Ajoolabady A, Wang S, Kroemer G et al (2021) Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics. Pharmacol Ther 225:107848

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bao MH, Szeto V, Yang BB, Zhu SZ, Sun HS, Feng ZP (2018) Long non-coding RNAs in ischemic stroke. Cell Death Dis 9:281

Article  PubMed  PubMed Central  Google Scholar 

Barthels D, Das H (2020) Current advances in ischemic stroke research and therapies. Biochim Biophys Acta Mol Basis Dis 1866:165260

Article  CAS  PubMed  Google Scholar 

Bonfante S, Della Giustina A, Danielski LG et al (2020) Stanniocalcin-1 ameliorates cerebral ischemia by decrease oxidative stress and blood brain barrier permeability. Microvasc Res 128:103956

Article  PubMed  Google Scholar 

Chen T, Ma Z, Zhu L et al (2016) Suppressing receptor-interacting protein 140: a new sight for salidroside to treat cerebral ischemia. Mol Neurobiol 53:6240–6250

Article  CAS  PubMed  Google Scholar 

Chiang T, Messing RO, Chou WH (2011) Mouse model of middle cerebral artery occlusion. J Visual Exp JoVE. https://doi.org/10.3791/2761

Article  Google Scholar 

Dunbar M, Kirton A (2019) Perinatal stroke. Semin Pediatr Neurol 32:100767

Article  PubMed  Google Scholar 

Fan F, Yang L, Li R et al (2020) Salidroside as a potential neuroprotective agent for ischemic stroke: a review of sources, pharmacokinetics, mechanism and safety. Biomed Pharmacother 129:110458

Article  CAS  PubMed  Google Scholar 

Feng J, Niu P, Chen K et al (2018a) Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury. Exp Ther Med 15:4599–4614

CAS  PubMed  PubMed Central  Google Scholar 

Feng J, Chen K, Xia Y et al (2018b) Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-kappaB and TGF-beta1/Smad3 pathways. Drug Des Dev Ther 12:1837–1853

Article  CAS  Google Scholar 

Fluck F, Augustin AM, Bley T, Kickuth R (2020) Current treatment options in acute limb ischemia. RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin 192:319–326

Article  PubMed  Google Scholar 

Gao XJ, Xie GN, Liu L, Fu ZJ, Zhang ZW, Teng LZ (2017) Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury. Exp Ther Med 14:841–847

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gong L, Tang Y, An R, Lin M, Chen L, Du J (2017) RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways. Cell Death Dis 8:e3080

Article  PubMed  PubMed Central  Google Scholar 

Guan X, Li X, Yang X et al (2019) The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation. Life Sci 235:116795

Article  CAS  PubMed  Google Scholar 

Gui D, Cui Z, Zhang L et al (2017) Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway. BMC Pulm Med 17:191

Article  PubMed  PubMed Central  Google Scholar 

He J, Zhou D, Yan B (2020) Eriocitrin alleviates oxidative stress and inflammatory response in cerebral ischemia reperfusion rats by regulating phosphorylation levels of Nrf2/NQO-1/HO-1/NF-kappaB p65 proteins. Ann Transl Med 8:757

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu S, Wu Y, Zhao B et al (2018) Panax notoginseng saponins protect cerebral microvascular endothelial cells against oxygen-glucose deprivation/reperfusion-induced barrier dysfunction via activation of PI3K/Akt/Nrf2 antioxidant signaling pathway. Molecules 23:2781

Article  PubMed Central  Google Scholar 

Jin M, Wang C, Xu Y, Zhang Z, Wu X, Ye R, Zhang Q, Han D (2022) Pharmacological effects of salidroside on central nervous system diseases. Biomed Pharmacother 156:113746

Article  CAS  PubMed  Google Scholar 

Ke J, Wang J, Wu X, Yan Y (2022) Salidroside ameliorates ultraviolet-induced keratinocyte injury by inducing SIRT1-dependent autophagy. Clin Cosmet Investig Dermatol 15:1499–1508

Article  PubMed  PubMed Central  Google Scholar 

Kumar P, Nagarajan A and Uchil PD (2018) analysis of cell viability by the MTT assay. Cold Spring Harbor Protoc 2018

Li P, Stetler RA, Leak RK et al (2018) Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery. Neuropharmacology 134:208–217

Article  CAS  PubMed  Google Scholar 

Li F, Mao Q, Wang J, Zhang X, Lv X, Wu B, Yan T, Jia Y (2022) Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative stress and apoptosis via Nrf2/Trx1 signaling pathway. Metab Brain Dis. https://doi.org/10.1007/s11011-022-01061-x (online ahead of print)

Article  PubMed  PubMed Central  Google Scholar 

Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84–91

Article  CAS  PubMed  Google Scholar 

Mehta SL, Manhas N, Raghubir R (2007) Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Res Rev 54:34–66

Article  CAS  PubMed  Google Scholar 

Pei D, Tian S, Bao Y, Zhang J, Xu D, Piao M (2022) Protective effect of salidroside on streptozotocin-induced diabetic nephropathy by inhibiting oxidative stress and inflammation in rats via the Akt/GSK-3β signalling pathway. Pharm Biol 60:1732–1738

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng J, Wang H, Gong Z et al (2020) Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity. Mol Immunol 123:74–87

Article  CAS  PubMed  Google Scholar 

Shi CX, Jin J, Wang XQ et al (2020) Sevoflurane attenuates brain damage through inhibiting autophagy and apoptosis in cerebral ischemia-reperfusion rats. Mol Med Rep 21:123–130

CAS  PubMed  Google Scholar 

Sun AQ, Ju XL (2021) Advances in research on anticancer properties of salidroside. Chin J Integr Med 27:153–160

Article  CAS  PubMed  Google Scholar 

Sun X, Wang D, Zhang T et al (2020a) Eugenol attenuates cerebral ischemia-reperfusion injury by enhancing autophagy via AMPK-mTOR-P70S6K pathway. Front Pharmacol 11:84

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun S, Tuo Q, Li D et al (2020b) Antioxidant effects of salidroside in the cardiovascular system. Evid Based Complement Altern Med Ecam 2020:9568647

Article  Google Scholar 

Tucker LB, Velosky AG, McCabe JT (2018) Applications of the Morris water maze in translational traumatic brain injury research. Neurosci Biobehav Rev 88:187–200

Article  PubMed  Google Scholar 

Wang G, Wang T, Zhang Y, Li F, Yu B, Kou J (2019) Schizandrin protects against OGD/R-induced neuronal injury by suppressing autophagy: involvement of the AMPK/mTOR pathway. Molecules 24:3624

Article  CAS  PubMed Central  Google Scholar 

Wu R, Li X, Xu P et al (2017) TREM2 protects against cerebral ischemia/reperfusion injury. Mol Brain 10:20

Article  PubMed  PubMed Central  Google Scholar 

Yao L, Chen H, Wu Q, Xie K (2019) Hydrogen-rich saline alleviates inflammation and apoptosis in myocardial I/R injury via PINK-mediated autophagy. Int J Mol Med 44:1048–1062

CAS  PubMed  PubMed Central  Google Scholar 

Yin WY, Ye Q, Huang HJ et al (2016) Salidroside protects cortical neurons against glutamate-induced cytotoxicity by inhibiting autophagy. Mol Cell Biochem 419:53–64

Article  CAS  PubMed  Google Scholar 

You L, Zhang D, Geng H, Sun F, Lei M (2021) Salidroside protects endothelial cells against LPS-induced inflammatory injury by inhibiting NLRP3 and enhancing autophagy. BMC Complement Med Ther 21:146

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu S, Liu M, Gu X, Ding F (2008) Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation. Cell Mol Neurobiol 28:1067–1078

Article  CAS  PubMed  Google Scholar 

Yu S, Yu M, He X, Wen L, Bu Z, Feng J (2019) KCNQ1OT1 promotes autophagy by regulating miR-200a/FOXO3/ATG7 pathway in cerebral ischemic stroke. Aging Cell 18:e12940

Article  PubMed  PubMed Central  Google Scholar 

Zha H, Fan Y, Yang L et al (2021) Autophagy protects against cerebral ischemic reperfusion injury by inhibiting neuroinflammation. Am J Transl Res 13:4726–4737

CAS  PubMed