Schulman S, Ageno W, Konstantinides SV. Venous thromboembolism: Past, present and future. Thromb Haemost. 2017;117(7):1219–29.
Becattini C, Vedovati MC, Ageno W, Dentali F, Agnelli G. Incidence of arterial cardiovascular events after venous thromboembolism: a systematic review and a meta-analysis. J Thromb Haemost. 2010;8(5):891–7.
Kahn SR. The post-thrombotic syndrome. Hematology Am Soc Hematol Educ Program. 2016;2016(1):413–8.
Article PubMed PubMed Central Google Scholar
Cohen D. Current issues in venous thromboembolism. Postgrad Med. 2021;133(sup1):1–2.
Xu Y, Sun Z. Molecular basis of Klotho: from gene to function in aging. Endocr Rev. 2015;36(2):174–93.
Article PubMed PubMed Central Google Scholar
Lanzani C, Citterio L, Vezzoli G. Klotho: a link between cardiovascular and non-cardiovascular mortality. Clin Kidney J. 2020;13(6):926–32.
Article PubMed PubMed Central Google Scholar
Xu JP, Zeng RX, He MH, Lin SS, Guo LH, Zhang MZ. Associations Between Serum Soluble alpha-Klotho and the Prevalence of Specific Cardiovascular Disease. Front Cardiovasc Med. 2022;9: 899307.
Article PubMed PubMed Central Google Scholar
Lee J, Kim D, Lee HJ, Choi JY, Min JY, Min KB. Association between serum klotho levels and cardiovascular disease risk factors in older adults. BMC Cardiovasc Disord. 2022;22(1):442.
Article PubMed PubMed Central Google Scholar
Sun X, Chen L, He Y, Zheng L. Circulating alpha-Klotho Levels in Relation to Cardiovascular Diseases: A Mendelian Randomization Study. Front Endocrinol (Lausanne). 2022;13: 842846.
Saghazadeh A, Rezaei N. Inflammation as a cause of venous thromboembolism. Crit Rev Oncol Hematol. 2016;99:272–85.
Wang Q, Zennadi R: Oxidative Stress and Thrombosis during Aging: The Roles of Oxidative Stress in RBCs in Venous Thrombosis. Int J Mol Sci 2020, 21(12).
Davey Smith G, Hemani G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet. 2014;23(R1):R89-98.
Article PubMed PubMed Central Google Scholar
Davies NM, Holmes MV, Davey Smith G. Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ. 2018;362: k601.
Article PubMed PubMed Central Google Scholar
Bowden J, Del Greco MF, Minelli C, Zhao Q, Lawlor DA, Sheehan NA, Thompson J, Davey Smith G. Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption. Int J Epidemiol. 2019;48(3):728–42.
Navarro-Gonzalez JF, Donate-Correa J. Muros de Fuentes M, Perez-Hernandez H, Martinez-Sanz R, Mora-Fernandez C: Reduced Klotho is associated with the presence and severity of coronary artery disease. Heart. 2014;100(1):34–40.
Mizia-Stec K, Wieczorek J, Polak M, Wybraniec MT, Wozniak-Skowerska I, Hoffmann A, Nowak S, Wikarek M, Wnuk-Wojnar A, Chudek J, et al. Lower soluble Klotho and higher fibroblast growth factor 23 serum levels are associated with episodes of atrial fibrillation. Cytokine. 2018;111:106–11.
Chen CD, Podvin S, Gillespie E, Leeman SE, Abraham CR. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A. 2007;104(50):19796–801.
Article PubMed PubMed Central Google Scholar
Ligumsky H, Merenbakh-Lamin K, Keren-Khadmy N, Wolf I, Rubinek T. The role of alpha-klotho in human cancer: molecular and clinical aspects. Oncogene. 2022;41(40):4487–97.
Martin-Nunez E, Perez-Castro A, Tagua VG, Hernandez-Carballo C, Ferri C, Perez-Delgado N, Rodriguez-Ramos S, Cerro-Lopez P, Lopez-Castillo A, Delgado-Molinos A, et al. Klotho expression in peripheral blood circulating cells is associated with vascular and systemic inflammation in atherosclerotic vascular disease. Sci Rep. 2022;12(1):8422.
Article PubMed PubMed Central Google Scholar
Saghazadeh A, Hafizi S, Rezaei N. Inflammation in venous thromboembolism: Cause or consequence? Int Immunopharmacol. 2015;28(1):655–65.
Munzer P, Negro R, Fukui S, di Meglio L, Aymonnier K, Chu L, Cherpokova D, Gutch S, Sorvillo N, Shi L, et al. NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions. Front Immunol. 2021;12: 683803.
Article PubMed PubMed Central Google Scholar
Zhang Y, Cui J, Zhang G, Wu C, Abdel-Latif A, Smyth SS, Shiroishi T, Mackman N, Wei Y, Tao M, et al. Inflammasome activation promotes venous thrombosis through pyroptosis. Blood Adv. 2021;5(12):2619–23.
Article PubMed PubMed Central Google Scholar
Campos J, Ponomaryov T, De Prendergast A, Whitworth K, Smith CW, Khan AO, Kavanagh D, Brill A. Neutrophil extracellular traps and inflammasomes cooperatively promote venous thrombosis in mice. Blood Adv. 2021;5(9):2319–24.
Article PubMed PubMed Central Google Scholar
Krick S, Grabner A, Baumlin N, Yanucil C, Helton S, Grosche A, Sailland J, Geraghty P, Viera L, Russell DW et al: Fibroblast growth factor 23 and Klotho contribute to airway inflammation. Eur Respir J 2018, 52(1).
Gergei I, Zheng J, Andlauer TFM, Brandenburg V, Mirza-Schreiber N, Muller-Myhsok B, Kramer BK, Richard D, Falk L, Moverare-Skrtic S, et al. GWAS meta-analysis followed by Mendelian randomization revealed potential control mechanisms for circulating alpha-Klotho levels. Hum Mol Genet. 2022;31(5):792–802.
Federico LE, Johnson TM, England BR, Wysham KD, George MD, Sauer B, Hamilton BC, Hunter CD, Duryee MJ, Thiele GM, et al. Circulating Adipokines and Associations With Incident Cardiovascular Disease in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2023;75(4):768–77.
Zee RY, Michaud SE, Ridker PM. Mean telomere length and risk of incident venous thromboembolism: a prospective, nested case-control approach. Clin Chim Acta. 2009;406(1–2):148–50.
Article PubMed PubMed Central Google Scholar
Vostatek R, Hohensinner P, Nopp S, Haider P, Englisch C, Pointner J, Pabinger I, Ay C. Association of telomere length and mitochondrial DNA copy number, two biomarkers of biological aging, with the risk of venous thromboembolism. Thromb Res. 2023;223:168–73.
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