Hepatitis B virus virion secretion is a CRM1-spike-mediated late event

Blumberg BS. Australia antigen and the biology of hepatitis B. Science. 1977;197(4298):17–25.

CAS  PubMed  Article  Google Scholar 

Shih C, Yang CC, Choijilsuren G, Chang CH, Liou AT. Hepatitis B virus. Trends Microbiol. 2018;26(4):386–7.

CAS  PubMed  Article  Google Scholar 

Shih C, Chou SF, Yang CC, Huang JY, Choijilsuren G, Jhou RS. Control and eradication strategies of hepatitis B virus. Trends Microbiol. 2016;24(9):739–49.

CAS  PubMed  Article  Google Scholar 

Zlotnick A, Venkatakrishnan B, Tan Z, Lewellyn E, Turner W, Francis S. Core protein: a pleiotropic keystone in the HBV lifecycle. Antiviral Res. 2015;121:82–93.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Summers J, Mason WS. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell. 1982;29(2):403–15.

CAS  PubMed  Article  Google Scholar 

Yuan TT, Sahu GK, Whitehead WE, Greenberg R, Shih C. The mechanism of an immature secretion phenotype of a highly frequent naturally occurring missense mutation at codon 97 of human hepatitis B virus core antigen. J Virol. 1999;73(7):5731–40.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Schormann W, Kraft A, Ponsel D, Bruss V. Hepatitis B virus particle formation in the absence of pregenomic RNA and reverse transcriptase. J Virol. 2006;80(8):4187–90.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wu SY, Chang YS, Chu TH, Shih C. Persistence of hepatitis B virus DNA and the tempos between virion secretion and genome maturation in a mouse model. J Virol. 2019;93(22):e01001-e1019.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Shih C, Wu SY, Chou SF, Yuan TT. Virion secretion of hepatitis B virus naturally occurring core antigen variants. Cells. 2020;10(1):43.

PubMed Central  Article  CAS  Google Scholar 

Le Pogam S, Shih C. Influence of a putative intermolecular interaction between core and the Pre-S1 domain of the large envelope protein on hepatitis B virus secretion. J Virol. 2002;76:6510–7.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Gerin JL, Ford EC, Purcell RH. Biochemical characterization of Australia antigen. Evidence for defective particles of hepatitis B virus. Am J Pathol. 1975;81(3):651–68.

CAS  PubMed  PubMed Central  Google Scholar 

Kaplan PM, Ford EC, Purcell RH, Gerin JL. Demonstration of subpopulations of Dane particles. J Virol. 1976;17(3):885–93.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Alberti A, Diana S, Scullard GH, Eddleston WF, Williams R. Full and empty Dane particles in chronic hepatitis B virus infection: relation to hepatitis B e antigen and presence of liver damage. Gastroenterology. 1978;75(5):869–74.

CAS  PubMed  Article  Google Scholar 

Sakamoto Y, Yamada G, Mizuno M, Nishihara T, Kinoyama S, Kobayashi T, et al. Full and empty particles of hepatitis B virus in hepatocytes from patients with HBsAg-positive chronic active hepatitis. Lab Invest. 1983;48(6):678–82.

CAS  PubMed  Google Scholar 

Kimura T, Ohno N, Terada N, Rokuhara A, Matsumoto A, Yagi S, et al. Hepatitis B virus DNA-negative Dane particles lack core protein but contain a 22-kDa precore protein without C-terminal arginine-rich domain. J Biol Chem. 2005;280(23):21713–9.

CAS  PubMed  Article  Google Scholar 

Ning X, Nguyen D, Mentzer L, Adams C, Lee H, Ashley R, et al. Secretion of genome-free hepatitis B virus—single strand blocking model for virion morphogenesis of para-retrovirus. PLoS Pathog. 2011;7(9): e1002255.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Su PY, Yang CJ, Chu TH, Chang CH, Chiang C, Tang FM, et al. HBV maintains electrostatic homeostasis by modulating negative charges from phosphoserine and encapsidated nucleic acids. Sci Rep. 2016;6:38959.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Chua PK, Wang RY, Lin MH, Masuda T, Suk FM, Shih C. Reduced secretion of virions and hepatitis B virus (HBV) surface antigen of a naturally occurring HBV variant correlates with the accumulation of the small S envelope protein in the endoplasmic reticulum and Golgi apparatus. J Virol. 2005;79(21):13483–96.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Lambert C, Doring T, Prange R. Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin. J Virol. 2007;81(17):9050–60.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Prange R. Host factors involved in hepatitis B virus maturation, assembly, and egress. Med Microbiol Immunol. 2012;201(4):449–61.

CAS  PubMed  Article  Google Scholar 

Stieler JT, Prange R. Involvement of ESCRT-II in hepatitis B virus morphogenesis. PLoS ONE. 2014;9(3): e91279.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Chou SF, Tsai ML, Huang JY, Chang YS, Shih C. The dual role of an ESCRT-0 component HGS in HBV transcription and naked capsid secretion. PLoS Pathog. 2015;11(10): e1005123.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Zeyen L, Doring T, Prange R. Hepatitis B virus exploits ERGIC-53 in conjunction with COPII to exit cells. Cells. 2020;9(8):1889. https://doi.org/10.3390/cells9081889.

CAS  Article  PubMed Central  Google Scholar 

Li HC, Huang EY, Su PY, Wu SY, Yang CC, Lin YS, et al. Nuclear export and import of human hepatitis B virus capsid protein and particles. PLoS Pathog. 2010;6(10): e1001162.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Lubyova B, Hodek J, Zabransky A, Prouzova H, Hubalek M, Hirsch I, et al. PRMT5: a novel regulator of hepatitis B virus replication and an arginine methylase of HBV core. PLoS ONE. 2017;12(10): e0186982.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Yang CC, Huang EY, Li HC, Su PY, Shih C. Nuclear export of human hepatitis B virus core protein and pregenomic RNA depends on the cellular NXF1-p15 machinery. PLoS ONE. 2014;9(10): e106683.

PubMed  PubMed Central  Article  CAS  Google Scholar 

Hutten S, Kehlenbach RH. CRM1-mediated nuclear export: to the pore and beyond. Trends Cell Biol. 2007;17(4):193–201.

CAS  PubMed  Article  Google Scholar 

Fornerod M, Ohno M, Yoshida M, Mattaj IW. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell. 1997;90(6):1051–60.

CAS  PubMed  Article  Google Scholar 

Yang CC, Chang CH, Chen HL, Chou MC, Yang CJ, Jhou RS, et al. CRM1-spike-mediated nuclear export of hepatitis B virus encapsidated viral RNA. Cell Rep. 2022;38(10): 110472.

CAS  PubMed  Article  Google Scholar 

Nakabayashi H, Taketa K, Miyano K, Yamane T, Sato J. Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. Cancer Res. 1982;42(9):3858–63.

CAS  PubMed  Google Scholar 

Nassal M. The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly. J Virol. 1992;66(7):4107–16.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Wang IH, Burckhardt CJ, Yakimovich A, Morf MK, Greber UF. The nuclear export factor CRM1 controls juxta-nuclear microtubule-dependent virus transport. J Cell Sci. 2017;130(13):2185–95.

CAS  PubMed  Google Scholar 

Hilliard M, Frohnert C, Spillner C, Marcone S, Nath A, Lampe T, et al. The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein export. J Biol Chem. 2010;285(29):22202–10.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Conway JF, Watts NR, Belnap DM, Cheng N, Stahl SJ, Wingfield PT, et al. Characterization of a conformational epitope on hepatitis B virus core antigen and quasiequivalent variations in antibody binding. J Virol. 2003;77(11):6466–73.

CAS  PubMed  PubMed Central  Article  Google Scholar 

Soderberg O, Gullberg M, Jarvius M, Ridderstrale K, Leuchowius KJ, Jarvius J, et al. Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods. 2006;3(12):995–1000.

PubMed  Article  CAS  Google Scholar 

Hilditch CM, Rogers LJ, Bishop DH. Physicochemical analysis of the hepatitis B virus core antigen produced by a baculovirus expression vector. J Gen Virol. 1990;71(Pt 11):2755–9.

CAS 

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