Emerging role of Nrf2 in Parkinson’s disease therapy: a critical reassessment

Abdelsalam RM, Safar MM (2015) Neuroprotective effects of vildagliptin in rat rotenone Parkinson’s disease model: role of RAGE-NF κB and Nrf2‐antioxidant signaling pathways. J Neurochem 133(5):700–707. https://doi.org/10.1111/jnc.13087

Article  CAS  PubMed  Google Scholar 

Alural B, Ozerdem A, Allmer J, Genc K, Genc S (2015) Lithium protects against paraquat neurotoxicity by NRF2 activation and miR-34a inhibition in SH-SY5Y cells. Front Cell Neurosci 9:209

Article  PubMed  PubMed Central  Google Scholar 

Allen Reish HE, Standaert DG (2015) Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease. Journal of Parkinson’s disease 5(1):1–9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anis E, Zafeer MF, Firdaus F, Islam SN, Khan AA, Hossain MM (2020) Perillyl alcohol mitigates behavioural changes and limits cell death and mitochondrial changes in unilateral 6-OHDA lesion model of Parkinson’s disease through alleviation of oxidative stress. Neurotox Res 38:461–477

Article  CAS  PubMed  Google Scholar 

Arab HH, Safar MM, Shahin NN (2021) Targeting ROS-dependent Akt/GSK-3β/NF-κB and DJ-1/Nrf2 pathways by dapagliflozin attenuates neuronal injury and motor dysfunction in rotenone-induced Parkinson’s disease rat model. ACS Chem Neurosci 12(4):689–703

Article  CAS  PubMed  Google Scholar 

Armeli F, Mengoni B, Laskin DL, Businaro R (2024) Interplay among oxidative stress, Autophagy, and the Endocannabinoid System in neurodegenerative diseases: role of the Nrf2-p62/SQSTM1 pathway and nutraceutical activation. Curr Issues Mol Biol 46(7):6868

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arruri VK, Gundu C, Kalvala AK, Sherkhane B, Khatri DK, Singh SB (2022) Carvacrol abates NLRP3 inflammasome activation by augmenting Keap1/Nrf-2/p62 directed autophagy and mitochondrial quality control in neuropathic pain. Nutr Neurosci 25(8):1731–1746

Article  CAS  PubMed  Google Scholar 

Bae EJ, Ho DH, Park E, Jung JW, Cho K, Hong JH, Lee HJ, Kim KP, Lee SJ (2013) Lipid peroxidation product 4-hydroxy-2-nonenal promotes seeding-capable oligomer formation and cell-to-cell transfer of α-synuclein. Antioxid Redox Signal 18(7):770–783. https://doi.org/10.1089/ars.2011.4429

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bai J, Yu XJ, Liu KL, Wang FF, Jing GX, Li HB, Zhang Y, Huo CJ, Li X, Gao HL, Qi J (2017) Central administration of tert-butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats. Toxicol Appl Pharmcol 333:100–109

Article  CAS  Google Scholar 

Baluchnejadmojarad T, Rabiee N, Zabihnejad S, Roghani M (2017) Ellagic acid exerts protective effect in intrastriatal 6-hydroxydopamine rat model of Parkinson’s disease: possible involvement of ERβ/Nrf2/HO-1 signaling. Brain Res 1662:23–30

Article  CAS  PubMed  Google Scholar 

Bao B, Zhang MQ, Chen ZY, Wu XB, Xia ZB, Chai JY, Yin XP (2019) Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway. Mol Med Rep 19(6):4890–4896

CAS  PubMed  PubMed Central  Google Scholar 

Behl T, Kaur G, Fratila O, Buhas C, Judea-Pusta CT, Negrut N, Bustea C, Bungau S (2021a) Cross-talks among GBA mutations, glucocerebrosidase, and α-synuclein in GBA-associated Parkinson’s disease and their targeted therapeutic approaches: a comprehensive review. Translational Neurodegeneration 10:1–3

Article  Google Scholar 

Behl T, Kaur G, Sehgal A, Bhardwaj S, Singh S, Buhas C, Judea-Pusta C, Uivarosan D, Munteanu MA, Bungau S (2021b) Multifaceted role of matrix metalloproteinases in neurodegenerative diseases: pathophysiological and therapeutic perspectives. Int J Mol Sci 22(3):1413

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bjørklund G, Peana M, Maes M, Dadar M, Severin B (2021) The glutathione system in Parkinson’s disease and its progression. Neurosci Biobehavioral Reviews 120:470–478

Article  Google Scholar 

Cao B, Zhang Y, Chen J, Wu P, Dong Y, Wang Y (2022) Neuroprotective effects of liraglutide against inflammation through the AMPK/NF-κB pathway in a mouse model of Parkinson’s disease. Metab Brain Dis 37(2):451–462. https://doi.org/10.1007/s11011-021-00879-1

Article  CAS  PubMed  Google Scholar 

Chakkittukandiyil A, Sajini DV, Karuppaiah A, Selvaraj D (2022) The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson’s disease. Neurochem Int 156:105325

Article  CAS  PubMed  Google Scholar 

Chen JH, Ou HP, Lin CY, Lin FJ, Wu CR, Chang SW, Tsai CW (2012) Carnosic acid prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells via mediation of glutathione synthesis. Chem Res Toxicol 25(9):1893–1901

Article  CAS  PubMed  Google Scholar 

Chen J, Xu J, Huang P, Luo Y, Shi Y, Ma P (2022) The potential applications of traditional Chinese medicine in Parkinson’s disease: a new opportunity. Biomed Pharmacother 149:112866

Article  CAS  PubMed  Google Scholar 

Choi JH, Jang M, Lee JI, Chung WS, Cho IH (2018) Neuroprotective effects of a traditional multi-herbal medicine kyung-ok-ko in an animal model of Parkinson’s disease: inhibition of MAPKs and NF-κB pathways and activation of keap1-Nrf2 pathway. Front Pharmacol 9:1444

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi EH, Kim MH, Park SJ (2024) Targeting mitochondrial dysfunction and reactive oxygen species for neurodegenerative Disease treatment. Int J Mol Sci 25(14):7952

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coukos R, Krainc D (2024) Key genes and convergent pathogenic mechanisms in Parkinson disease. Nat Reviews Neurosci 25(6), 393–413.

Cuadrado A, Moreno-Murciano P, Pedraza-Chaverri J (2009) The transcription factor Nrf2 as a new therapeutic target in Parkinson’s disease. Expert Opin Ther Targets 13(3):319–329

Article  CAS  PubMed  Google Scholar 

Cuadrado A, Manda G, Hassan A, Alcaraz MJ, Barbas C, Daiber A, Ghezzi P, León R, López MG, Oliva B, Pajares M (2018) Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach. Pharmacol Rev 70(2):348–383

Article  CAS  PubMed  Google Scholar 

Curry DW, Stutz B, Andrews ZB, Elsworth JD (2018) Targeting AMPK signaling as a neuroprotective strategy in Parkinson’s disease. J Parkinson’s Disease 8(2):161–181

Article  Google Scholar 

dos Santos Nunes RG, Pereira PS, Elekofehinti OO, Fidelis KR, da Silva CS, Ibrahim M, Barros LM, da Cunha FA, Lukong KE, de Menezes IR, Tsopmo A (2019) Possible involvement of transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effect of caffeic acid on paraquat-induced oxidative damage in Drosophila melanogaster. Pestic Biochem Physiol 157:161–168

Article  PubMed  Google Scholar 

Fão L, Mota SI, Rego AC (2019) Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases. Ageing Res Rev 54:100942

Article  PubMed  Google Scholar 

Fukutomi T, Takagi K, Mizushima T, Ohuchi N, Yamamoto M (2014) Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1. Molecular and cellular biology. 34(5):832–846. https://doi.org/10.1128/MCB.01191-13

Gaballah HH, Zakaria SS, Elbatsh MM, Tahoon NM (2016) Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson’s disease. Chemico-Biol Interact 251:10–16

Article  CAS  Google Scholar 

Guo C, Zhu J, Wang J, Duan J, Ma S, Yin Y, Quan W, Zhang W, Guan Y, Ding Y, Wen A (2019) Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson’s disease. Aging 11(21):9424

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hao S, Cho BO, Wang F, Shin JY, Shin DJ, Jang SI (2022) Zingiber officinale attenuates 6-hydroxydopamine induced oxidative stress and apoptosis through AKT, Nrf2, MAPK, NF-κB signaling pathway in PC12 cells. Food Sci Technol. 42,: e11122142.

Houldsworth A (2024) Role of oxidative stress in neurodegenerative disorders: a review of reactive oxygen species and prevention by antioxidants. Brain Commun 6(1):fcad356

Article  PubMed  PubMed Central  Google Scholar 

Huang LP, Deng MZ, He YP, Fang YQ (2015) β-asarone and levodopa co‐administration protects against 6‐hydroxydopamine‐induced damage in parkinsonian rat mesencephalon by regulating autophagy: down‐expression Beclin‐1 and light chain 3B and up‐expression P62. Clin Exp Pharmacol Physiol 42(3):269–277. https://doi.org/10.1111/1440-1681.12344

Article  CAS 

留言 (0)

沒有登入
gif