LRP1 in the Vascular Wall

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Zhou L, Takayama Y, Boucher P, et al. LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One. 2009;4:e6922. https://doi.org/10.1371/journal.pone.0006922.

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Calvier L, Herz J, Hansmann G. Interplay of low-density lipoprotein receptors, LRPs, and Lipoproteins in pulmonary hypertension. JACC Basic Transl Sci. 2022;7:164–80. https://doi.org/10.1016/j.jacbts.2021.09.011. This is a great paper that shows multiple molecular mechanisms guided by the LDLR receptor family and interplays particularly LRP1 with its broad implications in pulmonary vascular wall integrity within other intermediate pathways like Wnt, ApoER2, among others.

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Calvier L, Boucher P, Herz J, Hansmann G. LRP1 deficiency in vascular SMC leads to pulmonary arterial hypertension that is reversed by PPARγ activation. Circ Res. 2019;124:1778–85. Identified and extensively described the importance of LRP1 in smooth muscle cells in the vascular wall in the process of pulmonary hypertension. It relates the findings in this disease model where the deficiency of LRP1 highlights its tissue-specific importance in the process of vascular dysfunction

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