Skin Pharmacology and Physiology

Hassan A.S. · Al-dhoun M.Q. · Shaker O.G. · AlOrbani A.M.

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Article / Publication Details Abstract

Background: Signal transducer and activator of transcription (STAT)-3 belongs to a group of latent transcription factors phosphorylated and activated by several protein tyrosine kinases, including members of Janus-kinases (JAKs) family. It is has been implicated that the JAK-STAT pathway activation could promote quiescence in the hair cycle, and topical treatment of mouse and human skin with JAK-inhibitors was shown to result in rapid hair growth. Objective: Our aim was to assess the tissue expression of STAT3 in patients with androgenetic alopecia and correlate it with disease severity and clinical parameters. Methods: Twenty five androgenetic alopecia patients who served as both cases and controls were included in this study. Full clinical examination was done and tissue STAT3 gene expression was then measured by real-time polymerase chain reaction. Results: Scalp tissue affected by androgenetic alopecia show significantly higher STAT3 gene expression levels compared to unaffected (androgen independent) areas. (P

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