1. Colombo, G, Gessa, GL. Suppressing effect of baclofen on multiple alcohol-related behaviors in laboratory animals. Front Psychiatry. 2018;9:475.
Google Scholar | Crossref | Medline2. Agabio, R, Colombo, G. GABAB receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence. Front Neurosci. 2014;8:140.
Google Scholar | Crossref | Medline3. Dario, A, Tomei, G. A benefit-risk assessment of baclofen in severe spinal spasticity. Drug Saf. 2004;27(11):799–818.
Google Scholar | Crossref | Medline | ISI4. Gulezian, D, Jacobson-Kram, D, Bruce McCullough, C, et al. Use of transgenic animals for carcinogenicity testing: considerations and implications for risk assessment. Toxicol Pathol. 2000;28(3):482–499.
Google Scholar | SAGE Journals | ISI5. Morton, D, Alden, CL, Roth, AJ, Usui, T. The Tg rasH2 mouse in cancer hazard identification. Toxicol Pathol. 2002;30(1):139–146.
Google Scholar | SAGE Journals | ISI6. Bourcier, T, McGovern, T, Stavitskaya, L, Kruhlak, N, Jacobson-Kram, D. Improving prediction of carcinogenicity to reduce, refine, and replace the use of experimental animals. J Am Assoc Lab Anim Sci. 2015;54(2):163–169.
Google Scholar | Medline7. Nambiar, P, Morton, D. The rasH2 mouse model for assessing carcinogenic potential of pharmaceuticals. Toxicol Pathol. 2013;41(8):1058–1067.
Google Scholar | SAGE Journals | ISI8. Morton, D, Sistare, FD, Nambiar, PR, Turner, OC, Radi, Z, Bower, N. Regulatory forum commentary: alternative mouse models for future cancer risk assessment. Toxicol Pathol. 2014;42(5):799–806.
Google Scholar | SAGE Journals | ISI9. Paranjpe, MG, Belich, JL, Mann, PC, et al. A comparison of spontaneous tumors in Tg.rasH2 mice in 26-week carcinogenicity studies conducted at a single test facility during 2004 to 2012 and 2013 to 2018. Toxicol Pathol. 2019;47(1):18–25.
Google Scholar | SAGE Journals | ISI10. WHO/IARC/RITA . Mohr, U , ed. International Classification of Rodent Tumors. The Mouse. WHO/IARC/RITA; 2001.
Google Scholar11. Peto, R, Pike, MC, Day, NE, et al. Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments. IARC Monograph. 1980;2(Suppl):311–426.
Google Scholar12. Robinson, DE, MacDonald, JS. Background and framework for ILSI’s collaborative evaluation program on alternative models for carcinogenicity assessment. Toxicol Pathol. 2001;29(suppl):13–19.
Google Scholar | SAGE Journals | ISI13. Usui, T, Mutai, M, Hisada, S, et al. CB6F1-rasH2 mouse: overview of available data. Toxicol Pathol. 2001;29(Suppl):90–108.
Google Scholar | SAGE Journals | ISI14. Takaoka, M, Sehata, S, Maejima, T, et al. Interlaboratory comparison of short-term carcinogenicity studies using CB F1-rasH2 transgenic mice. Toxicol Pathol. 2003;31(2):191–199.
Google Scholar | SAGE Journals | ISI15. Kanno, H, Tanakamaru, ZY, Ishimura, Y, Kandori, H, Yamasaki, H, Sasaki, S. Historical background data in CB6F1-Tg-rasH mice and CB6F1-non Tg-rasH2 mice over a 26-week experimental period. Toxicol Pathol. 2003;16:267–274.
Google Scholar | Crossref16. Paranjpe, MG, Denton, MD, Elbekai, RH. The 26-week Tg.Rash2 mice carcinogenicity studies: microscopic examination of only select tissues in low- and mid-dose groups. Toxicol Pathol. 2014;42(7):1153–1157.
Google Scholar | SAGE Journals | ISI17. Palazzi, X, Burkhardt, JE, Caplain, H, et al. Characterizing “adversity” of pathology findings in nonclinical toxicity studies: results from the 4th ESTP International Expert Workshop. Toxicol Pathol. 2016;44(6):810–824.
Google Scholar | SAGE Journals | ISI18. Everds, NE, Snyder, PW, Bailey, KL, et al. Interpreting stress responses during routine toxicity studies: a review of the biology, impact, and assessment. Toxicol Pathol. 2013;41(4):560–614.
Google Scholar | SAGE Journals | ISI19. Nambiar, PR, Turnqist, SE, Morton, D. Spontaneous tumor incidence in rasH2 mice: review of internal data and published literature. Toxicol Pathol. 2012;40(4):614–623.
Google Scholar | SAGE Journals | ISI20. Paranjpe, MG, Elbekai, RH, Shah, SA, Hickman, M, Wenk, ML, Zahalka, EA. Historical control data of spontaneous tumors in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice. Int J Toxicol. 2013;32(1):48–57.
Google Scholar | SAGE Journals | ISI21. Paranjpe, MG, Shah, SA, Denton, MD, Elbekai, RH. Incidence of spontaneous non-neoplastic lesions in transgenic CBYB6F1-Tg(HRAS)2Jic mice. Toxicol Pathol. 2013;41(8):1137–1145.
Google Scholar | SAGE Journals | ISI