Stenflo J. Structure-function relationships of epidermal growth factor modules in vitamin K-dependent clotting factors. Blood. 1991;78:1637–51.
Article CAS PubMed Google Scholar
Rezaie AR, Esmon CT. Tryptophans 231 and 234 in protein C report the Ca2+-dependent conformational change required for activation by the thrombin-thrombomodulin complex. Biochemistry. 1995;34:12221–6.
Article CAS PubMed Google Scholar
Stojanovski BM, Pelc LA, Zuo X, Cera ED. Zymogen and activated protein C have similar structural architecture. J Biol Chem. 2020;295:15236.
Article CAS PubMed PubMed Central Google Scholar
Dahlbäck B, Villoutreix BO. Molecular recognition in the protein C anticoagulant pathway. J Thromb Haemost. 2003;1:1525–34.
Taylor FB Jr, Peer GT, Lockhart MS, Ferrell G, Esmon CT. Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood. 2001;97:1685–8.
Article CAS PubMed Google Scholar
Mahmoodi BK, Brouwer JLP, Ten kate MK, Lijfering WM, Veeger NJGM, Mulder AB, et al. A prospective cohort study on the absolute risks of venous thromboembolism and predictive value of screening asymptomatic relatives of patients with hereditary deficiencies of protein S, protein C or antithrombin. J Thromb Haemost. 2010;8:1193–200.
Article CAS PubMed Google Scholar
Tiong IY, Alkotob ML, Ghaffari S. Protein C deficiency manifesting as an acute myocardial infarction and ischaemic stroke. Heart. 2003;89: e7.
Article CAS PubMed PubMed Central Google Scholar
Imai Y, Nagaya S, Araiso Y, Meguro-Horike M, Togashi T, Horike S, et al. Functional analysis of two abnormal antithrombin proteins with different intracellular kinetics. Thromb Res. 2023;230:18–26.
Article CAS PubMed Google Scholar
Akdel M, Pires DEV, Pardo EP, Jänes J, Zalevsky AO, Mészáros B, et al. A structural biology community assessment of AlphaFold2 applications. Nat Struct Mol Biol. 2022;29:1056.
Article CAS PubMed PubMed Central Google Scholar
Di Minno MND, Ambrosino P, Ageno W, Rosendaal F, Di Minno G, Dentali F. Natural anticoagulants deficiency and the risk of venous thromboembolism: a meta-analysis of observational studies. Thromb Res. 2015;135:923–32.
Mahmoodi BK, Brouwer J-LP, Veeger NJGM, van der Meer J. Hereditary deficiency of protein C or protein S confers increased risk of arterial thromboembolic events at a young age. Circulation. 2008;118:1659–67.
Article CAS PubMed Google Scholar
Chiasakul T, De Jesus E, Tong J, Chen Y, Crowther M, Garcia D, et al. Inherited thrombophilia and the risk of arterial ischemic stroke: a systematic review and meta-analysis. J Am Heart Assoc. 2019;8: e012877.
Article PubMed PubMed Central Google Scholar
Kenet G, Lütkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, et al. Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. Circulation. 2010;121:1838–47.
Schooling CM, Zhong Y. Plasma levels of the anti-coagulation protein C and the risk of ischaemic heart disease. A Mendelian randomisation study. Thromb Haemost. 2017;117:262–8.
Zakai NA, Judd SE, Kissela B, Howard G, Safford MM, Cushman M. Factor VIII, protein C and cardiovascular disease risk: the reasons for geographic and racial differences in stroke study (REGARDS). Thromb Haemost. 2018;118:1305–15.
Article PubMed PubMed Central Google Scholar
Chen T, Dai Y, Hu C, Lin Z, Wang S, Yang J, et al. Cellular and molecular mechanisms of the blood–brain barrier dysfunction in neurodegenerative diseases. Fluids Barriers CNS. 2024;21:60.
Article PubMed PubMed Central Google Scholar
Krshnan L, Van De Weijer ML, Carvalho P. Endoplasmic reticulum–associated protein degradation. Cold Spring Harb Perspect Biol. 2022;a041247.
Foster DC, Yoshitake S, Davie EW. The nucleotide sequence of the gene for human protein C. Proc Natl Acad Sci. 1985;82:4673–7.
Article CAS PubMed PubMed Central Google Scholar
Mather T, Oganessyan V, Hof P, Huber R, Foundling S, Esmon C, et al. The 2.8 A crystal structure of Gla-domainless activated protein C. EMBO J. 1996;15:6822.
Article CAS PubMed PubMed Central Google Scholar
Zhou R, Cai X, Xie S, Wang X, Wang H. Molecular mechanism for hereditary protein C deficiency in two Chinese families with thrombosis. J Thromb Haemost. 2006;4:1154–6.
Article CAS PubMed Google Scholar
Alhenc-Gelas M, Plu-Bureau G, Mauge L, Gandrille S, Présot I, Thrombophilia GSG on G. Genotype-phenotype relationships in a large French cohort of subjects with inherited protein C deficiency. Thromb Haemost. 2020;120:1270–81.
Rovida E, Merati G, D’Ursi P, Zanardelli S, Marino F, Fontana G, et al. Identification and computationally-based structural interpretation of naturally occurring variants of human protein C. Hum Mutat. 2007;28:345–55.
Article CAS PubMed Google Scholar
Tanratana P, Seanoon K, Payongsri P, Kadegasem P, Chuansumrit A, Sirachainan N. Unraveling the molecular pathogenesis of protein C deficiency–associated VTE: insights from protein C mutations C238G and R189W in Thai patients. Thromb Haemost. 2024;a-2408-9529.
留言 (0)