1. Starobova, H, Vetter, I. Pathophysiology of chemotherapy-induced peripheral neuropathy. Front Mol Neurosci. 2017;10:174. doi:10.3389/fnmol.2017.00174
Google Scholar | Crossref | Medline2. Seretny, M, Currie, GL, Sena, ES, et al. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis. Pain. 2014;155:2461-2470. doi:10.1016/j.pain.2014.09.020
Google Scholar | Crossref | Medline | ISI3. Lee, G, Grovey, B, Furnish, T, Wallace, M. Medical cannabis for neuropathic pain. Curr Pain Headache Rep. 2018;22:8. doi:10.1007/s11916-018-0658-8
Google Scholar | Crossref | Medline4. Gewandter, JS, Dworkin, RH, Finnerup, NB, Mohile, NA. Painful chemotherapy-induced peripheral neuropathy: lack of treatment efficacy or the wrong clinical trial methodology? Pain. 2017;158:30-33. doi:10.1097/j.pain.0000000000000653
Google Scholar | Crossref | Medline | ISI5. Flatters, SJL, Dougherty, PM, Colvin, LA. Clinical and preclinical perspectives on chemotherapy-induced peripheral neuropathy (CIPN): a narrative review. Br J Anaesth. 2017;119:737-749. doi:10.1093/bja/aex229
Google Scholar | Crossref | Medline6. Blanton, HL, Brelsfoard, J, DeTurk, N, et al. Cannabinoids: current and future options to treat chronic and chemotherapy-induced neuropathic pain. Drugs. 2019;79:969-995. doi:10.1007/s40265-019-01132-x
Google Scholar | Crossref | Medline7. Zajączkowska, R, Kocot-Kępska, M, Leppert, W, Wrzosek, A, Mika, J, Wordliczek, J. Mechanisms of chemotherapy-induced peripheral neuropathy. Int J Mol Sci. 2019;20:1451. doi:10.3390/ijms20061451
Google Scholar | Crossref8. Schmidt, BL, Hamamoto, DT, Simone, DA, Wilcox, GL. Mechanism of cancer pain. Mol Interv. 2010;10:164-178. doi:10.1124/mi.10.3.7
Google Scholar | Crossref | Medline9. Sherif, MA, Cortes-Briones, JA, Ranganathan, M, Skosnik, PD. Cannabinoid-glutamate interactions and neural oscillations: implications for psychosis. Eur J Neurosci. 2018;48:2890-2902. doi:10.1111/ejn.13800
Google Scholar | Crossref | Medline10. Omran, M, Belcher, EK, Mohile, NA, et al. Review of the role of the brain in chemotherapy-induced peripheral neuropathy. Front Mol Biosci. 2021;8:693133. doi:10.3389/fmolb.2021.693133
Google Scholar | Crossref | Medline11. Johnson, JR, Lossignol, D, Burnell-Nugent, M, Fallon, MT. An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics. J Pain Symptom Manag. 2013;46:207-218. doi:10.1016/j.jpainsymman.2012.07.014
Google Scholar | Crossref | Medline | ISI12. Brown, D, Watson, M, Schloss, J. Pharmacological evidence of medicinal cannabis in oncology: a systematic review. Support Care Cancer. 2019;27:3195-3207. doi:10.1007/s00520-019-04774-5
Google Scholar | Crossref | Medline13. Nugent, SM, Morasco, BJ, O’Neil, ME, et al. The effects of cannabis among adults with chronic pain and an overview of general Harms. Ann Intern Med. 2017;167:319-331. doi:10.7326/m17-0155
Google Scholar | Crossref | Medline14. Wilsey, B, Marcotte, T, Tsodikov, A, et al. A randomized, placebo-controlled, crossover trial of cannabis cigarettes in neuropathic pain. J Pain. 2008;9:506-521. doi:10.1016/j.jpain.2007.12.010
Google Scholar | Crossref | Medline | ISI15. Abrams, DI, Jay, CA, Shade, SB, et al. Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial. Neurology. 2007;68:515-521. doi:10.1212/01.wnl.0000253187.66183.9c
Google Scholar | Crossref | Medline | ISI16. Ellis, RJ, Toperoff, W, Vaida, F, et al. Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. Neuropsychopharmacology. 2009;34:672-680. doi:10.1038/npp.2008.120
Google Scholar | Crossref | Medline | ISI17. Ware, MA, Wang, T, Shapiro, S, et al. Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. CMAJ. 2010;182:E694-E701. doi:10.1503/cmaj.091414
Google Scholar | Crossref | Medline18. Wilsey, B, Marcotte, T, Deutsch, R, Gouaux, B, Sakai, S, Donaghe, H. Low-dose vaporized cannabis significantly improves neuropathic pain. J Pain. 2013;14:136-148. doi:10.1016/j.jpain.2012.10.009
Google Scholar | Crossref | Medline19. Hoggart, B, Ratcliffe, S, Ehler, E, et al. A multicentre, open-label, follow-on study to assess the long-term maintenance of effect, tolerance and safety of THC/CBD oromucosal spray in the management of neuropathic pain. J Neurol. 2015;262:27-40. doi:10.1007/s00415-014-7502-9
Google Scholar | Crossref | Medline20. Andreae, MH, Carter, GM, Shaparin, N, et al. Inhaled cannabis for chronic neuropathic pain: a meta-analysis of individual patient data. J Pain. 2015;16:1221-1232. doi:10.1016/j.jpain.2015.07.009
Google Scholar | Crossref | Medline21. Lynch, ME, Cesar-Rittenberg, P, Hohmann, AG. A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain. J Pain Symptom Manag. 2014;47:166-173. doi:10.1016/j.jpainsymman.2013.02.018
Google Scholar | Crossref | Medline | ISI22. Pertwee, RG. Cannabinoid pharmacology: the first 66 years. Br J Pharmacol. 2006;147:S163-S171. doi:10.1038/sj.bjp.0706406
Google Scholar | Crossref | Medline23. Showalter, VM, Compton, DR, Martin, BR, Abood, ME. Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther. 1996;278:989-999.
Google Scholar | Medline | ISI24. Thomas, A, Baillie, GL, Phillips, AM, Razdan, RK, Ross, RA, Pertwee, RG. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol. 2007;150:613-623. doi:10.1038/sj.bjp.0707133
Google Scholar | Crossref | Medline | ISI25. Niesink, RJ, van Laar, MW. Does cannabidiol protect against adverse psychological effects of THC? Front Psychiatry. 2013;4:130. doi:10.3389/fpsyt.2013.00130
Google Scholar | Crossref | Medline26. Masocha, W. Targeting the endocannabinoid system for prevention or treatment of chemotherapy-induced neuropathic pain: studies in animal models. Pain Res Manag. 2018;2018:5234943. doi:10.1155/2018/5234943
Google Scholar | Crossref | Medline27. Vučković, S, Srebro, D, Vujović, KS, Vučetić, Č, Prostran, M. Cannabinoids and pain: new insights from old molecules. Front Pharmacol. 2018;9:1259. doi:10.3389/fphar.2018.01259
Google Scholar | Crossref | Medline28. Muller, C, Morales, P, Reggio, PH. Cannabinoid ligands targeting TRP channels. Front Mol Neurosci. 2018;11:487. doi:10.3389/fnmol.2018.00487
Google Scholar | Crossref | Medline29. Donvito, G, Nass, SR, Wilkerson, JL, et al. The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain. Neuropsychopharmacology. 2018;43:52-79. doi:10.1038/npp.2017.204
Google Scholar | Crossref | Medline30. Fernández-Ruiz, J, Sagredo, O, Pazos, MR, et al. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? Br J Clin Pharmacol. 2013;75:323-333. doi:10.1111/j.1365-2125.2012.04341.x
Google Scholar | Crossref | Medline | ISI31. Costa, B, Trovato, AE, Comelli, F, Giagnoni, G, Colleoni, M. The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain. Eur J Pharmacol. 2007;556:75-83. doi:10.1016/j.ejphar.2006.11.006
Google Scholar | Crossref | Medline32. Toth, CC, Jedrzejewski, NM, Ellis, CL, Frey, WH. Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain. Mol Pain. 2010;6:16. doi:10.1186/1744-8069-6-16
Google Scholar | SAGE Journals33. Xiong, W, Cui, T, Cheng, K, et al. Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors. J Exp Med. 2012;209:1121-1134. doi:10.1084/jem.20120242
Google Scholar | Crossref | Medline | ISI34. Ward, SJ, McAllister, SD, Kawamura, R, Murase, R, Neelakantan, H, Walker, EA. Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy. Br J Pharmacol. 2014;171:636-645. doi:10.1111/bph.12439
Google Scholar | Crossref | Medline35. Booz, GW. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. Free Radic Biol Med. 2011;51:1054-1061. doi:10.1016/j.freeradbiomed.2011.01.007
Google Scholar | Crossref | Medline | ISI36. Kleckner, AS, Kleckner, IR, Kamen, CS, et al. Opportunities for cannabis in supportive care in cancer. Ther Adv Med Oncol. 2019;11:1758835919866362. doi:10.1177/1758835919866362
Google Scholar | SAGE Journals | ISI37. Behl, D, D’Andre, SD, Parise, C. Patterns of use of medical cannabis in a community oncology clinic. J Clin Oncol. 2020;38:e24111-e24111. doi:10.1200/JCO.2020.38.15_suppl.e24111
Google Scholar | Crossref38. Pergam, SA, Woodfield, MC, Lee, CM, et al. Cannabis use among patients at a comprehensive cancer center in a state with legalized medicinal and recreational use. Cancer. 2017;123:4488-4497. doi:10.1002/cncr.30879
Google Scholar | Crossref | Medline39. Martell, K, Fairchild, A, LeGerrier, B, et al. Rates of cannabis use in patients with cancer. Curr Oncol. 2018;25:219-225. doi:10.3747/co.25.3983
Google Scholar | Crossref | Medline40. Donovan, KA, Oberoi-Jassal, R, Chang, YD, et al. Cannabis use in young adult cancer patients. J Adolesc Young Adult Oncol. 2020;9:30-35. doi:10.1089/jayao.2019.0039
Google Scholar | Crossref | Medline41. Paudel, KS, Hammell, DC, Agu, RU, Valiveti, S, Stinchcomb, AL. Cannabidiol bioavailability after nasal and transdermal application: effect of permeation enhancers. Drug Dev Ind Pharm. 2010;36:1088-1097. doi:10.3109/03639041003657295
Google Scholar | Crossref | Medline | ISI42. Stinchcomb, AL, Valiveti, S, Hammell, DC, Ramsey, DR. Human skin permeation of Delta8-tetrahydrocannabinol, cannabidiol and cannabinol. J Pharm Pharmacol. 2004;56:291-297. doi:10.1211/0022357022791
Google Scholar | Crossref | Medline43. Xu, DH, Cullen, BD, Tang, M, Fang, Y. The effectiveness of topical cannabidiol oil in symptomatic relief of peripheral neuropathy of the lower extremities. Curr Pharm Biotechnol. 2020;21:390-402. doi:10.2174/1389201020666191202111534
Google Scholar |