Phillippe HM. Overview of venous thromboembolism. Am J Manag Care. 2017;23(20 Suppl):S376–82.

PubMed  Google Scholar 

Heit JA. Epidemiology of venous thromboembolism. Nat Rev Cardiol. 2015;12(8):464–74.

Article  PubMed  PubMed Central  Google Scholar 

Raskob GE, Angchaisuksiri P, Blanco AN, Buller H, Gallus A, Hunt BJ, et al. Thrombosis: a major contributor to global disease burden. Arterioscler Thromb Vasc Biol. 2014;34(11):2363–71.

Article  CAS  PubMed  Google Scholar 

Heit JA, Ashrani A, Crusan DJ, McBane RD, Petterson TM, Bailey KR. Reasons for the persistent incidence of venous thromboembolism. Thromb Haemost. 2017;117(2):390–400.

Article  PubMed  Google Scholar 

Nopp S, Ay C. Bleeding Risk Assessment in Patients with Venous Thromboembolism. Hamostaseologie. 2021;41(4):267–74.

Article  PubMed  Google Scholar 

Klok FA, Kooiman J, Huisman MV, Konstantinides S, Lankeit M. Predicting anticoagulant-related bleeding in patients with venous thromboembolism: a clinically oriented review. Eur Respir J. 2015;45(1):201–10.

Article  CAS  PubMed  Google Scholar 

Khan F, Tritschler T, Kimpton M, Wells PS, Kearon C, Weitz JI, et al. Long-Term Risk for Major Bleeding During Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism : A Systematic Review and Meta-analysis. Ann Intern Med. 2021;174(10):1420–9.

Article  PubMed  Google Scholar 

Benham AM. The protein disulfide isomerase family: key players in health and disease. Antioxid Redox Signal. 2012;16(8):781–9.

Article  CAS  PubMed  Google Scholar 

Hatahet F, Ruddock LW. Protein disulfide isomerase: a critical evaluation of its function in disulfide bond formation. Antioxid Redox Signal. 2009;11(11):2807–50.

Article  CAS  PubMed  Google Scholar 

Jordan PA, Stevens JM, Hubbard GP, Barrett NE, Sage T, Authi KS, et al. A role for the thiol isomerase protein ERP5 in platelet function. Blood. 2005;105(4):1500–7.

Article  CAS  PubMed  Google Scholar 

Holbrook LM, Sasikumar P, Stanley RG, Simmonds AD, Bicknell AB, Gibbins JM. The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function. J Thromb Haemost. 2012;10(2):278–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holbrook LM, Sandhar GK, Sasikumar P, Schenk MP, Stainer AR, Sahli KA, et al. A humanized monoclonal antibody that inhibits platelet-surface ERp72 reveals a role for ERp72 in thrombosis. J Thromb Haemost. 2018;16(2):367–77.

Article  PubMed  Google Scholar 

Cho J, Furie BC, Coughlin SR, Furie B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest. 2008;118(3):1123–31.

CAS  PubMed  PubMed Central  Google Scholar 

Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, et al. The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis. J Clin Invest. 2015;125(12):4391–406.

Article  PubMed  PubMed Central  Google Scholar 

Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, et al. The disulfide isomerase ERp72 supports arterial thrombosis in mice. Blood. 2017;130(6):817–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou J, Wu Y, Rauova L, Koma G, Wang L, Poncz M, et al. A novel role for endoplasmic reticulum protein 46 (ERp46) in platelet function and arterial thrombosis in mice. Blood. 2022;139(13):2050–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao Z, Wang Y, Yang A, Lu Y, Yan X, Peng M, et al. A novel role for thioredoxin-related transmembrane protein TMX4 in platelet activation and thrombus formation. J Thromb Haemost. 2024:S1538-7836(24):00549-X.

Koupenova M, Kehrel BE, Corkrey HA, Freedman JE. Thrombosis and platelets: an update. Eur Heart J. 2017;38(11):785–91.

CAS  PubMed  Google Scholar 

Alanen HI, Williamson RA, Howard MJ, Lappi AK, Jäntti HP, Rautio SM, et al. Functional characterization of ERp18, a new endoplasmic reticulum-located thioredoxin superfamily member. J Biol Chem. 2003;278(31):28912–20.

Article  CAS  PubMed  Google Scholar 

Rowe ML, Ruddock LW, Kelly G, Schmidt JM, Williamson RA, Howard MJ. Solution structure and dynamics of ERp18, a small endoplasmic reticulum resident oxidoreductase. Biochemistry. 2009;48(21):4596–606.

Article  CAS  PubMed  Google Scholar 

Jeong W, Lee DY, Park S, Rhee SG. ERp16, an endoplasmic reticulum-resident thiol-disulfide oxidoreductase: biochemical properties and role in apoptosis induced by endoplasmic reticulum stress. J Biol Chem. 2008;283(37):25557–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Yang A, Zhao Z, Chen F, Yan X, Han Y, et al. Protein disulfide isomerase is essential for spermatogenesis in mice. JCI Insight. 2024;9(12):e177743.

Zhou J, Wu Y, Wang L, Rauova L, Hayes VM, Poncz M, et al. The disulfide isomerase ERp57 is required for fibrin deposition in vivo. J Thromb Haemost. 2014;12(11):1890–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012;209(4):819–35.

Article  Google Scholar 

Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, et al. Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost. 2012;10(1):136–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raturi A, Mutus B. Characterization of redox state and reductase activity of protein disulfide isomerase under different redox environments using a sensitive fluorescent assay. Free Radic Biol Med. 2007;43(1):62–70.

Article  CAS  PubMed  Google Scholar 

Mackman N. New insights into the mechanisms of venous thrombosis. J Clin Invest. 2012;122(7):2331–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michels A, Dwyer CN, Mewburn J, Nesbitt K, Kawecki C, Lenting P, et al. von Willebrand Factor Is a Critical Mediator of Deep Vein Thrombosis in a Mouse Model of Diet-Induced Obesity. Arterioscler Thromb Vasc Biol. 2020;40(12):2860–74.

Article  CAS  PubMed  Google Scholar 

Brill A, Fuchs TA, Chauhan AK, Yang JJ, De Meyer SF, Köllnberger M, et al. von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models. Blood. 2011;117(4):1400–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou J, May L, Liao P, Gross PL, Weitz JI. Inferior vena cava ligation rapidly induces tissue factor expression and venous thrombosis in rats. Arterioscler Thromb Vasc Biol. 2009;29(6):863–9.

Article  CAS  PubMed  Google Scholar 

Oka OB, van Lith M, Rudolf J, Tungkum W, Pringle MA, Bulleid NJ. ERp18 regulates activation of ATF6α during unfolded protein response. Embo j. 2019;38(15): e100990.

Article  PubMed  PubMed Central  Google Scholar 

Zifkos K, Bochenek ML, Gogiraju R, Robert S, Pedrosa D, Kiouptsi K, et al. Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation. Circ Res. 2024;134(10):e93–111.

Article  CAS  PubMed  Google Scholar 

Butera D, Passam F, Ju L, Cook KM, Woon H, Aponte-Santamaría C, et al. Autoregulation of von Willebrand factor function by a disulfide bond switch. Sci Adv. 2018;4(2):eaaq1477.