Maurer M, Abuzakouk M, Bérard F et al (2017) The burden of chronic spontaneous urticaria is substantial: real-world evidence from ASSURE-CSU. Allergy 72(12):2005–2016. https://doi.org/10.1111/all.13209

CAS  Article  PubMed  Google Scholar 

Fricke J, Ávila G, Keller T et al (2020) Prevalence of chronic urticaria in children and adults across the globe: systematic review with meta-analysis. Allergy 75(2):423–432. https://doi.org/10.1111/all.14037

Article  PubMed  Google Scholar 

Balp MM, Weller K, Carboni V et al (2018) Prevalence and clinical characteristics of chronic spontaneous urticaria in pediatric patients. Pediatr Allergy Immunol 29(6):630–636. https://doi.org/10.1111/pai.12910

Article  PubMed  Google Scholar 

Saini SS, Kaplan AP (2018) Chronic spontaneous urticaria: the devil’s itch. J Allergy Clin Immunol Pract 6(4):1097–1106. https://doi.org/10.1016/j.jaip.2018.04.013

Article  PubMed  PubMed Central  Google Scholar 

Sharma VK, Gupta V, Pathak M, Ramam M (2017) An open-label prospective clinical study to assess the efficacy of increasing levocetirizine dose up to four times in chronic spontaneous urticaria not controlled with standard dose. J Dermatol Treat 28(6):539–543. https://doi.org/10.1080/09546634.2016.1246705

CAS  Article  Google Scholar 

Sotés PI, Armisén M, Usero-Bárcena T et al (2021) Efficacy and safety of up-dosing antihistamines in chronic spontaneous urticaria: a systematic review of the literature. J Investig Allergol Clin Immunol 31(4):282–291. https://doi.org/10.18176/jiaci.0649

CAS  Article  PubMed  Google Scholar 

Zuberbier T, Abdul Latiff AH, Abuzakouk M et al (2022) The international EAACI/GA2LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy 77(3):734–766. https://doi.org/10.1111/all.15090

Article  PubMed  Google Scholar 

Bernstein JA, Lang DM, Khan DA et al (2014) The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol 133(5):1270–1277. https://doi.org/10.1016/j.jaci.2014.02.036

Article  PubMed  Google Scholar 

Endo T, Toyoshima S, Kanegae K et al (2019) Identification of biomarkers for predicting the response to cyclosporine A therapy in patients with chronic spontaneous urticaria. Allergol Int 68(2):270–273. https://doi.org/10.1016/j.alit.2018.09.006

CAS  Article  PubMed  Google Scholar 

Sussman G, Hébert J, Gulliver W et al (2020) Omalizumab re-treatment and step-up in patients with chronic spontaneous urticaria: OPTIMA trial. J Allergy Clin Immunol Pract 8(7):2372-2378.e5. https://doi.org/10.1016/j.jaip.2020.03.022

Article  PubMed  Google Scholar 

Kaplan A, Ledford D, Ashby M et al (2013) Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy. J Allergy Clin Immunol 132(1):101–109. https://doi.org/10.1016/j.jaci.2013.05.013

CAS  Article  PubMed  Google Scholar 

Nettis E, Cegolon L, Di Leo E et al (2018) Omalizumab in chronic spontaneous urticaria: efficacy, safety, predictors of treatment outcome, and time to response. Ann Allergy Asthma Immunol 121(4):474–478. https://doi.org/10.1016/j.anai.2018.06.014

CAS  Article  PubMed  Google Scholar 

Bernstein JA, Kavati A, Tharp MD et al (2018) Effectiveness of omalizumab in adolescent and adult patients with chronic idiopathic/spontaneous urticaria: a systematic review of “real-world” evidence. Expert Opin Biol Ther 18(4):425–448. https://doi.org/10.1080/14712598.2018.1438406

CAS  Article  PubMed  Google Scholar 

Bernstein JA, Singh U, Rao MB, Berendts K, Zhang X, Mutasim D (2020) Benralizumab for chronic spontaneous urticaria. N Engl J Med 383(14):1389–1391. https://doi.org/10.1056/NEJMc2016395

Article  PubMed  Google Scholar 

Kaul M, End P, Cabanski M et al (2021) Remibrutinib (LOU064): a selective potent oral BTK inhibitor with promising clinical safety and pharmacodynamics in a randomized phase I trial. Clin Transl Sci. https://doi.org/10.1111/cts.13005

Article  PubMed  PubMed Central  Google Scholar 

Giménez-Arnau AM, Salman A (2020) Targeted therapy for chronic spontaneous urticaria: rationale and recent progress. Drugs 80(16):1617–1634. https://doi.org/10.1007/s40265-020-01387-9

Article  PubMed  Google Scholar 

Kocatürk E, Maurer M, Metz M, Grattan C (2017) Looking forward to new targeted treatments for chronic spontaneous urticaria. Clin Transl Allergy 7:1. https://doi.org/10.1186/s13601-016-0139-2

CAS  Article  PubMed  PubMed Central  Google Scholar 

Altrichter S, Frischbutter S, Fok JS et al (2020) The role of eosinophils in chronic spontaneous urticaria. J Allergy Clin Immunol 145(6):1510–1516. https://doi.org/10.1016/j.jaci.2020.03.005

CAS  Article  PubMed  Google Scholar 

Bansal CJ, Bansal AS (2019) Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria. Allergy Asthma Clin Immunol 15:56. https://doi.org/10.1186/s13223-019-0372-z

Article  PubMed  PubMed Central  Google Scholar 

Bracken SJ, Abraham S, MacLeod AS (2019) Autoimmune theories of chronic spontaneous urticaria. Front Immunol 10:627. https://doi.org/10.3389/fimmu.2019.00627

CAS  Article  PubMed  PubMed Central  Google Scholar 

Hide M, Francis DM, Grattan CE, Hakimi J, Kochan JP, Greaves MW (1993) Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med 328(22):1599–1604. https://doi.org/10.1056/NEJM199306033282204

CAS  Article  PubMed  Google Scholar 

Grattan CE, Francis DM, Hide M, Greaves MW (1991) Detection of circulating histamine releasing autoantibodies with functional properties of anti-IgE in chronic urticaria. Clin Exp Allergy 21(6):695–704. https://doi.org/10.1111/j.1365-2222.1991.tb03198.x

CAS  Article  PubMed  Google Scholar 

Dabija D, Tadi P (2021) Chronic urticaria. In: StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/pubmed/32310370. Accessed 29 Sept 2021

Gu H, Li L, Gu M, Zhang G (2015) Association between Helicobacter pylori infection and chronic urticaria: a meta-analysis. Gastroenterol Res Pract 2015:486974. https://doi.org/10.1155/2015/486974

Article  PubMed  PubMed Central  Google Scholar 

Gaig P, García-Ortega P, Enrique E, Papo M, Quer JC, Richard C (2002) Efficacy of the eradication of Helicobacter pylori infection in patients with chronic urticaria. A placebo-controlled double blind study. Allergol Immunopathol 30(5):255–258. https://doi.org/10.1016/s0301-0546(02)79133-7

CAS  Article  Google Scholar 

Yanase Y, Takahagi S, Hide M (2018) Chronic spontaneous urticaria and the extrinsic coagulation system. Allergol Int 67(2):191–194. https://doi.org/10.1016/j.alit.2017.09.003

CAS  Article  PubMed  Google Scholar 

Cugno M, Marzano AV, Tedeschi A, Fanoni D, Venegoni L, Asero R (2009) Expression of tissue factor by eosinophils in patients with chronic urticaria. Int Arch Allergy Immunol 148(2):170–174. https://doi.org/10.1159/000155748

CAS  Article  PubMed  Google Scholar 

Ying S, Kikuchi Y, Meng Q, Kay AB, Kaplan AP (2002) TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: comparison with the allergen-induced late-phase cutaneous reaction. J Allergy Clin Immunol 109(4):694–700. https://doi.org/10.1067/mai.2002.123236

CAS  Article  PubMed  Google Scholar 

Toyoda M, Maruyama T, Morohashi M, Bhawan J (1996) Free eosinophil granules in urticaria: a correlation with the duration of wheals. Am J Dermatopathol 18(1):49–57. https://doi.org/10.1097/00000372-199602000-00008

CAS  Article  PubMed  Google Scholar 

Hon KL, Leung AKC, Ng WGG, Loo SK (2019) Chronic urticaria: an overview of treatment and recent patents. Recent Pat Inflamm Allergy Drug Discov 13(1):27–37. https://doi.org/10.2174/1872213X13666190328164931

CAS  Article  PubMed  PubMed Central  Google Scholar 

Church MK, Maurer M, Simons FER et al (2010) Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper. Allergy 65(4):459–466. https://doi.org/10.1111/j.1398-9995.2009.02325.x

CAS  Article  PubMed  Google Scholar 

Phinyo P, Koompawichit P, Nochaiwong S, Tovanabutra N, Chiewchanvit S, Chuamanochan M (2021) Comparative efficacy and acceptability of licensed dose second-generation antihistamines in chronic spontaneous urticaria: a network meta-analysis. J Allergy Clin Immunol Pract 9(2):956-970.e57. https://doi.org/10.1016/j.jaip.2020.08.055

CAS  Article  PubMed  Google Scholar 

Staevska M, Popov TA, Kralimarkova T et al (2010) The effectiveness of levocetirizine and desloratadine in up to 4 times conventional doses in difficult-to-treat urticaria. J Allergy Clin Immunol 125(3):676–682. https://doi.org/10.1016/j.jaci.2009.11.047

CAS  Article  PubMed  Google Scholar 

Siebenhaar F, Degener F, Zuberbier T, Martus P, Maurer M (2009) High-dose desloratadine decreases wheal volume and improves cold provocation thresholds compared with standard-dose treatment in patients with acquired cold urticaria: a randomized, placebo-controlled, crossover study. J Allergy Clin Immunol 123(3):672–679. https://doi.org/10.1016/j.jaci.2008.12.008

CAS  Article  PubMed  Google Scholar 

van den Elzen MT, van Os-Medendorp H, van den Brink I et al (2017) Effectiveness and safety of antihistamines up to fourfold or higher in treatment of chronic spontaneous urticaria. Clin Transl Allergy. https://doi.org/10.1186/s13601-017-0141-3

Article  PubMed  PubMed Central  Google Scholar 

Nayak AS, Berger WE, LaForce CF et al (2017) Randomized, placebo-controlled study of cetirizine and loratadine in children with seasonal allergic rhinitis. Allergy Asthma Proc 38(3):222–230. https://doi.org/10.2500/aap.2017.38.4050

CAS  Article  PubMed  Google Scholar 

Gupta S, Khalilieh S, Kantesaria B, Banfield C (2007) Pharmacokinetics of desloratadine in children between 2 and 11 years of age. Br J Clin Pharmacol 63(5):534–540. https://doi.org/10.1111/j.1365-2125.2006.02810.x