Amiri et al.20 RCT Iran Rotterdam Age: 25.6 ± 4.02 Metf, Flu, Metf+ Flu, Placebo 6 months BMI, WHR, WC, FBG, LDL, HDL, TG BMI: 28.9 ± 5 FAI. J.Ahmad et al.75 RCT India NIH Age: 22.81 ± 4.52 Rosig, Metf 12 months WHR, BMI BMI: 27.66 ± 5.44 Aroda et al.63 RCT USA NIH Age: 27.87 ± 0.87 Piog, Placebo 6 months Weight, BMI, WHR, WC, FBG, FI BMI: 36.29 ± 1.34 Ashraf Ganie et al.64 RCT India NIH Age: 22.9 ± 5.3 Spironolactone vs Met 3 months BMI, FBG, FI, WHR BMI: 26.8 ± 4.0 Batista et al.73 RCT Brazil AES-2006 Age: 24.5 ± 4.33 Rosig, placebo 12 weeks FBG.FI, HOMA-IR BMI: 27.89 ± 6.10 Brettenthaler et al.21 RCT Switzerland Rotterdam Age: 30.2 ± 1.4 Piog, placebo 3 months BMI, WHR, FBG, FI, HOMA-IR BMI: 29.4 ± 1.7 Cataldo et al.76 RCT USA NICHD Age: 29.3 ± 1.5 Rosig 2 mg, 4 mg, 8 mg 12 weeks BMI, WHR, Wt BMI: 37.2 ± 2.1 Cheng et al.77 RCT Australia Rotterdam Age: 26 ± 4 Metf, placebo 6 months Wt, BMI, WC, WHR, LDL,HDL, BMI: 24.2 ± 5.3 TG, TC, HOMA-IR, HOMA-B Chou et al.78 RCT Brazil N/A Age: 24 ± 5 Metf, placebo 3 months BMI, WHR, FBG, FI, TG, TC, HDL, LDL BMI: 35.6 ± 4.9 Cetinkalp et al.22 RCT Turkey Rotterdam Age: N/A Met, Rosigl, ECA 4 months FBG, FI, Wt, BMI, HOMA-IR, TC, BMA: 25.82 ± 6.12 TG, HDL, LDL Cho et al.23 RCT UK Rotterdam Age: 26·4 ± 1·5 Metf, Orlistat, Piog 12 weeks BMI, HOMA-IR BMI: 36·0 ± 1·2 Ciotta et al.79 RCT Italy N/A Age: 20.5 ± 0.6 Acarbose, Placebo 3 months BMI, PRL BMI: 22.7 ± 0.34 Dereli et al80 Turkey NICHD Age: 31.4 ± 0.9 Rosig 2 mg, 4 mg 8 months BMI, WHR BMI: 24.2 ± 1.3 Diamanti-Kandarakis et al25 RCT RCT Greece Rotterdam Age: 27·52 ± 5·77 Orli, placebo 6 months BMI, WHR, HOMA BMI: 35·43 ± 5·3 Devin et al.24 RCT-cross over USA Rotterdam Age: N/A Sitag, placebo 4 weeks BMI, WHR, WC, LDL.HDL, TC BMI: N/A Elkind-Hirsch et al.27 RCT USA Rotterdam Age: 28.2 ± 1.1 Exen, Metf,Exen+Metf 24 weeks Wt, BMI, CRP, TG, TC, HDL, LDL BMI: 39.9 ± 1.5 Elkind-Hirsch et al.65 RCT USA NIH Age: 29.9 ± 7 Sax, Metf, Sax+Metf 16 weeks FBG, FI, HDL,TG, LDL, HOMA-IR BMA: 42.1 ± 7.3 Eisenhardt et al.26 RCT Germany Rotterdam Age: 27.0 Metf,Placebo 12 weeks FBG.FI, HOMA-IR BMI: 28.9 Ferjan et al.28 RCT Slovenia Rotterdam Age: 34.3 ± 6.8 Metf, Metf+Sitag 12 weeks Wt, BMI, WC TC, TG, LDL, HDL, BMI: 36.3 ± 5.2 HOMA-IR Ferjan et al.29 RCT Slovenia Rotterdam Age: 35.0 ± 7.2 Sitag, Placebo 12 weeks HOMA-IR, BMI, HOMA-B, FBG BMI: 36.9 ± 5.5 Glintborg et al.81 RCT USA N/A Age: 32 Piog, Placebo 16 weeks FI, HOMA-IR BMI: N/A Glintborg et al.82 RCT USA N/A Age: 32 Piog,Plcebo 16 weeks BMI, WHR, WC, FI BMI: 32.2 Glintborg et al.83 RCT Denmark N/A Age: N/A Piog, placebo 16 weeks BMI, CRP, LDL BMI: 33·1 Gambineri et al.84 RCT Italy N/A Age: 27·1 ± 3·6 Plac, metfo, flut, metf + flut 6 months FBG, FI, Wt, BMI, HOMA-IR BMI: 37·6 ± 4·1 Ghandi et al.30 RCT Iran Rotterdam Age: 27 ± 4.92 Orlistat, Metf 3 months BMI, WC, TC, TG BMI: 34.88 ± 4.90 Ganie et al.66 RCT USA NIH Age: 22.6 ± 5.0 Spironolactone, Metf 6 months WHR,BMI,FBG,FI BMI: 26.5 ± 5.6 Hanjalic-Beck et al.67 RCT Germany NIH Age: N/A Metf, Acarbose 12 weeks BMI, FBG, FI BMI: N/A Heidari et al.31 RCT USA Rotterdam Age: 32.47.5 Metf, placebo 3 months BMI, WC, WHR, Weight BMI: 37.19.1 Jayagopal et al.85 RCT UK N/A Age: 27 ± 0.9 Orlistat, Metf 3 months FBG, FI, TC, TG, HDL BMI: 36.7 ± 3.3 Javanmanesh et al.32 RCT Iran Rotterdam Age: 29.75 ± 4.90 Metf, NAC 24 weeks BMI, FBG, FI, LDL, TC, TG, HDL BMI: 29.05 ± 2.80 HOMA-IR Jensterle et al.86 RCT Slovenia NIH Age: 27.6 ± 7.2 Metf, Lira 12 weeks BMI, WC, TC, TG, LDL, HDL BMI: 39.5 ± 6.2 Jensterle et al.69 RCT Slovenia Rotterdam Age: 30.7 ± 7.9 Metf,Lira, Rofl 12 weeks Wt, BMI, WC, FI, FBG, HOMA-IR BMI: 38.6 ± 6.0 Jensterle et al.34 RCT Slovenia Rotterdam Age: 33.1 ± 6.1 Met+Lira, Lira 12 weeks BMI, Wt, WC, FBG, FI, HOMA-IR BMI: 37.2 ± 4.5 Jensterle et al.35 RCT Slovenia Rotterdam Age: 34.4 ± 6.5 Met+Lira,Lira 12 weeks Wt, BMI, WC, FI, FBG, BMI: 39.0 ± 4.9 Jensterle Sever et al.71 RCT Slovenia NIH Age: 31.3 ± 7.1 Lira,Metf, Lira+Metf 12 weeks FBG, BMI, WC, FI, TC, TG, HDL, LDL BMI: 37.1 ± 4.6 Jensterle et al.33 RCT Slovenia NIH Age: 23.5 ± 0.7 Metf,Rosi 6 months FBG, FI, BMI, HOMA-IR BMI: 20.9 ± 0.73 Jensterle et al.70 RCT Slovenia NIH Age: 23.1 ± 3.7 Metf, Rosi 6 months WC, BMI, FI, FBG, TC, TG, BMI: 29.6 ± 6.9 LDL, HDL, HOMA-IR Kilicdag et al.38 RCT Turkey Rotterdam Age: 24.13 ± 1.42 Metf, Rosi 3 months BMI, FI, FBG, TC, TG, HOMA-IR BMI: 26.17 ± 1.44 Kocak et al.39 RCT Turkey Rotterdam Age: 26.2 ± 3.7 Metf, Placebo 2 months BMI, FI, FBG, WHR BMI: 31.91 ± 5.38 Karimzadeh et al.