DUSP3 regulates phosphorylation-mediated degradation of occludin and is required for maintaining epithelial tight junction

Citi S, Guerrera D, Spadaro D, Shah J. Epithelial junctions and Rho family GTPases: the zonular signalosome. Small GTPase. 2014;5:1–15.

Article  CAS  Google Scholar 

Brune K, Frank J, Schwingshackl A, Finigan J, Sidhaye VK. Pulmonary epithelial barrier function: some new players and mechanisms. Am J Physiol Lung Cell Mol Physiol. 2015;308:L731–45.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Yu Y, Elble RC. Homeostatic signaling by cell-cell junctions and its dysregulation during cancer progression. J Clin Med. 2016;5:26–45.

PubMed Central  Article  CAS  Google Scholar 

Martin TA. The role of tight junctions in cancer metastasis. Seminar Cell Dev Biol. 2014;36:224–31.

CAS  Article  Google Scholar 

Cummins PM. Occludin: one protein, many forms. Mol Cell Biol. 2012;32:242–50.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Mayor R, Etienne-Manneville S. The front and rear of collective cell migration. Nat Rev Mol Cell Biol. 2015;17:97–109.

Article  CAS  Google Scholar 

Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, et al. Protein tyrosine phosphatases in the human genome. Cell. 2004;117:699–711.

CAS  PubMed  Article  Google Scholar 

Huang C-Y, Tan T-H. DUSPs, to MAP kinases and beyond. Cell & Biosci. 2012;2:24–34.

CAS  Article  Google Scholar 

Chen H-F, Chuang H-C, Tan TH. Regulation of dual-specificity phosphatase (DUSP) ubiquitination and protein stability. Int J Mol Sci. 2019;20:2668.

CAS  PubMed Central  Article  Google Scholar 

Chen AJ, Zhou G, Juan T, Colicos SM, Cannon JP, Cabriera-Hansen M, et al. The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway. J Biol Chem. 2002;277:36592–601.

CAS  PubMed  Article  Google Scholar 

Hood KL, Tobin JF, Yoon C. Identification and characterization of two novel low-molecular-weight dual specificity phosphatases. Biochem Biophys Res Commun. 2002;298:545–51.

CAS  PubMed  Article  Google Scholar 

Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylates ADF/Coffilin. Cell. 2002;108:233–46.

CAS  PubMed  Article  Google Scholar 

Wang JY, Lin C-H, Yang C-H, Tan TH, Chen YR. Biochemical and biological characterization of a neuroendocrine-associated phosphatase. J Neurochem. 2006;98:89–101.

CAS  PubMed  Article  Google Scholar 

Lee JY, Yun JH, Lee J, Choi C, Kim JH. Blockade of dual-specificity phosphatase 28 decreases chemoresistance and migration in human pancreatic cancer cells. Sci Rep. 2015;5:12296–307.

PubMed  PubMed Central  Article  Google Scholar 

Zhao BM, Keasey SL, Tropea JE, Lountos GT, Dyas BK, Cherry S, et al. Phosphotyrosine substrate sequence motifs for dual specificity phosphatases. PLoS ONE. 2015;10: e0134984.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Hoyt R, Zhu W, Cerignoli F, Alonso A, Mustelin T, David M. Selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. J Immunol. 2007;179:3402–6.

CAS  PubMed  Article  Google Scholar 

Li J-P, Fu Y-N, Chen Y-R, Tan T-H. JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J Biol Chem. 2010;285:5472–8.

CAS  PubMed  Article  Google Scholar 

Wang J-Y, Yeh C-L, Chou H-C, Yang C-H, Fu Y-N, Chen Y-T, et al. Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer. J Biol Chem. 2011;286:10177–84.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Li J-P, Yang C-Y, Chuang H-C, Lan J-L, Chen D-Y, Chen Y-M, et al. The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Nat Comm. 2014;5:3618–31.

Article  CAS  Google Scholar 

Gallegos LL, Ng MR, Sowa ME, Selfors LM, White A, Zervantonakis IK, et al. A protein interaction map for cell cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin. Sci Rep. 2016;6:27114–28.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Ishibashi T, Bottaro DP, Chan A, Miki T, Aaronson SA. Expression cloing of a human dual-specificity phosphatase. Proc Natl Acad Sci USA. 1992;89:12170–4.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Todd JL, Rigas JD, Rafty LA, Denu JM. Dual-specificity protein tyrosine phosphatase VHR down-regulates c-Jun N-terminal kinase (JNK). Oncogene. 2002;21:2573–83.

CAS  PubMed  Article  Google Scholar 

Todd JL, Tanner KG, Denu JM. Extracellular regulated kinases (ERK) 1 and ERK 2 are authentic substrates for the dual specificity protein-tyrosine phosphatase VHR. J Biol Chem. 1999;274:13271–80.

CAS  PubMed  Article  Google Scholar 

Alonso A, Saxena M, Williams S, Mustellin T. Inhibitory role for dual-specificity phosphatase VHR in T cell antigen receptor and CD28-induced ERK and JNK activation. J Biol Chem. 2001;276:4766–71.

CAS  PubMed  Article  Google Scholar 

Zhou B, Wang Z-X, Zhao Y, Brautigan DL, Zhang Z-Y. The specificity of extracellular signal-regulated kinase 2 dephosphorylation by protein phosphatases. J Biol Chem. 2002;277:31818–25.

CAS  PubMed  Article  Google Scholar 

Hoyt R, Zhu W, Cerignoli F, Alonso A, Mustelin T, David M. Selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. J Immunol. 2007;179:3402–6.

CAS  PubMed  Article  Google Scholar 

Amand M, Erpicum C, Bajou K, Cerignoli F, Blacher S, Martin M, et al. DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase. Mol Cancer. 2014;13:108–25.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Musumeci L, Kuijpers MJ, Gilio K, Hego A, Theatre E, Maurissen L, et al. Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis. Circulation. 2015;131:656–68.

CAS  PubMed  Article  Google Scholar 

Singh P, Dejager L, Amand M, Theatre E, Vandereyken M, Zurashvili T, et al. DUSP3 genetic deletion confers M2-like macrophage-dependent tolerance to septic shock. J Immunol. 2015;194:4951–62.

CAS  PubMed  Article  Google Scholar 

Chen Y-R, Chou H-C, Yang C-H, Chen H-Y, Liu Y-W, Lin T-Y, et al. Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration. Oncogene. 2017;36:6509–17.

CAS  PubMed  Article  Google Scholar 

Yang C-H, Chou H-C, Fu Y-N, Yeh CLC, Chang I-C, Liu K-J, et al. EGFR over-expression in non-small cell lung cancers harboring EGFR mutations is associated with marked down-regulation of CD82. BBA-Mol Basis Dis. 2015;1852:1540–9.

CAS  Article  Google Scholar 

Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham VS, PhosphoSitePlus E. mutations, PTMs and recalibrations. Nucleic Acids Res. 2014;2015(43):D512–20.

Google Scholar 

PhosphoSitePlus. https://www.phosphosite.org/proteinAction.action?id=7592&showAllSites=true. Accessed 30 Dec 2020.

Elias BCS, Seth A, Giorgianni F, Kale G, Shen L, Turner JRN, et al. Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. J Biol Chem. 2009;284:1559–69.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Fredriksson S, Gullberg M, Jarvius J, Olsson C, Pietras K, Gustafsdottir SM, et al. Protein detection using proximity-dependent DNA ligation assays. Nat Biotechnol. 2002;20:473–7.

CAS  PubMed  Article  Google Scholar 

Kumar G. A simple method for detecting phosphorylation of proteins by using Zn2+-phos-tag SDS-PAGE at neutral pH. Methods Mol Biol. 2018;1853:223–9.

CAS  PubMed  Article  Google Scholar 

Nagy A, Munkacsy G, Gyorffy B. Pancancer survival analysis of cancer hallmark genes. Sci Rep. 2021;11:6047.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Kaplan Meier plotter. http://kmplot.com/analysis/index.php?p = service&cancer=pancancer_rnaseq. Accessed 24 Jul 2021.

Denu JM, Zhou G, Wu L, Zhao R, Yuvaniyama J, Saper MA, et al. The purification and characterization of a human dual-specific protein tyrosine phosphatase. J Biol Chem. 1995;270:3769–803.

Google Scholar 

Schumacher MA, Todd JL, Rice AE, Tanner KG, Denu JM. Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein phosphatase. Biochemistry. 2002;41:3009–17.

CAS  PubMed  Article  Google Scholar 

Xiao Q, Luechapanichkul R, Zhai Y, Pei D. Specificity profiling of protein phosphatases toward phosphoseryl and phosphothreonyl peptides. J Am Chem Soc. 2013;135:9760–7.

留言 (0)

沒有登入
gif