Complement C3 deficiency alleviates alkylation-induced retinal degeneration in mice

Handa JT, Bowes Rickman C, Dick AD, Gorin MB, Miller JW, Toth CA, et al. A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. Nat Commun. 2019;10(1):3347.

Article  Google Scholar 

Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014;2(2):e106–16.

Article  Google Scholar 

Age-Related Eye Disease Study Research Group. Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: Age-Related Eye Disease Study Report Number 3. Ophthalmology. 2000;107(12):2224–32.

Article  Google Scholar 

Fu D, Calvo JA, Samson LD. Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer. 2012;12(2):104–20.

CAS  Article  Google Scholar 

Burton MJ, Ramke J, Marques AP, Bourne RRA, Congdon N, Jones I, et al. The Lancet Global Health Commission on Global Eye Health: vision beyond 2020. Lancet Glob Health. 2021;9(4):e489-551.

Article  Google Scholar 

Komeima K, Rogers BS, Lu L, Campochiaro PA. Antioxidants reduce cone cell death in a model of retinitis pigmentosa. Proc Natl Acad Sci USA. 2006;103(30):11300–5.

CAS  Article  Google Scholar 

Spadaro A, Rao M, Lorenti M, Romano MR, Augello A, Eandi CM, et al. New Brilliant Blue G derivative as pharmacological tool in retinal surgery. Front Pharmacol. 2020;11:708.

CAS  Article  Google Scholar 

Allocca M, Corrigan JJ, Mazumder A, Fake KR, Samson LD. Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration. Sci Signal. 2019;12(568):eaau9216.

CAS  Article  Google Scholar 

Nakajima M, Yuge K, Senzaki H, Shikata N, Miki H, Uyama M, et al. Photoreceptor apoptosis induced by a single systemic administration of N-methyl-N-nitrosourea in the rat retina. Am J Pathol. 1996;148(2):631–41.

CAS  PubMed  PubMed Central  Google Scholar 

Meira LB, Moroski-Erkul CA, Green SL, Calvo JA, Bronson RT, Shah D, et al. Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice. Proc Natl Acad Sci USA. 2009;106(3):888–93.

CAS  Article  Google Scholar 

Rai G, Vyjayanti VN, Dorjsuren D, Simeonov A, Jadhav A, Wilson DM, et al. Small molecule inhibitors of the human apurinic/apyrimidinic endonuclease 1 (APE1). In: Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010.

Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010;11(9):785–97.

CAS  Article  Google Scholar 

Ricklin D, Reis ES, Mastellos DC, Gros P, Lambris JD. Complement component C3—The “Swiss Army Knife” of innate immunity and host defense. Immunol Rev. 2016;274(1):33–58.

CAS  Article  Google Scholar 

Liszewski MK, Java A, Schramm EC, Atkinson JP. Complement dysregulation and disease: insights from contemporary genetics. Annu Rev Pathol. 2017;12:25–52.

CAS  Article  Google Scholar 

van Lookeren CM, Strauss EC, Yaspan BL. Age-related macular degeneration: complement in action. Immunobiology. 2016;221(6):733–9.

Article  Google Scholar 

Mohlin C, Sandholm K, Ekdahl KN, Nilsson B. The link between morphology and complement in ocular disease. Mol Immunol. 2017;89:84–99.

CAS  Article  Google Scholar 

Kim BJ, Mastellos DC, Li Y, Dunaief JL, Lambris JD. Targeting complement components C3 and C5 for the retina: key concepts and lingering questions. Prog Retin Eye Res. 2021;83:100936.

Article  Google Scholar 

Linetsky M, Bondelid KS, Losovskiy S, Gabyak V, Rullo MJ, Stiadle TI, et al. 4-hydroxy-7-oxo-5-heptenoic acid lactone is a potent inducer of the complement pathway in human retinal pigmented epithelial cells. Chem Res Toxicol. 2018;31(8):666–79.

CAS  Article  Google Scholar 

Stephan AH, Barres BA, Stevens B. The complement system: an unexpected role in synaptic pruning during development and disease. Annu Rev Neurosci. 2012;35:369–89.

CAS  Article  Google Scholar 

Chi ZL, Yoshida T, Lambris JD, Iwata T. Suppression of drusen formation by compstatin, a peptide inhibitor of complement C3 activation, on cynomolgus monkey with early-onset macular degeneration. Adv Exp Med Biol. 2010;703:127–35.

CAS  Article  Google Scholar 

Ramos de Carvalho JE, Klaassen I, Vogels IM, Schipper-Krom S, van Noorden CJ, Reits E, et al. Complement factor C3a alters proteasome function in human RPE cells and in an animal model of age-related RPE degeneration. Invest Ophthalmol Vis Sci. 2013;54(10):6489–501.

CAS  Article  Google Scholar 

Park DH, Connor KM, Lambris JD. The challenges and promise of complement therapeutics for ocular diseases. Front Immunol. 2019;10:1007.

CAS  Article  Google Scholar 

Di Carlo E, Augustin AJ. Prevention of the onset of age-related macular degeneration. J Clin Med. 2021;10(15):3297.

Article  Google Scholar 

Allocca M, Corrigan JJ, Fake KR, Calvo JA, Samson LD. PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration. Oncotarget. 2017;8(40):68707–20.

Article  Google Scholar 

Wang J, Iacovelli J, Spencer C, Saint-Geniez M. Direct effect of sodium iodate on neurosensory retina. Invest Ophthalmol Vis Sci. 2014;55(3):1941–53.

CAS  Article  Google Scholar 

Wang S, Poli S, Liang X, Peng GH. Longitudinal single-cell RNA-seq of hESCs-derived retinal organoids. Sci China Life Sci. 2021;64(10):1661–76.

CAS  Article  Google Scholar 

Schindelin J, Rueden CT, Hiner MC, Eliceiri KW. The ImageJ ecosystem: an open platform for biomedical image analysis. Mol Reprod Dev. 2015;82(7–8):518–29.

CAS  Article  Google Scholar 

Zou T, Gao L, Zeng Y, Li Q, Li Y, Chen S, et al. Organoid-derived C-Kit(+)/SSEA4(−) human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents. Nat Commun. 2019;10(1):1205.

Article  Google Scholar 

Wang S, Du L, Peng GH. Optogenetic stimulation inhibits the self-renewal of mouse embryonic stem cells. Cell Biosci. 2019;9:73.

Article  Google Scholar 

Shi Q, Chowdhury S, Ma R, Le KX, Hong S, Caldarone BJ, et al. Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Sci Transl Med. 2017;9(392):eaaf6295.

Article  Google Scholar 

Fitzgerald KC, Kim K, Smith MD, Aston SA, Fioravante N, Rothman AM, et al. Early complement genes are associated with visual system degeneration in multiple sclerosis. Brain. 2019;142(9):2722–36.

Article  Google Scholar 

Natoli R, Fernando N, Jiao H, Racic T, Madigan M, Barnett NL, et al. Retinal macrophages synthesize C3 and activate complement in AMD and in models of focal retinal degeneration. Invest Ophthalmol Vis Sci. 2017;58(7):2977–90.

CAS  Article  Google Scholar 

Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, et al. Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents. Nat Commun. 2019;10(1):2538.

Article  Google Scholar 

留言 (0)

沒有登入
gif