Joham AE, Norman RJ, Stener-Victorin E, Legro RS, Franks S, Moran LJ, Boyle J, Teede HJ. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 2022;10(9):668–80.
Article CAS PubMed Google Scholar
Christ JP, Cedars MI. Current guidelines for diagnosing PCOS. Diagnostics (Basel). 2023;13(6):1113.
Article CAS PubMed Google Scholar
Hoeger KM, Dokras A, Piltonen T. Update on PCOS: consequences, challenges, and guiding treatment. J Clin Endocrinol Metab. 2021;106(3):e1071–83.
Rao P, Bhide P. Controversies in the diagnosis of polycystic ovary syndrome. Ther Adv Reprod Health. 2020;14:2633494120913032.
Article PubMed PubMed Central Google Scholar
Lai Q, Xiang W, Li Q, Zhang H, Li Y, Zhu G, Xiong C, Jin L. Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with polycystic ovary syndrome. Front Med. 2018;12(5):518–24.
Gharaei R, Alyasin A, Mahdavinezhad F, Samadian E, Ashrafnezhad Z, Amidi F. Randomized controlled trial of astaxanthin impacts on antioxidant status and assisted reproductive technology outcomes in women with polycystic ovarian syndrome. J Assist Reprod Genet. 2022;39(4):995–1008.
Article PubMed PubMed Central Google Scholar
Ardehjani NA, Agha-Hosseini M, Nashtaei MS, Khodarahmian M, Shabani M, Jabarpour M, Fereidouni F, Rastegar T, Amidi F. Resveratrol ameliorates mitochondrial biogenesis and reproductive outcomes in women with polycystic ovary syndrome undergoing assisted reproduction: a randomized, triple-blind, placebo-controlled clinical trial. J Ovarian Res. 2024;17(1):143.
Article CAS PubMed PubMed Central Google Scholar
Miller BH, Takahashi JS. Central circadian control of female reproductive function. Front Endocrinol (Lausanne). 2014;4:195.
Shao S, Zhao H, Lu Z, Lei X, Zhang Y. Circadian rhythms within the female HPG axis: from physiology to etiology. Endocrinology. 2021;162(8):bqab117.
Article PubMed PubMed Central Google Scholar
Zhang J, Liu J, Zhu K, Hong Y, Sun Y, Zhao X, Du Y, Chen ZJ. Effects of BMAL1-SIRT1-positive cycle on estrogen synthesis in human ovarian granulosa cells: an implicative role of BMAL1 in PCOS. Endocrine. 2016;53(2):574–84.
Article CAS PubMed Google Scholar
Kawamura T, Dai Y, Ono M, Kikuchi T, Yamanaka A, Ueno K, Kojima J, Fujiwara T, Daikoku T, Maida Y, Ando H, Fujiwara H, Kuji N, Nishi H. BMAL1 positively correlates with genes regulating steroidogenesis in human luteinized granulosa cells. Reproduction. 2024;167(2): e230225.
Wang W, Yin L, Bai L, Ma G, Zhao C, Xiang A, Pang W, Yang G, Chu G. Bmal1 interference impairs hormone synthesis and promotes apoptosis in porcine granulosa cells. Theriogenology. 2017;1(99):63–8.
Mereness AL, Murphy ZC, Forrestel AC, Butler S, Ko C, Richards JS, Sellix MT. Conditional deletion of Bmal1 in ovarian theca cells disrupts ovulation in female mice. Endocrinology. 2016;157(2):913–27.
Article CAS PubMed Google Scholar
Ono M, Ando H, Daikoku T, Fujiwara T, Mieda M, Mizumoto Y, Iizuka T, Kagami K, Hosono T, Nomura S, Toyoda N, Sekizuka-Kagami N, Maida Y, Kuji N, Nishi H, Fujiwara H. The circadian clock, nutritional signals and reproduction: a close relationship. Int J Mol Sci. 2023;24(2):1545.
Article CAS PubMed PubMed Central Google Scholar
Xu J, Li Y, Wang Y, Xu Y, Zhou C. Loss of Bmal1 decreases oocyte fertilization, early embryo development and implantation potential in female mice. Zygote. 2016;24(5):760–7.
Article CAS PubMed Google Scholar
Ono M, Toyoda N, Kagami K, Hosono T, Matsumoto T, Horike SI, Yamazaki R, Nakamura M, Mizumoto Y, Fujiwara T, Ando H, Fujiwara H, Daikoku T. Uterine deletion of Bmal1 impairs placental vascularization and induces intrauterine fetal death in mice. Int J Mol Sci. 2022;23(14):7637.
Article CAS PubMed PubMed Central Google Scholar
Lv S, Wang N, Ma J, Li WP, Chen ZJ, Zhang C. Impaired decidualization caused by downregulation of circadian clock gene BMAL1 contributes to human recurrent miscarriage. Biol Reprod. 2019;101(1):138–47.
Emori C, Sugiura K. Role of oocyte-derived paracrine factors in follicular development. Anim Sci J. 2014;85(6):627–33.
Article CAS PubMed PubMed Central Google Scholar
Sugiura K, Su YQ, Eppig JJ. Does bone morphogenetic protein 6 (BMP6) affect female fertility in the mouse? Biol Reprod. 2010;83(6):997–1004.
Article CAS PubMed PubMed Central Google Scholar
Song S, Ding W, Yao H, Wang L, Li B, Wang Y, Tang X, Zhang Y, Huang D, Xu D, Zhao Z. BMP6 promotes the secretion of 17 beta-estradiol and progesterone in goat ovarian granulosa cells. Animals (Basel). 2022;12(16):2132.
Wang L, Wang Y, Li B, Zhang Y, Song S, Ding W, Xu D, Zhao Z. BMP6 regulates AMH expression via SMAD1/5/8 in goat ovarian granulosa cells. Theriogenology. 2023;197:167–76.
Article CAS PubMed Google Scholar
Liu Y, Chen M, Zhao X, Ren X, Shao S, Zou M, Zhang L. Bone morphogenetic protein 6 expression in cumulus cells is negatively associated with oocyte maturation. Hum Fertil (Camb). 2021;24(4):290–7.
Article CAS PubMed Google Scholar
Khalaf M, Morera J, Bourret A, Reznik Y, Denoual C, Herlicoviez M, Mittre H, Benhaim A. BMP system expression in GCs from polycystic ovary syndrome women and the in vitro effects of BMP4, BMP6, and BMP7 on GC steroidogenesis. Eur J Endocrinol. 2013;168(3):437–44.
Article CAS PubMed Google Scholar
De Conto E, Matte U, Cunha-Filho JS. BMP-6 and SMAD4 gene expression is altered in cumulus cells from women with endometriosis-associated infertility. Acta Obstet Gynecol Scand. 2021;100(5):868–75.
Tasaki H, Zhao L, Isayama K, et al. Inhibitory role of REV-ERBα in the expression of bone morphogenetic protein gene family in rat uterus endometrium stromal cells. Am J Physiol Cell Physiol. 2015;308(7):528–38.
Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19–25.
Jia R, Liu Y, Jiang R, Zhu X, Zhou L, Chen P, et al. The optimal number of oocytes retrieved from PCOS patients receiving IVF to obtain associated with maximum cumulative live birth rate and live birth after fresh embryo transfer. Front Endocrinol (Lausanne). 2022;23(13):878214.
Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril. 2000;73(6):1155–8.
Article CAS PubMed Google Scholar
Shen Q, Liu Y, Li H, Zhang L. Effect of mitophagy in oocytes and granulosa cells on oocyte quality. Biol Reprod. 2021;104(2):294–304.
Gong Y, Luo S, Fan P, Zhu H, Li Y, Huang W. Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome. Reprod Biol Endocrinol. 2020;18(1):121.
Article CAS PubMed PubMed Central Google Scholar
Liu Y, Liu H, Li Z, Fan H, Yan X, Liu X, Xuan J, Feng D, Wei X. The release of peripheral immune inflammatory cytokines promote an inflammatory cascade in PCOS patients via altering the follicular microenvironment. Front Immunol. 2021;12: 685724.
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