Metastasis to the Lung: Clinical and Experimental Perspectives. Int. J. Mol. Sci. 20, 2272 (2019)

Article  CAS  Google Scholar 

N.J. Birkbak, N. McGranahan, Cancer Genome Evolutionary Trajectories in Metastasis. Cancer Cell 37, 8–19 (2020)

Article  CAS  Google Scholar 

Y.L. Hsu, M.S. Huang, J.Y. Hung, W.A. Chang, Y.M. Tsai, Y.C. Pan, Y.S. Lin, H.P. Tsai, P.L. Kuo, Bone-marrow-derived cell-released extracellular vesicle miR-92a regulates hepatic pre-metastatic niche in lung cancer. Oncogene 39, 739–753 (2020)

Article  CAS  Google Scholar 

M. Umakoshi, S. Takahashi, G. Itoh, S. Kuriyama, Y. Sasaki, K. Yanagihara, M. Yashiro, D. Maeda, A. Goto, M. Tanaka, Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment. Oncogene 38, 2162–2176 (2019)

Article  CAS  Google Scholar 

S. Wu, Q. Zheng, X. Xing, Y. Dong, Y. Wang, Y. You, R. Chen, C. Hu, J. Chen, D. Gao et al., Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation. J Exp Clin Cancer Res 37, 99 (2018)

Article  Google Scholar 

M. Qi, Y. Xia, Y. Wu, Z. Zhang, X. Wang, L. Lu, C. Dai, Y. Song, K. Xu, W. Ji et al., Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression. Nat Commun 13, 897 (2022)

Article  CAS  Google Scholar 

C.M. Calejman, W.G. Doxsey, D.J. Fazakerley, D.A. Guertin, Integrating adipocyte insulin signaling and metabolism in the multi-omics era. Trends Biochem Sci 47, 531–546 (2022)

Article  CAS  Google Scholar 

K. Hönigova, J. Navratil, B. Peltanova, H.H. Polanska, M. Raudenska, M. Masarik, Metabolic tricks of cancer cells. Biochim Biophys Acta Rev Cancer 1887, 188705 (2022)

K. Masui, W.K. Cavenee, P.S. Mischel, N. Shibata, The metabolomic landscape plays a critical role in glioma oncogenesis. Cancer Sci 113, 1555–1563 (2022)

Article  CAS  Google Scholar 

Y. Niu, T. Mayr, M.H. Muders, Competition for nutrients or cell intrinsic programming? – Metabolic mechanisms behind the tumor promoting immune microenvironment in cancer. Signal Transduct. Target. Ther. 6, 279 (2021)

Article  Google Scholar 

I. Frades, C. Foguet, M. Cascante, M.J. Araúzo-Bravo, Genome Scale Modeling to Study the Metabolic Competition between Cells in the Tumor Microenvironment. Cancers (Basel) 13, 4609 (2021)

Article  CAS  Google Scholar 

K.C. Corn, M.A. Windham, M. Rafat, Lipids in the tumor microenvironment: From cancer progression to treatment. Prog Lipid Res 80, 101055 (2020)

Article  CAS  Google Scholar 

H. Wang, J. Lu, S. Kulkarni, W. Zhang, J.E. Gorka, J.A. Mandel, E.S. Goetzman, E.V. Prochownik, Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts. J Biol Chem 294, 5466–5486 (2019)

Article  CAS  Google Scholar 

T.L. Wong, N. Che, S. Ma, Reprogramming of central carbon metabolism in cancer stem cells. Biochim. Biophys. Acta (BBA) – Molec. Basis Dis. 1863:1728–1738 (2017)

U. Bruning, F. Morales-Rodriguez, J. Kalucka, J. Goveia, F. Taverna, K.C.S. Queiroz, C. Dubois, A.R. Cantelmo, R. Chen, S. Loroch et al., Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation. Cell Metab 28, 866-880.e815 (2018)

Article  CAS  Google Scholar 

X. Gao, S.H. Lin, F. Ren, J.T. Li, J.J. Chen, C.B. Yao, H.B. Yang, S.X. Jiang, G.Q. Yan, D. Wang et al., Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun 7, 11960 (2016)

Article  CAS  Google Scholar 

I. Marmisolle, J. Martínez, J. Liu, M. Mastrogiovanni, M.M. Fergusson, I.I. Rovira, L. Castro, A. Trostchansky, M. Moreno, L. Cao et al., Reciprocal regulation of acetyl-CoA carboxylase 1 and senescence in human fibroblasts involves oxidant mediated p38 MAPK activation. Arch Biochem Biophys 613, 12–22 (2017)

Article  CAS  Google Scholar 

J. Campisi, F. d’Adda di Fagagna, Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8, 729–740 (2007)

Article  CAS  Google Scholar 

N. Alessio, D. Aprile, T. Squillaro, G. Di Bernardo, M. Finicelli, M.A. Melone, G. Peluso, U. Galderisi, The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells. Aging (Albany NY). 11(15), 5817–5828 (2019)

Article  CAS  Google Scholar 

T. Liu, J. Yu, C. Ge, F. Zhao, J. Chen, C. Miao, W. Jin, Q. Zhou, Q. Geng, H. Lin, et al, Sperm associated antigen 4 promotes SREBP1-mediated de novo lipogenesis via interaction with lamin A/C and contributes to tumor progression in hepatocellular carcinoma. Cancer Lett. 215642 (2022)

S. García-Silva, A. Benito-Martín, L. Nogués, A. Hernández-Barranco, M.S. Mazariegos, V. Santos, M. Hergueta-Redondo, P. Ximénez-Embún, R.P. Kataru, A.A. Lopez et al., Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism. Nat Cancer 2, 1387–1405 (2021)

Article  Google Scholar 

L. Gillot, L. Baudin, L. Rouaud, F. Kridelka, A. Noël, The pre-metastatic niche in lymph nodes: formation and characteristics. Cell Mol Life Sci 78, 5987–6002 (2021)

Article  CAS  Google Scholar 

D. Oelschlaegel, T. Weiss Sadan, S. Salpeter, S. Krug, G. Blum, W. Schmitz, A. Schulze, P. Michl, Cathepsin Inhibition Modulates Metabolism and Polarization of Tumor-Associated Macrophages. Cancers (Basel) 12, 2579 (2020)

Article  CAS  Google Scholar 

J.Y. Low, W.N. Brennen, A.K. Meeker, E. Ikonen, B.W. Simons, M. Laiho, Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling. Mol Cancer Res 18, 1414–1426 (2020)

Article  CAS  Google Scholar 

C. Zhang, X.Y. Wang, P. Zhang, T.C. He, J.H. Han, R. Zhang, J. Lin, J. Fan, L. Lu, W.W. Zhu et al., Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts. Cell Death Dis 13, 57 (2022)

Article  CAS  Google Scholar 

M.A. Moresco, L. Raccosta, G. Corna, D. Maggioni, M. Soncini, S. Bicciato, C. Doglioni, V. Russo, Enzymatic Inactivation of Oxysterols in Breast Tumor Cells Constraints Metastasis Formation by Reprogramming the Metastatic Lung Microenvironment. Front Immunol 9, 2251 (2018)

Article  Google Scholar 

Y. Tabe, S. Yamamoto, K. Saitoh, K. Sekihara, N. Monma, K. Ikeo, K. Mogushi, M. Shikami, V. Ruvolo, J. Ishizawa et al., Bone Marrow Adipocytes Facilitate Fatty Acid Oxidation Activating AMPK and a Transcriptional Network Supporting Survival of Acute Monocytic Leukemia Cells. Cancer Res 77, 1453–1464 (2017)

Article  CAS  Google Scholar 

J. Gong, Y. Lin, H. Zhang, C. Liu, Z. Cheng, X. Yang, J. Zhang, Y. Xiao, N. Sang, X. Qian et al., Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells. Cell Death Dis 11, 267 (2020)

Article  CAS  Google Scholar 

P. Su, Q. Wang, E. Bi, X. Ma, L. Liu, M. Yang, J. Qian, Q. Yi, Enhanced Lipid Accumulation and Metabolism Are Required for the Differentiation and Activation of Tumor-Associated Macrophages. Cancer Res 80, 1438–1450 (2020)

Article  CAS  Google Scholar 

M. Rios Garcia, B. Steinbauer, K. Srivastava, M. Singhal, F. Mattijssen, A. Maida, S. Christian, H. Hess-Stumpp, H.G. Augustin, K. Müller-Decker et al., Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence. Cell Metab 26, 842-855.e845 (2017)

Article  CAS  Google Scholar 

M. Fane, A.T. Weeraratna, How the ageing microenvironment influences tumour progression. Nat Rev Cancer 20, 89–106 (2020)

Article  CAS  Google Scholar 

A.M. Nicolas, M. Pesic, E. Engel, P.K. Ziegler, M. Diefenhardt, K.B. Kennel, F. Buettner, C. Conche, V. Petrocelli, E. Elwakeel et al., Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer. Cancer Cell 40, 168-184.e113 (2022)

Article  CAS  Google Scholar 

J. Li, X. Shu, J. Xu, S.M. Su, U.I. Chan, L. Mo, J. Liu, X. Zhang, R. Adhav, Q. Chen et al., S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy. Nat Commun 13, 1481 (2022)

Article  Google Scholar 

H. Wang, K. Luo, Z. Guan, Z. Li, J. Xiang, S. Ou, Y. Tao, S. Ran, J. Ye, T. Ma et al., Identification of the Crucial Role of CCL22 in F. nucleatum-Related Colorectal Tumorigenesis that Correlates With Tumor Microenvironment and Immune Checkpoint Therapy. Front Genet 13, 811900 (2022)

Article  CAS  Google Scholar 

C. Yang, Z. Wang, L. Li, Z. Zhang, X. Jin, P. Wu, S. Sun, J. Pan, K. Su, F. Jia et al., Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis. J Immunother Cancer 9, e002875 (2021)

Article  Google Scholar 

S.M. Morrissey, F. Zhang, C. Ding, D.E. Montoya-Durango, X. Hu, C. Yang, Z. Wang, F. Yuan, M. Fox, H.G. Zhang et al., Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming. Cell Metab 33, 2040-2058.e2010 (2021)

Article  CAS  Google Scholar 

D. Zeng, M. Wang, J. Wu, S. Lin, Z. Ye, R. Zhou, G. Wang, J. Wu, H. Sun, J. Bin et al., Immunosuppressive Microenvironment Revealed by Immune Cell Landscape in Pre-metastatic Liver of Colorectal Cancer. Front Oncol 11, 620688 (2021)

Article  Google Scholar 

K. Ohl, K. Tenbrock, Reactive Oxygen Species as Regulators of MDSC-Mediated Immune Suppression. Front. Immunol. 9, 2499 (2018)

Article  Google Scholar 

M.L. Sprouse, T. Welte, D. Boral, H.N. Liu, W. Yin, M. Vishnoi, D. Goswami-Sewell, L. Li, G. Pei, P. Jia et al., PMN-MDSCs Enhance CTC Metastatic Properties through Reciprocal Interactions via ROS/Notch/Nodal Signaling. Int. J. Mol. Sci. 2019, 20 (1916)

Google Scholar 

P. Gu, M. Sun, L. Li, Y. Yang, Z. Jiang, Y. Ge, W. Wang, W. Mu, H. Wang, Breast Tumor-Derived Exosomal MicroRNA-200b-3p Promotes Specific Organ Metastasis Through Regulating CCL2 Expression in Lung Epithelial Cells. Front Cell Dev Biol 9, 657158–657158 (2021)

Google Scholar 

S. Hiratsuka, A. Watanabe, Y. Sakurai, S. Akashi-Takamura, S. Ishibashi, K. Miyake, M. Shibuya, S. Akira, H. Aburatani, Y. Maru, The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase. Nat. Cell Biol. 10, 1349–1355 (2008)

Article  CAS  Google Scholar 

Y.S. Lee, T. Zhang, V. Saxena, L. Li, W. Piao, J.S. Bromberg, J.R. Scalea, Myeloid-derived suppressor cells expand after transplantation and their augmentation increases graft survival. Am J Transplant 20, 2343–2355 (2020)

Article  CAS