Ademokun, A., Wu, Y.-C., Dunn-Walters, D. (2010). The ageing B cell population: Composition and function. Biogerontology, 11(2), 125–137. https://doi.org/10.1007/s10522-009-9256-9
Google Scholar | Crossref | Medline Anthony, I. C., Crawford, D. H., Bell, J. E. (2003). B lymphocytes in the normal brain: Contrasts with HIV-associated lymphoid infiltrates and lymphomas. Brain: A Journal of Neurology, 126(Pt 5), 1058–1067. https://doi.org/10.1093/brain/awg118
Google Scholar | Crossref | Medline Beard, J. R., Officer, A., de Carvalho, I. A., Sadana, R., Pot, A. M., Michel, J.-P., Lloyd-Sherlock, P., Epping-Jordan, J. E., Peeters, G. G., Mahanani, W. R., Thiyagarajan, J. A., Chatterji, S. (2016). The world report on ageing and health: A policy framework for healthy ageing. Lancet (London, England), 387(10033), 2145–2154. https://doi.org/10.1016/S0140-6736(15)00516-4
Google Scholar | Crossref | Medline Bennett, D. A., Schneider, J. A., Arvanitakis, Z., Wilson, R. S. (2012a). Overview and findings from the religious orders study. Current Alzheimer Research, 9(6), 628–645. https://doi.org/10.2174/156720512801322573
Google Scholar | Crossref | Medline Bennett, D. A., Schneider, J. A., Buchman, A. S., Barnes, L. L., Boyle, P. A., Wilson, R. S. (2012b). Overview and findings from the rush memory and aging project. Current Alzheimer Research, 9(6), 646–663. https://doi.org/10.2174/156720512801322663
Google Scholar | Crossref | Medline Bø, L., Vedeler, C. A., Nyland, H., Trapp, B. D., Mørk, S. J. (2003). Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration. Multiple Sclerosis Journal, 9(4), 323–331. https://doi.org/10.1191/1352458503ms917oa
Google Scholar | SAGE Journals | ISI Breitbart, E., Wang, X., Leka, L. S., Dallal, G. E., Meydani, S. N., Stollar, B. D. (2002). Altered memory B-Cell homeostasis in human aging. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 57(8), B304–B311. https://doi.org/10.1093/gerona/57.8.B304
Google Scholar | Crossref | Medline Busse, S., Busse, M., Schiltz, K., Bielau, H., Gos, T., Brisch, R., Mawrin, C., Schmitt, A., Jordan, W., Müller, U. J., Bernstein, H.-G., Bogerts, B., Steiner, J. (2012). Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: Further evidence for disease course-related immune alterations? Brain, Behavior, and Immunity, 26(8), 1273–1279. https://doi.org/10.1016/j.bbi.2012.08.005
Google Scholar | Crossref | Medline Doyle, K. P., Quach, L. N., Sole, M., Axtell, R. C., Nguyen, T.-V V., Soler-Llavina, G. J., Jurado, S., Han, J., Steinman, L., Longo, F. M., Schneider, J. A., Malenka, R. C., Buckwalter, M. S. (2015). B-lymphocyte-mediated delayed cognitive impairment following stroke. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 35(5), 2133–2145. https://doi.org/10.1523/JNEUROSCI.4098-14.2015
Google Scholar | Crossref | Medline Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., Wyss-Coray, T., Weissman, I. L., Vogel, H., Davis, M. M., Brunet, A. (2019). Single-cell analysis reveals T cell infiltration in old neurogenic niches. Nature, 571(7764), 205–210. https://doi.org/10.1038/s41586-019-1362-5
Google Scholar | Crossref | Medline Frasca, D., Diaz, A., Romero, M., Landin, A. M., Blomberg, B. B. (2011). Age effects on B cells and humoral immunity in humans. Ageing Research Reviews, 10(3), 330–335. https://doi.org/10.1016/j.arr.2010.08.004
Google Scholar | Crossref | Medline Frasca, D., Landin, A. M., Lechner, S. C., Ryan, J. G., Schwartz, R., Riley, R. L., Blomberg, B. B. (2008). Aging down-regulates the transcription factor E2A, activation-induced cytidine deaminase, and Ig class switch in human B cells. Journal of Immunology (Baltimore, MD.: 1950), 180(8), 5283–5290. https://doi.org/10.4049/jimmunol.180.8.5283
Google Scholar | Crossref | Medline Freitas, G. R. R., da Luz Fernandes, M., Agena, F., Jaluul, O., Silva, S. C., Lemos, F. B. C., Coelho, V., Elias, D.-N., Galante, N. Z. (2019). Aging and end stage renal disease cause a decrease in absolute circulating lymphocyte counts with a shift to a memory profile and diverge in Treg population. Aging and Disease, 10(1), 49–61. https://doi.org/10.14336/AD.2018.0318
Google Scholar | Crossref | Medline Gate, D., Saligrama, N., Leventhal, O., Yang, A. C., Unger, M. S., Middeldorp, J., Chen, K., Lehallier, B., Channappa, D., Santos, M. B. D. L., McBride, A., Pluvinage, J., Elahi, F., Tam, G. K.-Y., Kim, Y., Greicius, M., Wagner, A. D., Aigner, L., Galasko, D. R., Davis, M. M., Wyss-Coray, T. (2020). Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease. Nature, 577(7790), 399–404. https://doi.org/10.1038/s41586-019-1895-7
Google Scholar | Crossref | Medline Grinberg, L. T., de Lucena Ferretti, R. E., Farfel, J. M., Leite, R., Pasqualucci, C. A., Rosemberg, S., Nitrini, R., Saldiva, P. H. N., Jacob Filho, W., & Brazilian Aging Brain Study Group. (2007). Brain bank of the Brazilian aging brain study group—A milestone reached and more than 1,600 collected brains. Cell and Tissue Banking, 8(2), 151–162. https://doi.org/10.1007/s10561-006-9022-z
Google Scholar | Crossref | Medline Jentsch-Ullrich, K., Koenigsmann, M., Mohren, M., Franke, A. (2005). Lymphocyte subsets’ reference ranges in an age- and gender-balanced population of 100 healthy adults—A monocentric German study. Clinical Immunology, 116(2), 192–197. https://doi.org/10.1016/j.clim.2005.03.020
Google Scholar | Crossref | Medline Koellhoffer, E. C., McCullough, L. D., Ritzel, R. M. (2017). Old maids: Aging and its impact on microglia function. International Journal of Molecular Sciences, 18(4), 769. https://doi.org/10.3390/ijms18040769
Google Scholar | Crossref | Medline Landrith, T. A., Harris, T. H., Wilson, E. H. (2015). Characteristics and critical function of CD8+ T cells in the toxoplasma-infected brain. Seminars in Immunopathology, 37(3), 261–270. https://doi.org/10.1007/s00281-015-0487-3
Google Scholar | Crossref | Medline Machado-Santos, J., Saji, E., Tröscher, A. R., Paunovic, M., Liblau, R., Gabriely, G., Bien, C. G., Bauer, J., Lassmann, H. (2018). The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells. Brain: A Journal of Neurology, 141(7), 2066–2082. https://doi.org/10.1093/brain/awy151
Google Scholar | Crossref | Medline Merlini, M., Kirabali, T., Kulic, L., Nitsch, R. M., Ferretti, M. T. (2018). Extravascular CD3+ T cells in brains of Alzheimer disease patients correlate with tau but not with amyloid pathology: An immunohistochemical study. Neuro-Degenerative Diseases, 18(1), 49–56. https://doi.org/10.1159/000486200
Google Scholar | Crossref | Medline Mrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., Greter, M., Becher, B. (2018). High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease. Immunity, 48(2), 380–395.e6. https://doi.org/10.1016/j.immuni.2018.01.011
Google Scholar | Crossref | Medline Nikolich-Žugich, J. (2018). The twilight of immunity: Emerging concepts in aging of the immune system. Nature Immunology, 19(1), 10–19. https://doi.org/10.1038/s41590-017-0006-x
Google Scholar | Crossref | Medline Ogawa, T., Kitagawa, M., Hirokawa, K. (2000). Age-related changes of human bone marrow: A histometric estimation of proliferative cells, apoptotic cells, T cells, B cells and macrophages. Mechanisms of Ageing and Development, 117(1–3), 57–68. https://doi.org/10.1016/s0047-6374(00)00137-8
Google Scholar | Crossref | Medline Palmer, A. L., Ousman, S. S. (2018). Astrocytes and aging. Frontiers in Aging Neuroscience, 10, 337. https://doi.org/10.3389/fnagi.2018.00337
Google Scholar | Crossref | Medline Pluvinage, J. V., Wyss-Coray, T. (2020). Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration. Nature Reviews Neuroscience, 21(2), 93–102. https://doi.org/10.1038/s41583-019-0255-9
Google Scholar | Crossref | Medline Ramos, G. S., van den Berg, A., Nunes-Silva, V., Weirather, J., Peters, L., Burkard, M., Friedrich, M., Pinnecker, J., Abeßer, M., Heinze, K. G., Schuh, K., Beyersdorf, N., Kerkau, T., Demengeot, J., Frantz, S., Hofmann, U. (2017). Myocardial aging as a T-cell-mediated phenomenon. Proc Natl Acad Sci U S A, 114(12), E2420–E2429.
Google Scholar | Crossref | Medline Schneider, J. A., Aggarwal, N. T., Barnes, L., Boyle, P., Bennett, D. A. (2009). The neuropathology of older persons with and without dementia from community versus clinic cohorts. Journal of Alzheimer’s Disease, 18(3), 691–701. https://doi.org/10.3233/JAD-2009-1227
Google Scholar | Crossref | Medline Schneider, J. A., Arvanitakis, Z., Bang, W., Bennett, D. A. (2007). Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology, 69(24), 2197–2204. https://doi.org/10.1212/01.wnl.0000271090.28148.24
Google Scholar | Crossref | Medline | ISI Scholz, J. L., Diaz, A., Riley, R. L., Cancro, M. P., Frasca, D. (2013). A comparative review of aging and B cell function in mice and humans. Current Opinion in Immunology, 25(4), 504–510. https://doi.org/10.1016/j.coi.2013.07.006
Google Scholar | Crossref | Medline Sokol, C. L., Luster, A. D. (2015). The chemokine system in innate immunity. Cold Spring Harbor Perspectives in Biology, 7(5), a016303. https://doi.org/10.1101/cshperspect.a016303
Google Scholar | Crossref | Medline Suemoto, C. K., Ferretti-Rebustini, R. E. L., Rodriguez, R. D., Leite, R. E. P., Soterio, L., Brucki, S. M. D., Spera, R. R., Cippiciani, T. M., Farfel, J. M., Chiavegatto Filho, A., Naslavsky, M. S., Zatz, M., Pasqualucci, C. A., Jacob-Filho, W., Nitrini, R., Grinberg, L. T. (2017). Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study. PLoS Medicine, 14(3), e1002267.
Google Scholar | Crossref | Medline Togo, T., Akiyama, H., Iseki, E., Kondo, H., Ikeda, K., Kato, M., Oda, T., Tsuchiya, K., Kosaka, K. (2002). Occurrence of T cells in the brain of Alzheimer’s disease and other neurological diseases. Journal of Neuroimmunology, 124(1–2), 83–92. https://doi.org/10.1016/S0165-5728(01)00496-9
Google Scholar | Crossref | Medline Wong, W. (2013). Microglial aging in the healthy CNS: Phenotypes, drivers, and rejuvenation. Frontiers in Cellular Neuroscience, 7, 22. https://doi.org/0.3389/fncel.2013.00022
Google Scholar | Crossref | Medline | ISI Yoshikawa, T. T. (2000). Epidemiology and unique aspects of aging and infectious diseases. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 30(6), 931–933. https://doi.org/10.1086/313792
Google Scholar | Crossref | Medline | ISI Yousef, H., Czupalla, C. J., Lee, D., Chen, M. B., Burke, A. N., Zera, K. A., Zandstra, J., Berber, E., Lehallier, B., Mathur, V., Nair, R. V., Bonanno, L. N., Yang, A. C., Peterson, T., Hadeiba, H., Merkel, T., Körbelin, J., Schwaninger, M., Buckwalter, M. S., Wyss-Coray, T., (2019). Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1. Nature Medicine, 25(6), 988–1000. https://doi.org/10.1038/s41591-019-0440-4
Google Scholar | Crossref | Medline