Front. Oncol.

Sec. Surgical Oncology

Volume 14 - 2024 | doi: 10.3389/fonc.2024.1456920

Provisionally accepted

The final, formatted version of the article will be published soon.

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Introduction: Low grade appendiceal mucinous neoplasms (LAMN) are indolent tumors that lack invasive potential but may present as pseudomyxoma peritonei. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) significantly improves both overall and recurrence free survival. While systemic chemotherapy is generally considered ineffective for LAMN, little literature is available to support this notion. We evaluated outcomes for individuals with LAMN who did and did not receive systemic chemotherapy in combination with CRS+HIPEC.Methods: A multicenter retrospective cohort study was performed using the US HIPEC Collaborative that included patients with LAMN who underwent CRS+HIPEC. The overall survival (OS) and recurrence-free survival (RFS) of patients who did and did not receive systemic chemotherapy were compared. Survival and variables associated with survival were evaluated with the Kaplan-Meier analysis and cox regression, respectively.Results: Among the 529 included patients with LAMN, 63 (11.9%) received systemic chemotherapy and CRS+HIPEC, while 466 (88.1%) were treated with only CRS+HIPEC.Patients selected for systemic chemotherapy had a higher burden of disease (mean peritoneal cancer index: 18.8 +/-8.6 versus 14.3 +/-8.8, p

Keywords: HIPEC, Cytoreductive surgery, low grade appendiceal mucinous neoplasm, LAMN, chemotherapy

Received: 29 Jun 2024; Accepted: 13 Dec 2024.

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