Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007; 357(11):1121–1135.

Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest. 2013; 123(1):192–100.

Hillis Ld Fau - Lange RA, Lange RA. Myocardial infarction and the open-artery hypothesis. N Engl J Med. 2006;355(323):2475–2477.

Andrassy M, Volz HC, Igwe JC, Funke B, Eichberger SN, Kaya Z, Buss S, Autschbach F, Pleger ST, Lukic IK, et al. High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation. 2008; 117(25):3216–3226.

Lesnefsky EJ, Chen Q, Tandler B, Hoppel CL. Mitochondrial Dysfunction and Myocardial Ischemia-Reperfusion: Implications for Novel Therapies. Annu Rev Pharmacol Toxicol. 2017; 57:535–565.

Westermann B. Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol. 2010;11(12):872–884.

Youle RJ, van der Bliek AM. Mitochondrial fission, fusion, and stress. Science. 2012;337(6098):1062–5.

Zepeda R, Kuzmicic J Fau - Parra V, Parra V Fau - Troncoso R, Troncoso R Fau - Pennanen C, Pennanen C Fau - Riquelme JA, Riquelme Ja Fau - Pedrozo Z, Pedrozo Z Fau - Chiong M, Chiong M Fau - Sánchez G, Sánchez G Fau - Lavandero S, Lavandero S. Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury. J Cardiovasc Pharmacol. 2014;63(66):477–487.

Sharp WW, Fang Yh Fau - Han M, Han M Fau - Zhang HJ, Zhang Hj Fau - Hong Z, Hong Z Fau - Banathy A, Banathy A Fau - Morrow E, Morrow E Fau - Ryan JJ, Ryan Jj Fau - Archer SL, Archer SL. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. FASEB J. 2014;28(21):316–26.

Disatnik MH, Ferreira JC, Campos JC, Gomes KS, Dourado PM, Qi X, Mochly-Rosen D. Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction. J Am Heart Assoc. 2013;2(5):e000461.

Vasquez-Trincado C, Garcia-Carvajal I, Pennanen C, Parra V, Hill JA, Rothermel BA, Lavandero S. Mitochondrial dynamics, mitophagy and cardiovascular disease. J Physiol. 2016;594(3):509–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Zhou H. Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury. Acta Pharm Sin B. 2020;10(10):1866–79.

Article  PubMed  PubMed Central  Google Scholar 

Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, et al. HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. Proc Natl Acad Sci U S A. 2014;111(118):3032–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

M D, R N, B R, L M, A J, S T, S C-L, B R, L L, A M, et al. Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nature Commun. 2013;4:2180. https://doi.org/10.1038/ncomms3180.

El-Naggar AM, Clarkson PW, Negri GL, Turgu B, Zhang F, Anglesio MS, Sorensen PH. HACE1 is a potential tumor suppressor in osteosarcoma. Cell Death Disease. 2019;10(11):21.

Anglesio MS, Evdokimova V, Melnyk N, Zhang L, Fernandez CV, Grundy PE, Leach S, Marra MA, Brooks-Wilson AR, Penninger J, et al. Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. Human Mol Genetics. 2004;13(18):2061–2074.

Kumar B, Roy A, Asha K, Sharma-Walia N, Ansari MA, Chandran B. HACE1, an E3 Ubiquitin Protein Ligase, Mitigates Kaposi's Sarcoma-Associated Herpesvirus Infection-Induced Oxidative Stress by Promoting Nrf2 Activity. J Virol. 2019;93(19):e01812–01818.

Razaghi B, Steele SL, Prykhozhij SV, Stoyek MR, Hill JA, Cooper MD, McDonald L, Lin W, Daugaard M, Crapoulet N, et al. hace1 Influences zebrafish cardiac development via ROS-dependent mechanisms. Dev Dynamics. 2018;247(242):289–303.

Ugarteburu O, Sanchez-Viles M, Ramos J, Barcos-Rodriguez T, Garrabou G, Garcia-Villoria J, Ribes A, Tort F. Physiopathological Bases of the Disease Caused by HACE1 Mutations: Alterations in Autophagy, Mitophagy and Oxidative Stress Response. J Clin Med. 2020;29(24):913.

Zhang L, Chen X, Sharma P, Moon M, Sheftel AD, Dawood F, Nghiem MP, Wu J, Li RK, Gramolini AO, et al. HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nat Commun. 2014;15:3430.

Chen TY, Zheng SA-O. Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway. In Vitro Cell Dev Biol Anim. 2022;58(59):830–9.

Ehrnhoefer DE, Southwell AL, Sivasubramanian M, Qiu X, Villanueva EB, Xie Y, Waltl S, Anderson L, Fazeli A, Casal L, et al. HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo. Human Mol Genetics. 2018;27(12):239–253.

Ong SB, Subrayan S, Lim SY, Yellon DM, Davidson SM, Hausenloy DJ. Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury. Circulation. 2010;121(118):2012–2022.

Gao E, Lei YH, Shang X, Huang ZM, Zuo L, Boucher M, Fan Q, Chuprun JK, Ma XL, Koch WJ. A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res. 2010;107(112):1445–1453.

Gao S, Ho D, Vatner DE, Vatner SF. Echocardiography in Mice. Curr Protoc Mouse Biol. 2011;1:71–83. https://doi.org/10.1002/9780470942390.mo100130.

Liu Z, Chen P, Gao H, Gu Y, Yang J, Peng H, Xu X, Wang H, Yang M, Liu X, et al. Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression. Cancer Cell. 2014;26(11):106–120.

Razaghi B, Steele SL, Prykhozhij SV, Stoyek MR, Hill JA, Cooper MD, McDonald L, Lin W, Daugaard M, Crapoulet N, et al. hace1 Influences zebrafish cardiac development via ROS-dependent mechanisms. Dev Dynamics. 2018;247(2):289–303.

Article  CAS  Google Scholar 

Zhang L, Chen X, Sharma P, Moon M, Sheftel AD, Dawood F, Nghiem MP, Wu J, Li R-K, Gramolini AO, et al. HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nat Commun. 2014;5:3430.

Article  PubMed  Google Scholar 

Wu QQ, Xiao Y, Yuan Y, Ma ZG, Liao HH, Liu C, Zhu JX, Yang Z, Deng W, Tang QZ. Mechanisms contributing to cardiac remodelling. Clin Sci (Lond). 2017;131(118):2319–2345.

Jahangiri A, Leifert WR, Kind KL, McMurchie EJ. Dietary fish oil alters cardiomyocyte Ca2+ dynamics and antioxidant status. Free Radical Biol Med. 2006;40(9):1592–602.

Article  CAS  Google Scholar 

Yao H, Xie Q, He Q, Zeng L, Long J, Gong Y, Li X, Li X, Liu W, Xu Z, et al. Pretreatment with Panaxatriol Saponin Attenuates Mitochondrial Apoptosis and Oxidative Stress to Facilitate Treatment of Myocardial Ischemia-Reperfusion Injury via the Regulation of Keap1/Nrf2 Activity. Oxid Med Cell Longev. 2022;2022:9626703.

Shen Y, Liu X, Shi J, Wu X.: Involvement of Nrf2 in myocardial ischemia and reperfusion injury. Int J Biol Macromol. 2019;125:496–502.

Izyumov DS, Domnina LV, Nepryakhina OK, Avetisyan AV, Golyshev SA, Ivanova OY, Korotetskaya MV, Lyamzaev KG, Pletjushkina OY, Popova EN, et al. Mitochondria as source of reactive oxygen species under oxidative stress. Study with novel mitochondria-targeted antioxidants--the "Skulachev-ion" derivatives. Biochemistry (Mosc). 2010;75(2):123–129.

Matsui Y, Takagi H Fau - Qu X, Qu X Fau - Abdellatif M, Abdellatif M Fau - Sakoda H, Sakoda H Fau - Asano T, Asano T Fau - Levine B, Levine B Fau - Sadoshima J, Sadoshima J. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res. 2007;100(106):914–122.

Stone GW, Selker HP, Thiele H, Patel MR, Udelson JE, Ohman EM, Maehara A, Eitel I, Granger CB, Jenkins PL, et al. Relationship Between Infarct Size and Outcomes Following Primary PCI: Patient-Level Analysis From 10 Randomized Trials. J Am Coll Cardiol. 2016;67(14):1674–1683.

Zhou H, Wang J, Zhu P, Zhu H, Toan S, Hu S, Ren J, Chen Y. NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α. Basic Res Cardiol. 2018;113(114):123.

Jin Q, Li R, Hu N, Xin T, Zhu P, Hu S, Ma S, Zhu H, Ren J, Zhou H. DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways. Redox Biol. 2018;14:576–587.

Maneechote C, Palee S, Kerdphoo S, Jaiwongkam T, Chattipakorn SC, Chattipakorn N. Differential temporal inhibition of mitochondrial fission by Mdivi-1 exerts effective cardioprotection in cardiac ischemia/reperfusion injury. Clin Sci (Lond). 2018;132(115):1669–1683.

Percie du Sert NA-O, Ahluwalia AA-O, Alam SA-O, Avey MA-O, Baker M, Browne WA-O, Clark AA-O, Cuthill IA-O, Dirnagl UA-O, Emerson M, et al. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PLoS Biol. 2020; 18(7):e3000411(1545–7885).