1. Sogaard, KK, Schmidt, M, Pedersen, L, et al. 30-year mortality after venous thromboembolism: a population-based cohort study. Circulation 2014; 130: 829–836.
Google Scholar | Crossref | Medline | ISI2. Meyer, G, Sanchez, O, Jimenez, D. Risk assessment and management of high and intermediate risk pulmonary embolism. Presse Med 2015; 44: e401–408.
Google Scholar | Crossref | Medline3. Miller, RL, Das, S, Anandarangam, T, et al. Association between right ventricular function and perfusion abnormalities in hemodynamically stable patients with acute pulmonary embolism. Chest 1998; 113: 665–670.
Google Scholar | Crossref | Medline4. Vedovati, MC, Germini, F, Agnelli, G, et al. Prognostic role of embolic burden assessed at computed tomography angiography in patients with acute pulmonary embolism: systematic review and meta-analysis. J Thromb Haemost 2013; 11: 2092–2102.
Google Scholar | Crossref | Medline | ISI5. Kabrhel, C, Okechukwu, I, Hariharan, P, et al. Factors associated with clinical deterioration shortly after PE. Thorax 2014; 69: 835–842.
Google Scholar | Crossref | Medline6. Smulders, YM. Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction. Cardiovasc Res 2000; 48: 23–33.
Google Scholar | Crossref | Medline | ISI7. Stratmann, G, Gregory, GA. Neurogenic and humoral vasoconstriction in acute pulmonary thromboembolism. Anesth Analg 2003; 97: 341–354.
Google Scholar | Crossref | Medline | ISI8. Reeves, WC, Demers, LM, Wood, MA, et al. The release of thromboxane A2 and prostacyclin following experimental acute pulmonary embolism. Prostaglandins Leukot Med 1983; 11: 1–10.
Google Scholar | Crossref | Medline9. Battistini, B. Modulation and roles of the endothelins in the pathophysiology of pulmonary embolism. Can J Physiol Pharmacol 2003; 81: 555–569.
Google Scholar | Crossref | Medline | ISI10. Tsang, JY, Lamm, WJ. Estimation of endothelin-mediated vasoconstriction in acute pulmonary thromboembolism. Pulm Circ 2012; 2: 67–74.
Google Scholar | SAGE Journals11. Wang, T, El Kebir, D, Blaise, G. Inhaled nitric oxide in 2003: a review of its mechanisms of action. Can J Anaesth 2003; 50: 839–846.
Google Scholar | Crossref | Medline | ISI12. Bhat, T, Neuman, A, Tantary, M, et al. Inhaled nitric oxide in acute pulmonary embolism: a systematic review. Rev Cardiovasc Med 2015; 16: 1–8.
Google Scholar | Medline | ISI13. Summerfield, DT, Desai, H, Levitov, A, et al. Inhaled nitric oxide as salvage therapy in massive pulmonary embolism: a case series. Respir Care 2012; 57: 444–448.
Google Scholar | Crossref | Medline14. Szold, O, Khoury, W, Biderman, P, et al. Inhaled nitric oxide improves pulmonary functions following massive pulmonary embolism: a report of four patients and review of the literature. Lung 2006; 184: 1–5.
Google Scholar | Crossref | Medline15. Schultz, J, Andersen, A, Gade, IL, et al. Riociguat, sildenafil and inhaled nitric oxide reduces pulmonary vascular resistance and improves right ventricular function in a porcine model of acute pulmonary embolism. Eur Heart J Acute Cardiovasc Care. Epub ahead of print 27 April 2019. DOI: 10.1177/2048872619840772.
Google Scholar16. Lyhne, MD, Kline, JA, Nielsen-Kudsk, JE, et al. Pulmonary vasodilation in acute pulmonary embolism – a systematic review. Pulm Circ 2020; 10: 2045894019899775.
Google Scholar | SAGE Journals | ISI17. Kline, JA, Puskarich, MA, Jones, AE, et al. Inhaled nitric oxide to treat intermediate risk pulmonary embolism: a multicenter randomized controlled trial. Nitric Oxide. Epub ahead of print 1 December 2019. DOI: 10.1016/j.niox.2019.01.006.
Google Scholar18. Schultz, J, Andersen, A, Gade, IL, et al. A porcine in-vivo model of acute pulmonary embolism. Pulm Circ 2018; 8: 2045893217738217.
Google Scholar | SAGE Journals | ISI19. Kilkenny, C, Browne, WJ, Cuthill, IC, et al. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol 2010; 8: e1000412.
Google Scholar | Crossref | Medline | ISI20. Konstam, MA, Kiernan, MS, Bernstein, D, et al. Evaluation and management of right-sided heart failure: a scientific statement from the American Heart Association. Circulation 2018; 137: e578–e622.
Google Scholar | Crossref | Medline21. Konstantinides, SV, Meyer, G, Becattini, C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. Epub ahead of print 11 September 2019. DOI: 10.1093/eurheartj/ehz405.
Google Scholar22. Zwissler, B, Welte, M, Habler, O, et al. Effects of inhaled prostacyclin as compared with inhaled nitric oxide in a canine model of pulmonary microembolism and oleic acid edema. J Cardiothorac Vasc Anesth 1995; 9: 634–640.
Google Scholar | Crossref | Medline23. Bottiger, BW, Motsch, J, Dorsam, J, et al. Inhaled nitric oxide selectively decreases pulmonary artery pressure and pulmonary vascular resistance following acute massive pulmonary microembolism in piglets. Chest 1996; 110: 1041–1047.
Google Scholar | Crossref | Medline | ISI24. Capellier, G, Jacques, T, Balvay, P, et al. Inhaled nitric oxide in patients with pulmonary embolism. Intensive Care Med 1997; 23: 1089–1092.
Google Scholar | Crossref | Medline25. Tanus-Santos, JE, Moreno, H Jr, Moreno, RA, et al. Inhaled nitric oxide improves hemodynamics during a venous air infusion (VAI) in dogs. Intensive Care Med 1999; 25: 983–989.
Google Scholar | Crossref | Medline26. Pepke-Zaba, J, Higenbottam, TW, Dinh-Xuan, AT, et al. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet 1991; 338: 1173–1174.
Google Scholar | Crossref | Medline | ISI27. Weimann, J, Zink, W, Schnabel, PA, et al. Selective vasodilation by nitric oxide inhalation during sustained pulmonary hypertension following recurrent microembolism in pigs. J Crit Care 1999; 14: 133–140.
Google Scholar | Crossref | Medline28. Weimann, J, Zink, W, Gebhard, MM, et al. Effects of oxygen and nitric oxide inhalation in a porcine model of recurrent microembolism. Acta Anaesthesiol Scand 2000; 44: 1109–1115.
Google Scholar | Crossref | Medline29. Frostell, C, Fratacci, MD, Wain, JC, et al. Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 1991; 83: 2038–2047.
Google Scholar | Crossref | Medline | ISI30. Olsen, AK. The pig as a model in blood coagulation and fibrinolysis research. Scand J Lab Anim Sci 1999; 26: 214–224.
Google Scholar31. Dyar, O, Young, JD, Xiong, L, et al. Dose-response relationship for inhaled nitric oxide in experimental pulmonary hypertension in sheep. Br J Anaesth 1993; 71: 702–708.
Google Scholar | Crossref | Medline32. Emil, SG, Berkeland, JE, Atkinson, JB. Nitric oxide dose response during moderate and severe hypoxia in swine. Ann Thorac Surg 1997; 63: 414–418.
Google Scholar | Crossref | Medline33. Solina, AR, Ginsberg, SH, Papp, D, et al. Dose response to nitric oxide in adult cardiac surgery patients. J Clin Anesth 2001; 13: 281–286.
Google Scholar | Crossref | Medline | ISI34. Lee, JH, Kim, S, Park, BK, et al. The effect of a combination of inhaled nitric oxide and an endothelin A-receptor antagonist on hemodynamic dysfunction in experimental acute pulmonary thromboembolism. Lung 2005; 183: 139–149.
Google Scholar | Crossref | Medline | ISI35. Petit, PC, Fine, DH, Vasquez, GB, et al. The pathophysiology of nitrogen dioxide during inhaled nitric oxide therapy. ASAIO J 2017; 63: 7–13.
Google Scholar | Crossref | Medline36. Greenbaum, R, Bay, J, Hargreaves, MD, et al. Effects of higher oxides of nitrogen on the anaesthetized dog. Br J Anaesth 1967; 39: 393–404.
Google Scholar | Crossref | Medline37. Karam, O, Gebistorf, F, Wetterslev, J, et al. The effect of inhaled nitric oxide in acute respiratory distress syndrome in children and adults: a Cochrane systematic review with trial sequential analysis. Anaesthesia 2017; 72: 106–117.
Google Scholar | Crossref | Medline38. Alstrup AKO. Anaesthesia and analgesia of the Ellegaard Göttingen minipig. 1 ed. Dalmose: Jannerup, 2010. p. 51.
Google Scholar