Criqui MH (2001) Systemic atherosclerosis risk and the mandate for intervention in atherosclerotic peripheral arterial disease. Am J Cardiol 88(7B):43J–47J. https://doi.org/10.1016/s0002-9149(01)01881-1

Hardman RL, Jazaeri O, Yi J, Smith M, Gupta R (2014) Overview of classification systems in peripheral artery disease. Semin Intervent Radiol 31(4):378–388. https://doi.org/10.1055/s-0034-1393976

Article  PubMed  PubMed Central  Google Scholar 

Fowkes FG, Rudan D, Rudan I, Aboyans V, Denenberg JO, McDermott MM, Norman PE, Sampson UK, Williams LJ, Mensah GA, Criqui MH (2013) Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis. Lancet 382(9901):1329–1340. https://doi.org/10.1016/S0140-6736(13)61249-0

Article  PubMed  Google Scholar 

Marso SP, Hiatt WR (2006) Peripheral arterial disease in patients with diabetes. J Am Coll Cardiol 47(5):921–929. https://doi.org/10.1016/j.jacc.2005.09.065

Article  PubMed  Google Scholar 

Bonaca MP, Creager MA (2015) Pharmacological treatment and current management of peripheral artery disease. Circ Res 116(9):1579–1598. https://doi.org/10.1161/CIRCRESAHA.114.303505

CAS  Article  PubMed  Google Scholar 

Cooke JP, Losordo DW (2015) Modulating the vascular response to limb ischemia: angiogenic and cell therapies. Circ Res 116(9):1561–1578. https://doi.org/10.1161/CIRCRESAHA.115.303565

CAS  Article  PubMed  PubMed Central  Google Scholar 

Beach JM (2021) Revascularization strategies for acute and chronic limb ischemia. Cardiol Clin 39(4):483–494. https://doi.org/10.1016/j.ccl.2021.06.006

Article  PubMed  Google Scholar 

Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136(2):215–233. https://doi.org/10.1016/j.cell.2009.01.002

CAS  Article  PubMed  PubMed Central  Google Scholar 

Icli B, Wara AK, Moslehi J, Sun X, Plovie E, Cahill M, Marchini JF, Schissler A, Padera RF, Shi J, Cheng HW, Raghuram S, Arany Z, Liao R, Croce K, MacRae C, Feinberg MW (2013) MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ Res 113(11):1231–1241. https://doi.org/10.1161/CIRCRESAHA.113.301780

CAS  Article  PubMed  PubMed Central  Google Scholar 

Icli B, Wu W, Ozdemir D, Li H, Cheng HS, Haemmig S, Liu X, Giatsidis G, Avci SN, Lee N, Guimaraes RB, Manica A, Marchini JF, Rynning SE, Risnes I, Hollan I, Croce K, Yang X, Orgill DP, Feinberg MW (2019) MicroRNA-615-5p regulates angiogenesis and tissue repair by targeting AKT/eNOS (protein kinase b/endothelial nitric oxide synthase) signaling in endothelial cells. Arterioscler Thromb Vasc Biol 39(7):1458–1474. https://doi.org/10.1161/ATVBAHA.119.312726

CAS  Article  PubMed  PubMed Central  Google Scholar 

Climent M, Quintavalle M, Miragoli M, Chen J, Condorelli G, Elia L (2015) TGFbeta triggers miR-143/145 transfer from smooth muscle cells to endothelial cells, thereby modulating vessel stabilization. Circ Res 116(11):1753–1764. https://doi.org/10.1161/CIRCRESAHA.116.305178

CAS  Article  PubMed  Google Scholar 

Liang YZ, Li JJ, Xiao HB, He Y, Zhang L, Yan YX (2020) Identification of stress-related microRNA biomarkers in type 2 diabetes mellitus: a systematic review and meta-analysis. J Diabetes 12(9):633–644. https://doi.org/10.1111/1753-0407.12643

CAS  Article  PubMed  Google Scholar 

Zhou H, Peng C, Huang DS, Liu L, Guan P (2020) microRNA expression profiling based on microarray approach in human diabetic retinopathy: a systematic review and meta-analysis. DNA Cell Biol 39(3):441–450. https://doi.org/10.1089/dna.2019.4942

CAS  Article  PubMed  Google Scholar 

Perez-Cremades D, Cheng HS, Feinberg MW (2020) Noncoding RNAs in critical limb ischemia. Arterioscler Thromb Vasc Biol 40(3):523–533. https://doi.org/10.1161/ATVBAHA.119.312860

CAS  Article  PubMed  PubMed Central  Google Scholar 

Morrow DA, Braunwald E, Bonaca MP, Ameriso SF, Dalby AJ, Fish MP, Fox KA, Lipka LJ, Liu X, Nicolau JC, Ophuis AJ, Paolasso E, Scirica BM, Spinar J, Theroux P, Wiviott SD, Strony J, Murphy SA, Committee TPTS, Investigators (2012) Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med 366(15):1404–1413. https://doi.org/10.1056/NEJMoa1200933

Vlachos IS, Paraskevopoulou MD, Karagkouni D, Georgakilas G, Vergoulis T, Kanellos I, Anastasopoulos IL, Maniou S, Karathanou K, Kalfakakou D, Fevgas A, Dalamagas T, Hatzigeorgiou AG (2015) DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions. Nucleic Acids Res 43 (Database issue):D153–159. https://doi.org/10.1093/nar/gku1215

CAS  Article  Google Scholar 

McGeary SE, Lin KS, Shi CY, Pham TM, Bisaria N, Kelley GM, Bartel DP (2019) The biochemical basis of microRNA targeting efficacy. Science. https://doi.org/10.1126/science.aav1741

Chen Y, Wang X (2020) miRDB: an online database for prediction of functional microRNA targets. Nucleic Acids Res 48(D1):D127–D131. https://doi.org/10.1093/nar/gkz757

CAS  Article  PubMed  Google Scholar 

Mussbacher M, Salzmann M, Brostjan C, Hoesel B, Schoergenhofer C, Datler H, Hohensinner P, Basilio J, Petzelbauer P, Assinger A, Schmid JA (2019) Cell type-specific roles of NF-kappaB linking inflammation and thrombosis. Front Immunol 10:85. https://doi.org/10.3389/fimmu.2019.00085

CAS  Article  PubMed  PubMed Central  Google Scholar 

Martin A, Komada MR, Sane DC (2003) Abnormal angiogenesis in diabetes mellitus. Med Res Rev 23(2):117–145. https://doi.org/10.1002/med.10024

CAS  Article  PubMed  Google Scholar 

Mills JL, Sr., Conte MS, Armstrong DG, Pomposelli FB, Schanzer A, Sidawy AN, Andros G, Society for Vascular Surgery Lower Extremity Guidelines C (2014) The society for vascular surgery lower extremity threatened limb classification system: risk stratification based on wound, ischemia, and foot infection (WIfI). J Vasc Surg 59(1):220–234e221–222. https://doi.org/10.1016/j.jvs.2013.08.003

Li X (2014) MiR-375, a microRNA related to diabetes. Gene 533(1):1–4. https://doi.org/10.1016/j.gene.2013.09.105

CAS  Article  PubMed  Google Scholar 

Avnit-Sagi T, Vana T, Walker MD (2012) Transcriptional mechanisms controlling miR-375 gene expression in the pancreas. Exp Diabetes Res 2012:891216. https://doi.org/10.1155/2012/891216

Ding L, Xu Y, Zhang W, Deng Y, Si M, Du Y, Yao H, Liu X, Ke Y, Si J, Zhou T (2010) MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res 20(7):784–793. https://doi.org/10.1038/cr.2010.79

CAS  Article  PubMed  Google Scholar 

Higuchi C, Nakatsuka A, Eguchi J, Teshigawara S, Kanzaki M, Katayama A, Yamaguchi S, Takahashi N, Murakami K, Ogawa D, Sasaki S, Makino H, Wada J (2015) Identification of circulating miR-101, miR-375 and miR-802 as biomarkers for type 2 diabetes. Metabolism 64(4):489–497. https://doi.org/10.1016/j.metabol.2014.12.003

CAS  Article  PubMed  Google Scholar 

Wellen KE, Hotamisligil GS (2005) Inflammation, stress, and diabetes. J Clin Invest 115(5):1111–1119. https://doi.org/10.1172/JCI25102

CAS  Article  PubMed  PubMed Central  Google Scholar 

Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, Quagliaro L, Ceriello A, Giugliano D (2002) Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation 106(16):2067–2072. https://doi.org/10.1161/01.cir.0000034509.14906.ae

CAS  Article  PubMed  Google Scholar 

Quagliaro L, Piconi L, Assaloni R, Da Ros R, Maier A, Zuodar G, Ceriello A (2005) Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production. Atherosclerosis 183(2):259–267. https://doi.org/10.1016/j.atherosclerosis.2005.03.015

CAS  Article  PubMed  Google Scholar 

Findley CM, Mitchell RG, Duscha BD, Annex BH, Kontos CD (2008) Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease. J Am Coll Cardiol 52(5):387–393. https://doi.org/10.1016/j.jacc.2008.02.045

CAS  Article  PubMed  PubMed Central  Google Scholar 

Quan A, Pan Y, Singh KK, Polemidiotis J, Teoh H, Leong-Poi H, Verma S (2017) Cardiovascular inflammation is reduced with methotrexate in diabetes. Mol Cell Biochem 432(1–2):159–167. https://doi.org/10.1007/s11010-017-3006-0

CAS  Article  PubMed  Google Scholar 

Rumore MM, Kim KS (2010) Potential role of salicylates in type 2 diabetes. Ann Pharmacother 44(7–8):1207–1221. https://doi.org/10.1345/aph.1M483

CAS  Article  PubMed  Google Scholar 

Peiro C, Lorenzo O, Carraro R, Sanchez-Ferrer CF (2017) IL-1beta inhibition in cardiovascular complications associated to diabetes mellitus. Front Pharmacol 8:363. https://doi.org/10.3389/fphar.2017.00363

CAS  Article  PubMed  PubMed Central  Google Scholar 

Wang F, Ge J, Huang S, Zhou C, Sun Z, Song Y, Xu Y, Ji Y (2021) KLF5/LINC00346/miR148a3p axis regulates inflammation and endothelial cell injury in atherosclerosis. Int J Mol Med. https://doi.org/10.3892/ijmm.2021.4985

Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (2003) Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain. Mol Cell Biol 23(23):8528–8541. https://doi.org/10.1128/MCB.23.23.8528-8541.2003

CAS  Article  PubMed  PubMed Central  Google Scholar 

Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I (2005) Significance of the transcription factor KLF5 in cardiovascular remodeling. J Thromb Haemost 3(8):1569–1576. https://doi.org/10.1111/j.1538-7836.2005.01366.x

CAS  Article  PubMed  Google Scholar 

Ding D, Jiang H, He Y, Li X, Liu X (2021) miR-320-3p regulates the proliferation, migration and apoptosis of hypoxia-induced pulmonary arterial smooth muscle cells via KLF5 and HIF1alpha. Am J Transl Res 13(4):2283–2295

CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Zheng B, Zhou PP, Zhang RN, He M, Yang Z, Wen JK (2014) Vascular calcification is coupled with phenotypic conversion of vascular smooth muscle cells through Klf5-mediated transactivation of the Runx2 promoter. Biosci Rep 34(6):e00148. https://doi.org/10.1042/BSR20140103

CAS  Article  PubMed  PubMed Central  Google Scholar 

Nan S, Wang Y, Xu