1. Ferlay, J, Shin, HR, Bray, F, Forman, D, Mathers, C, Parkin, DM. Estimates of worldwide burden of cancer in 2008: gLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–2917.
Google Scholar | Crossref | Medline | ISI2. Grivennikov, SI, Greten, FR, Karin, M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883–899.
Google Scholar | Crossref | Medline | ISI3. Satomi, A, Murakami, S, Ishida, K, Mastuki, M, Hashimoto, T, Sonoda, M. Significance of increased neutrophils in patients with advanced colorectal cancer. Acta oncologica (Stockholm, Sweden). 1995;34(1):69–73.
Google Scholar | Crossref | Medline4. Gu, XB, Tian, T, Tian, XJ, Zhang, XJ. Prognostic significance of neutrophil-to-lymphocyte ratio in non-small cell lung cancer: a meta-analysis. Sci Rep. 2015;5:12493.
Google Scholar | Crossref | Medline5. Grenader, T, Waddell, T, Peckitt, C, et al. Prognostic value of neutrophil-to-lymphocyte ratio in advanced oesophago-gastric cancer: exploratory analysis of the REAL-2 trial. Annals of oncology : official journal of the European Society for Medical Oncology. 2016;27(4):687–692.
Google Scholar | Crossref | Medline6. Zhang, P, Xi, M, Li, QQ, et al. The modified glasgow prognostic score is an independent prognostic factor in patients with inoperable thoracic esophageal squamous cell carcinoma undergoing chemoradiotherapy. J Cancer. 2014;5(8):689–695.
Google Scholar | Crossref | Medline7. Yang, X, Huang, Y, Feng, JF, Liu, JS. Prognostic significance of neutrophil-to- lymphocyte ratio in esophageal cancer: a meta-analysis. Onco Targets Ther. 2015;8:789–794.
Google Scholar | Crossref | Medline8. Yodying, H, Matsuda, A, Miyashita, M, et al. Prognostic significance of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in oncologic outcomes of esophageal cancer: a systematic review and meta-analysis. Ann Surg Oncol. 2016;23(2):646–654.
Google Scholar | Crossref | Medline9. Huang, Y, Sun, Y, Peng, P, Zhu, S, Sun, W, Zhang, P. Prognostic and clinicopathologic significance of neutrophil-to-lymphocyte ratio in esophageal squamous cell carcinoma: evidence from a meta-analysis. Onco Targets Ther. 2017;10:1165–1172.
Google Scholar | Crossref | Medline10. Stroup, DF, Berlin, JA, Morton, SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of observational studies in epidemiology (MOOSE) group. Jama. 2000;283(15):2008–2012.
Google Scholar | Crossref | Medline | ISI11. Moher, D, Liberati, A, Tetzlaff, J, Altman, DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.
Google Scholar | Crossref | Medline | ISI12. Wells, G, Shea, B, O’Connell, D, et al. The Newcastle-Ottawa Scale (NOS)for assessing the quality of nonrandomized studies in meta-analysis. 2017. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed December 14, 2017.
Google Scholar13. Zhou, XL, Li, YQ, Zhu, WG, et al. Neutrophil-to-lymphocyte ratio as a prognostic biomarker for patients with locally advanced esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Sci Rep. 2017;7:42581.
Google Scholar | Crossref | Medline14. Zhang, JY, Chen, YD, Zhou, M. Prognostic role of preoperative neutrophil-to-lymphocyte ratio of squamous cell carci­noma in middle and lower thoracic esophagus after radical resection through left-sided thoracic incision. Modern Oncology. 2017;25(7):1061–1064.
Google Scholar15. Nakamura, K, Yoshida, N, Baba, Y, et al. Elevated preoperative neutrophil-to-lymphocytes ratio predicts poor prognosis after esophagectomy in T1 esophageal cancer. Int J Clin Oncol. 2017;22(3):469–475.
Google Scholar | Crossref | Medline16. Hirahara, N, Matsubara, T, Kawahara, D, Nakada, S, Ishibashi, S, Tajima, Y. Prognostic significance of preoperative inflammatory response biomarkers in patients undergoing curative thoracoscopic esophagectomy for esophageal squamous cell carcinoma. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2017;43(2):493–501.
Google Scholar | Medline17. He, YF, Luo, HQ, Wang, W, et al. Preoperative NLR and PLR in the middle or lower ESCC patients with radical operation. Eur J Cancer Care. 2017;26(2).
Google Scholar | Crossref | Medline18. Zhu, S, Miao, CW, Wang, ZT, Peng, L, Li, B. Sensitivity value of hematological markers in patients receiving chemoradiotherapy for esophageal squamous cell carcinoma. Onco Targets Ther. 2016;9:6187–6193.
Google Scholar | Crossref | Medline19. Zhang, P, Xi, M, Zhao, L, et al. Comparison of two inflammation-based prognostic scores in patients with thoracic esophageal cancer undergoing chemoradiotherapy. Int J Clin Exp Med. 2016;9(2):1764–1771.
Google Scholar20. Xiao, Q, Zhang, B, Deng, X, et al. The preoperative neutrophil-To-lymphocyte ratio Is a novel immune parameter for the prognosis of esophageal basaloid squamous cell carcinoma. PloS one. 2016;11(12):e0168299.
Google Scholar | Crossref | Medline21. Toyokawa, T, Kubo, N, Tamura, T, et al. The pretreatment controlling nutritional Status (CONUT) score is an independent prognostic factor in patients with resectable thoracic esophageal squamous cell carcinoma: results from a retrospective study. BMC cancer. 2016;16(1):722.
Google Scholar | Crossref | Medline22. Miyazaki, T, Sakai, M, Sohda, M, et al. Prognostic significance of inflammatory and nutritional parameters in patients with esophageal cancer. Anticancer Res. 2016;36(12):6557–6562.
Google Scholar | Crossref | Medline23. Liu, XM, Li, MH, Kong, L, Yu, JM. Prognostic role of neutrophil-lymphocyte ratio on esophageal cancer patients who received definitive chemoradiotherapy. CHIN J CANCER PREV TREAT. 2016;23(21):1431–1436.
Google Scholar24. Kosumi, K, Baba, Y, Ishimoto, T, et al. Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients. Surg Today. 2016;46(4):405–413.
Google Scholar | Crossref | Medline25. Ji, WH, Jiang, YH, Ji, YL, Li, B, Mao, WM. Prechemotherapy neutrophil : lymphocyte ratio is superior to the platelet : lymphocyte ratio as a prognostic indicator for locally advanced esophageal squamous cell cancer treated with neoadjuvant chemotherapy. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 2016;29(5):403–411.
Google Scholar | Crossref | Medline26. Hirahara, N, Matsubara, T, Mizota, Y, Ishibashi, S, Tajima, Y. Prognostic value of preoperative inflammatory response biomarkers in patients with esophageal cancer who undergo a curative thoracoscopic esophagectomy. BMC Surg. 2016;16(1):66.
Google Scholar | Crossref | Medline27. Yutong, H, Xiaoli, X, Shumei, L, Shan, S, Di, L, Baoen, S. Increased neutrophil-lymphocyte ratio Is a poor prognostic factor in patients with esophageal cancer in a high incidence area in China. Arch Med Res. 2015;46(7):557–563.
Google Scholar | Crossref | Medline28. Wu, Y, Yu, HM. Prognostic role of neutrophil-to-lymphocyte ratio on the radiotherapy of esophageal squamous cell carcinoma. Chinese and Foreign Medical Research. 2015;13(13):1–3.
Google Scholar29. Su, ZJ, Pan, QX, Wang, CR, Zhang, JH. Preoperative neutrophil-lymphocyte ratio as a prognostic factor in patients with esophageal cancer. Tumor. 2015;35(11):1258–1264.
Google Scholar30. Shao, Y, Ning, Z, Chen, J, et al. Prognostic nomogram integrated systemic inflammation score for patients with esophageal squamous cell carcinoma undergoing radical esophagectomy. Sci Rep. 2015;5:18811.
Google Scholar | Crossref | Medline31. Liu, JS, Huang, Y, Yang, X, Feng, JF. A nomogram to predict prognostic values of various inflammatory biomarkers in patients with esophageal squamous cell carcinoma. Am J Cancer Res. 2015;5(7):2180–2189.
Google Scholar | Medline32. Hirahara, N, Matsubara, T, Hayashi, H, Takai, K, Fujii, Y, Tajima, Y. Impact of inflammation-based prognostic score on survival after curative thoracoscopic esophagectomy for esophageal cancer. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2015;41(10):1308–1315.
Google Scholar | Medline33. Han, LH, Jia, YB, Song, QX, Wang, JB, Wang, NN, Cheng, YF. Prognostic significance of preoperative lymphocyte-monocyte ratio in patients with resectable esophageal squamous cell carcinoma. Asian Pacific journal of cancer prevention : APJCP. 2015;16(6):2245–2250.
Google Scholar | Crossref | Medline34. Duan, H, Zhang, X, Wang, FX, et al. Prognostic role of neutrophil-lymphocyte ratio in operable esophageal squamous cell carcinoma. World J Gastroenterol. 2015;21(18):5591–5597.
Google Scholar | Crossref | Medline35. Xie, X, Luo, KJ, Hu, Y, Wang, JY, Chen, J. Prognostic value of preoperative platelet-lymphocyte and neutrophil-lymphocyte ratio in patients undergoing surgery for esophageal squamous cell cancer. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. 2016;29(1):79–85.
Google Scholar | Crossref | Medline36. Yoo, EJ, Park, JC, Kim, EH, et al. Prognostic value of neutrophil-to-lymphocyte ratio in patients treated with concurrent chemoradiotherapy for locally advanced oesophageal cancer. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2014;46(9):846–853.
Google Scholar | Medline37. Wang, J, Jia, Y, Wang, N, et al. The clinical significance of tumor-infiltrating neutrophils and neutrophil-to-CD8 + lymphocyte ratio in patients with resectable esophageal squamous cell carcinoma. J Transl Med. 2014;12(7).
Google Scholar38. Feng, JF, Huang, Y, Chen, QX. Preoperative platelet lymphocyte ratio (PLR) is superior to neutrophil lymphocyte ratio (NLR) as a predictive factor in patients with esophageal squamous cell carcinoma. World J Surg Oncol. 2014;12(58).
Google Scholar39. Chen, H, He, J. [Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after radical resection of esophageal squamous cell carcinoma]. Zhonghua zhong liu za zhi [Chinese journal of oncology. 2014;36(4):294–297.
Google Scholar | Medline40. Feng, JF, Huang, Y, Zhao, Q, Chen, QX. Clinical significance of preoperative neutrophil lymphocyte ratio versus platelet lymphocyte ratio in patients with small cell carcinoma of the esophagus. TheScientificWorldJournal. 2013;2013:504365.
Google Scholar | Crossref | Medline41. Feng, JF, Huang, Y, Liu, JS. Combination of neutrophil lymphocyte ratio and platelet lymphocyte ratio is a useful predictor of postoperative survival in patients with esophageal squamous cell carcinoma. Onco Targets Ther. 2013;6:1605–1612.
Google Scholar | Medline42. Sharaiha, RZ, Halazun, KJ, Mirza, F, et al. Elevated preoperative neutrophil:lymphocyte ratio as a predictor of postoperative disease recurrence in esophageal cancer. Ann Surg Oncol. 2011;18(12):3362–3369.
Google Scholar | Crossref | Medline43. Miyata, H, Yamasaki, M, Kurokawa, Y, et al. Prognostic value of an inflammation-based score in patients undergoing pre-operative chemotherapy followed by surgery for esophageal cancer. Exp Ther Med. 2011;2(5):879–885.
Google Scholar | Crossref | Medline44. Dutta, S, Crumley, AB, Fullarton, GM, Horgan, PG, McMillan, DC. Comparison of the prognostic value of tumour- and patient-related factors in patients undergoing potentially curative resection of oesophageal cancer. World J Surg. 2011;35(8):1861–1866.
Google Scholar | Crossref | Medline45. Szkandera, J, Stotz, M, Absenger, G, et al. Validation of C-reactive protein levels as a prognostic indicator for survival in a large cohort of pancreatic cancer patients. Br J Cancer. 2014;110(1):183–188.
Google Scholar | Crossref | Medline46. Zhang, WW, Liu, KJ, Hu, GL, Liang, WJ. Preoperative platelet/lymphocyte ratio is a superior prognostic factor compared to other systemic inflammatory response markers in ovarian cancer patients. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2015;36(11):8831–8837.
Google Scholar | Crossref | Medline47. Hanahan, D, Weinberg, RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–674.
Google Scholar | Crossref | Medline | ISI48. Mantovani, A, Allavena, P, Sica, A, Balkwill, F. Cancer-related inflammation. Nature. 2008;454(7203):436–444.
Google Scholar | Crossref | Medline | ISI49. Kusumanto, YH, Dam, WA, Hospers, GA, Meijer, C, Mulder, NH. Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis. 2003;6(4):283–287.
Google Scholar |