Venous blood sampling for less invasive in vivo quantification of synaptic density with constant infusion of [18F]SynVesT-1 and PET

Bajjalieh SM, Frantz G, Weimann JM, McConnell SK, Scheller R. Differential expression of synaptic vesicle protein 2 (SV2) isoforms. J Neurosci. 1994;14:5223–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buckley K, Kelly RB. Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells. J Cell Biol. 1985;100:1284–94. https://doi.org/10.1083/jcb.100.4.1284.

Article  CAS  PubMed  Google Scholar 

Dunn AR, Hoffman CA, Stout KA, Ozawa M, Dhamsania RK, Miller GW. Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain. Brain Res. 2019;1702:85–95. https://doi.org/10.1016/j.brainres.2017.12.029.

Article  CAS  PubMed  Google Scholar 

Floor E, Feist BE. Most synaptic vesicles isolated from rat brain carry three membrane proteins, SV2, synaptophysin, and p65. J Neurochem. 1989;52:1433–7. https://doi.org/10.1111/j.1471-4159.1989.tb09190.x.

Article  CAS  PubMed  Google Scholar 

Finnema SJ, Li S, Cai Z, Naganawa M, Chen M-K, Matuskey D, et al. PET imaging of synaptic vesicle protein 2A. In: Dierckx RAJO, Otte A, de Vries EFJ, van Waarde A, Lammertsma AA, editors. PET and SPECT of Neurobiological systems. Cham: Springer International Publishing; 2021. pp. 993–1019.

Chapter  Google Scholar 

Nabulsi NB, Mercier J, Holden D, Carré S, Najafzadeh S, Vandergeten M-C, et al. Synthesis and preclinical evaluation of 11 C-UCB-J as a PET tracer for imaging the synaptic vesicle glycoprotein 2A in the brain. J Nucl Med. 2016;57:777–84.

Article  CAS  PubMed  Google Scholar 

Finnema S, Nabulsi N, Eid T, Detyniecki K, Lin S, Chen M, et al. Imaging synaptic density in the living human brain by positron emission tomography. Sci Transl Med. 2016;8:348ra96.

Article  PubMed  Google Scholar 

Li S, Cai Z, Wu X, Holden D, Pracitto R, Kapinos M, et al. Synthesis and in vivo evaluation of a novel PET Radiotracer for imaging of synaptic vesicle glycoprotein 2A (SV2A) in Nonhuman Primates. ACS Chem Neurosci. 2019;10:1544–54. https://doi.org/10.1021/acschemneuro.8b00526.

Article  CAS  PubMed  Google Scholar 

Naganawa M, Li S, Nabulsi N, Henry S, Zheng M-Q, Pracitto R, et al. First-in-human evaluation of 18F-SynVesT-1, a Radioligand for PET imaging of synaptic vesicle glycoprotein 2A. J Nucl Med. 2021;62:561–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, et al. Lower synaptic density is associated with depression severity and network alterations. Nat Commun. 2019;10:1529.

Article  PubMed  PubMed Central  Google Scholar 

Asch RH, Abdallah CG, Carson RE, Esterlis I. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression. Neuropsychopharmacology. 2024. https://doi.org/10.1038/s41386-024-01913-3.

Article  PubMed  Google Scholar 

Finnema SJ, Toyonaga T, Detyniecki K, Chen M-K, Dias M, Wang Q, et al. Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: a [11 C]UCB-J positron emission tomography study. Epilepsia. 2020;61:2183–93. https://doi.org/10.1111/epi.16653.

Article  CAS  PubMed  Google Scholar 

Chen M-K, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin S-f, et al. Assessing synaptic density in Alzheimer disease with synaptic vesicle glycoprotein 2A positron emission tomographic imaging. JAMA Neurol. 2018;75:1215–24.

Article  PubMed  PubMed Central  Google Scholar 

Matuskey D, Tinaz S, Wilcox KC, Naganawa M, Toyonaga T, Dias M, et al. Synaptic changes in Parkinson disease assessed with in vivo imaging. Ann Neurol. 2020;87:329–38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mecca AP, Chen M-K, O’Dell RS, Naganawa M, Toyonaga T, Godek TA, et al. In vivo measurement of widespread synaptic loss in Alzheimer’s disease with SV2A PET. Alzheimer’s Dement. 2020;16:974–82. https://doi.org/10.1002/alz.12097.

Article  Google Scholar 

Carson RE, Naganawa M, Toyonaga T, Koohsari S, Yang Y, Chen MK, et al. Imaging of synaptic density in neurodegenerative disorders. J Nucl Med. 2022;63:s60–7. https://doi.org/10.2967/jnumed.121.263201.

Article  CAS  Google Scholar 

Michiels L, Delva A, van Aalst J, Ceccarini J, Vandenberghe W, Vandenbulcke M, et al. Synaptic density in healthy human aging is not influenced by age or sex: a 11 C-UCB-J PET study. NeuroImage. 2021;232:117877.

Article  CAS  PubMed  Google Scholar 

Rossano S, Toyonaga T, Berg E, Lorence I, Fowles K, Nabulsi N et al. Imaging the fetal nonhuman primate brain with SV2A positron emission tomography (PET). Eur J Nucl Med Mol Imaging. 2022:1–13.

Li S, Naganawa M, Pracitto R, Najafzadeh S, Holden D, Henry S, et al. Assessment of test-retest reproducibility of [(18)F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A. Eur J Nucl Med Mol Imaging. 2021;48:1327–38. https://doi.org/10.1007/s00259-020-05149-3.

Article  CAS  PubMed  Google Scholar 

Asch RH, Naganawa M, Nabulsi N, Huan Y, Esterlis I, Carson RE. Evaluating infusion methods and simplified quantification of synaptic density in vivo with [(11)C]UCB-J and [(18)F]SynVesT-1 PET. J Cereb Blood Flow Metab. 2023;43:2120–9. https://doi.org/10.1177/0271678x231200423.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chim H, Bakri K, Moran SL. Complications related to radial artery occlusion, radial artery harvest, and arterial lines. Hand Clin. 2015;31:93–100.

Article  PubMed  Google Scholar 

Everett BA, Oquendo MA, Abi-Dargham A, Nobler MS, Devanand DP, Lisanby SH, et al. Safety of radial arterial catheterization in PET research subjects. J Nucl Med. 2009;50:1742.

Article  PubMed  Google Scholar 

Hilton J, Yokoi F, Dannals RF, Ravert HT, Szabo Z, Wong DF. Column-switching HPLC for the analysis of plasma in PET imaging studies. Nucl Med Biol. 2000;27:627–30.

Article  CAS  PubMed  Google Scholar 

Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, et al. Kinetic evaluation and test-retest reproducibility of [(11)C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans. J Cereb Blood Flow Metab. 2018;38:2041–52. https://doi.org/10.1177/0271678x17724947.

Article  CAS  PubMed  Google Scholar 

Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage. 2002;15:273–89. https://doi.org/10.1006/nimg.2001.0978.

Article  CAS  PubMed  Google Scholar 

Rossano S, Toyonaga T, Finnema SJ, Naganawa M, Lu Y, Nabulsi N, et al. Assessment of a white matter reference region for (11)C-UCB-J PET quantification. J Cereb Blood flow Metabolism: Official J Int Soc Cereb Blood Flow Metabolism. 2020;40:1890–901. https://doi.org/10.1177/0271678X19879230.

Article  CAS  Google Scholar 

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