Tahami Monfared AA, Byrnes MJ, White LA, Zhang Q. Alzheimer’s Disease: Epidemiology and Clinical Progression. Neurol Ther. 2022;11(2):553–69.
Article PubMed PubMed Central Google Scholar
Alzheimer’s disease facts and figures. Alzheimers Dement. 2023;19(4):1598–695.
Perneczky R, Jessen F, Grimmer T, Levin J, Flöel A, Peters O, et al. Anti-amyloid antibody therapies in Alzheimer’s disease. Brain. 2023;146(3):842–9.
Song C, Shi J, Zhang P, Zhang Y, Xu J, Zhao L, et al. Immunotherapy for Alzheimer’s disease: targeting β-amyloid and beyond. Transl Neurodegener. 2022;11(1):18.
Article CAS PubMed PubMed Central Google Scholar
Nicoll JAR, Buckland GR, Harrison CH, Page A, Harris S, Love S, et al. Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer’s disease. Brain. 2019;142(7):2113–26.
Article PubMed PubMed Central Google Scholar
Kim CK, Lee YR, Ong L, Gold M, Kalali A, Sarkar J. Alzheimer’s Disease: Key Insights from Two Decades of Clinical Trial Failures. J Alzheimers Dis. 2022;87(1):83–100.
Article PubMed PubMed Central Google Scholar
Yiannopoulou KG, Anastasiou AI, Zachariou V, Pelidou SH. Reasons for failed trials of disease-modifying treatments for alzheimer disease and their contribution in recent research. Biomedicines. 2019;7(4):97. https://doi.org/10.3390/biomedicines7040097.
van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, et al. Lecanemab in Early Alzheimer’s Disease. N Engl J Med. 2022;388(1):9–21.
Diniz BS. Immunotherapy in alzheimer's disease: from the bench to the bedside. Am J Geriatr Psychiatry. 2024;32(5):584–5.
Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, et al. Vascular dysfunction-The disregarded partner of Alzheimer’s disease. Alzheimers Dement. 2019;15(1):158–67.
Eisenmenger LB, Peret A, Famakin BM, Spahic A, Roberts GS, Bockholt JH, et al. Vascular contributions to Alzheimer’s disease. Transl Res. 2023;254:41–53.
Article CAS PubMed Google Scholar
Sur S, Lin Z, Li Y, Yasar S, Rosenberg P, Moghekar A, et al. Association of cerebrovascular reactivity and Alzheimer pathologic markers with cognitive performance. Neurology. 2020;95(8):e962–72.
Article CAS PubMed PubMed Central Google Scholar
Luckhaus C, Flüß MO, Wittsack HJ, Grass-Kapanke B, Jänner M, Khalili-Amiri R, et al. Detection of changed regional cerebral blood flow in mild cognitive impairment and early Alzheimer’s dementia by perfusion-weighted magnetic resonance imaging. Neuroimage. 2008;40(2):495–503.
Thomas B, Sheelakumari R, Kannath S, Sarma S, Menon RN. Regional Cerebral Blood Flow in the Posterior Cingulate and Precuneus and the Entorhinal Cortical Atrophy Score Differentiate Mild Cognitive Impairment and Dementia Due to Alzheimer Disease. AJNR Am J Neuroradiol. 2019;40(10):1658–64.
CAS PubMed PubMed Central Google Scholar
Montagne A, Nation DA, Pa J, Sweeney MD, Toga AW, Zlokovic BV. Brain imaging of neurovascular dysfunction in Alzheimer’s disease. Acta Neuropathol. 2016;131(5):687–707.
Article CAS PubMed PubMed Central Google Scholar
Swinford CG, Risacher SL, Vosmeier A, Deardorff R, Chumin EJ, Dzemidzic M, et al. Amyloid and tau pathology are associated with cerebral blood flow in a mixed sample of nondemented older adults with and without vascular risk factors for Alzheimer’s disease. Neurobiol Aging. 2023;130:103–13.
Article CAS PubMed PubMed Central Google Scholar
Swinford CG, Risacher SL, Wu YC, Apostolova LG, Gao S, Bice PJ, et al. Altered cerebral blood flow in older adults with Alzheimer’s disease: a systematic review. Brain Imaging Behav. 2023;17(2):223–56.
Iadecola C, Nedergaard M. Glial regulation of the cerebral microvasculature. Nat Neurosci. 2007;10(11):1369–76.
Article CAS PubMed Google Scholar
Kugler EC, Greenwood J, MacDonald RB. The “neuro-glial-vascular” unit: the role of glia in neurovascular unit formation and dysfunction. Frontiers in Cell and Developmental Biology. 2021;9: 732820.
Article PubMed PubMed Central Google Scholar
Soto-Rojas LO, Pacheco-Herrero M, Martínez-Gómez PA, Campa-Córdoba BB, Apátiga-Pérez R, Villegas-Rojas MM, et al. The neurovascular unit dysfunction in Alzheimer’s disease. Int J Mol Sci. 2021;22(4):2022.
Schaeffer S, Iadecola C. Revisiting the neurovascular unit. Nat Neurosci. 2021;24(9):1198–209.
Article CAS PubMed PubMed Central Google Scholar
Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV. The role of brain vasculature in neurodegenerative disorders. Nat Neurosci. 2018;21(10):1318–31.
Article CAS PubMed PubMed Central Google Scholar
Iadecola C. The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Neuron. 2017;96(1):17–42.
Article CAS PubMed PubMed Central Google Scholar
Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR Jr, Beckett LA, et al. Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer’s disease and mild cognitive impairment. Brain. 2014;137(Pt 5):1550–61.
Article PubMed PubMed Central Google Scholar
Lourenço CF, Santos RM, Barbosa RM, Cadenas E, Radi R, Laranjinha J. Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide. Free Radic Biol Med. 2014;73:421–9.
Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, et al. Capillary pericytes regulate cerebral blood flow in health and disease. Nature. 2014;508(7494):55–60.
Article CAS PubMed PubMed Central Google Scholar
Sweeney MD, Ayyadurai S, Zlokovic BV. Pericytes of the neurovascular unit: key functions and signaling pathways. Nat Neurosci. 2016;19(6):771–83.
Article CAS PubMed PubMed Central Google Scholar
Sagare AP, Bell RD, Zlokovic BV. Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med. 2012;2(10):a011452.
Koizumi K, Wang G, Park L. Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations. Cell Mol Neurobiol. 2016;36(2):155–65.
Article CAS PubMed Google Scholar
Wang D, Chen F, Han Z, Yin Z, Ge X, Lei P. Relationship Between Amyloid-β Deposition and Blood-Brain Barrier Dysfunction in Alzheimer’s Disease. Front Cell Neurosci. 2021;15: 695479.
Article CAS PubMed PubMed Central Google Scholar
Solis E Jr, Hascup KN, Hascup ER. Alzheimer’s Disease: The Link Between Amyloid-β and Neurovascular Dysfunction. J Alzheimers Dis. 2020;76(4):1179–98.
Article CAS PubMed PubMed Central Google Scholar
Huang Z, Wong LW, Su Y, Huang X, Wang N, Chen H, et al. Blood-brain barrier integrity in the pathogenesis of Alzheimer’s disease. Front Neuroendocrinol. 2020;59: 100857.
Article CAS PubMed Google Scholar
İş Ö, Wang X, Reddy JS, Min Y, Yilmaz E, Bhattarai P, et al. Gliovascular transcriptional perturbations in Alzheimer’s disease reveal molecular mechanisms of blood brain barrier dysfunction. Nat Commun. 2024;15(1):4758.
Article PubMed PubMed Central Google Scholar
Reddy JS, Allen M, Ho CC, Oatman SR, İş Ö, Quicksall ZS, et al. Genome-wide analysis identifies a novel LINC-PINT splice variant associa
留言 (0)