Research progress on N6-methyladenosine RNA modification in osteosarcoma: functions, mechanisms, and potential clinical applications

Messerschmitt PJ, et al. Osteosarcoma. J Am Acad Orthop Surg. 2009;17(8):515–27.

Article  PubMed  Google Scholar 

Mirabello L, Troisi RJ, Savage SA. International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons. Int J Cancer. 2009;125(1):229–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ottaviani G, Jaffe N. The etiology of osteosarcoma. Cancer Treat Res. 2009;152:15–32.

Article  PubMed  Google Scholar 

Ferguson JL, Turner SP. Bone cancer: diagnosis and treatment principles. Am Fam Physician. 2018;98(4):205–13.

PubMed  Google Scholar 

Wang D, et al. Multiregion sequencing reveals the genetic heterogeneity and evolutionary history of osteosarcoma and matched pulmonary metastases. Cancer Res. 2019;79(1):7–20.

Article  CAS  PubMed  Google Scholar 

Martin JW, Squire JA, Zielenska M. The genetics of osteosarcoma. Sarcoma. 2012;2012:627254.

Article  PubMed  PubMed Central  Google Scholar 

Ji Z, et al. Targeting signaling pathways in osteosarcoma: Mechanisms and clinical studies. MedComm. 2023;4(4):e308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marley K, Bracha S, Seguin B. Osteoprotegerin activates osteosarcoma cells that co-express RANK and RANKL. Exp Cell Res. 2015;338(1):32–8.

Article  CAS  PubMed  Google Scholar 

Moya IM, Halder G. Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine. Nat Rev Mol Cell Biol. 2019;20(4):211–26.

Article  CAS  PubMed  Google Scholar 

Behjati S, et al. Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma. Nat Commun. 2017;8:15936.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jafari F, et al. Osteosarcoma: a comprehensive review of management and treatment strategies. Ann Diagn Pathol. 2020;49: 151654.

Article  PubMed  Google Scholar 

Yang S, et al. m(6)A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat Commun. 2019;10(1):2782.

Article  PubMed  PubMed Central  Google Scholar 

Cao ZZ, et al. Gene identification and transcriptome analysis of low cadmium accumulation rice mutant (lcd1) in response to cadmium stress using MutMap and RNA-seq. BMC Plant Biol. 2019;19(1):1–13.

Article  Google Scholar 

Karthiya R, Khandelia P. m6A RNA methylation: ramifications for gene expression and human health. Mol Biotechnol. 2020;62(10):467–84.

Article  CAS  PubMed  Google Scholar 

Liu N, et al. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature. 2015;518(7540):560–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meyer KD, et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3’ UTRs and near stop codons. Cell. 2012;149(7):1635–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Zhang J. Human C-to-U coding RNA editing is largely nonadaptive. Mol Biol Evol. 2018;35(4):963–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou C, et al. Genome-wide maps of m6A circRNAs identify widespread and cell-type-specific methylation patterns that are distinct from mRNAs. Cell Rep. 2017;20(9):2262–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu B, et al. Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1. Nat Commun. 2018;9(1):420.

Article  PubMed  PubMed Central  Google Scholar 

Jayasree PJ, et al. Crosstalk between m6A RNA methylation and miRNA biogenesis in cancer: an unholy nexus. Mol Biotechnol. 2024;66(11):3042–58.

Article  CAS  PubMed  Google Scholar 

Kwok CT, et al. Genetic alterations of m(6)A regulators predict poorer survival in acute myeloid leukemia. J Hematol Oncol. 2017;10(1):39.

Article  PubMed  PubMed Central  Google Scholar 

Huang W, et al. Determination of DNA and RNA methylation in circulating tumor cells by mass spectrometry. Anal Chem. 2016;88(2):1378–84.

Article  CAS  PubMed  Google Scholar 

Huang Y, et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell. 2019;35(4):677-91.e10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, et al. Regulatory role of N6-methyladenosine (m(6)A) modification in osteosarcoma. Front Oncol. 2021;11: 683768.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou C, et al. N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1. EBioMedicine. 2020;59: 102955.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, et al. Dysregulated m6A-related regulators are associated with tumor metastasis and poor prognosis in osteosarcoma. Front Oncol. 2020;10:769.

Article  PubMed  PubMed Central  Google Scholar 

Murik O, et al. Topologies of N(6) -adenosine methylation (m(6) A) in land plant mitochondria and their putative effects on organellar gene expression. Plant J. 2020;101(6):1269–86.

Article  CAS  PubMed  Google Scholar 

Fu Y, et al. Gene expression regulation mediated through reversible m⁶A RNA methylation. Nat Rev Genet. 2014;15(5):293–306.

Article  CAS  PubMed  Google Scholar 

Jia G, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 2011;7(12):885–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng G, et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013;49(1):18–29.

Article  CAS  PubMed  Google Scholar 

Geuens T, Bouhy D, Timmerman V. The hnRNP family: insights into their role in health and disease. Hum Genet. 2016;135(8):851–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang L, et al. Knockout of OsNramp5 using the CRISPR/Cas9 system produces low Cd-accumulating indica rice without compromising yield. Sci Rep. 2017;7(1):14438.

Article  PubMed  PubMed Central 

留言 (0)

沒有登入
gif