Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA. 2001;285(18):2370–5.

Article  CAS  PubMed  Google Scholar 

Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991;22(8):983–8.

Article  CAS  PubMed  Google Scholar 

Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med. 2007;146(12):857–67.

Article  PubMed  Google Scholar 

Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42(5):373–498.

Article  PubMed  Google Scholar 

Glikson M, Wolff R, Hindricks G, Mandrola J, Camm AJ, Lip GYH, et al. EHRA/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion - an update. EuroIntervention. 2020;15(13):1133–80.

Article  PubMed  Google Scholar 

Lakkireddy D, Thaler D, Ellis CR, Swarup V, Sondergaard L, Carroll J, et al. Amplatzer Amulet Left Atrial Appendage Occluder Versus Watchman Device for Stroke Prophylaxis (Amulet IDE): A Randomized. Controlled Trial Circulation. 2021;144(19):1543–52.

PubMed  Google Scholar 

Bai Y, Tang X, Xu X, Zhao X, Xu Y, Chen W, et al. A newly designed disk-lobe occluder with isogenous barbs for left atrial appendage closure: Initial multicenter experience. Frontiers in cardiovascular medicine. 2022;9: 974994.

Article  PubMed  PubMed Central  Google Scholar 

Tang X, Zhang Z, Wang F, Bai Y, Xu X, Huang X, et al. Percutaneous Left Atrial Appendage Closure With LACBES(®) Occluder - A Preclinical Feasibility Study. Circ J. 2017;82(1):87–92.

Article  PubMed  Google Scholar 

Hemam ME, Kuroki K, Schurmann PA, Dave AS, Rodríguez DA, Sáenz LC, et al. Left atrial appendage closure with the Watchman device using intracardiac vs transesophageal echocardiography: Procedural and cost considerations. Heart Rhythm. 2019;16(3):334–42.

Article  PubMed  PubMed Central  Google Scholar 

Kleinecke C, Yu J, Neef P, Buffle E, de Marchi S, Fuerholz M, et al. Clinical outcomes of Watchman vs. Amplatzer occluders for left atrial appendage closure (WATCH at LAAC). Europace. 2020;22(6):916–23.

Bai Y, Zhang S, Qin YW, Zhao XX. Percutaneous occlusion of transseptal puncture-related free wall perforation at the coronary sinus with a ventricular septal occluder during left atrial appendage closure: A case report. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 2020;96(7):E755–7.

Article  Google Scholar 

Reddy VY, Doshi SK, Kar S, Gibson DN, Price MJ, Huber K, et al. 5-Year Outcomes After Left Atrial Appendage Closure: From the PREVAIL and PROTECT AF Trials. J Am Coll Cardiol. 2017;70(24):2964–75.

Article  PubMed  Google Scholar 

Price MJ, Slotwiner D, Du C, Freeman JV, Turi Z, Rammohan C, et al. Clinical Outcomes at 1 Year Following Transcatheter Left Atrial Appendage Occlusion in the United States. JACC Cardiovasc Interv. 2022;15(7):741–50.

Article  PubMed  PubMed Central  Google Scholar 

Nielsen-Kudsk JE, Korsholm K, Damgaard D, Valentin JB, Diener HC, Camm AJ, et al. Clinical Outcomes Associated With Left Atrial Appendage Occlusion Versus Direct Oral Anticoagulation in Atrial Fibrillation. JACC Cardiovasc Interv. 2021;14(1):69–78.

Article  PubMed  Google Scholar 

Hildick-Smith D, Landmesser U, Camm AJ, Diener HC, Paul V, Schmidt B, et al. Left atrial appendage occlusion with the Amplatzer™ Amulet™ device: full results of the prospective global observational study. Eur Heart J. 2020;41(30):2894–901.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Romiti GF, Corica B, Mei DA, Bisson A, Boriani G, Olshansky B, et al. Patterns of comorbidities in patients with atrial fibrillation and impact on management and long-term prognosis: an analysis from the Prospective Global GLORIA-AF Registry. BMC Med. 2024;22(1):151.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simard TJ, Hibbert B, Alkhouli MA, Abraham NS, Holmes DR Jr. Device-related thrombus following left atrial appendage occlusion. EuroIntervention. 2022;18(3):224–32.

Article  PubMed  Google Scholar 

Asmarats L, Cruz-González I, Nombela-Franco L, Arzamendi D, Peral V, Nietlispach F, et al. Recurrence of Device-Related Thrombus After Percutaneous Left Atrial Appendage Closure. Circulation. 2019;140(17):1441–3.

Article  PubMed  Google Scholar 

Aggarwal R, Ruff CT, Virdone S, Perreault S, Kakkar AK, Palazzolo MG, et al. Development and Validation of the DOAC Score: A Novel Bleeding Risk Prediction Tool for Patients With Atrial Fibrillation on Direct-Acting Oral Anticoagulants. Circulation. 2023;148(12):936–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mei DA, Imberti JF, Bonini N, Romiti GF, Corica B, Proietti M, et al. Performance of HAS-BLED and DOAC scores to predict major bleeding events in atrial fibrillation patients treated with direct oral anticoagulants: A report from a prospective European observational registry. Eur J Intern Med. 2024;128:63–70.

Article  CAS  PubMed  Google Scholar 

Galea R, De Marco F, Meneveau N, Aminian A, Anselme F, Gräni C, et al. Amulet or Watchman Device for Percutaneous Left Atrial Appendage Closure: Primary Results of the SWISS-APERO Randomized Clinical Trial. Circulation. 2022;145(10):724–38.

Article  PubMed  Google Scholar 

Reddy VY, Gibson DN, Kar S, O'Neill W, Doshi SK, Horton RP, et al. Post-Approval U.S. Experience With Left Atrial Appendage Closure for Stroke Prevention in Atrial Fibrillation. J Am Coll Cardiol. 2017;69(3):253–61.

Freeman JV, Varosy P, Price MJ, Slotwiner D, Kusumoto FM, Rammohan C, et al. The NCDR Left Atrial Appendage Occlusion Registry. J Am Coll Cardiol. 2020;75(13):1503–18.

Article  PubMed  PubMed Central  Google Scholar 

Dukkipati SR, Kar S, Holmes DR, Doshi SK, Swarup V, Gibson DN, et al. Device-Related Thrombus After Left Atrial Appendage Closure: Incidence, Predictors, and Outcomes. Circulation. 2018;138(9):874–85.

Article  PubMed  Google Scholar 

Alkhouli M, Busu T, Shah K, Osman M, Alqahtani F, Raybuck B. Incidence and Clinical Impact of Device-Related Thrombus Following Percutaneous Left Atrial Appendage Occlusion: A Meta-Analysis. JACC Clinical electrophysiology. 2018;4(12):1629–37.

Article  PubMed  Google Scholar 

Saw J, Tzikas A, Shakir S, Gafoor S, Omran H, Nielsen-Kudsk JE, et al. Incidence and Clinical Impact of Device-Associated Thrombus and Peri-Device Leak Following Left Atrial Appendage Closure With the Amplatzer Cardiac Plug. JACC: Cardiovascular Interventions. 2017;10(4):391–9.

Plicht B, Konorza TF, Kahlert P, Al-Rashid F, Kaelsch H, Jánosi RA, et al. Risk factors for thrombus formation on the Amplatzer Cardiac Plug after left atrial appendage occlusion. JACC Cardiovasc Interv. 2013;6(6):606–13.

Article  PubMed  Google Scholar 

Saw J, Nielsen-Kudsk JE, Bergmann M, Daniels MJ, Tzikas A, Reisman M, et al. Antithrombotic Therapy and Device-Related Thrombosis Following Endovascular Left Atrial Appendage Closure. JACC: Cardiovascular Interventions. 2019;12(11):1067–76.

Simard T, Jung RG, Lehenbauer K, Piayda K, Pracoń R, Jackson GG, et al. Predictors of Device-Related Thrombus Following Percutaneous Left Atrial Appendage Occlusion. J Am Coll Cardiol. 2021;78(4):297–313.

Article  PubMed  Google Scholar 

Tzikas A, Shakir S, Gafoor S, Omran H, Berti S, Santoro G, et al. Left atrial appendage occlusion for stroke prevention in atrial fibrillation: multicentre experience with the AMPLATZER Cardiac Plug. EuroIntervention. 2016;11(10):1170–9.

Article  PubMed  Google Scholar 

Korsholm K, Jensen JM, Nørgaard BL, Samaras A, Saw J, Berti S, et al. Peridevice Leak Following Amplatzer Left Atrial Appendage Occlusion: Cardiac Computed Tomography Classification and Clinical Outcomes. JACC Cardiovasc Interv. 2021;14(1):83–93.

Article  PubMed  Google Scholar 

Dukkipati SR, Holmes DR Jr, Doshi SK, Kar S, Singh SM, Gibson D, et al. Impact of Peridevice Leak on 5-Year Outcomes After Left Atrial Appendage Closure. J Am Coll Cardiol. 2022;80(5):469–83.

Article  PubMed  Google Scholar