D. Schadendorf, A.C.J. van Akkooi, C. Berking et al., Melanoma Lancet. 392(10151), 971–984 (2018)

Article  PubMed  Google Scholar 

R.L. Siegel, K.D. Miller, N.S. Wagle, A. Jemal, Cancer statistics, 2023. CA: Cancer J. Clin. 73(1), 17–48 (2023)

Google Scholar 

A. Benito-Martín, M.G. Jasiulionis, S. García-Silva, Extracellular vesicles and melanoma: new perspectives on tumor microenvironment and metastasis. Front. Cell. Dev. Biol. 10, 1061982 (2023)

Article  PubMed  PubMed Central  Google Scholar 

J.Y. Song, Y.J. Ryu, H.K. Lee et al., Risk factors for sentinel lymph node metastasis in Korean acral and non-acral melanoma patients. Pigment Cell. Melanoma Res. 00, 1–11 (2023)

Google Scholar 

D. Bellomo, S.M. Arias-Mejias, C. Ramana et al., Model combining Tumor Molecular and clinicopathologic risk factors predicts Sentinel Lymph Node Metastasis in primary cutaneous melanoma. JCO Precis Oncol. 4, 319–334 (2020)

Article  PubMed  Google Scholar 

D.L. Morton, J.F. Thompson, A.J. Cochran et al., Final trial report of sentinel-node biopsy versus nodal observation in melanoma. N Engl. J. Med. 370(7), 599–609 (2014)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.E. Gershenwald, R.A. Scolyer, K.R. Hess et al., Melanoma staging: evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA Cancer J. Clin. 67(6), 472–492 (2017)

Article  PubMed  PubMed Central  Google Scholar 

A.C. Huang, R. Zappasodi, A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance. Nat. Immunol. 23(5), 660–670 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

P. Malvi, R. Janostiak, A. Nagarajan, X. Zhang, N. Wajapeyee, N-acylsphingosine amidohydrolase 1 promotes melanoma growth and metastasis by suppressing peroxisome biogenesis-induced ROS production. Mol. Metab. 48, 101217 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S.A. Weiss, J.D. Wolchok, M. Sznol, Immunotherapy of Melanoma: facts and hopes. Clin. Cancer Res. 25(17), 5191–5201 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

L. Yang, D. Wang, H. Jia et al., Tumor-specific peroxynitrite overproduction disrupts metabolic homeostasis for sensitizing melanoma immunotherapy. Adv. Mater. 35(29), e2301455 (2023)

K. DePeaux, G.M. Delgoffe, Metabolic barriers to cancer immunotherapy. Nat. Rev. Immunol. 21(12), 785–797 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

R. Zappasodi, I. Serganova, I.J. Cohen et al., CTLA-4 blockade drives loss of T(reg) stability in glycolysis-low tumours. Nature. 591(7851), 652–658 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

H. Peinado, H. Zhang, I.R. Matei et al., Pre-metastatic niches: organ-specific homes for metastases. Nat. Rev. Cancer. 17(5), 302–317 (2017)

Article  CAS  PubMed  Google Scholar 

R. Gowda, B.M. Robertson, S. Iyer et al., The role of exosomes in metastasis and progression of melanoma. Cancer Treat. Rev. 85, 101975 (2020)

Article  CAS  PubMed  Google Scholar 

L.C. Dieterich, Mechanisms of extracellular vesicle-mediated immune evasion in melanoma. Front. Immunol. 13, 1002551 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

F. Pucci, C. Garris, C.P. Lai et al., SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science. 352(6282), 242–246 (2016)

Article  CAS  PubMed  PubMed Central  Google Scholar 

L.C. Dieterich, C. Tacconi, L. Ducoli, Detmar. Lymphatic vessels in cancer. Physiol. Rev. 102(4), 1837–1879 (2022)

Article  CAS  PubMed  Google Scholar 

S. Suman, S.N. Markovic, Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis. Trends Immunol. 44(9), 724–743 (2023)

Article  CAS  PubMed  PubMed Central  Google Scholar 

N. Leary, S. Walser, Y. He et al., Melanoma-derived extracellular vesicles mediate lymphatic remodelling and impair tumour immunity in draining lymph nodes. J. Extracell. Vesicles 11(2), e12197 (2022)

S.P. Leong, K. Naxerova, L. Keller, K. Pantel, M. Witte, Molecular mechanisms of cancer metastasis via the lymphatic versus the blood vessels. Clin. Exp. Metastasis. 39(1), 159–179 (2022)

Article  CAS  PubMed  Google Scholar 

A.S. Mansfield, S.G. Holtan, T.E. Grotz et al., Regional immunity in melanoma: immunosuppressive changes precede nodal metastasis. Mod. Pathol. 24(4), 487–494 (2011)

Article  CAS  PubMed  Google Scholar 

A. Riedel, D. Shorthouse, L. Haas, B.A. Hall, J. Shields, Tumor-induced stromal reprogramming drives lymph node transformation. Nat. Immunol. 17(9), 1118–1127 (2016)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Gassenmaier, T.K. Eigentler, U. Keim et al., Serial or parallel metastasis of cutaneous melanoma? A study of the German Central Malignant Melanoma Registry. J. Invest. Dermatol. 137(12), 2570–2577 (2017)

Article  CAS  PubMed  Google Scholar 

L. Calomarde-Rees, R. García-Calatayud, C. Requena Caballero et al., Risk factors for lymphatic and hematogenous dissemination in patients with stages I to II cutaneous melanoma. JAMA Dermatol. 155(6), 679 (2019)

Article  PubMed  PubMed Central  Google Scholar 

J.M. Ubellacker, A. Tasdogan, V. Ramesh et al., Lymph protects metastasizing melanoma cells from ferroptosis. Nature. 585(7823), 113–118 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

L.R. Arslanbaeva, M.M. Santoro, Adaptive redox homeostasis in cutaneous melanoma. Redox Biol. 37, 101753 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M. Emanuelli, D. Sartini, E. Molinelli et al., The double-edged Sword of oxidative stress in skin damage and melanoma: from physiopathology to Therapeutical approaches. Antioxid. (Basel). 11(4), 612 (2022)

Article  CAS  Google Scholar 

F. Liu-Smith, R. Dellinger, F.L. Meyskens, Updates of reactive oxygen species in melanoma etiology and progression. Arch. Biochem. Biophys. 563, 51–55 (2014)

Article  CAS  PubMed  Google Scholar 

M. Benlloch, S. Mena, P. Ferrer et al., Bcl-2 and Mn-SOD antisense oligodeoxynucleotides and a glutamine-enriched Diet facilitate elimination of highly resistant B16 melanoma cells by Tumor Necrosis Factor-α and chemotherapy. J. Biol. Chem. 281(1), 69–79 (2006)

Article  CAS  PubMed  Google Scholar 

Y. Yu, D. Ladeiras, Y. Xiong et al., Arginase-II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling. J. Cell. Physiol. 235(12), 9997–10011 (2020)

Article  CAS  PubMed  Google Scholar 

C. Luo, J. Lim, Y. Lee et al., A PGC1α-mediated transcriptional axis suppresses melanoma metastasis. Nature. 537(7620), 422–426 (2016)

Article  CAS  PubMed  PubMed Central  Google Scholar 

C. Jessen, J.K.C. Kreß, A. Baluapuri et al., The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression. Oncogene. 39(44), 6841–6855 (2020)

Article