A versatile untargeted metabolomics-driven technology for rapid phytochemical profiling of stem barks of Zanthoxylum species with antioxidant and antimicrobial activities

Acamovic T, Brooker JD (2005) Biochemistry of plant secondary metabolites and their effects in animals. Proc Nutr Soc 64:403–412

Article  Google Scholar 

Adamczak A, Ożarowski M, Karpiński TM (2020) Antibacterial activity of some flavonoids and organic acids widely distributed in plants. J Clin Med 9:109

Article  Google Scholar 

Adesina SK (2005) The Nigerian Zanthoxylum; chemical and biological values. Afr J Tradit Complement Altern Med 2:282–301

Article  Google Scholar 

Albrecht CF (2012) LC–MS-based metabolomics assists with quality assessment and traceability of wild and cultivated plants of Sutherlandia frutescens (Fabaceae ). S Afr J Bot 82:33–45. https://doi.org/10.1016/j.sajb.2012.07.018

Article  Google Scholar 

Ambriz-Pérez DL, Leyva-López N, Gutierrez-Grijalva EP, Heredia JB (2016) Phenolic compounds: natural alternative in inflammation treatment. Rev Cogent Food Agric 2:1131412

Google Scholar 

Amenu D (2014) Antimicrobial activity of medicinal plant extracts and their synergistic effect on some selected pathogens. Am J Ethnomed 1:18–29

Google Scholar 

Appelhans MS, Reichelt N, Groppo M, Paetzold C, Wen J (2018) Phylogeny and biogeography of the pantropical genus Zanthoxylum and its closest relatives in the proto-Rutaceae group (Rutaceae). Mol Phylogenet Evol 126:31–44

Article  Google Scholar 

Beentje H, Adamson J, Bhanderi D (1994) Kenya trees, shrubs, and lianas. National Museums of Kenya

Benzie IFF, Strain JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem 239:70–76

Article  Google Scholar 

Bino RJ, Hall RD, Fiehn O, Kopka J, Saito K, Draper J, Nikolau BJ, Mendes P, Roessner-Tunali U, Beale MH (2004) Potential of metabolomics as a functional genomics tool. Trends Plant Sci 9:418–425

Article  Google Scholar 

Björkman M, Klingen I, Birch ANE, Bones AM, Bruce TJA, Johansen TJ, Meadow R, Mølmann J, Seljåsen R, Smart LE (2011) Phytochemicals of Brassicaceae in plant protection and human health: influences of climate, environment and agronomic practice. Phytochemistry 72:538–556

Article  Google Scholar 

Buyinza D (2012) Phytochemical investigation of Zanthoxylum holstzianum for antimicrobial activity. MSc thesis, University of Nairobi

Chagas-Paula DA, Oliveira TB, Zhang T, Edrada-Ebel R, Da Costa FB (2015) Prediction of anti-inflammatory plants and discovery of their biomarkers by machine learning algorithms and metabolomic studies. Planta Med 81:450–458

Article  Google Scholar 

Compean KL, Ynalvez RA (2014) Antimicrobial activity of plant secondary metabolites: a review. Res J Med Plants 8:204–213

Article  Google Scholar 

Cos P, Calomme M, Pieters L, Vlietinck AJ, Vanden BD (2000) Structure-activity relationship of flavonoids as antioxidant and pro-oxidant compounds. Stud Nat Prod Chem 22:307–341

Article  Google Scholar 

Cox DG, Oh J, Keasling A, Colson KL, Hamann MT (2014) The utility of metabolomics in natural product and biomarker characterization. Biochim Biophys Acta (BBA) Gen Stud 1840:3460–3474

Article  Google Scholar 

Farasat M, Khavari-Nejad R-A, Nabavi SMB, Namjooyan F (2014) Antioxidant activity, total phenolics and flavonoid contents of some edible green seaweeds from northern coasts of the Persian Gulf. Iran J Pharm Res IJPR 13:163

Google Scholar 

Fattorusso E, Taglialatela-Scafati O (2007) Modern alkaloids: structure, isolation, synthesis, and biology. John Wiley & Sons

Book  Google Scholar 

Fawole OA, Makunga NP, Opara UL (2012) Antibacterial, antioxidant and tyrosinase-inhibition activities of pomegranate fruit peel methanolic extract. BMC Complement Altern Med 12:1–11

Article  Google Scholar 

Gan J, Feng Y, He Z, Li X, Zhang H (2017) Correlations between antioxidant activity and alkaloids and phenols of maca (Lepidium meyenii). J Food Qual 2017:1−10

Gaya CH, Kawaka JF, Muchugi A, Ngeranwa JJ (2013) Variation of alkaloids in the Kenyan Zanthoxylum gilletii (De Wild Waterman). Afr J Plant Sci 7:438–444

Article  Google Scholar 

He W, Van PL, De KN, Verbruggen L, Anthonissen K, Van der Flaas M, Bosselaers J, Mathenge SG, Mudida FP (2002) Chemical constituents and biological activities of Zanthoxylum usambarense. Phytother Res 16:66–70

Article  Google Scholar 

Heim KE, Tagliaferro AR, Bobilya DJ (2002) Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem 13:572–584

Article  Google Scholar 

Jawhari FZ, Moussaoui AE, Bourhia M, Imtara H, Saghrouchni H, Ammor K, Bari A (2021) Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus (Ball) Maire: correlation between total phenolic and flavonoid contents with antioxidant and antimicrobial activities of chemically characterized extracts. Plants 10:149

Article  Google Scholar 

Kaigongi MM (2014a) Antimicrobial activity, toxicity and phytochemical analysis of four medicinal plants traditionally used in Msambweni district, Kenya. MSc Diss, University of Nairobi

Kaigongi MM, Dossaji SF, Nguta JM, Lukhoba CW, Musila FM (2014b) Antimicrobial activity, toxicity and phytochemical screening of four medicinal plants traditionally used in Msambweni district, Kenya. J Biol Agric Healthc 4:6−12

Kaigongi MM, Lukhoba CW, Taylor M, Yenesew A, Makunga NP (2020a) LC-MS-based metabolomics for the chemosystematics of Kenyan Dodonaea viscosa Jacq (Sapindaceae) Populations. Molecules 25:4130

Article  Google Scholar 

Kaigongi MM, Lukhoba CW, Yaouba S, Makunga NP, Githiomi J, Yenesew A (2020b) In vitro antimicrobial and antiproliferative activities of the root bark extract and isolated chemical constituents of Zanthoxylum paracanthum Kokwaro (Rutaceae). Plants 9:920

Article  Google Scholar 

Kaigongi MM, Lukhoba CW (2021) The chemosystematics of the genus Zanthoxylum L. (Rutaceae) in Kenya. Biochem Syst Ecol 98:104319

Article  Google Scholar 

Kaigongi M, Musila F (2015) Ethnobotanical study of medicinal plants used by Tharaka people of Kenya. Int J Ethnobiol Ethnomed 1:1–8

Google Scholar 

Karou D, Savadogo A, Canini A, Yameogo S, Montesano C, Simpore J, Colizzi V, Traore AS (2005) Antibacterial activity of alkaloids from Sida acuta. Afr J Biotechnol 4:195–200

Kimondo J, Mutai P, Njogu P, Kimwele C (2019) Evaluation of the antioxidant activity of nine plants used medicinally by the Ilkisonko Maasai community of Kenya. Free Radic Antioxi 9:29–34

Article  Google Scholar 

Kokwaro JO (2009) Medicinal plants of east Africa. University of Nairobi press

Koleva II, Van Beek TA, Linssen JPH, de Groot A, Evstatieva LN (2002) Screening of plant extracts for antioxidant activity: a comparative study on three testing methods. Phytochem Anal Int J Plant Chem Biochem Tech 13:8–17

Article  Google Scholar 

Kumar PS, Sucheta S, Deepa VS, Selvamani P, Latha S (2008) Antioxidant activity in some selected Indian medicinal plants. Afr J Biotechnol 7:1826–1828

Lattanzio V, Kroon PA, Quideau S, Treutter D (2008) Plant phenolics—secondary metabolites with diverse functions. Recent Adv Polyphen Res 1:1–35

Google Scholar 

Lautie E, Russo O, Ducrot P, Boutin JA (2020) Unraveling plant natural chemical diversity for drug discovery purposes. Front Pharmacol 11:397

Article  Google Scholar 

Manandhar S, Luitel S, Dahal RK (2019) In vitro antimicrobial activity of some medicinal plants against human pathogenic bacteria. J Trop Med 2019:1895340

Marquez L, Aguero J, Hernandez I, Garrido G, Martinez I, Dieguez R, Prieto S, Rivas Y, Molina-Torres J, Curini M (2005) Anti-inflammatory evaluation and phytochemical characterization of some plants of the Zanthoxylum genus. Acta Farm Bonaer 24:325

Google Scholar 

Matu EN, Van Staden J (2003) Antibacterial and anti-inflammatory activities of some plants used for medicinal purposes in Kenya. J Ethnopharmacol 87:35–41

Article  Google Scholar 

Maundu P, Berger D, Ole Saitabau C, Nasieku J, Kipelian M, Mathenge S, Morimoto Y, Höft R (2001) Ethnobotany of the Loita Maasai. People Plants Work Pap 8:1–34

Musila FM, Nguta JM, Lukhoba CW, Dossaji SF (2017) Antibacterial and antifungal activities of 10 Kenyan Plectranthus species in the Coleus clade. J Pharm Res 11:1003–1015

Google Scholar 

Nantongo JS, Odoi JB, Abigaba G, Gwali S (2018) Variability of phenolic and alkaloid content in different plant parts of Carissa edulis Vahl and Zanthoxylum chalybeum Engl. BMC Res Notes 11:1–5

Article  Google Scholar 

Neugart S, Baldermann S, Hanschen FS, Klopsch R, Wiesner-Reinhold M, Schreiner M (2018) The intrinsic quality of brassicaceous vegetables: how secondary plant metabolites are affected by genetic, environmental, and agronomic factors. Sci Hortic (amst) 233:460–478

Article  Google Scholar 

Nithya TG, Jayanthi J, Ragunathan MG (2016) Antioxidant activity, total phenol, flavonoid, alkaloid, tannin, and saponin contents of leaf extracts of Salvinia molesta DS Mitchell (1972). Asian J Pharm Clin Res 9:200–203

Google Scholar 

Nunes XP, Silva FS, Almeida JRG da S, Barbosa Filho JM, de Lima JT, de Araújo Ribeiro LA, Júnior LJQ (2012) Biological oxidations and antioxidant activity of natural products. INTECH Open Access Publisher, New York

Nyunja ARO, Onyango JC, Erwin B (2009) The Kakamega forest medicinal plant resources and their utilization by the adjacent Luhya community. Int J Trop Med 4:82–90

Google Scholar 

Odongo E, Mungai N, Mutai P, Karumi E, Mwangi J, Kimondo J, Omale J, Simiyu J (2017) Antioxidant and anti-inflammatory activities of selected medicinal plants from western Kenya. Afr J Pharmacol Ther 6:178–182

Okagu IU, Ndefo JC, Aham EC, Udenigwe CC (2021) Zanthoxylum species: a comprehensive review of traditional uses, phytochemistry. Pharmacol Nutraceutical Appl Mol 26:4023

Google Scholar 

Osman MA, Mahmoud GI, Shoman SS (2020) Correlation between total phenols content, antioxidant power and cytotoxicity. Biointerface Res Appl Chem 11:10640–10653

Article  Google Scholar 

Özkan M, Mutiso PBC, Nahar L, Liu P, Brown S, Wang W, Sarker SD (2013) Zanthoxylum usambarense (Engl.) Kokwaro (Rutaceae) extracts inhibit the growth of the breast cancer cell lines MDA-MB-231 and MCF-7, but not the brain tumour cell line U251 in vitro. Phytother Res 27:787–790

Article  Google Scholar 

Patiño LOJ, Prieto RJA, Cuca SLE (2012) Zanthoxylum genus as potential source of bioactive compounds. Bioact Compd Phytomed 10:185–218

Google Scholar 

Plazas E, Casoti R, Murillo MA, Da Costa FB, Cuca LE (2019) Metabolomic profiling of Zanthoxylum species: identification of anti-cholinesterase alkaloids candidates. Phytochemistry 168:112128

Article  Google Scholar 

Rocchetti G, Pagnossa JP, Blasi F, Cossignani L, Piccoli RH, Zengin G, Montesano D, Cocconcelli PS, Lucini L (2020) Phenolic profiling and in vitro bioactivity of Moringa oleifera leaves as affected by different extraction solvents. Food Res Int 127:108712

Article  Google Scholar 

Rønsted N, Symonds MRE, Birkholm T, Christensen SB, Meerow AW, Molander M, Mølgaard P, Petersen G, Rasmussen N, Van Staden J (2012) Can phylogeny predict chemical diversity and potential medicinal activity of plants? A case study of Amaryllidaceae. BMC Evol Biol 12:1–12

Article  Google Scholar 

Rumbaoa RGO, Cornago DF, Geronimo IM (2009) Phenolic content and antioxidant capacity of Philippine sweet potato (Ipomoea batatas) varieties. Food Chem 113:1133–1138

Article  Google Scholar 

Şensoy Í, Rosen RT, Ho C-T, Karwe MV (2006) Effect of processing on buckwheat phenolics and antioxidant activity. Food Chem 99:388–393

Article  Google Scholar 

Soobrattee MA, Neergheen VS, Luximon-Ramma A, Aruoma OI, Bahorun T (2005) Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutat Res Mol Mech Mutagen 579:200–213

Article  Google Scholar 

Tian Y, Zhang C, Guo M (2017) Comparative study on alkaloids and their anti-proliferative activities from three Zanthoxylum species. BMC Complement Altern Med 17:1–16

Article  Google Scholar 

Tungmunnithum D, Thongboonyou A, Pholboon A, Yangsabai A (2018) Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: an overview. Medicines 5:93

Article  Google Scholar 

Valgas C, de Souza SM, Smânia EFA, Smânia A Jr (2007) Screening methods to determine antibacterial activity of natural products. Braz J Microbiol 38:369–380

Article  Google Scholar 

Vázquez-León LA, Páramo-Calderón DE, Robles-Olvera VJ, Valdés-Rodríguez OA, Pérez-Vázquez A, García-Alvarado MA, Rodríguez-Jimenes GC (2017) Variation in bioactive compounds and antiradical activity of Moringa oleifera leaves: influence of climatic factors, tree age, and soil parameters. Eur Food Res Technol 243:1593–1608

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