1. Nielsen, N, Wetterslev, J, Cronberg, T, et al. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 2013; 369: 2197–2206. https://doi.org/10.1056/NEJMoa1310519
Google Scholar | Crossref | Medline | ISI2. Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346: 549–556. https://doi.org/10.1056/NEJMoa012689
Google Scholar | Crossref | Medline | ISI3. Kirkegaard, H, Rasmussen, BS, de Haas, I, et al. Time-differentiated target temperature management after out-of-hospital cardiac arrest: a multicentre, randomised, parallel-group, assessor-blinded clinical trial (the TTH48 trial): study protocol for a randomised controlled trial. Trials 2016; 17: 228. https://doi.org/10.1186/s13063-016-1338-9
Google Scholar | Crossref | Medline4. Kirkegaard, H, Søreide, E, de Haas, I, et al. Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: a randomized clinical trial. JAMA 2017; 318: 341–350. https://doi.org/10.1001/jama.2017.8978
Google Scholar | Crossref | Medline | ISI5. Nolan, JP, Soar, J, Cariou, A, et al. European Resuscitation Council and European Society of Intensive Care Medicine Guidelines for Post-resuscitation Care 2015: section 5 of the European Resuscitation Council Guidelines for Resuscitation 2015. Resuscitation 2015; 95: 202–222. https://doi.org/10.1016/j.resuscitation.2015.07.018
Google Scholar | Crossref | Medline | ISI6. Nolan, JP, Neumar, RW, Adrie, C, et al. Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A scientific statement from the International Liaison Committee on Resuscitation; the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; the Council on Stroke. Resuscitation 2008; 79: 350–379. https://doi.org/10.1016/j.resuscitation.2008.09.017
Google Scholar | Crossref | Medline | ISI7. Grand, J, Lilja, G, Kjaergaard, J, et al. Arterial blood pressure during targeted temperature management after out-of-hospital cardiac arrest and association with brain injury and long-term cognitive function. Eur Heart J Acute Cardiovasc Care 2019. Epub ahead of print 27 June 2019. DOI: 10.1177/2048872619860804.
Google Scholar | SAGE Journals8. Thomsen, JH, Nielsen, N, Hassager, C, et al. Bradycardia during targeted temperature management: an early marker of lower mortality and favorable neurologic outcome in comatose out-of-hospital cardiac arrest patients. Crit Care Med 2016; 44: 308–318. https://doi.org/10.1097/CCM.0000000000001390
Google Scholar | Crossref | Medline9. Bro-Jeppesen, J, Hassager, C, Wanscher, M, et al. Targeted temperature management at 33°C versus 36°C and impact on systemic vascular resistance and myocardial function after out-of-hospital cardiac arrest: a sub-study of the Target Temperature Management Trial. Circ Cardiovasc Interv 2014; 7: 663–672. https://doi.org/10.1161/CIRCINTERVENTIONS.114.001556
Google Scholar | Crossref | Medline10. Bernard, SA, Gray, TW, Buist, MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002; 346: 557–563. https://doi.org/10.1056/NEJMoa003289
Google Scholar | Crossref | Medline | ISI11. Grand, J, Kjaergaard, J, Bro-Jeppesen, J, et al. Cardiac output, heart rate and stroke volume during targeted temperature management after out-of-hospital cardiac arrest: association with mortality and cause of death. Resuscitation 2019; 142: 136–143. https://doi.org/10.1016/j.resuscitation.2019.07.024
Google Scholar | Crossref | Medline12. Bro-Jeppesen, J, Annborn, M, Hassager, C, et al. Hemodynamics and vasopressor support during targeted temperature management at 33°C versus 36°C after out-of-hospital cardiac arrest: a post hoc study of the target temperature management trial*. Crit Care Med 2015; 43: 318–327. https://doi.org/10.1097/CCM.0000000000000691
Google Scholar | Crossref | Medline13. Beylin, ME, Perman, SM, Abella, BS, et al. Higher mean arterial pressure with or without vasoactive agents is associated with increased survival and better neurological outcomes in comatose survivors of cardiac arrest. Intensive Care Med 2013; 39: 1981–1988. https://doi.org/10.1007/s00134-013-3075-9
Google Scholar | Crossref | Medline14. Kilgannon, JH, Roberts, BW, Jones, AE, et al. Arterial blood pressure and neurologic outcome after resuscitation from cardiac arrest*. Crit Care Med 2014; 42: 2083–2091. https://doi.org/10.1097/CCM.0000000000000406
Google Scholar | Crossref | Medline15. Russo, JJ, Di Santo, P, Simard, T, et al. Optimal mean arterial pressure in comatose survivors of out-of-hospital cardiac arrest: an analysis of area below blood pressure thresholds. Resuscitation 2018; 128: 175–180. https://doi.org/10.1016/j.resuscitation.2018.04.028
Google Scholar | Crossref | Medline16. Roberts, BW, Kilgannon, JH, Hunter, BR, et al. Association between elevated mean arterial blood pressure and neurologic outcome after resuscitation from cardiac arrest: results from a multicenter prospective cohort study. Crit Care Med 2019; 47: 93–100. https://doi.org/10.1097/CCM.0000000000003474
Google Scholar | Crossref | Medline17. Laurikkala, J, Wilkman, E, Pettilä, V, et al. Mean arterial pressure and vasopressor load after out-of-hospital cardiac arrest: associations with one-year neurologic outcome. Resuscitation 2016; 105: 116–122. https://doi.org/10.1016/j.resuscitation.2016.05.026
Google Scholar | Crossref | Medline18. Grand, J, Hassager, C, Winther-Jensen, M, et al. Mean arterial pressure during targeted temperature management and renal function after out-of-hospital cardiac arrest. J Crit Care 2019; 50: 234–241. https://doi.org/10.1016/j.jcrc.2018.12.009
Google Scholar | Crossref | Medline19. Bhate, TD, McDonald, B, Sekhon, MS, et al. Association between blood pressure and outcomes in patients after cardiac arrest: A systematic review. Resuscitation 2015; 97: 1–6. https://doi.org/10.1016/j.resuscitation.2015.08.023
Google Scholar | Crossref | Medline | ISI20. Grand, J, Meyer, AS, Kjaergaard, J, et al. A randomised double-blind pilot trial comparing a mean arterial pressure target of 65 mm Hg versus 72 mm Hg after out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care 2020. Epub ahead of print 31 January 2020. DOI: 10.1177/2048872619900095.
Google Scholar | SAGE Journals21. Jakkula, P, Pettilä, V, Skrifvars, MB, et al. Targeting low-normal or high-normal mean arterial pressure after cardiac arrest and resuscitation: a randomised pilot trial. Intensive Care Med 2018; 44: 2091–2101. https://doi.org/10.1007/s00134-018-5446-8
Google Scholar | Crossref | Medline22. Ameloot, K, De Deyne, C, Ferdinande, B, et al. Mean arterial pressure of 65 mm Hg versus 85-100 mm Hg in comatose survivors after cardiac arrest: Rationale and study design of the Neuroprotect post-cardiac arrest trial. Am Heart J 2017; 191: 91–98. https://doi.org/10.1016/j.ahj.2017.06.010
Google Scholar | Crossref | Medline23. Hylands, M, Moller, MH, Asfar, P, et al. A systematic review of vasopressor blood pressure targets in critically ill adults with hypotension. Can J Anaesth J Can Anesth 2017; 64: 703–715. https://doi.org/10.1007/s12630-017-0877-1
Google Scholar | Crossref | Medline24. Vincent, JL, Moreno, R, Takala, J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22: 707–710. https://doi.org/10.1007/bf01709751
Google Scholar | Crossref | Medline | ISI25. Bro-Jeppesen, J, Johansson, PI, Hassager, C, et al. Endothelial activation/injury and associations with severity of post-cardiac arrest syndrome and mortality after out-of-hospital cardiac arrest. Resuscitation 2016; 107: 71–79. https://doi.org/10.1016/j.resuscitation.2016.08.006
Google Scholar | Crossref | Medline26. Bro-Jeppesen, J, Kjaergaard, J, Wanscher, M, et al. The inflammatory response after out-of-hospital cardiac arrest is not modified by targeted temperature management at 33°C or 36°C. Resuscitation 2014; 85: 1480–1487. https://doi.org/10.1016/j.resuscitation.2014.08.007
Google Scholar | Crossref | Medline27. Sundgreen, C, Larsen, FS, Herzog, TM, et al. Autoregulation of cerebral blood flow in patients resuscitated from cardiac arrest. Stroke 2001; 32: 128–132. https://doi.org/10.1161/01.str.32.1.128
Google Scholar | Crossref | Medline | ISI28. Lee, JK, Brady, KM, Mytar, JO, et al. Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia. Crit Care Med 2011; 39: 2337–2345. https://doi.org/10.1097/CCM.0b013e318223b910
Google Scholar | Crossref | Medline | ISI29. Trzeciak, S, Jones, AE, Kilgannon, JH, et al. Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med 2009; 37: 2895–2903; quiz 2904. https://doi.org/10.1097/ccm.0b013e3181b01d8c
Google Scholar | Crossref | Medline30. Sekhon, MS, Gooderham, P, Menon, DK, et al. The burden of brain hypoxia and optimal mean arterial pressure in patients with hypoxic ischemic brain injury after cardiac arrest. Crit Care Med 2019; 47: 960–969. https://doi.org/10.1097/CCM.0000000000003745
Google Scholar | Crossref | Medline