Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K. Stages in the development of Parkinson’s disease-related pathology. Cell Tissue Res. 2004;318(1):121–34.

PubMed  Article  Google Scholar 

Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP, et al. The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord. 2009;24(11):1641–9.

Tandberg E, Larsen JP, Karlsen K. A community-based study of sleep disorders in patients with Parkinson’s disease. Mov Disord. 1998;13(6):895–9.

Poewe W. Non-motor symptoms in Parkinson’s disease. Eur J Neurol. 2008;15:14–20.

PubMed  Article  Google Scholar 

Gómez-Esteban JC, Tijero B, Somme J, Ciordia R, Berganzo K, Rouco I, et al. Impact of psychiatric symptoms and sleep disorders on the quality of life of patients with Parkinson’s disease. J Neurol. 2011;258(3):494–9.

PubMed  Article  Google Scholar 

Frucht S, Rogers J, Greene P, Gordon M, Fahn S. Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology. 1999;52(9):1908-.

Paus S, Brecht HM, Köster J, Seeger G, Klockgether T, Wüllner U. Sleep attacks, daytime sleepiness, and dopamine agonists in Parkinson’s disease. Mov Disord. 2003;18(6):659–67.

PubMed  Article  Google Scholar 

Garcia-Borreguero D, Larrosa O, Bravo M. Parkinson’s disease and sleep. Sleep Med Rev. 2003;7(2):115–29.

PubMed  Article  Google Scholar 

Sixel-Döring F, Trautmann E, Mollenhauer B, Trenkwalder C. Associated factors for REM sleep behavior disorder in Parkinson disease. Neurology. 2011;77(11):1048–54.

PubMed  Article  CAS  Google Scholar 

Comella CL, Nardine TM, Diederich NJ, Stebbins GT. Sleep-related violence, injury, and REM sleep behavior disorder in Parkinson’s disease. Neurology. 1998;51(2):526–9.

CAS  PubMed  Article  Google Scholar 

Gjerstad MD, Boeve B, Wentzel-Larsen T, Aarsland D, Larsen J. Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson’s disease over time. J Neurol Neurosurg Psychiatry. 2008;79(4):387–91.

CAS  PubMed  Article  Google Scholar 

Claassen D, Josephs KA, Ahlskog J, Silber M, Tippmann-Peikert M, Boeve BF. REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century. Neurology. 2010;75(6):494–9.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Boeve B. Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann NY Acad Sci. 2010;1184:15–54.

CAS  PubMed  Article  Google Scholar 

Gagnon J-F, Postuma RB, Mazza S, Doyon J, Montplaisir J. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. The Lancet Neurology. 2006;5(5):424–32.

PubMed  Article  Google Scholar 

Schenck CH, Boeve BF, Mahowald MW. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med. 2013;14(8):744–8.

PubMed  Article  Google Scholar 

Sateia MJ. International classification of sleep disorders. Chest. 2014;146(5):1387–94.

PubMed  Article  Google Scholar 

Appiah-Kubi L, Pal S, Chaudhuri KR. Restless legs syndrome (RLS), Parkinson’s disease, and sustained dopaminergic therapy for RLS. Sleep Med. 2002;3(SUPPL. 1):S51–5.

PubMed  Article  Google Scholar 

Fereshtehnejad SM, Shafieesabet M, Shahidi G, Delbari A, Lökk J. Restless legs syndrome in patients with Parkinson’s disease: a comparative study on prevalence, clinical characteristics, quality of life and nutritional status. Acta Neurol Scand. 2015;131(4):211–8.

PubMed  Article  Google Scholar 

• Obayashi K, Saeki K, Yamagami Y, Kurumatani N, Sugie K, Kataoka H. Circadian activity rhythm in Parkinson's disease: findings from the PHASE study. Sleep Med. 2021;85:8–14. doi: https://doi.org/10.1016/j.sleep.2021.06.023. This cross-sectional study showed that circadian rhythm changes in rest and activity are more advanced in phase and lower in amplitude in Parkinson's disease compared to healthy controls, and these changes are more pronounced with disease severity.

Videnovic A, Noble C, Reid KJ, Peng J, Turek FW, Marconi A, et al. Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease. JAMA Neurol. 2014;71(4):463–9.

PubMed  PubMed Central  Article  Google Scholar 

Breen DP, Vuono R, Nawarathna U, Fisher K, Shneerson JM, Reddy AB, et al. Sleep and circadian rhythm regulation in early Parkinson disease. JAMA Neurol. 2014;71(5):589–95.

PubMed  PubMed Central  Article  Google Scholar 

Bolitho SJ, Naismith SL, Rajaratnam SM, Grunstein RR, Hodges JR, Terpening Z, et al. Disturbances in melatonin secretion and circadian sleep–wake regulation in Parkinson disease. Sleep Med. 2014;15(3):342–7.

CAS  PubMed  Article  Google Scholar 

Li L, Zhao Z, Ma J, Zheng J, Huang S, Hu S, et al. Elevated plasma melatonin levels are correlated with the non-motor symptoms in Parkinson’s disease: a cross-sectional study. Front Neurosci. 2020;14:505. https://doi.org/10.3389/fnins.2020.00505.

Article  PubMed  PubMed Central  Google Scholar 

De Pablo-Fernández E, Courtney R, Warner TT, Holton JL. A histologic study of the circadian system in Parkinson disease, multiple system atrophy, and progressive supranuclear palsy. JAMA Neurol. 2018;75(8):1008–12.

PubMed  PubMed Central  Article  Google Scholar 

Apps M, Sheaff P, Ingram D, Kennard C, Empey D. Respiration and sleep in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1985;48(12):1240–5.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Schwartz JR, Roth T. Neurophysiology of sleep and wakefulness: basic science and clinical implications. Curr Neuropharmacol. 2008;6(4):367–78.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Rye DB, Jankovic J. Emerging views of dopamine in modulating sleep/wake state from an unlikely source: PD. Neurology. 2002;58(3):341–6.

PubMed  Article  Google Scholar 

Thannickal TC, Lai Y-Y, Siegel JM. Hypocretin (orexin) cell loss in Parkinson’s disease. Brain. 2007;130(6):1586–95.

PubMed  Article  Google Scholar 

Verwey M, Dhir S, Amir S. Circadian influences on dopamine circuits of the brain: regulation of striatal rhythms of clock gene expression and implications for psychopathology and disease. F1000Research. 2016;5:F1000 Faculty Rev-2062.

Cai Y, Liu S, Sothern R, Xu S, Chan P. Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson’s disease. Eur J Neurol. 2010;17(4):550–4.

CAS  PubMed  Article  Google Scholar 

Boeve B, Silber M, Saper C, Ferman T, Dickson D, Parisi J, et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain. 2007;130(11):2770–88.

CAS  PubMed  Article  Google Scholar 

Lees AJ, Blackburn NA, Campbell VL. The nighttime problems of Parkinson’s disease. Clin Neuropharmacol. 1988;11(6):512–9.

CAS  PubMed  Article  Google Scholar 

Chaudhuri KR, Schapira AH. Non-motor symptoms of Parkinson’s disease: dopaminergic pathophysiology and treatment. The Lancet Neurology. 2009;8(5):464–74.

CAS  PubMed  Article  Google Scholar 

Uchiyama T, Sakakibara R, Hattori T, Yamanishi T. Short-term effect of a single levodopa dose on micturition disturbance in Parkinson’s disease patients with the wearing-off phenomenon. Mov Disord. 2003;18(5):573–8.

PubMed  Article  Google Scholar 

Singaram C, Gaumnitz E, Torbey C, Ashraf W, Quigley E, Sengupta A, et al. Dopaminergic defect of enteric nervous system in Parkinson’s disease patients with chronic constipation. The Lancet. 1995;346(8979):861–4.

CAS  Article  Google Scholar 

Larsen JP, Tandberg E. Sleep disorders in patients with Parkinson’s disease. CNS Drugs. 2001;15(4):267–75.

CAS  PubMed  Article  Google Scholar 

Zesiewicz TA, Hauser RA. Depression in Patients with Parkinson’s Disease. CNS Drugs. 2000;13(4):253–64.

CAS  Article  Google Scholar 

Sharf B, Moskovitz C, Lupton M, Klawans H. Dream phenomena induced by chronic levodopa therapy. J Neural Transm. 1978;43(2):143–51.

CAS  PubMed  Article  Google Scholar 

Morawska MM, Moreira CG, Ginde VR, Valko PO, Weiss T, Büchele F, et al. Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson’s disease. Science translational medicine. 2021;13(623):eabe7099.

• Sundaram S, Hughes RL, Peterson E, Müller-Oehring EM, Brontë-Stewart HM, Poston KL, et al. Establishing a framework for neuropathological correlates and glymphatic system functioning in Parkinson’s disease. Neuroscience & Biobehavioral Reviews. 2019;103:305–15. This review summarizes potential mechanisms by which sleep disruption promotes neurotoxic protein accumulation in Parkinson's disease.

Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373–7.

Hablitz LM, Vinitsky HS, Sun Q, Stæger FF, Sigurdsson B, Mortensen KN, et al. Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia. Sci Adv. 2019;5(2):eaav5447.

Naidoo N. Cellular stress/the unfolded protein response: relevance to sleep and sleep disorders. Sleep Med Rev. 2009;13(3):195–204.

PubMed  PubMed Central  Article  Google Scholar 

Moreno-López C, Santamaría J, Salamero M, Del Sorbo F, Albanese A, Pellecchia MT, et al. Excessive daytime sleepiness in multiple system atrophy (SLEEMSA study). Arch Neurol. 2011;68(2):223–30.

PubMed  Article  Google Scholar 

Shimohata T, Nakayama H, Tomita M, Ozawa T, Nishizawa M. Daytime sleepiness in Japanese patients with multiple system atrophy: prevalence and determinants. BMC Neurol. 2012;12(1):1–6.

Article  Google Scholar 

Ghorayeb I, Yekhlef F, Chrysostome V, Balestre E, Bioulac B, Tison F. Sleep disorders and their determinants in multiple system atrophy. J Neurol Neurosurg Psychiatry. 2002;72(6):798–800.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Schmeichel A, Buchhalter L, Low P, Parisi J, Boeve B, Sandroni P, et al. Mesopontine cholinergic neuron involvement in Lewy body dementia and multiple system atrophy. Neurology. 2008;70(5):368–73.

CAS  PubMed  Article