Ranasinghe P, Mathangasinghe Y, Jayawardena R, Hills AP, Misra A. Prevalence and trends of metabolic syndrome among adults in the asia-pacific region: a systematic review. BMC Public Health. 2017;17:101.

Article  CAS  PubMed  PubMed Central  Google Scholar 

do Vale Moreira NC, Hussain A, Bhowmik B, Mdala I, Siddiquee T, Fernandes VO et al. Prevalence of Metabolic Syndrome by different definitions, and its association with type 2 diabetes, pre-diabetes, and cardiovascular disease risk in Brazil. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2020;14:1217–24.

Saklayen MG. The global epidemic of the metabolic syndrome. Curr Hypertens Rep. 2018;20:12.

Article  PubMed  PubMed Central  Google Scholar 

Moore JX, Chaudhary N, Akinyemiju T. Metabolic syndrome prevalence by Race/Ethnicity and sex in the United States, National Health and Nutrition Examination Survey, 1988–2012. Prev Chronic Dis. 2017;14:E24.

Article  PubMed  PubMed Central  Google Scholar 

Ndumele CE, Rangaswami J, Chow SL, Neeland IJ, Tuttle KR, Khan SS, et al. Cardiovascular-kidney-metabolic health: a Presidential Advisory from the American Heart Association. Circulation. 2023;148:1606–35.

Article  PubMed  Google Scholar 

Li W, Chen D, Peng Y, Lu Z, Kwan M-P, Tse LA. Association between metabolic syndrome and mortality: prospective cohort study. JMIR Public Health Surveillance. 2023;9:e44073.

Article  PubMed  PubMed Central  Google Scholar 

Cheong KC, Lim KH, Ghazali SM, Teh CH, Cheah YK, Baharudin A, et al. Association of metabolic syndrome with risk of cardiovascular disease mortality and all-cause mortality among Malaysian adults: a retrospective cohort study. BMJ Open. 2021;11:e047849.

Article  Google Scholar 

Rezzani R, Franco C, Liver. Oxidative stress and metabolic syndromes. Nutrients. 2021;13:301.

Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, et al. Metabolic syndrome: updates on pathophysiology and management in 2021. Int J Mol Sci. 2022;23:786.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langi P, Kiokias S, Varzakas T, Proestos C, Carotenoids. From Plants to Food and Feed Industries. In: Barreiro C, Barredo J-L, editors. Microbial Carotenoids [Internet]. New York, NY: Springer New York; 2018 [cited 2024 Apr 28]. pp. 57–71. Available from: http://link.springer.com/https://doi.org/10.1007/978-1-4939-8742-9_3

Fiedor J, Burda K. Potential role of carotenoids as antioxidants in human health and disease. Nutrients. 2014;6:466–88.

Article  PubMed  PubMed Central  Google Scholar 

Lim S, Eckel RH. Pharmacological treatment and therapeutic perspectives of metabolic syndrome. Rev Endocr Metab Disord. 2014;15:329–41.

Article  CAS  PubMed  Google Scholar 

Beydoun MA, Chen X, Jha K, Beydoun HA, Zonderman AB, Canas JA. Carotenoids, vitamin A, and their association with the metabolic syndrome: a systematic review and meta-analysis. Nutr Rev. 2019;77:32–45.

Article  PubMed  Google Scholar 

Sugiura M, Nakamura M, Ogawa K, Ikoma Y, Yano M. High serum carotenoids associated with lower risk for the metabolic syndrome and its components among Japanese subjects: Mikkabi cohort study. Br J Nutr. 2015;114:1674–82.

Article  CAS  PubMed  Google Scholar 

Beydoun MA, Nalls MA, Canas JA, Evans MK, Zonderman AB. Gene polymorphisms and gene scores linked to low serum carotenoid status and their associations with metabolic disturbance and depressive symptoms in African-American adults. Br J Nutr. 2014;112:992–1003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moy FM, Ng YH, Tan SS. Association of Serum Beta-Carotene with metabolic risk factors among a work cohort in Malaysia. J Nutri Sci Vitaminol. 2023;69:463–70.

Article  CAS  Google Scholar 

Buijsse B, Feskens EJM, Kwape L, Kok FJ, Kromhout D. Both α- and β-Carotene, but not tocopherols and Vitamin C, are inversely related to 15-Year Cardiovascular Mortality in Dutch Elderly Men1,2. J Nutr. 2008;138:344–50.

Article  CAS  PubMed  Google Scholar 

Qiu Z, Chen X, Geng T, Wan Z, Lu Q, Li L, et al. Associations of serum carotenoids with risk of Cardiovascular Mortality among individuals with type 2 diabetes: results from NHANES. Diabetes Care. 2022;45:1453–61.

Article  CAS  PubMed  Google Scholar 

X Z, I C, Y T, Q MS et al. Z, R G,. Associations of Serum Carotenoids With Risk of All-Cause and Cardiovascular Mortality in Hypertensive Adults. Journal of the American Heart Association [Internet]. 2023 [cited 2024 Apr 22];12. Available from: https://pubmed.ncbi.nlm.nih.gov/36752230/

Peng X, Zhu J, Lynn HS, Zhang X. Serum nutritional biomarkers and all-cause and cause-specific mortality in U.S. adults with metabolic syndrome: the results from National Health and Nutrition Examination Survey 2001–2006. Nutrients. 2023;15:553.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Q, Wu H, Cao X, Tang S, Zhao J. The association between statin use and depression in diabetes. J Affect Disord. 2024;349:342–8.

Article  CAS  PubMed  Google Scholar 

Nguyen TTB, Jin YY, Chung H-J, Hong S-T. Pharmabiotics as an emerging medication for metabolic syndrome and its related diseases. Molecules. 2017;22:1795.

Article  PubMed  PubMed Central  Google Scholar 

Vasankari T, Ahotupa M, Viikari J, Nuotio I, Strandberg T, Vanhanen H, et al. Effect of 12-month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations. Ann Med. 2004;36:618–22.

Article  CAS  PubMed  Google Scholar 

Sundl I, Pail E, Mellitzer K, Toplak H, Winklhofer-Roob BM. Effects of orlistat therapy on plasma concentrations of oxygenated and hydrocarbon carotenoids. Lipids. 2006;41:113–8.

Article  CAS  PubMed  Google Scholar 

Motta BP, Pinheiro CG, Figueiredo ID, Cardoso FN, Oliveira JO, Machado RTA, et al. Combined effects of Lycopene and Metformin on decreasing oxidative stress by triggering endogenous antioxidant defenses in Diet-Induced obese mice. Molecules. 2022;27:8503.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moran NE, Mohn ES, Hason N, Erdman JW, Johnson EJ. Intrinsic and extrinsic factors impacting absorption, metabolism, and Health effects of Dietary carotenoids. Adv Nutr. 2018;9:465–92.

Article  PubMed  PubMed Central  Google Scholar 

Białkowska A, Górnicka M, Zielinska-Pukos MA, Hallmann E, Hamulka J. Plasma carotenoids and polyphenols and their association with MetS: the need for nutritional interventions. Antioxid (Basel). 2023;12:1336.

Article  Google Scholar 

Stahl W, van den Berg H, Arthur J, Bast A, Dainty J, Faulks RM, et al. Bioavailability and metabolism. Mol Aspects Med. 2002;23:39–100.

Article  CAS  PubMed  Google Scholar 

Tan C, Xue J, Lou X, Abbas S, Guan Y, Feng B, et al. Liposomes as delivery systems for carotenoids: comparative studies of loading ability, storage stability and in vitro release. Food Funct. 2014;5:1232–40.

Article  CAS  PubMed  Google Scholar 

Muls E, Kolanowski J, Scheen A, Gaal LV. The effects of orlistat on weight and on serum lipids in obese patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled, multicentre study. International Journal of Obesity.

Rad NR, Movahedian A, Feizi A, Aminorroaya A, Aarabi MH. Antioxidant effects of astaxanthin and metformin combined therapy in type 2 diabetes mellitus patients: a randomized double-blind controlled clinical trial.

Chen F, Du M, Blumberg JB, Chui KKH, Ruan M, Rogers G, et al. Association between Dietary Supplement Use, Nutrient Intake, and Mortality among US adults: a Cohort Study. Ann Intern Med. 2019;170:604–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA et al. /ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139:e1082–143.

Lopez-Neyman SM, Davis K, Zohoori N, Broughton KS, Moore CE, Miketinas D. Racial disparities and prevalence of cardiovascular disease risk factors, cardiometabolic risk factors, and cardiovascular health metrics among US adults: NHANES 2011–2018. Sci Rep. 2022;12:19475.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Chen Y, Zou L, Jin L, Yang B, Shu Y, et al. Dose–response relationship between dietary antioxidant intake and diabetic kidney disease in the US adults with diabetes. Acta Diabetol. 2023;60:1365–75.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Zhai X, Chai H, Liu K, Ma W, Li S, et al. Associations of different isomeric forms of serum lycopene with cardiovascular disease and all-cause mortality. Int J Vitam Nutr Res. 2024;94:108–19.

Article