Improving timing resolution of BGO for TOF-PET: a comparative analysis with and without deep learning

Gong K, Berg E, Cherry SR, Qi J. Machine learning in PET: From photon detection to quantitative image reconstruction. Proc IEEE. 2020;108(1):51–68. https://doi.org/10.1109/jproc.2019.2936809.

Article  CAS  Google Scholar 

Conti M, Bendriem B. The new opportunities for high time resolution clinical TOF PET. Clin Transl Imaging. 2019;7(2):139–47. https://doi.org/10.1007/s40336-019-00316-5.

Article  Google Scholar 

Lecoq P, Morel C, Prior JO, Visvikis D, Gundacker S, Auffray E, et al. Roadmap toward the 10 ps time-of-flight PET challenge. Phys Med Biol. 2020;65(21):21RM01. https://doi.org/10.1088/1361-6560/ab9500.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schaart DR, Schramm G, Nuyts J, Surti S. Time of flight in perspective: instrumental and computational aspects of time resolution in positron emission tomography. IEEE Trans Radiat Plasma Med Sci. 2021;5(5):598–618. https://doi.org/10.1109/trpms.2021.3084539.

Article  PubMed  PubMed Central  Google Scholar 

Schaart DR. Physics and technology of time-of-flight PET detectors. Phys Med Biol. 2021;66(9):09TR01. https://doi.org/10.1088/1361-6560/abee56.

Article  CAS  Google Scholar 

Lecoq P, Gonzalez AJ, Auffray E, Konstantinou G, Nuyts J, Prior JO, et al. Fast timing in medical imaging. IEEE Trans Radiat Plasma Med Sci. 2023;7(5):429–52. https://doi.org/10.1109/trpms.2023.3259464.

Article  Google Scholar 

Gundacker S, Turtos RM, Kratochwil N, Pots RH, Paganoni M, Lecoq P, et al. Experimental time resolution limits of modern SiPMs and TOF-PET detectors exploring different scintillators and Cherenkov emission. Phys Med Biol. 2020;65(2):025001. https://doi.org/10.1088/1361-6560/ab63b4.

Article  CAS  PubMed  Google Scholar 

Piemonte C, Acerbi F, Ferri A, Gola A, Paternoster G, Regazzoni V, et al. Performance of NUV-HD silicon photomultiplier technology. IEEE Trans Electron Dev. 2016;63(3):1111–6. https://doi.org/10.1109/ted.2016.2516641.

Article  CAS  Google Scholar 

Gola A, Acerbi F, Capasso M, Marcante M, Mazzi A, Paternoster G, et al. NUV-sensitive silicon photomultiplier technologies developed at Fondazione Bruno Kessler. Sensors. 2019;19(2):308. https://doi.org/10.3390/s19020308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cates JW, Gundacker S, Auffray E, Lecoq P, Levin CS. Improved single photon time resolution for analog SiPMs with front end readout that reduces influence of electronic noise. Phys Med Biol. 2018;63(18):185022. https://doi.org/10.1088/1361-6560/aadbcd.

Article  CAS  PubMed  Google Scholar 

Gundacker S, Turtos RM, Auffray E, Paganoni M, Lecoq P. High-frequency SiPM readout advances measured coincidence time resolution limits in TOF-PET. Phys Med Biol. 2019;64(5):055012. https://doi.org/10.1088/1361-6560/aafd52.

Article  PubMed  Google Scholar 

Merzi S, Brunner SE, Gola A, Inglese A, Mazzi A, Paternoster G, et al. NUV-HD SiPMs with metal-filled trenches. J Instrum. 2023;18(05):P05040. https://doi.org/10.1088/1748-0221/18/05/p05040.

Article  CAS  Google Scholar 

Nadig V, Herweg K, Chou MMC, Lin JWC, Chin E, Li CA, et al. Timing advances of commercial divalent-ion co-doped LYSO: Ce and SiPMs in sub-100 ps time-of-flight positron emission tomography. Phys Med Biol. 2023;68(7):075002. https://doi.org/10.1088/1361-6560/acbde4.

Article  CAS  Google Scholar 

Kratochwil N, Gundacker S, Lecoq P, Auffray E. Pushing Cherenkov PET with BGO via coincidence time resolution classification and correction. Phys Med Biol. 2020;65(11):115004. https://doi.org/10.1088/1361-6560/ab87f9.

Article  CAS  PubMed  Google Scholar 

Kratochwil N, Auffray E, Gundacker S. Exploring Cherenkov emission of BGO for TOF-PET. IEEE Trans Radiat Plasma Med Sci. 2021;5(5):619–29. https://doi.org/10.1109/trpms.2020.3030483.

Article  Google Scholar 

Gonzalez-Montoro A, Pourashraf S, Cates JW, Levin CS. Cherenkov radiation-based coincidence time resolution measurements in BGO scintillators. Front Phys. 2022;10:384. https://doi.org/10.3389/fphy.2022.816384.

Article  Google Scholar 

Gundacker S, Borghi G, Cherry SR, Gola A, Lee D, Merzi S, et al. On timing-optimized SiPMs for Cherenkov detection to boost low cost time-of-flight PET. Phys Med Biol. 2023;68(16): 165016. https://doi.org/10.1088/1361-6560/ace8ee.

Article  PubMed Central  Google Scholar 

Berg E, Roncali E, Hutchcroft W, Qi J, Cherry SR. Improving depth, energy and timing estimation in PET detectors with deconvolution and maximum likelihood pulse shape discrimination. IEEE Trans Med Imaging. 2016;35(11):2436–46. https://doi.org/10.1109/tmi.2016.2577539.

Article  PubMed  PubMed Central  Google Scholar 

Ruiz-Gonzalez M, Bora V, Furenlid LR. Maximum-likelihood estimation of scintillation pulse timing. IEEE Trans Radiat Plasma Med Sci. 2018;2(1):1–6. https://doi.org/10.1109/trpms.2017.2765316.

Article  PubMed  Google Scholar 

Loignon-Houle F, Gundacker S, Toussaint M, Camirand Lemyre F, Auffray E, Fontaine R, et al. DOI estimation through signal arrival time distribution: a theoretical description including proof of concept measurements. Phys Med Biol. 2021;66(9): 095015. https://doi.org/10.1088/1361-6560/abf604.

Article  CAS  Google Scholar 

Lemaire W, Nolet F, Dubois F, Therrien AC, Pratte JF, Fontaine R. Embedded time of arrival estimation for digital silicon photomultipliers with in-pixel TDCs. Nucl Instrum Methods Phys Res A. 2020;959:163538. https://doi.org/10.1016/j.nima.2020.163538.

Article  CAS  Google Scholar 

Berg E, Cherry SR. Using convolutional neural networks to estimate time-of-flight from PET detector waveforms. Phys Med Biol. 2018;63(2):02LT01. https://doi.org/10.1088/1361-6560/aa9dc5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kwon SI, Ota R, Berg E, Hashimoto F, Nakajima K, Ogawa I, et al. Ultrafast timing enables reconstruction-free positron emission imaging. Nat Photonics. 2021;15(12):914–8. https://doi.org/10.1038/s41566-021-00871-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Onishi Y, Hashimoto F, Ote K, Ota R. Unbiased TOF estimation using leading-edge discriminator and convolutional neural network trained by single-source-position waveforms. Phys Med Biol. 2022;67(4):04NT01. https://doi.org/10.1088/1361-6560/ac508f.

Article  CAS  Google Scholar 

Brunner SE, Gruber L, Marton J, Suzuki K, Hirtl A. Studies on the Cherenkov effect for improved time resolution of TOF-PET. IEEE Trans Nucl Sci. 2014;61(1):443–7. https://doi.org/10.1109/tns.2013.2281667.

Article  CAS  Google Scholar 

Brunner SE, Schaart DR. BGO as a hybrid scintillator / Cherenkov radiator for cost-effective time-of-flight PET. Phys Med Biol. 2017;62(11):4421–39. https://doi.org/10.1088/1361-6560/aa6a49.

Article  CAS  PubMed  Google Scholar 

Arino-Estrada G, Roncali E, Selfridge AR, Du J, Glodo J, Shah KS, et al. Study of Čerenkov light emission in the semiconductors TlBr and TlCl for TOF-PET. IEEE Trans Radiat Plasma Med Sci. 2021;5(5):630–7. https://doi.org/10.1109/trpms.2020.3024032.

Article  PubMed  Google Scholar 

Kratochwil N, Gundacker S, Auffray E. A roadmap for sole Cherenkov radiators with SiPMs in TOF-PET. Phys Med Biol. 2021;66(19): 195001. https://doi.org/10.1088/1361-6560/ac212a.

Article  CAS  Google Scholar 

Terragni G, Pizzichemi M, Roncali E, Cherry SR, Glodo J, Shah K, et al. Time resolution studies of thallium based Cherenkov semiconductors. Front Phys. 2022;10:27. https://doi.org/10.3389/fphy.2022.785627.

Article  Google Scholar 

Kratochwil N, Roncali E, Cates JW, Arino-Estrada G. Timing perspective with dual-ended high-frequency SiPM readout for TOF-PET. In: 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD); 2024. p. 1-1. Available from: http://dx.doi.org/10.1109/NSS/MIC/RTSD57108.2024.10655496.

Nuyts J, Defrise M, Gundacker S, Roncali E, Lecoq P. The SNR of positron emission data With Gaussian and non-Gaussian time-of-flight kernels, with application to prompt photon coincidence. IEEE Trans Med Imag. 2023;42(5):1254–64. https://doi.org/10.1109/tmi.2022.3225433.

Article  Google Scholar 

Loignon-Houle F, Toussaint M, Bertrand É, Lemyre FC, Lecomte R. Timing estimation and limits in TOF-PET detectors producing prompt photons. IEEE Trans Rad P

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