Conflict of interest

A Azaro, Advisory and Consulting: Amcure GmbH and Orion Corporation. C Massard, Advisory and Consulting: Amgen, Astellas, AstraZeneca, Bayer, BeiGene, BMS, Celgene, Debiopharm, Genentech, Ipsen, Janssen, Lilly, MedImmune, MSD, Novartis, Pfizer, Roche, Sanofi, Orion; Principal/Sub-Investigator of Clinical Trials: Abbvie, Aduro, Agios, Amgen, Argen-x, Astex, AstraZeneca, Aveo pharmaceuticals, Bayer, Beigene, Blueprint, BMS, Boeringer Ingelheim, Celgene, Chugai, Clovis, Daiichi Sankyo, Debiopharm, Eisai, Eos, Exelixis, Forma, Gamamabs, Genentech, Gortec, GSK, H3 biomedecine, Incyte, Innate Pharma, Janssen, Kura Oncology, Kyowa, Lilly, Loxo, Lysarc, Lytix Biopharma, Medimmune, Menarini, Merus, MSD, Nanobiotix, Nektar Therapeutics, Novartis, Octimet, Oncoethix, Oncopeptides AB, Orion, Pfizer, Pharmamar, Pierre Fabre, Roche, Sanofi, Servier, Sierra Oncology, Taiho, Takeda, Tesaro, and Xencor, outside of submitted work. PA Cassier, received honoraria from Amgen, AstraZeneca, Blueprint Medicines, Novartis, Roche/Genentech, and Merck Serono; Investigator/Sub-Investigator of Clinical Trials: Abbvie, AstraZeneca, Bayer, Blueprint Medicines, Bristol-Myers Squibb, Celgene, Eli Lilly and Company, Glaxo Smith Kline, Innate Pharma, Janssen, Merck Serono, Merck Sharp Dohme, Novartis, Plexxikon, Genetech/Roche, Taiho Pharmaceuticals, and Transgene, outside of submitted work; Travel Accommodations and Expenses: Amgen, Bristol-Myers Squibb, Merck Sharp and Dohme, Netris Pharma, Novartis, and Roche. S Pant, Advisory and Consulting: Tyme, Inc., 4D-Pharma, Xencor, Ipsen; Principal/Sub-Investigator for Clinical Trials: Arcus, Arqule, Bristol-Myers Squibb, Eli Lilly, Five Prime Therapeutics, Glaxo Smith Kline, Holy Stone Healthcare Co., Tyme, Inc., Ipsen, Mirati Therapeutics, Inc., Novartis, Onco Response, Red Hill Biopharma, Ltd., Rgenix, Sanofi-Aventis, Xencor, Astellas, and Janssen, outside of submitted work. B Anderson, E Yuen, D Yu, G Oakley III, and KA Benhadji are current or past employees of Eli Lilly and Company and may hold company stocks. B Anderson is an employee of PRA Health Sciences and KA Benhadji is an employee of Taiho Oncology, and may hold company stocks.

Ethics approval

The study was approved by independent ethics committees or institutional review boards at each site. The study was registered at ClinicalTrials.gov as NCT02784795.

Informed consent

All patients provided written informed consent before enrollment.