Prehospital lactate analysis in suspected sepsis improves detection of patients with increased mortality risk: an observational study

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–10.

Article  PubMed  PubMed Central  Google Scholar 

Rhee C, Dantes R, Epstein L, Murphy DJ, Seymour CW, Iwashyna TJ, et al. Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009–2014. JAMA. 2017;318(13):1241–9.

Article  PubMed  PubMed Central  Google Scholar 

Andersson M, Ostholm-Balkhed A, Fredrikson M, Holmbom M, Hallgren A, Berg S, et al. Delay of appropriate antibiotic treatment is associated with high mortality in patients with community-onset sepsis in a Swedish setting. Eur J Clin Microbiol Infect Dis. 2019;38(7):1223–34.

Article  PubMed  PubMed Central  Google Scholar 

Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34(6):1589–96.

Article  PubMed  Google Scholar 

Ferrer R, Martin-Loeches I, Phillips G, Osborn TM, Townsend S, Dellinger RP, et al. Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program. Crit Care Med. 2014;42(8):1749–55.

Article  PubMed  Google Scholar 

Seymour CW, Gesten F, Prescott HC, Friedrich ME, Iwashyna TJ, Phillips GS, et al. Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med. 2017;376(23):2235–44.

Article  PubMed  PubMed Central  Google Scholar 

Pak TR, Young J, McKenna CS, Agan A, DelloStritto L, Filbin MR, et al. Risk of misleading conclusions in observational studies of time-to-antibiotics and mortality in suspected sepsis. Clin Infect Dis. 2023;77(11):1534–43.

Article  PubMed  PubMed Central  Google Scholar 

Widgren BR, Jourak M. Medical emergency triage and treatment system (METTS): a new protocol in primary triage and secondary priority decision in emergency medicine. J Emerg Med. 2011;40(6):623–8.

Article  PubMed  Google Scholar 

Physicians RCo. National Ealy Warning Score (NEWS 2) 2012 [Available from: https://www.rcplondon.ac.uk/projects/outputs/national-early-warning-score-news-2.

Lindskou TA, Ward LM, Sovso MB, Mogensen ML, Christensen EF. Prehospital early warning scores to predict mortality in patients using ambulances. JAMA Netw Open. 2023;6(8):e2328128.

Article  PubMed  PubMed Central  Google Scholar 

Malmer G, Ahlberg R, Svensson P, Af Ugglas B, Westerlund E. Age in addition to RETTS triage priority substantially improves 3-day mortality prediction in emergency department patients: a multi-center cohort study. Scand J Trauma Resusc Emerg Med. 2023;31(1):55.

Article  PubMed  PubMed Central  Google Scholar 

Sanguanwit P, Thudsaringkarnsakul W, Angkoontassaneeyarat C, Watcharakitpaisan S. Comparison of qSOFA, SIRS, NEWS and REWS scores in predicting severity and 28-day mortality of older suspected sepsis cases; a prognostic accuracy study. Arch Acad Emerg Med. 2024;12(1):e3.

PubMed  Google Scholar 

Wallgren UM, Antonsson VE, Castren MK, Kurland L. Longer time to antibiotics and higher mortality among septic patients with non-specific presentations–a cross sectional study of Emergency Department patients indicating that a screening tool may improve identification. Scand J Trauma Resusc Emerg Med. 2016;24:1.

Article  PubMed  PubMed Central  Google Scholar 

Shankar-Hari M, Phillips GS, Levy ML, Seymour CW, Liu VX, Deutschman CS, et al. Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):775–87.

Article  PubMed  PubMed Central  Google Scholar 

Hernandez G, Castro R, Romero C, de la Hoz C, Angulo D, Aranguiz I, et al. Persistent sepsis-induced hypotension without hyperlactatemia: is it really septic shock? J Crit Care. 2011;26(4):435–514.

Article  Google Scholar 

Gotmaker R, Peake SL, Forbes A, Bellomo R, Investigators A. Mortality is greater in septic patients with hyperlactatemia than with refractory hypotension. Shock. 2017;48(3):294–300.

Article  PubMed  Google Scholar 

Shetty A, MacDonald SP, Williams JM, van Bockxmeer J, de Groot B, Esteve Cuevas LM, et al. Lactate >/=2 mmol/L plus qSOFA improves utility over qSOFA alone in emergency department patients presenting with suspected sepsis. Emerg Med Australas. 2017;29(6):626–34.

Article  PubMed  Google Scholar 

Baumann BM, Greenwood JC, Lewis K, Nuckton TJ, Darger B, Shofer FS, et al. Combining qSOFA criteria with initial lactate levels: Improved screening of septic patients for critical illness. Am J Emerg Med. 2020;38(5):883–9.

Article  PubMed  Google Scholar 

Durantez-Fernandez C, Martin-Conty JL, Polonio-Lopez B, Castro Villamor MA, Maestre-Miquel C, Vinuela A, et al. Lactate improves the predictive ability of the National Early Warning Score 2 in the emergency department. Aust Crit Care. 2022;35(6):677–83.

Article  PubMed  Google Scholar 

Kumar A, Abbenbroek B, Delaney A, Hammond N, Grattan S, Finfer S. Sepsis triggers and tools to support early identification in healthcare settings: an integrative review. Aust Crit Care. 2023;36:1117.

Article  PubMed  Google Scholar 

Martin-Rodriguez F, Lopez-Izquierdo R, Delgado Benito JF, Sanz-Garcia A, Del Pozo VC, Castro Villamor MA, et al. Prehospital point-of-care lactate increases the prognostic accuracy of national early warning score 2 for early risk stratification of mortality: results of a multicenter, observational study. J Clin Med. 2020;9(4):1156.

Article  PubMed  PubMed Central  Google Scholar 

Olander A, Magnusson C, Sundler AJ, Bremer A, Andersson H, Herlitz J, et al. Prediction of the risk of sepsis by using analysis of plasma glucose and serum lactate in ambulance services: a prospective study. Prehosp Disaster Med. 2023;38(2):160–7.

Article  PubMed  Google Scholar 

Magnusson C, Herlitz J, Axelsson C, Hoglind R, Lokholm E, Hornfeldt TH, et al. Added predictive value of prehospital measurement of point-of-care lactate in an adult general EMS population in Sweden: a multi-centre observational study. Scand J Trauma Resusc Emerg Med. 2024;32(1):72.

Article  PubMed  PubMed Central  Google Scholar 

Wallgren UM, Sjolin J, Jarnbert-Pettersson H, Kurland L. The predictive value of variables measurable in the ambulance and the development of the Predict Sepsis screening tools: a prospective cohort study. Scand J Trauma Resusc Emerg Med. 2020;28(1):59.

Article  PubMed  PubMed Central  Google Scholar 

Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173(6):676–82.

Article  PubMed  Google Scholar 

Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med. 1996;22(7):707–10.

Article  PubMed  Google Scholar 

Rhee C, Zhang Z, Kadri SS, Murphy DJ, Martin GS, Overton E, et al. Sepsis surveillance using adult sepsis events simplified eSOFA criteria versus sepsis-3 sequential organ failure assessment criteria. Crit Care Med. 2019;47(3):307–14.

Article  PubMed  PubMed Central  Google Scholar 

Aakre C, Franco PM, Ferreyra M, Kitson J, Li M, Herasevich V. Prospective validation of a near real-time EHR-integrated automated SOFA score calculator. Int J Med Inform. 2017;103:1–6.

Article  PubMed  Google Scholar 

Valik JK, Mellhammar L, Sunden-Cullberg J, Ward L, Unge C, Dalianis H, et al. Peripheral oxygen saturation facilitates assessment of respiratory dysfunction in the sequential organ failure assessment score with implications for the sepsis-3 criteria. Crit Care Med. 2022;50(3):e272–83.

Article  PubMed  Google Scholar 

National Institute for Health and Care Excellence. Suspected sepsis: recognition, diagnosis and early management. (A) Evidence reviews for stratifying risk of severe illness or death from sepsis [Internet] Manchester: National Institute for Health and Care Excellence; 2024 [Available from: https://www.nice.org.uk/guidance/ng51/evidence/a-stratifying-risk-of-severe-illness-or-death-from-sepsis-pdf-13307978558.

Mellhammar L, Wollter E, Dahlberg J, Donovan B, Olseen CJ, Wiking PO, et al. Estimating sepsis incidence using administrative data and clinical medical record review. JAMA Netw Open. 2023;6(8):e2331168.

Article  PubMed  PubMed Central  Google Scholar 

Hamilton F, Arnold D, Baird A, Albur M, Whiting P. Early warning scores do not accurately predict mortality in sepsis: a meta-analysis and systematic review of the literature. J Infect. 2018;76(3):241–8.

Article  PubMed  Google Scholar 

Goodacre S, Sutton L, Thomas B, Hawksworth O, Iftikhar K, Croft S, et al. Prehospital early warning scores for adults with suspected sepsis: retrospective diagnostic cohort study. Emerg Med J. 2023;40(11):768–76.

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