Levine GN, Cohen BE, Commodore-Mensah Y, et al. Psychological Health, Well-Being, and the mind-heart-body connection: a Scientific Statement from the American Heart Association. Circulation Mar. 2021;9(10):e763–83. https://doi.org/10.1161/cir.0000000000000947.

Article  Google Scholar 

Song Y, Zhou D, Guan Z, Wang X. Disturbance of serum interleukin-2 and interleukin-8 levels in posttraumatic and non-posttraumatic stress disorder earthquake survivors in northern China. Neuroimmunomodulation. 2007;14(5):248–54. https://doi.org/10.1159/000112050.

Article  CAS  PubMed  Google Scholar 

Song Y, Zhou D, Wang X. Increased serum cortisol and growth hormone levels in earthquake survivors with PTSD or subclinical PTSD. Psychoneuroendocrinology Sep. 2008;33(8):1155–9. https://doi.org/10.1016/j.psyneuen.2008.05.005.

Article  CAS  Google Scholar 

Bookwalter DB, Roenfeldt KA, LeardMann CA, Kong SY, Riddle MS, Rull RP. Posttraumatic stress disorder and risk of selected autoimmune diseases among US military personnel. BMC Psychiatry Jan. 2020;15(1):23. https://doi.org/10.1186/s12888-020-2432-9.

Article  Google Scholar 

O’Donnell CJ, Schwartz Longacre L, Cohen BE, et al. Posttraumatic stress disorder and Cardiovascular Disease: state of the Science, Knowledge gaps, and Research opportunities. JAMA Cardiol Oct. 2021;1(10):1207–16. https://doi.org/10.1001/jamacardio.2021.2530.

Article  Google Scholar 

Allgire E, McAlees JW, Lewkowich IP, Sah R. Asthma and posttraumatic stress disorder (PTSD): emerging links, potential models and mechanisms. Brain Behav Immun Oct. 2021;97:275–85. https://doi.org/10.1016/j.bbi.2021.06.001.

Article  Google Scholar 

Vancampfort D, Rosenbaum S, Ward PB, et al. Type 2 diabetes among people with posttraumatic stress disorder: systematic review and Meta-analysis. Psychosom Med. May 2016;78(4):465–73. https://doi.org/10.1097/psy.0000000000000297.

Agyemang C, Goosen S, Anujuo K, Ogedegbe G. Relationship between post-traumatic stress disorder and diabetes among 105,180 asylum seekers in the Netherlands. Eur J Public Health Oct. 2012;22(5):658–62. https://doi.org/10.1093/eurpub/ckr138.

Article  Google Scholar 

Roberts AL, Agnew-Blais JC, Spiegelman D, et al. Posttraumatic stress disorder and incidence of type 2 diabetes mellitus in a sample of women: a 22-year longitudinal study. JAMA Psychiatry Mar. 2015;72(3):203–10. https://doi.org/10.1001/jamapsychiatry.2014.2632.

Article  Google Scholar 

Manzo LL, Dindinger RA, Batten J, Combellick JL, Basile-Ibrahim B. The Impact of Military Trauma Exposures on Servicewomen’s Pregnancy Outcomes: A Scoping Review. J Midwifery Womens Health Feb. 2024;21. https://doi.org/10.1111/jmwh.13620.

Davies NM, Holmes MV, Davey Smith G. Reading mendelian randomisation studies: a guide, glossary, and checklist for clinicians. Bmj Jul. 2018;12:362:k601. https://doi.org/10.1136/bmj.k601.

Article  Google Scholar 

Zhao Q, Liu D, Baranova A, Cao H, Zhang F. Novel insights into the Causal effects and Shared Genetics between Body Fat and Parkinson Disease. CNS Neurosci Ther Nov. 2024;30(11):e70132. https://doi.org/10.1111/cns.70132.

Article  CAS  Google Scholar 

Baranova A, Zhao Y, Cao H, Zhang F. Causal associations between major depressive disorder and COVID-19. Gen Psychiatr. 2023;36(2):e101006. https://doi.org/10.1136/gpsych-2022-101006.

Article  PubMed  Google Scholar 

Zhao Q, Baranova A, Cao H, Zhang F. Evaluating Causal effects of Gut Microbiome on Alzheimer’s Disease. J Prev Alzheimers Dis. 2024;11(6):1843–8. https://doi.org/10.14283/jpad.2024.113.

Article  CAS  PubMed  Google Scholar 

Sun W, Cao H, Liu D, Baranova A, Zhang F, Zhang X. Genetic association and drug target exploration of inflammation-related proteins with risk of major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry Oct. 2024;9:136:111165. https://doi.org/10.1016/j.pnpbp.2024.111165.

Article  CAS  Google Scholar 

Ahmed S, Hossain MA, Bristy SA, Ali MS, Rahman MH. Adopting Integrated Bioinformatics and Systems Biology Approaches to Pinpoint the COVID-19 patients’ risk factors that uplift the onset of posttraumatic stress disorder. Bioinform Biol Insights. 2024;18:11779322241274958. https://doi.org/10.1177/11779322241274958.

Article  PubMed  PubMed Central  Google Scholar 

Baranova A, Liu D, Chandhoke V, Cao H, Zhang F. Unraveling the genetic links between depression and type 2 diabetes. Prog Neuropsychopharmacol Biol Psychiatry Jan. 2025;19:137:111258. https://doi.org/10.1016/j.pnpbp.2025.111258.

Article  CAS  Google Scholar 

Baranova A, Chandhoke V, Cao H, Zhang F. Shared genetics and bidirectional causal relationships between type 2 diabetes and attention-deficit/hyperactivity disorder. Gen Psychiatr. 2023;36(2):e100996. https://doi.org/10.1136/gpsych-2022-100996.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu D, Baranova A, Zhang F. Evaluating the Causal Effect of type 2 diabetes on Alzheimer’s Disease using large-scale Genetic Data. J Prev Alzheimers Dis. 2024;11(5):1280–2. https://doi.org/10.14283/jpad.2024.148.

Article  CAS  PubMed  Google Scholar 

Baranova A, Liu D, Sun W, et al. Antidepressants account for the causal effect of major depressive disorder on type 2 diabetes. Prog Neuropsychopharmacol Biol Psychiatry Oct. 2024;5:136:111164. https://doi.org/10.1016/j.pnpbp.2024.111164.

Article  CAS  Google Scholar 

Sun W, Baranova A, Liu D, Cao H, Zhang X, Zhang F. Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases. Transl Psychiatry Dec. 2024;27(1):506. https://doi.org/10.1038/s41398-024-03216-z.

Article  CAS  Google Scholar 

Song Y, Zhao Y, Baranova A, Cao H, Yue W, Zhang F. Causal association of attention-deficit/hyperactivity disorder and autism spectrum disorder with post-traumatic stress disorder. Psychiatr Genet Apr. 2024;1(2):37–42. https://doi.org/10.1097/ypg.0000000000000357.

Article  Google Scholar 

Zhang F, Rao S, Cao H, et al. Genetic evidence suggests posttraumatic stress disorder as a subtype of major depressive disorder. J Clin Invest Feb. 2022;1(3). https://doi.org/10.1172/jci145942.

Cao H, Wang J, Baranova A, Zhang F. Classifying major mental disorders genetically. Prog Neuropsychopharmacol Biol Psychiatry Jan. 2022;10:112:110410. https://doi.org/10.1016/j.pnpbp.2021.110410.

Article  Google Scholar 

Nievergelt CM, Maihofer AX, Klengel T, et al. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nat Commun Oct. 2019;8(1):4558. https://doi.org/10.1038/s41467-019-12576-w.

Article  CAS  Google Scholar 

Mahajan A, Spracklen CN, Zhang W, et al. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet May. 2022;54(5):560–72. https://doi.org/10.1038/s41588-022-01058-3.

Article  CAS  Google Scholar 

Baker DG, West SA, Nicholson WE, et al. Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. Am J Psychiatry Apr. 1999;156(4):585–8. https://doi.org/10.1176/ajp.156.4.585.

Article  CAS  Google Scholar 

Herman JP, McKlveen JM, Ghosal S, et al. Regulation of the hypothalamic-pituitary-adrenocortical stress response. Compr Physiol Mar. 2016;15(2):603–21. https://doi.org/10.1002/cphy.c150015.

Article  Google Scholar 

Wei D, Liu X, Huo W, et al. Serum cortisone and glucocorticoid receptor gene (NR3C1) polymorphism in human dysglycemia. Horm (Athens) Sep. 2020;19(3):385–93. https://doi.org/10.1007/s42000-020-00196-9.

Article  Google Scholar 

Passos IC, Vasconcelos-Moreno MP, Costa LG, et al. Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression. Lancet Psychiatry Nov. 2015;2(11):1002–12. https://doi.org/10.1016/s2215-0366(15)00309-0.

Article  Google Scholar 

Muniz Carvalho C, Wendt FR, Maihofer AX, et al. Dissecting the genetic association of C-reactive protein with PTSD, traumatic events, and social support. Neuropsychopharmacol May. 2021;46(6):1071–7. https://doi.org/10.1038/s41386-020-0655-6.

Article  CAS  Google Scholar 

Hotamisligil GS. Inflammation, metaflammation and immunometabolic disorders. Nat Feb. 2017;8(7640):177–85. https://doi.org/10.1038/nature21363.

Article  CAS  Google Scholar 

Ferraù F, Korbonits M. Metabolic syndrome in Cushing’s syndrome patients. Front Horm Res. 2018;49:85–103. https://doi.org/10.1159/000486002.

Article  CAS  PubMed  Google Scholar 

Devang N, Satyamoorthy K, Rai PS, et al. Association of HSD11B1 gene polymorphisms with type 2 diabetes and metabolic syndrome in South Indian population. Diabetes Res Clin Pract Sep. 2017;131:142–8. https://doi.org/10.1016/j.diabres.2017.07.011.

Article  CAS  Google Scholar 

Krantz DS, Gabbay FH, Belleau EA, et al. PTSD, comorbidities, gender, and increased risk of Cardiovascular Disease in a large military cohort. medRxiv Apr. 2024;15. https://doi.org/10.1101/2024.04.13.24305769.