Marchesi N, Fahmideh F, Boschi F, Pascale A, Barbieri A. Ocular neurodegenerative diseases: interconnection between retina and cortical areas. Cells. 2021;10(9):2394.

PubMed  PubMed Central  Article  Google Scholar 

Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121(11):2081–90.

PubMed  Article  Google Scholar 

Sharif NA. Glaucomatous optic neuropathy treatment options: the promise of novel therapeutics, techniques and tools to help preserve vision. Neural Regen Res. 2018;13(7):1145–50.

PubMed  PubMed Central  Article  Google Scholar 

Casson RJ, Chidlow G, Wood JP, Crowston JG, Goldberg I. Definition of glaucoma: clinical and experimental concepts. Clin Exp Ophthalmol. 2012;40(4):341–9.

PubMed  Article  Google Scholar 

Heijl A, Bengtsson B, Oskarsdottir SE. Prevalence and severity of undetected manifest glaucoma: results from the early manifest glaucoma trial screening. Ophthalmology. 2013;120(8):1541–5.

PubMed  Article  Google Scholar 

Jammal AA, Thompson AC, Mariottoni EB, Urata CN, Estrela T, Berchuck SI, et al. Rates of glaucomatous structural and functional change from a large clinical population: the Duke Glaucoma Registry Study. Am J Ophthalmol. 2021;222:238–47.

PubMed  Article  Google Scholar 

Tamm ER, Ethier CR, Dowling JE, Downs C, Ellisman MH, Fisher S, et al. Biological aspects of axonal damage in glaucoma: a brief review. Exp Eye Res. 2017;157:5–12.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Tezel G. Immune regulation toward immunomodulation for neuroprotection in glaucoma. Curr Opin Pharmacol. 2013;13(1):23–31.

CAS  PubMed  Article  Google Scholar 

Nickells RW, Howell GR, Soto I, John SW. Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy. Annu Rev Neurosci. 2012;35:153–79.

CAS  PubMed  Article  Google Scholar 

Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, et al. Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J Clin Invest. 2012;122(4):1246–61.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Distante P, Lombardo S, Verticchio Vercellin AC, Raimondi M, Rolando M, Tinelli C, et al. Structure/function relationship and retinal ganglion cells counts to discriminate glaucomatous damages. BMC Ophthalmol. 2015;15:185.

PubMed  PubMed Central  Article  Google Scholar 

Vidal-Sanz M, Salinas-Navarro M, Nadal-Nicolás FM, Alarcón-Martínez L, Valiente-Soriano FJ, de Imperial JM, et al. Understanding glaucomatous damage: anatomical and functional data from ocular hypertensive rodent retinas. Prog Retin Eye Res. 2012;31(1):1–27.

PubMed  Article  Google Scholar 

Soto I, Howell GR. The complex role of neuroinflammation in glaucoma. Cold Spring Harb Perspect Med. 2014;4(8):a017269.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Qu J, Wang D, Grosskreutz CL. Mechanisms of retinal ganglion cell injury and defense in glaucoma. Exp Eye Res. 2010;91(1):48–53.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Allison K, Patel D, Alabi O. Epidemiology of glaucoma: the past, present, and predictions for the future. Cureus. 2020;12(11): e11686.

PubMed  PubMed Central  Google Scholar 

Bengtsson B, Heijl A. Lack of visual field improvement after initiation of intraocular pressure reducing treatment in the Early Manifest Glaucoma Trial. Invest Opthalmol Vis Sci. 2016;57(13):5611–5.

Article  Google Scholar 

Ahmed AYA, Althomali IHM, Althobaiti OMA, Assery MSF, Alsini AAN. Risk factors associated with glaucoma disease progression. Egypt J Hosp Med. 2018;73(3):6331–6.

Article  Google Scholar 

Zhang N, Wang J, Chen B, Li Y, Jiang B. Prevalence of primary angle closure glaucoma in the last 20 years: a meta-analysis and systematic review. Front Med (Lausanne). 2021;7:624179.

Article  Google Scholar 

Park HYL, Shin DY, Jeon SJ, Kim YC, Jung Y, Kim EK, et al. Predicting the development of normal tension glaucoma and related risk factors in normal tension glaucoma suspects. Sci Rep. 2021;11(1):16697.

CAS  PubMed  PubMed Central  Article  Google Scholar 

McMonnies CW. Glaucoma history and risk factors. J Optom. 2017;10(2):71–8.

PubMed  Article  Google Scholar 

Dikopf MS, Vajaranant TS, Edward DP. Topical treatment of glaucoma: established and emerging pharmacology. Expert Opin Pharmacother. 2017;18(9):885–98.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Barar J, Javadzadeh AR, Omidi Y. Ocular novel drug delivery: impacts of membranes and barriers. Expert Opin Drug Deliv. 2008;5(5):567–81.

CAS  PubMed  Article  Google Scholar 

Gaudana R, Jwala J, Boddu SH, Mitra AK. Recent perspectives in ocular drug delivery. Pharm Res. 2009;26(5):1197–216.

CAS  PubMed  Article  Google Scholar 

Hennessy AL, Katz J, Covert D, Protzko C, Robin AL. Videotaped evaluation of eyedrop instillation in glaucoma patients with visual impairment or moderate to severe visual field loss. Ophthalmology. 2010;117(12):2345–52.

PubMed  Article  Google Scholar 

Thygesen J, Burk R, Carassa R, Crichton A, Goñi FJ, Menage M, et al. Criteria for choosing clinically effective glaucoma treatment: a discussion panel consensus. Curr Ther Res Clin Exp. 2007;68(3):127–36.

PubMed  PubMed Central  Article  Google Scholar 

Kwon S, Kim SH, Khang D, Lee JY. Potential therapeutic usage of nanomedicine for glaucoma treatment. Int J Nanomed. 2020;15:5745–65.

CAS  Article  Google Scholar 

Duarte JN. Neuroinflammatory mechanisms of mitochondrial dysfunction and neurodegeneration in glaucoma. J Ophthalmol. 2021;2021:4581909.

PubMed  PubMed Central  Google Scholar 

Patabendige A, Singh A, Jenkins S, Sen J, Chen R. Astrocyte activation in neurovascular damage and repair following ischaemic stroke. Int J Mol Sci. 2021;22(8):4280.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Thurgur H, Pinteaux E. Microglia in the neurovascular unit: blood-brain barrier-microglia interactions after central nervous system disorders. Neuroscience. 2019;405:55–67.

CAS  PubMed  Article  Google Scholar 

Ghosh AK, Rao VR, Wisniewski VJ, Zigrossi AD, Floss J, Koulen P, et al. Differential activation of glioprotective intracellular signaling pathways in primary optic nerve head astrocytes after treatment with different classes of antioxidants. Antioxidants (Basel). 2020;9(4):324.

CAS  PubMed Central  Article  Google Scholar 

Liu Y, Wu J, Yan LJ, Clark AF. High glucose impairs optic nerve head astrocyte phagocytosis prior to retinal ganglion cell degeneration. Invest Opthalmol Vis Sci. 2018;59(9):3549.

Google Scholar 

Nguyen JV, Soto I, Kim KY, Bushong EA, Oglesby E, Valiente-Soriano FJ, et al. Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma. Proc Natl Acad Sci. 2011;108(3):1176–81.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Reichenbach A, Bringmann A. Glia of the human retina. Glia. 2020;68(4):768–96.

PubMed  Article  Google Scholar 

Vecino E, Rodriguez FD, Ruzafa N, Pereiro X, Sharma SC. Glia–neuron interactions in the mammalian retina. Prog Retin Eye Res. 2016;51:1–40.

CAS  PubMed  Article  Google Scholar 

Chong RS, Martin KR. Glial cell interactions and glaucoma. Curr Opin Ophthalmol. 2015;26(2):73–7.

PubMed  PubMed Central  Article  Google Scholar 

Ebneter A, Casson RJ, Wood JP, Chidlow G. Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injury. Invest Opthalmol Vis Sci. 2010;51(12):6448–60.

Article  Google Scholar 

Ginhoux F, Prinz M. Origin of microglia: current concepts and past controversies. Cold Spring Harb Perspect Biol. 2015;7(8):a020537.

PubMed  PubMed Central  Article  Google Scholar 

Chen M, Luo C, Zhao J, Devarajan G, Xu H. Immune regulation in the aging retina. Prog Retin Eye Res. 2019;69:159–72.

CAS  PubMed  Article  Google Scholar 

Silverman SM, Wong WT. Microglia in the retina: roles in development, maturity, and disease. Annu Rev Vis Sci. 2018;4:45–77.

PubMed  Article  Google Scholar 

Rathnasamy G, Foulds WS, Ling EA, Kaur C. Retinal microglia—a key player in healthy and diseased retina. Prog Neurobiol. 2019;173:18–40.

PubMed  Article  Google Scholar 

Abcouwer SF, Lin CM, Shanmugam S, Muthusamy A, Barber AJ, Antonetti DA. Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury. J Neuroinflamm. 2013;10:149.

Article  CAS