Paone P, Cani PD. Mucus barrier, mucins and gut microbiota: the expected slimy partners? Gut. 2020;69:2232–43. https://doi.org/10.1136/gutjnl-2020-322260
Article CAS PubMed Google Scholar
Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci. 2008;105:15064–9. https://doi.org/10.1073/pnas.0803124105
Article PubMed PubMed Central Google Scholar
Ermund A, Schütte A, Johansson ME, Gustafsson JK, Hansson GC. Studies of mucus in mouse stomach, small intestine, and colon. I. gastrointestinal mucus layers have different properties depending on location as well as over the Peyer’s patches. Am J Physiol Gastrointest Liver Physiol. 2013;305:341–7. https://doi.org/10.1152/ajpgi.00046.2013
Varum FJ, Veiga F, Sousa JS, Basit AW. An investigation into the role of mucus thickness on mucoadhesion in the gastrointestinal tract of pig. Eur J Pharm Sci. 2010;40:335–41. https://doi.org/10.1016/j.ejps.2010.04.007
Article CAS PubMed Google Scholar
Szentkuti L, Lorenz K. The thickness of the mucus layer in different segments of the rat intestine. Histochem J. 1995;27:466–72. https://doi.org/10.1007/BF02388803
Article CAS PubMed Google Scholar
Atuma C, Strugala V, Allen A, Holm L. The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am J Physiol Gastrointest Liver Physiol. 2001;280:G922–9. https://doi.org/10.1152/ajpgi.2001.280.5.G922
Article CAS PubMed Google Scholar
Zhang M, Wu C. The relationship between intestinal goblet cells and the immune response. Biosci Rep. 2020;40:BSR20201471. https://doi.org/10.1042/BSR20201471
Article CAS PubMed PubMed Central Google Scholar
Bajka BH, Rigby NM, Cross KL, Macierzanka A, Mackie AR. The influence of small intestinal mucus structure on particle transport ex vivo. Colloids Surf B Biointerfaces. 2015;135:73–80. https://doi.org/10.1016/j.colsurfb.2015.07.038
Article CAS PubMed Google Scholar
Johansson ME, Hansson GC. Immunological aspects of intestinal mucus and mucins. Nat Rev Immunol. 2016;16:639–49. https://doi.org/10.1038/nri.2016.88
Article CAS PubMed PubMed Central Google Scholar
Lang T, Hansson GC, Samuelsson T. Gel-forming mucins appeared early in metazoan evolution. Proc Natl Acad Sci. 2007;104:16209–14. https://doi.org/10.1073/pnas.0705984104
Article PubMed PubMed Central Google Scholar
Corfield AP. Mucins: a biologically relevant glycan barrier in mucosal protection. Biochim Biophys Acta Gen Subj. 2015;1850:236–52. https://doi.org/10.1016/j.bbagen.2014.05.003
Hattrup CL, Gendler SJ. Structure and function of the cell surface (tethered) mucins. Annu Rev Physiol. 2008;70:431–57. https://doi.org/10.1146/annurev.physiol.70.113006.100659
Article CAS PubMed Google Scholar
Lindén SK, Florin TH, McGuckin MA. Mucin dynamics in intestinal bacterial infection. PLoS ONE. 2008;3:e3952. https://doi.org/10.1371/journal.pone.0003952
Article CAS PubMed PubMed Central Google Scholar
Shibahara H, Higashi M, Koriyama C, Yokoyama S, Kitazono I, Kurumiya Y, Narita M, Kuze S, Kyokane T, Mita S. Pathobiological implications of mucin (MUC) expression in the outcome of small bowel cancer. PLoS ONE. 2014;9:e86111. https://doi.org/10.1371/journal.pone.0086111
Article CAS PubMed PubMed Central Google Scholar
Gum JR Jr, Crawley SC, Hicks JW, Szymkowski DE, Kim YS. MUC17, a novel membrane-tethered mucin. Biochem Biophys Res Commun. 2002;291:466–75. https://doi.org/10.1006/bbrc.2002.6475
Article CAS PubMed Google Scholar
Williams SJ, McGuckin MA, Gotley DC, Eyre HJ, Sutherland GR, Antalis TM. Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res. 1999;59:4083–9. PMID: 10463611.
Sheng Y, Triyana S, Wang R, Das I, Gerloff K, Florin T, Sutton P, McGuckin M. MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli. Mucosal Immunol. 2013;6:557–68. https://doi.org/10.1038/mi.2012.98
Article CAS PubMed Google Scholar
Liu Y, Yu X, Zhao J, Zhang H, Zhai Q, Chen W. The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression. Int J Biol Macromol. 2020;164:884–91. https://doi.org/10.1016/j.ijbiomac.2020.07.191
Article CAS PubMed Google Scholar
Larsson JMH, Karlsson H, Crespo JG, Johansson ME, Eklund L, Sjövall H, Hansson GC. Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation. Inflamm Bowel Dis. 2011;17:2299–307. https://doi.org/10.1002/ibd.21625
Hasnain SZ, Gallagher AL, Grencis RK, Thornton DJ. A new role for mucins in immunity: insights from gastrointestinal nematode infection. Int J Biochem Cell Biol. 2013;45:364–74. https://doi.org/10.1016/j.biocel.2012.10.011
Article CAS PubMed Google Scholar
Gustafsson JK, Ermund A, Ambort D, Johansson ME, Nilsson HE, Thorell K, Hebert H, Sjövall H, Hansson GC. Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. J Exp Med. 2012;209:1263–72. https://doi.org/10.1084/jem.20120562
Article CAS PubMed PubMed Central Google Scholar
Ambort D, Johansson ME, Gustafsson JK, Nilsson HE, Ermund A, Johansson BR, Koeck PJ, Hebert H, Hansson GC. Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin. Proc Natl Acad Sci USA. 2012;109:5645–50. https://doi.org/10.1073/pnas.1120269109
Article PubMed PubMed Central Google Scholar
Breugelmans T, Oosterlinck B, Arras W, Ceuleers H, De Man J, Hold GL, De Winter BY, Smet A. The role of mucins in gastrointestinal barrier function during health and disease. Lancet Gastroenterol Hepatol. 2022;7(5):455–71. https://doi.org/10.1016/s2468-1253(21)00431-3
Article CAS PubMed Google Scholar
Luis AS, Hansson GC. Intestinal mucus and their glycans: a habitat for thriving microbiota. Cell Host Microbe. 2023;31:1087–100. https://doi.org/10.1016/j.chom.2023.05.026
Article CAS PubMed PubMed Central Google Scholar
Raev SA, Amimo JO, Saif LJ, Vlasova AN. Intestinal mucin-type O-glycans: the major players in the host-bacteria-rotavirus interactions. Gut Microbes. 2023;15:2197833. https://doi.org/10.1080/19490976.2023.2197833
Article CAS PubMed PubMed Central Google Scholar
Schwegmann-Weßels C, Herrler G. Sialic acids as receptor determinants for coronaviruses. Glycoconj J. 2006;23:51–8. https://doi.org/10.1007/s10719-006-5437-9
Article CAS PubMed PubMed Central Google Scholar
Schwegmann-Wessels C, Zimmer G, Schröder B, Breves G, Herrler G. Binding of transmissible gastroenteritis coronavirus to brush border membrane sialoglycoproteins. J Virol. 2003;77:11846–8. https://doi.org/10.1128/jvi.77.21.11846-11848.2003
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